WO2007022255A3 - Pharmaceutical formulations for sustained release - Google Patents

Pharmaceutical formulations for sustained release Download PDF

Info

Publication number
WO2007022255A3
WO2007022255A3 PCT/US2006/031968 US2006031968W WO2007022255A3 WO 2007022255 A3 WO2007022255 A3 WO 2007022255A3 US 2006031968 W US2006031968 W US 2006031968W WO 2007022255 A3 WO2007022255 A3 WO 2007022255A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
pharmaceutically active
sustained release
pharmaceutical formulations
methods
Prior art date
Application number
PCT/US2006/031968
Other languages
French (fr)
Other versions
WO2007022255A2 (en
Inventor
Nicholas Barker
Janet L Wolfe
Original Assignee
Praecis Pharm Inc
Nicholas Barker
Janet L Wolfe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/205,296 external-priority patent/US20060293217A1/en
Application filed by Praecis Pharm Inc, Nicholas Barker, Janet L Wolfe filed Critical Praecis Pharm Inc
Publication of WO2007022255A2 publication Critical patent/WO2007022255A2/en
Publication of WO2007022255A3 publication Critical patent/WO2007022255A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Abstract

Sustained delivery pharmaceutical compositions comprising a solid ionic complex of a pharmaceutically active compound and an ionic macromolecule are provided by the present invention. The pharmaceutical compositions of the invention allow for loading of high concentrations of pharmaceutically active compounds and for delivery of a pharmaceutically active compound for prolonged periods of time, e.g., one month, after administration. Methods for preparing these pharmaceutical compositions, as well as methods of using them to treat a subject are also provided.
PCT/US2006/031968 2005-08-15 2006-08-15 Pharmaceutical formulations for sustained release WO2007022255A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/205,296 US20060293217A1 (en) 2001-03-19 2005-08-15 Pharmaceutical formulations for sustained release
US11/205,296 2005-08-15
US11/265,519 2005-11-02
US11/265,519 US20060198815A1 (en) 2001-03-19 2005-11-02 Pharmaceutical formulations for sustained release

Publications (2)

Publication Number Publication Date
WO2007022255A2 WO2007022255A2 (en) 2007-02-22
WO2007022255A3 true WO2007022255A3 (en) 2007-06-14

Family

ID=37758338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031968 WO2007022255A2 (en) 2005-08-15 2006-08-15 Pharmaceutical formulations for sustained release

Country Status (2)

Country Link
US (1) US20060198815A1 (en)
WO (1) WO2007022255A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
JP4031232B2 (en) * 2001-11-09 2008-01-09 カプスゲル・ジャパン株式会社 New capsule
EP2150242A2 (en) * 2007-04-20 2010-02-10 Wockhardt Research Centre Pharmaceutical compositions of duloxetine
EP2018864A1 (en) 2007-07-23 2009-01-28 Biomet Deutschland GmbH Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
PL2344329T3 (en) 2008-10-02 2013-05-31 Mylan Inc Method of making a multilayer adhesive laminate
WO2010133961A1 (en) 2009-05-22 2010-11-25 Inventia Healthcare Private Limited Extended release compositions of cyclobenzaprine
AU2010312309B2 (en) 2009-10-26 2016-10-06 Thomas Julius Borody Novel enteric combination therapy
EP2506709B2 (en) 2009-12-02 2019-10-09 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
WO2014204933A1 (en) 2013-06-17 2014-12-24 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
CN105310985B (en) * 2014-07-28 2018-06-08 洛阳惠中兽药有限公司 A kind of pharmaceutical composition and its preparation method and application
WO2017048566A1 (en) * 2015-09-15 2017-03-23 C.B. Fleet Company, Incorporated Bisacodyl compositions and delivery apparatus
CN105343009B (en) * 2015-11-09 2019-02-12 苏州维高能生物技术有限公司 Rupatadine fumarate taste masking dry suspensoid agent
CN110799516A (en) 2017-04-20 2020-02-14 来兴泰德基金会 Azithromycin derivatives containing phosphonium ions as anticancer agents
CN111148750A (en) 2017-04-20 2020-05-12 来兴泰德基金会 Azithromycin derivatives containing phosphonium ions as anticancer agents
MX2020002078A (en) 2017-08-24 2020-09-21 Adamas Pharma Llc Amantadine compositions, preparations thereof, and methods of use.
US11541120B2 (en) 2017-12-05 2023-01-03 Anthos Partners, Lp Phosphonium-based ionic drug conjugates
CN112444497A (en) * 2020-10-23 2021-03-05 马鞍山丰原制药有限公司 Method for detecting dobutamine hydrochloride content

