WO2007027843A3 - Nmr device for detection of analytes involving magnetic particles - Google Patents

Nmr device for detection of analytes involving magnetic particles Download PDF

Info

Publication number
WO2007027843A3
WO2007027843A3 PCT/US2006/033958 US2006033958W WO2007027843A3 WO 2007027843 A3 WO2007027843 A3 WO 2007027843A3 US 2006033958 W US2006033958 W US 2006033958W WO 2007027843 A3 WO2007027843 A3 WO 2007027843A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
magnetic particles
nmr device
liquid sample
involving magnetic
Prior art date
Application number
PCT/US2006/033958
Other languages
French (fr)
Other versions
WO2007027843A2 (en
Inventor
W David Lee
Original Assignee
Bioplex Systems Inc
W David Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioplex Systems Inc, W David Lee filed Critical Bioplex Systems Inc
Priority to AU2006284832A priority Critical patent/AU2006284832B2/en
Priority to EP06802676.4A priority patent/EP1932009B1/en
Priority to JP2008529259A priority patent/JP5295769B2/en
Priority to CA2620861A priority patent/CA2620861C/en
Publication of WO2007027843A2 publication Critical patent/WO2007027843A2/en
Publication of WO2007027843A3 publication Critical patent/WO2007027843A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/302—Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • G01R33/34053—Solenoid coils; Toroidal coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • G01R33/34061—Helmholtz coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • G01R33/34069—Saddle coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34084—Constructional details, e.g. resonators, specially adapted to MR implantable coils or coils being geometrically adaptable to the sample, e.g. flexible coils or coils comprising mutually movable parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/341—Constructional details, e.g. resonators, specially adapted to MR comprising surface coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34007—Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Abstract

This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.
PCT/US2006/033958 2005-08-31 2006-08-31 Nmr device for detection of analytes involving magnetic particles WO2007027843A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2006284832A AU2006284832B2 (en) 2005-08-31 2006-08-31 NMR device for detection of analytes involving magnetic particles
EP06802676.4A EP1932009B1 (en) 2005-08-31 2006-08-31 Nmr device for detection of analytes involving magnetic particles
JP2008529259A JP5295769B2 (en) 2005-08-31 2006-08-31 NMR apparatus for detecting analytes
CA2620861A CA2620861C (en) 2005-08-31 2006-08-31 Nmr device for detection of analytes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71317605P 2005-08-31 2005-08-31
US60/713,176 2005-08-31

Publications (2)

Publication Number Publication Date
WO2007027843A2 WO2007027843A2 (en) 2007-03-08
WO2007027843A3 true WO2007027843A3 (en) 2007-08-02

Family

ID=37709471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/033958 WO2007027843A2 (en) 2005-08-31 2006-08-31 Nmr device for detection of analytes involving magnetic particles

Country Status (6)

