WO2007030775A3 - Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods - Google Patents

Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods Download PDF

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Publication number
WO2007030775A3
WO2007030775A3 PCT/US2006/035179 US2006035179W WO2007030775A3 WO 2007030775 A3 WO2007030775 A3 WO 2007030775A3 US 2006035179 W US2006035179 W US 2006035179W WO 2007030775 A3 WO2007030775 A3 WO 2007030775A3
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WO
WIPO (PCT)
Prior art keywords
methods
methanesulfonamide
quinolin
ethoxymethyl
dimethylethyl
Prior art date
Application number
PCT/US2006/035179
Other languages
French (fr)
Other versions
WO2007030775A2 (en
Inventor
Tushar A Kshirsagar
Shri Niwas
Bryon A Merrill
Original Assignee
3M Innovative Properties Co
Tushar A Kshirsagar
Shri Niwas
Bryon A Merrill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co, Tushar A Kshirsagar, Shri Niwas, Bryon A Merrill filed Critical 3M Innovative Properties Co
Priority to CA002621831A priority Critical patent/CA2621831A1/en
Priority to JP2008530246A priority patent/JP2009507856A/en
Priority to AU2006287270A priority patent/AU2006287270A1/en
Priority to BRPI0615788-2A priority patent/BRPI0615788A2/en
Priority to EP06814391A priority patent/EP1922317A4/en
Priority to US11/991,663 priority patent/US8476292B2/en
Priority to EA200800782A priority patent/EA200800782A1/en
Publication of WO2007030775A2 publication Critical patent/WO2007030775A2/en
Publication of WO2007030775A3 publication Critical patent/WO2007030775A3/en
Priority to IL190033A priority patent/IL190033A0/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Amide and carbamate derivatives N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
PCT/US2006/035179 2005-09-09 2006-09-08 Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods WO2007030775A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002621831A CA2621831A1 (en) 2005-09-09 2006-09-08 Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods
JP2008530246A JP2009507856A (en) 2005-09-09 2006-09-08 Amide and carbamate derivatives of N- {2- [4-amino-2- (ethoxymethyl) -1H-imidazo [4,5-c] quinolin-1-yl] -1,1-dimethylethyl} methanesulfonamide and Method
AU2006287270A AU2006287270A1 (en) 2005-09-09 2006-09-08 Amide and carbamate derivatives of N-{2-[4-amino-2- (ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods
BRPI0615788-2A BRPI0615788A2 (en) 2005-09-09 2006-09-08 n- {2- [4-amino (ethoxymethyl) -1h-imidazo [4,5-c] quinolin-1-yl] -1,1-dimethylethyl} methanesulfonamide amide and carbamate derivatives, pharmaceutical composition of these and their uses
EP06814391A EP1922317A4 (en) 2005-09-09 2006-09-08 Amide and carbamate derivatives of n-{2-ý4-amino-2- (ethoxymethyl)-1h-imidazoý4,5-c¨quinolin-1-yl¨-1,1-dimethylethyl}methanesulfonamide and methods
US11/991,663 US8476292B2 (en) 2005-09-09 2006-09-08 Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods
EA200800782A EA200800782A1 (en) 2005-09-09 2006-09-08 AMIDA AND CARBAMATE DERIVATIVES N- {2- [4-AMINO-2- (ETOXIMETHYL) -1H-IMIDAZOLO [4,5-c] QUINOLIN-1-IL] -1,1-DIMETHYLETHYL} METHANE SULFONAMIDE AND METHODS
IL190033A IL190033A0 (en) 2005-09-09 2008-03-09 Amide and carbamate derivatives of n-{2-[4-amino-2-(ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71595005P 2005-09-09 2005-09-09
US60/715,950 2005-09-09

Publications (2)

Publication Number Publication Date
WO2007030775A2 WO2007030775A2 (en) 2007-03-15
WO2007030775A3 true WO2007030775A3 (en) 2007-07-12

Family

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PCT/US2006/035179 WO2007030775A2 (en) 2005-09-09 2006-09-08 Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods

Country Status (12)

Country Link
US (1) US8476292B2 (en)
EP (1) EP1922317A4 (en)
JP (1) JP2009507856A (en)
KR (1) KR20080045269A (en)
CN (1) CN101300254A (en)
AU (1) AU2006287270A1 (en)
BR (1) BRPI0615788A2 (en)
CA (1) CA2621831A1 (en)
EA (1) EA200800782A1 (en)
IL (1) IL190033A0 (en)
WO (1) WO2007030775A2 (en)
ZA (1) ZA200803028B (en)

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US9006264B2 (en) 2004-06-18 2015-04-14 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
US9107958B2 (en) 2011-06-03 2015-08-18 3M Innovative Properties Company Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom
US9145410B2 (en) 2003-10-03 2015-09-29 3M Innovative Properties Company Pyrazolopyridines and analogs thereof
US9242980B2 (en) 2010-08-17 2016-01-26 3M Innovative Properties Company Lipidated immune response modifier compound compositions, formulations, and methods
US9328110B2 (en) 2003-11-25 2016-05-03 3M Innovative Properties Company Substituted imidazo ring systems and methods
US9365567B2 (en) 2003-10-03 2016-06-14 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US9475804B2 (en) 2011-06-03 2016-10-25 3M Innovative Properties Company Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
US9546184B2 (en) 2005-02-09 2017-01-17 3M Innovative Properties Company Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines

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