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466038A1 (en) * 1990-07-12 1992-01-15 E.R. SQUIBB & SONS, INC. Water-dispersible polyene antifungal complexes
US6180608B1 (en) * 1996-12-11 2001-01-30 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
WO2002074247A2 (en) * 2001-03-19 2002-09-26 Praecis Pharmaceuticals Incorporated Pharmaceutical formulations for sustained release

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187703B1 (en) * 1985-01-11 1992-08-05 Teijin Limited Sustained release preparation
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
US5162110A (en) * 1990-12-19 1992-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Binding theophylline to ion exchange resins
US6063405A (en) * 1995-09-29 2000-05-16 L.A.M. Pharmaceuticals, Llc Sustained release delivery system
US5830883A (en) * 1995-11-06 1998-11-03 Duquesne University Of The Holy Ghost Methods of creating a unique chitosan and employing the same to form complexes with drugs, delivery of the same within a patient and a related dosage form

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466038A1 (en) * 1990-07-12 1992-01-15 E.R. SQUIBB & SONS, INC. Water-dispersible polyene antifungal complexes
US6180608B1 (en) * 1996-12-11 2001-01-30 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20030171296A1 (en) * 1996-12-11 2003-09-11 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
WO2002074247A2 (en) * 2001-03-19 2002-09-26 Praecis Pharmaceuticals Incorporated Pharmaceutical formulations for sustained release

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LELE B S ET AL: "INSOLUBLE IONIC COMPLEXES OF POLYACRYLIC ACID WITH A CATIONIC DRUG FOR USE AS A MUCOADHESIVE, OPHTHALMIC DRUG DELIVERY SYSTEM", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION, VSP, UTRECHT, NL, vol. 11, no. 12, 2000, pages 1319 - 1331, XP008058523, ISSN: 0920-5063 *

Also Published As

Publication number Publication date
US20060198815A1 (en) 2006-09-07
WO2007022255A2 (en) 2007-02-22

Similar Documents

Publication Publication Date Title
WO2007022255A3 (en) Pharmaceutical formulations for sustained release
WO2002074247A8 (en) Pharmaceutical formulations for sustained release
WO2005112633A3 (en) Compounds and compositions for delivering active agents
WO2007021970A3 (en) Stable pharmaceutical formulations and methods of use thereof
BRPI0508579A (en) compound, pharmaceutical composition, and use of a compound
WO2008057802A3 (en) Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
WO2008063910A3 (en) Method of preparing solid dosage forms of multi-phasic pharmaceutical compositions
WO2006067614A3 (en) Heteroaromatic derivatives useful as anticancer agents
WO2010065709A3 (en) Hydroxamic acid derivatives, preparation and therapeutic uses thereof
WO2011014850A3 (en) Topical eutectic-based formulations
MY143795A (en) Tetrahydropyridoindole derivatives
WO2009115178A3 (en) Gingival wafer
WO2006082523A3 (en) Pharmaceutical sustained release composition of metformin
MX2010010647A (en) Process for preparing orally administered dabigatran formulations.
ZA200809864B (en) Pharmaceutical formulations for the sustained release of active ingredients(s), as well as their applications, especially therapeutic
WO2007014124A3 (en) High drug load formulations and dosage forms
WO2007075825A3 (en) Lipophilic anticancer drug compounds
WO2007016388A3 (en) Liquid formulations for controlled delivery of benzisoxazole derivatives
WO2007146293A3 (en) Improved composition and method for taste masking
WO2007090661A3 (en) Active substance combination comprising azolylcarbinol compounds
WO2006134021A3 (en) Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
MX2010004556A (en) Pharmaceutical formulation of clavulanic acid.
WO2006102533A3 (en) Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates
WO2007087026A3 (en) Solid-state form of amg 706 and pharmaceutical compositions thereof
WO2007009691A3 (en) Combination of substituted pyrazolines and anti -addictive agent

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06801617

Country of ref document: EP

Kind code of ref document: A2