Country Link
US (12) US7564245B2 (en)
EP (1) EP1932009B1 (en)
JP (1) JP5295769B2 (en)
AU (1) AU2006284832B2 (en)
CA (1) CA2620861C (en)
WO (1) WO2007027843A2 (en)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697029B2 (en) * 2002-04-18 2014-04-15 The Regents Of The University Of Michigan Modulated physical and chemical sensors
AU2004273783A1 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
TW200632320A (en) * 2005-01-14 2006-09-16 Bayer Healthcare Llc Methods of in vitro analysis using time-domain nmr spectroscopy
US7781228B2 (en) * 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
US7742167B2 (en) * 2005-06-17 2010-06-22 Perkinelmer Health Sciences, Inc. Optical emission device with boost device
JP5295769B2 (en) 2005-08-31 2013-09-18 ティツー・バイオシステムズ・インコーポレーテッド NMR apparatus for detecting analytes
US8377419B2 (en) * 2005-09-28 2013-02-19 The President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
FR2891917B1 (en) * 2005-10-07 2008-01-11 Billanco MAGNETIC FIELD AND CURRENT SENSORS, CONTROL METHOD AND MAGNETIC CORE FOR THESE SENSORS
WO2007136799A2 (en) * 2006-05-18 2007-11-29 University Of Florida Research Foundation, Inc. Ic microfluidic platform with integrated magnetic resonance probe
US20090256572A1 (en) * 2008-04-14 2009-10-15 Mcdowell Andrew F Tuning Low-Inductance Coils at Low Frequencies
US8339135B2 (en) * 2006-08-21 2012-12-25 Stc.Unm Biological detector and method
WO2008057578A1 (en) * 2006-11-08 2008-05-15 T2 Biosystems, Inc. Nmr systems for in vivo detection of analytes
CN101568294A (en) * 2006-12-20 2009-10-28 皇家飞利浦电子股份有限公司 Arrangement and method for influencing and/or detecting magnetic particles in a region of action
US9068977B2 (en) 2007-03-09 2015-06-30 The Regents Of The University Of Michigan Non-linear rotation rates of remotely driven particles and uses thereof
US20100207631A1 (en) * 2007-03-27 2010-08-19 Mcdowell Andrew F System and Method for Detecting Labeled Entities Using Microcoil Magnetic MRI
WO2008120169A1 (en) * 2007-04-03 2008-10-09 Koninklijke Philips Electronics N. V. Sensor device with magnetic washing means
US8067938B2 (en) * 2007-05-03 2011-11-29 Abqmr, Inc. Microcoil NMR detectors
WO2008137910A2 (en) * 2007-05-07 2008-11-13 Massachusetts Instutute Of Technology Matrix stabilization of aggregation-based assays
JP5105410B2 (en) * 2007-05-31 2012-12-26 独立行政法人科学技術振興機構 Nuclear magnetic resonance imaging system and imaging method
US7994786B2 (en) * 2007-06-19 2011-08-09 Mary Hitchcock Memorial Hospital System and method for use of nanoparticles in imaging and temperature measurement
JP5099681B2 (en) * 2007-06-29 2012-12-19 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー Ultrasonic probe, ultrasonic diagnostic apparatus, and method for estimating surface temperature of ultrasonic probe
EP2175997A1 (en) * 2007-07-09 2010-04-21 Philips Intellectual Property & Standards GmbH Microelectronic sensor device with magnetic field generator and carrier
US8409463B1 (en) 2007-07-16 2013-04-02 University Of Central Florida Research Foundation, Inc. Aqueous method for making magnetic iron oxide nanoparticles
WO2009026164A1 (en) * 2007-08-17 2009-02-26 The General Hospital Corporation Magnetic resonance-based viscometers and methods
US20110070657A1 (en) * 2007-08-17 2011-03-24 The General Hospital Corporation Detecting ions and measuring ion concentrations
US7995002B2 (en) * 2007-09-19 2011-08-09 Global Oled Technology Llc Tiled passive matrix electro-luminescent display
US20100256481A1 (en) * 2007-09-27 2010-10-07 Mareci Thomas H Method and Apparatus for Providing a Wireless Multiple-Frequency MR Coil
CA2700970A1 (en) 2007-09-28 2009-04-09 T2 Biosystems, Inc. Nmr diagnostics by means of a plastic sample container
WO2009045551A1 (en) * 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
JP5539889B2 (en) * 2007-10-23 2014-07-02 アブクマー インコーポレイテッド Micro coil magnetic resonance detector
US9057094B1 (en) 2007-10-25 2015-06-16 University Of Central Florida Research Foundation, Inc. Nanoparticle-mediated methods for antimicrobial susceptibility testing of bacteria
WO2009061481A1 (en) * 2007-11-06 2009-05-14 T2 Biosystems, Inc. Small magnet and rf coil for magnetic resonance relaxometry
EP2905631A1 (en) * 2007-12-21 2015-08-12 T2 Biosystems, Inc. Magnetic resonance system with implantable components and methods of use thereof
EP2240205A4 (en) * 2008-01-10 2012-06-27 Harvard College Telemetry through remote detection of nmr-active particles
US20110275985A1 (en) 2008-07-03 2011-11-10 T2 Biosystems, Inc. Magnetic nanosensor compositions and bioanalytical assays therefor
US7671591B2 (en) * 2008-07-16 2010-03-02 International Business Machines Corporation Method and system for comparing micro-electronic devices using magnetic resonance imaging
US20100051552A1 (en) 2008-08-28 2010-03-04 Baxter International Inc. In-line sensors for dialysis applications
DE102008050347B4 (en) * 2008-10-02 2011-01-20 Siemens Aktiengesellschaft Method, magnetic resonance system and data carrier for determining a kidney function parameter
US9157974B2 (en) 2008-10-29 2015-10-13 T2 Biosystems, Inc. NMR detection of coagulation time
WO2010068812A1 (en) * 2008-12-10 2010-06-17 Abqmr, Inc. Nuclear magnetic resonance apparatus, methods and associated technology
JP5509418B2 (en) * 2009-03-10 2014-06-04 国立大学法人 東京大学 Method for analyzing residual dipole interaction and reagent for analyzing residual dipole interaction
ES2333766B2 (en) * 2009-07-02 2011-02-07 Universidad Politecnica De Madrid SYSTEM AND PROCEDURE FOR DETECTION OF MAGNETIC NANOPARTICLES BY MAGNETOENCEPHALOGRAPHY.
