WO2007024628A3 - Ply-gbs mutant lysins - Google Patents

Ply-gbs mutant lysins Download PDF

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Publication number
WO2007024628A3
WO2007024628A3 PCT/US2006/032176 US2006032176W WO2007024628A3 WO 2007024628 A3 WO2007024628 A3 WO 2007024628A3 US 2006032176 W US2006032176 W US 2006032176W WO 2007024628 A3 WO2007024628 A3 WO 2007024628A3
Authority
WO
WIPO (PCT)
Prior art keywords
gbs
lysins
piygbs
streptococci
bacteria
Prior art date
Application number
PCT/US2006/032176
Other languages
French (fr)
Other versions
WO2007024628A2 (en
Inventor
Vincent A Fischetti
Qi Cheng
Original Assignee
Univ Rockefeller
Vincent A Fischetti
Qi Cheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller, Vincent A Fischetti, Qi Cheng filed Critical Univ Rockefeller
Priority to US12/064,428 priority Critical patent/US8105585B2/en
Priority to JP2008527998A priority patent/JP2009506033A/en
Priority to DE602006018746T priority patent/DE602006018746D1/en
Priority to AT06813511T priority patent/ATE491026T1/en
Priority to EP06813511A priority patent/EP1917355B1/en
Priority to CA002620903A priority patent/CA2620903A1/en
Publication of WO2007024628A2 publication Critical patent/WO2007024628A2/en
Publication of WO2007024628A3 publication Critical patent/WO2007024628A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods, compositions and articles of manufacture useful for the treatment of various Group B streptococci (GBS) bacteria are provided. Various bacterial lysins, including certain PIyGBS mutant lysins, are provided. In particular, PIyGBS mutant lysins having lytic killing activity against Group B streptococci (GBS) bacteria are provided, including PIyGBS mutant lysins with greater killing activity against Group B streptococci (GBS) bacteria than the non- mutated PIyGBS bacterial lysin.
PCT/US2006/032176 2005-08-24 2006-08-17 Ply-gbs mutant lysins WO2007024628A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/064,428 US8105585B2 (en) 2005-08-24 2006-08-17 Ply-GBS mutant lysins
JP2008527998A JP2009506033A (en) 2005-08-24 2006-08-17 PLY-GBS mutant lysin
DE602006018746T DE602006018746D1 (en) 2005-08-24 2006-08-17 PLY-GBS MUTANT LYSINE
AT06813511T ATE491026T1 (en) 2005-08-24 2006-08-17 PLY-GBS-LYSINE MUTANTS
EP06813511A EP1917355B1 (en) 2005-08-24 2006-08-17 Ply-gbs mutant lysins
CA002620903A CA2620903A1 (en) 2005-08-24 2006-08-17 Ply-gbs mutant lysins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71093605P 2005-08-24 2005-08-24
US60/710,936 2005-08-24

Publications (2)

Publication Number Publication Date
WO2007024628A2 WO2007024628A2 (en) 2007-03-01
WO2007024628A3 true WO2007024628A3 (en) 2007-06-14

Family

ID=37772174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032176 WO2007024628A2 (en) 2005-08-24 2006-08-17 Ply-gbs mutant lysins

Country Status (9)

Country Link
US (1) US8105585B2 (en)
EP (2) EP2360248A1 (en)
JP (1) JP2009506033A (en)
CN (1) CN101297034A (en)
AT (1) ATE491026T1 (en)
CA (1) CA2620903A1 (en)
DE (1) DE602006018746D1 (en)
ES (1) ES2357626T3 (en)
WO (1) WO2007024628A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389469B2 (en) * 2005-06-06 2013-03-05 The Rockefeller University Bacteriophage lysins for Bacillus anthracis
CA2620903A1 (en) 2005-08-24 2007-03-01 The Rockefeller University Ply-gbs mutant lysins
AU2009266982B2 (en) * 2008-07-03 2015-06-25 The Rockefeller University A chimeric bacteriophage lysin with activity against staphylococci bacteria
CN108578685A (en) 2011-04-21 2018-09-28 洛克菲勒大学 The streptococcus bacteriophage lysin for detecting and treating for gram-positive bacteria
DK2764093T3 (en) 2011-10-05 2018-07-30 Univ Rockefeller DIMER BACTERYPHAGE LYSINES
CN102516398B (en) * 2011-12-27 2014-07-16 中国科学院遗传与发育生物学研究所 Method for constructing anti-mammitis transgenic mouse model and special vector for method
DK2846827T3 (en) 2012-05-09 2019-05-13 Contrafect Corp BIOFILESES INTEGRATION WITH PLYSS2 LYSIN
KR20230113404A (en) 2012-05-09 2023-07-28 콘트라펙트 코포레이션 Bacteriophage lysin and antibiotic combinations against gram positive bacteria
DE102013106455A1 (en) 2013-06-20 2014-12-24 Airbus Defence and Space GmbH Method for decontamination of bacteriological contaminants
CA3023730A1 (en) 2016-05-12 2017-11-16 Contrafect Corporation Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides
CN107083434B (en) * 2017-06-05 2020-09-08 武汉赛思锐微生物技术有限公司 Sample pretreatment method for non-diagnosis-purpose fluorescent PCR quantitative detection of group B streptococcus
EA202090748A1 (en) * 2017-06-16 2020-08-11 Борис Славинович ФАРБЕР BIOLOGICALLY ACTIVE COMBINATORY POLYSACCHARIDE DERIVATIVES
EP3771463A1 (en) * 2019-07-29 2021-02-03 Ludwig-Maximilians-Universität München Stabilizing therapeutic proteins with piperazin- or morpholine-containing zwitterionic buffering substances
CN112501189A (en) * 2020-12-30 2021-03-16 吉林大学 Lyase capable of killing streptococcus equi subsp equi species and medical application thereof
KR20240015756A (en) * 2022-07-26 2024-02-06 주식회사 인트론바이오테크놀로지 Composition of Antibacterial Protein for Treating Bovine Mastitis

Citations (1)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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PRITCHARD D.G. ET AL.: "The bifunctional peptidoglycan lysin of Streptococcs agalactiae bacteriophage B30", MICROBIOLOGY, vol. 150, July 2004 (2004-07-01), pages 2079 - 2087, XP002344697 *

Also Published As

Publication number Publication date
EP1917355B1 (en) 2010-12-08
EP1917355A4 (en) 2009-05-27
EP2360248A1 (en) 2011-08-24
US20080221035A1 (en) 2008-09-11
DE602006018746D1 (en) 2011-01-20
CA2620903A1 (en) 2007-03-01
JP2009506033A (en) 2009-02-12
WO2007024628A2 (en) 2007-03-01
ES2357626T3 (en) 2011-04-28
CN101297034A (en) 2008-10-29
ATE491026T1 (en) 2010-12-15
EP1917355A2 (en) 2008-05-07
US8105585B2 (en) 2012-01-31

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