WO2007024976A3 - Virus coat protein/receptor chimeras and methods of use - Google Patents
Virus coat protein/receptor chimeras and methods of use Download PDFInfo
- Publication number
- WO2007024976A3 WO2007024976A3 PCT/US2006/032957 US2006032957W WO2007024976A3 WO 2007024976 A3 WO2007024976 A3 WO 2007024976A3 US 2006032957 W US2006032957 W US 2006032957W WO 2007024976 A3 WO2007024976 A3 WO 2007024976A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor
- virus
- chimeric
- coat protein
- chimeric molecules
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 101710132601 Capsid protein Proteins 0.000 title 1
- 101710094648 Coat protein Proteins 0.000 title 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 title 1
- 101710125418 Major capsid protein Proteins 0.000 title 1
- 101710141454 Nucleoprotein Proteins 0.000 title 1
- 101710083689 Probable capsid protein Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 3
- 102000005962 receptors Human genes 0.000 abstract 3
- 108010041397 CD4 Antigens Proteins 0.000 abstract 1
- 108010041986 DNA Vaccines Proteins 0.000 abstract 1
- 229940021995 DNA vaccine Drugs 0.000 abstract 1
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co- receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occupancy of a co-receptor present on the cell. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HIV, SIV, FIV, FeLV, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CD4 receptors, fragments and mimetic thereof. DNA vaccines comprising nucleotide sequences encoding for such chimeric molecules is another aspect of the present invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71064605P | 2005-08-23 | 2005-08-23 | |
US60/710,646 | 2005-08-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007024976A2 WO2007024976A2 (en) | 2007-03-01 |
WO2007024976A3 true WO2007024976A3 (en) | 2009-04-09 |
Family
ID=37772338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/032957 WO2007024976A2 (en) | 2005-08-23 | 2006-08-23 | Virus coat protein/receptor chimeras and methods of use |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007024976A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2324755B1 (en) * | 2007-04-04 | 2010-05-31 | Consejo Superior De Investigaciones Cientificas (Csic) | PROTEIN GP120 POLYPEPTIDE ABLE TO INHIBIT THE VITAL CYCLE OF AIDS VIRUS. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908612B2 (en) * | 1999-10-08 | 2005-06-21 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
US7311920B1 (en) * | 1999-10-08 | 2007-12-25 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
-
2006
- 2006-08-23 WO PCT/US2006/032957 patent/WO2007024976A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908612B2 (en) * | 1999-10-08 | 2005-06-21 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
US7311920B1 (en) * | 1999-10-08 | 2007-12-25 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
Non-Patent Citations (1)
Title |
---|
ZAGHOUANI ET AL.: "Induction of antibodies to the human immunodeficiency virus type 1 by immunization of baboons with immunoglobulin molecules carrying the principal.neutralizing determinant of the envelope protein", PROC. NATL. ACAD. SCI. U S A., vol. 92, January 1995 (1995-01-01), pages 631 - 635, XP002017328 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007024976A2 (en) | 2007-03-01 |
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