US8193808B2 (en) * 2009-09-11 2012-06-05 Hewlett-Packard Development Company, L.P. Optically integrated biosensor based on optically detected magnetic resonance
US20110074403A1 (en) * 2009-09-30 2011-03-31 Herng-Er Horng High-sensitivity, in-vivo, and dynamic detection of magnetic particles within living organism using a probe-type squid system
US8825131B2 (en) 2009-10-14 2014-09-02 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
US8761860B2 (en) 2009-10-14 2014-06-24 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
US8264224B2 (en) * 2009-10-27 2012-09-11 University Of Seoul Industry Cooperation Foundation Detection of magnetic fields using nano-magnets
US8696567B2 (en) * 2009-12-03 2014-04-15 Ingenza Ltd. Assay for positioning a feeding tube and method thereof
US8289022B2 (en) * 2010-01-29 2012-10-16 University Of Seoul Industry Cooperation Foundation Magnetic resonance compatible magnetic field detection, based on diffuse reflectance of nano-magnet sets
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
WO2012044387A2 (en) * 2010-07-06 2012-04-05 T2 Biosystems, Inc. Methods and compositions for detection of analytes
US8432049B2 (en) * 2010-07-15 2013-04-30 Sukho JUNG Electrical generator
US8422539B2 (en) * 2010-08-19 2013-04-16 Industrial Technology Research Institute Multi-carrier receiver, multi-carrier transmitter and multi-carrier transceiver system
WO2012027747A2 (en) 2010-08-27 2012-03-01 The Regents Of The University Of Michigan Asynchronous magnetic bead rotation sensing systems and methods
US20120095325A1 (en) * 2010-10-15 2012-04-19 Chang Gung Medical Foundation, Linkou Branch Treatment of brain diseases via ultrasound/magnetic targeting delivery and tracing of therapeutic agents
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US9714940B2 (en) 2010-10-22 2017-07-25 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US9280718B2 (en) 2010-11-24 2016-03-08 Nocimed, Llc Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
BR112013014100A2 (en) * 2010-12-06 2016-08-02 Univ Ramot method for determining the presence / absence of a drug in a liquid medium, and device for determining the presence of a drug in a liquid medium
US20120197107A1 (en) * 2011-01-31 2012-08-02 Case Western Reserve University Glucose analyzing blood examiner (gabe)
ES2551922T3 (en) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
CN110441343A (en) 2011-03-22 2019-11-12 通用医疗公司 Utilize magnetic resonance testing goal object
US9816993B2 (en) 2011-04-11 2017-11-14 The Regents Of The University Of Michigan Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells
EP2515131A1 (en) * 2011-04-22 2012-10-24 Eidgenössische Technische Hochschule (ETH) Determination of axial magnetization of an object in a magnetic field
EP2515132A1 (en) * 2011-04-22 2012-10-24 Eidgenössische Technische Hochschule (ETH) Dynamic field camera arrangement for magnetic resonance applications and methods for operating the same
WO2012154555A1 (en) * 2011-05-06 2012-11-15 The General Hospital Corporation Nanocompositions for monitoring polymerase chain reaction (pcr)
CA2839865A1 (en) * 2011-05-19 2012-11-22 University Of Central Florida Research Foundation, Inc. Microbe detection via hybridizing magnetic relaxation nanosensors
EP3321373B1 (en) 2011-07-13 2020-01-15 T2 Biosystems, Inc. Nmr methods for monitoring blood clot formation
WO2013043858A1 (en) 2011-09-21 2013-03-28 T2 Biosystems, Inc. Nmr methods for endotoxin analysis
RU2014117040A (en) 2011-09-28 2015-11-10 Конинклейке Филипс Н.В. METHOD AND SYSTEM FOR QUANTITATIVE DETERMINATION OF FAT IN HUMAN LIVER
CN102565733B (en) * 2011-12-12 2014-07-16 中国科学院深圳先进技术研究院 Magnetic resonance multi-core array radio frequency device and magnetic resonance signal receiving method
WO2013112755A1 (en) * 2012-01-24 2013-08-01 The Trustees Of Columbia University In The City Of New York Field optimized assay devices, methods, and systems
US10159413B2 (en) 2012-02-08 2018-12-25 Anatech Advanced Nmr Algorithms Technologies Ltd. Apparatus and method for non-invasive measurement of blood parameters
US8965094B2 (en) 2012-04-14 2015-02-24 Nocimed, Llc Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
US9797817B2 (en) 2012-05-03 2017-10-24 The Regents Of The University Of Michigan Multi-mode separation for target detection
US10359378B2 (en) 2012-05-14 2019-07-23 Board Of Trustees Of Michigan State University Nuclear magnetic resonance apparatus, systems, and methods
JP2014095691A (en) * 2012-09-13 2014-05-22 Aspect Imaging Ltd Means and method for using paramagnetic materials for in vitro diagnostic applications
CA2893591A1 (en) 2012-12-07 2014-06-12 T2 Biosystems, Inc. Methods for monitoring tight clot formation
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
DE202013100627U1 (en) * 2013-02-12 2013-03-18 Aspect Imaging Ltd. Device for MRI imaging of the near surface of tissue samples
US10024932B2 (en) 2013-03-01 2018-07-17 Halliburton Energy Services, Inc. Miniature NMR drill cutting analyzer and methods of use
US10335075B2 (en) 2013-03-14 2019-07-02 Dexcom, Inc. Advanced calibration for analyte sensors
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
EP2984482B1 (en) 2013-04-12 2020-09-09 University of Maryland, Baltimore Biopharmaceutical aggregation assessment using magnetic resonance relaxometry
US9730635B2 (en) 2013-06-21 2017-08-15 Verily Life Sciences Llc Physiological measurement using wearable device
US9341639B2 (en) 2013-07-26 2016-05-17 Industrial Technology Research Institute Apparatus for microfluid detection
US20150064241A1 (en) * 2013-09-05 2015-03-05 Google Inc. Delivery of Functionalized Particles
WO2015037554A1 (en) * 2013-09-10 2015-03-19 三菱レイヨン株式会社 Method for producing powdered n-vinylcarboxamide polymer composition and polyvinylamine aqueous solution
US9504405B2 (en) * 2013-10-23 2016-11-29 Verily Life Sciences Llc Spatial modulation of magnetic particles in vasculature by external magnetic field
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9983110B2 (en) 2013-11-04 2018-05-29 The Regents Of The University Of Michigan Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes
US9504425B2 (en) 2013-12-16 2016-11-29 Verily Life Sciences Llc Method of location coordination via wireless protocol between multiple devices
WO2015131151A2 (en) * 2014-02-28 2015-09-03 Erythron, Llc Method and apparatus for determining markers of health by analysis of blood
US9451911B1 (en) 2014-06-18 2016-09-27 Verily Life Sciences Llc Test model for wearable devices
US9942232B2 (en) 2014-07-08 2018-04-10 Verily Life Sciences Llc User control of data de-identification
US9770600B1 (en) 2014-07-09 2017-09-26 Verily Life Sciences Llc Particle concentration and separation using magnets
US9788763B1 (en) 2014-07-09 2017-10-17 Verily Life Sciences Llc Methods for magnetic particle capture and separation
US9820690B1 (en) 2014-07-16 2017-11-21 Verily Life Sciences Llc Analyte detection system
US9910035B1 (en) 2014-07-16 2018-03-06 Verily Life Sciences Llc Polyvalent functionalized nanoparticle-based in vivo diagnostic system
US9874554B1 (en) 2014-07-16 2018-01-23 Verily Life Sciences Llc Aptamer-based in vivo diagnostic system
US9858328B2 (en) 2014-07-17 2018-01-02 Verily Life Sciences, LLC Data tagging
US10094897B2 (en) 2014-07-25 2018-10-09 Gersh Z. Taicher Nuclear magnetic resonance apparatus and methods
US10197564B2 (en) 2014-07-25 2019-02-05 Gersh Z. Taicher Nuclear magnetic resonance apparatus and methods
WO2016025698A1 (en) * 2014-08-13 2016-02-18 The Trustees Of Columbia University In The City Of New York Diagnostic devices, systems, and methods
US9999380B1 (en) 2014-09-22 2018-06-19 Verily Life Sciences Llc Segmented magnets
US10349870B1 (en) 2014-09-22 2019-07-16 Verily Life Sciences Llc Magnetic switching
US10076286B1 (en) 2014-10-21 2018-09-18 Verily Life Sciences Llc Methods and devices for circadian rhythm monitoring
JP6244289B2 (en) * 2014-10-29 2017-12-06 学校法人 神野学園 Detection method of quadrature septa
US9817094B2 (en) 2014-11-05 2017-11-14 Gersh Z. Taicher Nuclear magnetic resonance apparatus and methods
US9964501B2 (en) 2014-11-05 2018-05-08 Gersh Z. Taicher Nuclear magnetic resonance apparatus and methods
US20160270725A1 (en) * 2015-03-16 2016-09-22 Jeffrey Allen Gray Wearable lactate threshold monitor
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR20170132856A (en) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. Instruments and systems for rapid microbiological identification and antimicrobial susceptibility testing
EP3112853A1 (en) * 2015-07-03 2017-01-04 Memscap S.A. Apparatus for an atomic clock
US11660436B1 (en) 2015-08-04 2023-05-30 Verily Life Sciences Llc Device, system, and formulation for oral delivery of functionalized particles
US10492709B2 (en) 2015-11-19 2019-12-03 Verily Life Sciences Llc Magnetic probes for in vivo capture and detection of extracellular vesicles
US11519016B2 (en) 2016-01-21 2022-12-06 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
DE102016106411A1 (en) * 2016-04-07 2017-10-12 Samson Aktiengesellschaft Electropneumatic solenoid valve
WO2017222945A1 (en) 2016-06-19 2017-12-28 Nocimed, Inc. Magnetic resonance spectroscopy system and method for diagnosing pain or infection associated with propionic acid
US10859650B2 (en) 2016-06-29 2020-12-08 Bridgestone Corporation Methods for determining plant rubber content with low field NMR
US9747771B1 (en) * 2016-10-04 2017-08-29 Jacqueline Martinez Tracking and safety smart watch
US11346908B2 (en) 2016-12-02 2022-05-31 University Of Maryland, Baltimore Solvent nuclear magnetic resonance for noninvasive inspection of particle-containing products
US20180184973A1 (en) * 2016-12-29 2018-07-05 Krishna Nayak Magnetic measurement of fat fraction
CN107462847A (en) * 2017-06-27 2017-12-12 中国科学院电工研究所 A kind of magnetic nano particle detection means
JP6864291B2 (en) * 2017-07-14 2021-04-28 三菱重工業株式会社 Deterioration evaluation method for separation membrane equipment
SG10201800240YA (en) * 2018-01-10 2019-08-27 Delta Electronics Int’L Singapore Pte Ltd Multi-color fluorescence detection device
CN113167848A (en) * 2018-09-24 2021-07-23 洛桑联邦综合工科学校 micro-MR device comprising a cell culture microchamber and method for manufacturing such a device
US11585770B2 (en) 2018-10-04 2023-02-21 University Of Maryland, Baltimore In situ determination of alum filling evenness and sedimentation in pharmaceutical products using water proton NMR
US11543371B2 (en) 2018-10-04 2023-01-03 University Of Maryland, Baltimore In situ, real-time in-line detection of filling errors in pharmaceutical product manufacturing using water proton NMR
EP4076537A4 (en) 2019-12-20 2024-02-28 Univ Maryland Noninvasive quantitation of full versus empty capsids using water proton nmr
US11914013B2 (en) 2020-08-18 2024-02-27 University Of Maryland, Baltimore Real-time in situ monitoring of suspension sedimentation using water proton NMR
KR102433170B1 (en) * 2020-10-27 2022-08-18 광주과학기술원 Magnetic particle spectroscopy

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920061A (en) * 1984-03-02 1990-04-24 The University Of Texas System Biological magnetic colloids
US5492814A (en) * 1990-07-06 1996-02-20 The General Hospital Corporation Monocrystalline iron oxide particles for studying biological tissues
US5677133A (en) * 1993-02-17 1997-10-14 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US6342396B1 (en) * 1997-01-30 2002-01-29 Bio Merieux Method for isolating, in particular for detecting or quantifying an analyte in a medium
WO2002098364A2 (en) * 2001-06-06 2002-12-12 The General Hospital Corporation Magnetic-nanoparticle conjugates and methods of use

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913521B2 (en) * 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ Method for producing magnetic iron oxide/dextran complex
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5136095A (en) * 1987-05-19 1992-08-04 Syntex (U.S.A.) Inc. Reversible agglutination mediators
GB2219461B (en) * 1988-05-02 1992-11-18 Canon Kk Exposure control device
WO1990006045A2 (en) 1988-11-21 1990-06-14 Dynal As Nucleic acid probes
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
JP2726520B2 (en) * 1989-10-20 1998-03-11 名糖産業株式会社 Organic magnetic composite
US5254460A (en) * 1990-05-03 1993-10-19 Advanced Magnetics, Inc. Solvent mediated relaxation assay system
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
AU8951191A (en) * 1990-10-29 1992-05-26 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5424419A (en) * 1991-06-11 1995-06-13 Meito Sangyo Kabushiki Kaisha Oxidized complex comprising water-soluble carboxypolysaccharide and magnetic iron oxide
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
US5445971A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5445970A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
FR2710410B1 (en) * 1993-09-20 1995-10-20 Bio Merieux Method and device for determining an analyte in a sample.
US5505192A (en) 1993-11-12 1996-04-09 New-Med Corporation Dispenser monitoring system
US5411173A (en) 1993-12-17 1995-05-02 Weinstein; Albert Counter attachment for product dispensers
AU1947395A (en) 1994-02-28 1995-09-11 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use
US5482030A (en) 1994-06-13 1996-01-09 Klein; David Aerosol and non-aerosol spray counter
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5693784A (en) 1994-09-19 1997-12-02 Promega Corporation Methods for creating agglomerates from colloidal particles
US5705628A (en) * 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
JP3362192B2 (en) * 1994-12-06 2003-01-07 味の素株式会社 Test methods and test drugs
US6097188A (en) * 1995-01-31 2000-08-01 The Board Of Trustees Of The University Of Illinois Microcoil based micro-NMR spectrometer and method
US6500343B2 (en) * 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
WO1996026011A1 (en) * 1995-02-21 1996-08-29 Siddiqi Iqbal W Apparatus and method for mixing and separation employing magnetic particles
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
FR2732116B1 (en) * 1995-03-21 1997-05-09 Bio Merieux METHOD AND DEVICE FOR THE QUALITATIVE AND / OR QUANTITATIVE DETERMINATION OF AN ANALYTE, IN PARTICULAR OF A BACTERIA, IN A SAMPLE, BY MAGNETIC WAY
US6029659A (en) 1995-04-17 2000-02-29 Solar Shield Corporation Inhalation device with counter
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
US5676129A (en) 1996-03-14 1997-10-14 Oneida Research Services, Inc. Dosage counter for metered dose inhaler (MDI) systems using a miniature pressure sensor
JP2000510582A (en) 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション Analyte assays using particulate labeling
JP3996644B2 (en) * 1996-06-07 2007-10-24 イムニベスト・コーポレイション Magnetic separation with external and internal gradients
AU4043497A (en) 1996-07-29 1998-02-20 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP0928809B1 (en) * 1996-08-30 2003-10-22 Meito Sangyo Kabushiki Kaisha Polysaccharide derivative/magnetic metal oxide composite
US5922537A (en) 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
GB2320489A (en) 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
EP0859491B1 (en) 1997-02-18 2006-01-11 Alcatel Method for rerouting in hierarchically structured networks
WO1998052634A1 (en) 1997-05-23 1998-11-26 Pa Knowledge Limited Inhaler mechanism
TW533865U (en) 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
DE19822123C2 (en) * 1997-11-21 2003-02-06 Meinhard Knoll Method and device for the detection of analytes
GB9807558D0 (en) 1998-04-09 1998-06-10 Bason Neil P An indicator device
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6194900B1 (en) * 1998-06-19 2001-02-27 Agilent Technologies, Inc. Integrated miniaturized device for processing and NMR detection of liquid phase samples
US5973138A (en) * 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
US6159378A (en) * 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
DK1169062T3 (en) * 1999-04-09 2010-01-25 Amag Pharmaceuticals Inc Heat stable coated colloidal iron oxides
JP2003503699A (en) 1999-06-25 2003-01-28 ナノスフェアー インコーポレイテッド Oligonucleotide-Attached Nanoparticles and Methods of Use
AU6828500A (en) 1999-08-06 2001-03-05 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Method for detecting binding reactions through measurement of the relaxation of birefringence of magnetic nanoparticles
BR0014252A (en) 1999-09-14 2002-11-19 Biomedical Apherese Systeme Gm Magnetic nanoparticles having biochemical activity, method for their production and uses
US6294342B1 (en) * 1999-09-29 2001-09-25 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US7390675B2 (en) * 1999-10-15 2008-06-24 Christopher Feistel Multi-functional and configurable assay
FR2799858B1 (en) 1999-10-19 2002-01-18 Valois Sa DOSAGE COUNTER AND FLUID PRODUCT DISPENSER INCORPORATING SUCH A COUNTER
US6307372B1 (en) * 1999-11-02 2001-10-23 Glaxo Wellcome, Inc. Methods for high throughput chemical screening using magnetic resonance imaging
US6254830B1 (en) * 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
FR2800635B1 (en) * 1999-11-05 2002-07-26 Bio Merieux COMPOSITE NANOSPHERES, DERIVATIVE CONJUGATES, METHOD OF PREPARATION AND USES THEREOF
ATE285709T1 (en) * 2000-03-06 2005-01-15 Medos Sa IMPLANTABLE NUCLEAR RESONANCE SPECTROMETER
US6774635B1 (en) * 2000-07-25 2004-08-10 The United States Of America As Represented By The United States Department Of Energy Video toroid cavity imager
US6788061B1 (en) * 2000-08-01 2004-09-07 The Board Of Trustees Of The University Of Illinois Microcoil based micro-NMR spectrometer and method
GB0026646D0 (en) 2000-10-31 2000-12-13 Glaxo Group Ltd Medicament dispenser
JP3885484B2 (en) 2000-11-07 2007-02-21 カシオ計算機株式会社 Data communication processing apparatus and recording medium
WO2002052291A1 (en) * 2000-12-22 2002-07-04 Koninklijke Philips Electronics N.V. Mri apparatus
US7200430B2 (en) * 2001-03-29 2007-04-03 The Regents Of The University Of California Localized two-dimensional shift correlated MR spectroscopy of human brain
FR2824563B1 (en) * 2001-05-10 2004-12-03 Bio Merieux COMPOSITE PARTICLES, DERIVATIVES, PREPARATION METHOD AND APPLICATIONS
US6778316B2 (en) * 2001-10-24 2004-08-17 William Marsh Rice University Nanoparticle-based all-optical sensors
FR2832507B1 (en) * 2001-11-20 2004-02-20 Stago Diagnostica METHOD OF DETECTING ANALYTE (S) USING COLLOIDAL MAGNETIC PARTICLES
DE10162502A1 (en) * 2001-12-19 2003-07-03 Bsh Bosch Siemens Hausgeraete Multi-way valve and chiller with multi-way valve
US7018849B2 (en) * 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
US20030137971A1 (en) * 2002-01-22 2003-07-24 Mark Gibson Telecommunications system and method
US6798200B2 (en) * 2002-06-03 2004-09-28 Long-Sheng Fan Batch-fabricated gradient and RF coils for submicrometer resolution magnetic resonance imaging and manipulation
US7331340B2 (en) 2003-03-04 2008-02-19 Ivax Corporation Medicament dispensing device with a display indicative of the state of an internal medicament reservoir
US20040255936A1 (en) 2003-04-30 2004-12-23 David Urbanus Disposable metered dose inhaler with integrated electronic counter
US6990852B2 (en) * 2003-07-28 2006-01-31 Becton Dickinson & Company System and method for detecting particles
WO2005061724A1 (en) 2003-12-10 2005-07-07 The General Hospital Corporation Self-assembling nanoparticle conjugates
JP4825138B2 (en) 2004-02-16 2011-11-30 グラクソ グループ リミテッド Drug dispenser counter
US7561245B2 (en) * 2004-02-25 2009-07-14 Lg Display Co., Ltd. Liquid crystal display device and method of fabricating the same
EP1735668A2 (en) 2004-04-13 2006-12-27 President And Fellows Of Harvard College Methods and apparatus for manipulation and/or detection of biological samples and other objects
FR2869685B1 (en) 2004-04-29 2006-07-28 Valois Sas INDICATOR FOR DEVICE FOR DISPENSING FLUID OR PULVERULENT PRODUCT
SE0401787D0 (en) 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device counter
US7781228B2 (en) * 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
TWI442951B (en) 2005-04-14 2014-07-01 Astrazeneca Ab Inhaler counter
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
EP2385386B1 (en) 2005-05-09 2012-11-14 The General Hospital Corporation Magnetic resonance sensors for monitoring of an analyte concentration
CA2607743A1 (en) 2005-05-12 2006-11-23 Kos Life Sciences, Inc. Dose counter for metered dose inhalers
ATE464084T1 (en) 2005-05-24 2010-04-15 Letcat Aktiebolag DOSE COUNTER
US20070116600A1 (en) * 2005-06-23 2007-05-24 Kochar Manish S Detection device and methods associated therewith
WO2007025244A2 (en) * 2005-08-25 2007-03-01 Houle Philip R Treatment systems for delivery of sensitizer solutions
JP5295769B2 (en) * 2005-08-31 2013-09-18 ティツー・バイオシステムズ・インコーポレーテッド NMR apparatus for detecting analytes
FR2894970B1 (en) * 2005-12-15 2008-01-25 Biomerieux Sa PROCESS FOR THE PREPARATION OF COMPOSITE PARTICLES, COMPOSITE PARTICLES OBTAINED AND THEIR USE IN A DIAGNOSTIC TEST
US7345479B2 (en) * 2005-12-29 2008-03-18 Intel Corporation Portable NMR device and method for making and using the same
US20070166730A1 (en) * 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
ES2393758T3 (en) * 2006-03-15 2012-12-27 Micronics, Inc. Integrated nucleic acid assays
US20070295329A1 (en) 2006-06-13 2007-12-27 Lieberman Eric A Dose indicator
TWI322793B (en) * 2006-10-02 2010-04-01 Chung Cheng Inst Of Technology Nat Defense University Functionalized magnetizable microspheres and preparation thereof
WO2008057578A1 (en) 2006-11-08 2008-05-15 T2 Biosystems, Inc. Nmr systems for in vivo detection of analytes
CA2700970A1 (en) * 2007-09-28 2009-04-09 T2 Biosystems, Inc. Nmr diagnostics by means of a plastic sample container
JP5539889B2 (en) 2007-10-23 2014-07-02 アブクマー インコーポレイテッド Micro coil magnetic resonance detector
US7875769B1 (en) * 2009-07-09 2011-01-25 Monsanto Technology Llc Soybean variety A1016497
US8212566B2 (en) * 2009-07-24 2012-07-03 Agilent Technologies, Inc. Angular position sensing based on magnetically induced beam deformation
US20110031038A1 (en) 2009-08-07 2011-02-10 Sagatulo, Inc. Method and device for indicating doses in a drug delivery system
WO2011060033A1 (en) * 2009-11-10 2011-05-19 Immunolight, L.L.C. Up and down coversion systems for production of emitted light from various energy sources including radio frequency, microwave energy and magnetic induction sources for upconversion
US8409807B2 (en) * 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054588A2 (en) * 2010-10-22 2012-04-26 T2 Biosystems, Inc. Conduit-containing devices and methods for analyte processing and detection
US8563298B2 (en) * 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8499336B2 (en) * 2010-11-23 2013-07-30 Cisco Technology, Inc. Session redundancy among a server cluster

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920061A (en) * 1984-03-02 1990-04-24 The University Of Texas System Biological magnetic colloids
US5492814A (en) * 1990-07-06 1996-02-20 The General Hospital Corporation Monocrystalline iron oxide particles for studying biological tissues
US5677133A (en) * 1993-02-17 1997-10-14 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US6342396B1 (en) * 1997-01-30 2002-01-29 Bio Merieux Method for isolating, in particular for detecting or quantifying an analyte in a medium
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
WO2002098364A2 (en) * 2001-06-06 2002-12-12 The General Hospital Corporation Magnetic-nanoparticle conjugates and methods of use

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BOERO G ET AL: "An NMR magnetometer with planar microcoils and integrated electronics for signal detection and amplification", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 67, no. 1-3, 15 May 1998 (1998-05-15), pages 18 - 23, XP004130106, ISSN: 0924-4247 *
LEE C S ET AL: "MICROELECTROMAGNETS FOR THE CONTROL OF MAGNETIC NANOPARTICLES", APPLIED PHYSICS LETTERS, AIP, AMERICAN INSTITUTE OF PHYSICS, MELVILLE, NY, US, vol. 79, no. 20, 12 November 2001 (2001-11-12), pages 3308 - 3310, XP001103201, ISSN: 0003-6951 *
MAKIRANTA J J ET AL: "Modeling and Simulation of Magnetic Nanoparticle Sensor", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, 2005. IEEE-EMBS 2005. 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE SHANGHAI, CHINA 01-04 SEPT. 2005, PISCATAWAY, NJ, USA,IEEE, 1 September 2005 (2005-09-01), pages 1256 - 1259, XP010908000, ISBN: 0-7803-8741-4 *
MAKIRANTA JJ, LEKKALA JO: "Modeling and simulation of a magnetic particle sensor", MASTER OF SCIENCE THESIS, TAMPERE UNIVERSITY OF TECHNOLOGY, 13 October 2004 (2004-10-13), XP002423988 *
MASSIN C ET AL: "High-Q factor RF planar microcoils for micro-scale NMR spectroscopy", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 97-98, 1 April 2002 (2002-04-01), pages 280 - 288, XP004361613, ISSN: 0924-4247 *
RAMADAN Q ET AL: "On-chip micro-electromagnets for magnetic-based bio-molecules separation", JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 281, no. 2-3, October 2004 (2004-10-01), pages 150 - 172, XP004568417, ISSN: 0304-8853 *
RENAUD L ET AL: "Implantable planar rf microcoils for NMR microspectroscopy", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 99, no. 3, 5 June 2002 (2002-06-05), pages 244 - 248, XP004361689, ISSN: 0924-4247 *
RIDA A ET AL: "Long-range transport of magnetic microbeads using simple planar coils placed in a uniform magnetostatic field", APPLIED PHYSICS LETTERS, AIP, AMERICAN INSTITUTE OF PHYSICS, MELVILLE, NY, US, vol. 83, no. 12, 22 September 2003 (2003-09-22), pages 2396 - 2398, XP012035164, ISSN: 0003-6951 *
SILLERUD ET AL: "H NMR Detection of superparamagnetic nanoparticles at 1T using a microcoil and novel tuning circuit", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 181, no. 2, August 2006 (2006-08-01), pages 181 - 190, XP005569599, ISSN: 1090-7807 *
WENSINK H ET AL: "High signal to noise ratio in low field NMR on chip, simulations and experimental results", MICRO ELECTRO MECHANICAL SYSTEMS, 2004. 17TH IEEE INTERNATIONAL CONFERENCE ON. (MEMS) MAASTRICHT, NETHERLANDS 25-29 JAN. 2004, PISCATAWAY, NJ, USA,IEEE, US, 25 January 2004 (2004-01-25), pages 407 - 410, XP010767911, ISBN: 0-7803-8265-X *
ZHANG X ET AL: "A Probe Design for the Acquisition of Homonuclear, Heteronuclear, and Inverse Detected NMR Spectra from Multiple Samples", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 153, no. 2, December 2001 (2001-12-01), pages 254 - 258, XP004406548, ISSN: 1090-7807 *

Also Published As

Publication number Publication date
US8310232B2 (en) 2012-11-13
US20110018538A1 (en) 2011-01-27
US20170299668A1 (en) 2017-10-19
US20070116602A1 (en) 2007-05-24
AU2006284832A8 (en) 2008-05-01
AU2006284832B2 (en) 2011-06-02
JP5295769B2 (en) 2013-09-18
US7564245B2 (en) 2009-07-21
JP2009506345A (en) 2009-02-12
US20110021374A1 (en) 2011-01-27
US20090134869A1 (en) 2009-05-28
US20110020787A1 (en) 2011-01-27
US8102176B2 (en) 2012-01-24
US20210048491A1 (en) 2021-02-18
EP1932009B1 (en) 2014-02-12
CA2620861C (en) 2016-07-05
US20120313639A1 (en) 2012-12-13
US20110020953A1 (en) 2011-01-27
EP1932009A2 (en) 2008-06-18
CA2620861A1 (en) 2007-03-08
US8310231B2 (en) 2012-11-13
AU2006284832A1 (en) 2007-03-08
WO2007027843A2 (en) 2007-03-08
US20110020788A1 (en) 2011-01-27
US8344731B2 (en) 2013-01-01
US20130229179A1 (en) 2013-09-05
US8624592B2 (en) 2014-01-07
US8334693B2 (en) 2012-12-18
US20120107839A1 (en) 2012-05-03
US8704517B2 (en) 2014-04-22

Similar Documents

Publication Publication Date Title
WO2007027843A3 (en) Nmr device for detection of analytes involving magnetic particles
Gao et al. Wearable microsensor array for multiplexed heavy metal monitoring of body fluids
Korostynska et al. Microwave sensors for the non-invasive monitoring of industrial and medical applications
Mani et al. Microneedle pH sensor: direct, label-free, real-time detection of cerebrospinal fluid and bladder pH
WO2008085228A3 (en) Detection and quantification of analytes in bodily fluids
WO2008070865A3 (en) Materials and methods for efficient and accurate detection of analytes
TW200643400A (en) Optical-based sensing devices
NZ600747A (en) Microfluidic device and method for fluid clotting time determination
MX2009003572A (en) Reducing optical interference in a fluidic device.
MX2021011543A (en) Point-of-care fluidic systems and uses thereof.
WO2008039946A3 (en) Integrated meter for analyzing biological samples
WO2013040435A3 (en) Molecular diagnostic assay device and method of use
ATE519110T1 (en) DIAGNOSTIC NANOSENSOR AND ITS USE IN MEDICINE
WO2007106402A3 (en) Methods and apparatus for near field irradiation
TW200730129A (en) Method and apparatus for point of care osmolarity testing
ATE438853T1 (en) DIAGNOSTIC TEST APPARATUS
EP2545851A3 (en) Systems and methods for the identification of compounds in medical fluids using admittance spectroscopy
WO2014042979A1 (en) Apparatus and method for point-of-collection measurement of a biomolecular reaction
ATE332667T1 (en) METHOD AND DEVICE FOR COLLECTING PHYSIOLOGICAL SAMPLES
WO2008066607A3 (en) Device for detection of molecules in biological fluids
EP1953527A3 (en) Sample analyzer and computer program product
EP2166360A3 (en) Analyte testing systems
WO2009081291A3 (en) Field effect transistors for detection of nosocomial infection
WO2006105110A3 (en) Assay device and methods
EP2634573A3 (en) A cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2006284832

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2620861

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2008529259

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006802676

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006284832

Country of ref document: AU

Date of ref document: 20060831

Kind code of ref document: A