WO2007033176A3 - Continuous polymer synthesizer - Google Patents
Continuous polymer synthesizer Download PDFInfo
- Publication number
- WO2007033176A3 WO2007033176A3 PCT/US2006/035491 US2006035491W WO2007033176A3 WO 2007033176 A3 WO2007033176 A3 WO 2007033176A3 US 2006035491 W US2006035491 W US 2006035491W WO 2007033176 A3 WO2007033176 A3 WO 2007033176A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stations
- reaction
- array
- relative
- reaction scheme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
- B01J2219/00326—Movement by rotation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/0036—Nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00675—In-situ synthesis on the substrate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00693—Means for quality control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/115831—Condition or time responsive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/12—Condition responsive control
Abstract
Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008531251A JP5055282B2 (en) | 2005-09-14 | 2006-09-11 | Continuous polymer synthesizer |
EP06814519A EP1937400A4 (en) | 2005-09-14 | 2006-09-11 | Continuous polymer synthesizer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71737605P | 2005-09-14 | 2005-09-14 | |
US60/717,376 | 2005-09-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007033176A2 WO2007033176A2 (en) | 2007-03-22 |
WO2007033176A3 true WO2007033176A3 (en) | 2007-10-04 |
Family
ID=37865520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/035491 WO2007033176A2 (en) | 2005-09-14 | 2006-09-11 | Continuous polymer synthesizer |
Country Status (5)
Country | Link |
---|---|
US (3) | US20070117178A1 (en) |
EP (1) | EP1937400A4 (en) |
JP (1) | JP5055282B2 (en) |
CN (1) | CN101277758A (en) |
WO (1) | WO2007033176A2 (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8315817B2 (en) | 2007-01-26 | 2012-11-20 | Illumina, Inc. | Independently removable nucleic acid sequencing system and method |
WO2008092155A2 (en) * | 2007-01-26 | 2008-07-31 | Illumina, Inc. | Image data efficient genetic sequencing method and system |
US8852508B2 (en) * | 2008-01-23 | 2014-10-07 | Csem Centre Suisse D'electronique Et De Microtechnique Sa—Recherche Et Developpement | Microinjection apparatus and method |
EP2525905B1 (en) | 2010-01-19 | 2020-11-04 | Illumina, Inc. | Methods and compositions for processing chemical reactions |
US8612072B2 (en) * | 2010-02-11 | 2013-12-17 | Teleflex Canada, Inc. | System for automatically instancing marine engines |
US9029103B2 (en) | 2010-08-27 | 2015-05-12 | Illumina Cambridge Limited | Methods for sequencing polynucleotides |
JP5650970B2 (en) * | 2010-09-28 | 2015-01-07 | 富士フイルム株式会社 | Inspection apparatus, control method therefor, and reaction container for inspection |
US8575071B2 (en) | 2010-11-03 | 2013-11-05 | Illumina, Inc. | Reducing adapter dimer formation |
US20120297997A1 (en) * | 2011-05-25 | 2012-11-29 | Michael Novick | Image forming apparatuses and methods thereof |
WO2013117595A2 (en) | 2012-02-07 | 2013-08-15 | Illumina Cambridge Limited | Targeted enrichment and amplification of nucleic acids on a support |
JP2014219623A (en) * | 2013-05-10 | 2014-11-20 | ソニー株式会社 | Observation system, observation program, and observation method |
DK3030682T3 (en) | 2013-08-05 | 2020-09-14 | Twist Bioscience Corp | DE NOVO SYNTHESIZED GENE LIBRARIES |
CA3219413A1 (en) | 2014-05-16 | 2015-11-19 | Illumina, Inc. | Nucleic acid synthesis techniques |
EP3175022B1 (en) * | 2014-07-28 | 2020-09-16 | Sanofi Pasteur VaxDesign Corporation | Automated imaging and analysis of the hemagglutination inhibition assay (hai) |
US10040048B1 (en) | 2014-09-25 | 2018-08-07 | Synthego Corporation | Automated modular system and method for production of biopolymers |
WO2016090266A1 (en) | 2014-12-05 | 2016-06-09 | Amyris, Inc. | High-throughput sequencing of polynucleotides |
US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
WO2017049231A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
US11512347B2 (en) | 2015-09-22 | 2022-11-29 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
WO2017165630A1 (en) * | 2016-03-23 | 2017-09-28 | Truvian Sciences, Inc. | Systems and methods for multianalyte detection |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
AU2018284227A1 (en) | 2017-06-12 | 2020-01-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
KR20200047706A (en) | 2017-09-11 | 2020-05-07 | 트위스트 바이오사이언스 코포레이션 | GPCR binding protein and method for synthesis thereof |
SG11202003574TA (en) | 2017-10-20 | 2020-05-28 | Twist Bioscience Corp | Heated nanowells for polynucleotide synthesis |
EP3495038B1 (en) | 2017-12-11 | 2020-06-10 | The Institute of Organic Chemistry and Biochemistry AV CR | Device for parallel oligomer synthesis, method of parallel oligomer synthesis and use thereof |
WO2019155029A1 (en) * | 2018-02-09 | 2019-08-15 | General Electric Company | Disposable kit for bioprocessing |
US11920119B2 (en) | 2018-02-09 | 2024-03-05 | Global Life Sciences Solutions Usa Llc | Systems and methods for bioprocessing |
US11932842B2 (en) | 2018-02-09 | 2024-03-19 | Global Life Sciences Solutions Usa Llc | Bioprocessing apparatus |
CN111479818A (en) * | 2018-02-13 | 2020-07-31 | 深圳华大生命科学研究院 | Method and system for synthesizing oligonucleotides |
WO2019222706A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
GB2606472A (en) * | 2018-07-05 | 2022-11-09 | Synthego Corp | Automated modular system and method for production of biopolymers |
WO2020037194A1 (en) * | 2018-08-17 | 2020-02-20 | Sierra Biosystems, Inc. | Row-independent oligonucleotide synthesis |
SG11202012748TA (en) | 2018-12-14 | 2021-01-28 | Illumina Cambridge Ltd | Decreasing phasing with unlabeled nucleotides during sequencing |
WO2020126593A1 (en) | 2018-12-17 | 2020-06-25 | Illumina Cambridge Limited | Compositions for use in polyunucleotide sequencing |
AU2019411267A1 (en) | 2018-12-17 | 2021-01-07 | Illumina Cambridge Limited | Primer oligonucleotide for sequencing |
WO2020176680A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
US20220176334A1 (en) * | 2019-04-10 | 2022-06-09 | Nitto Denko Avecia Inc. | Process and apparatus for sequential synthesis of biological polymers |
CN114729342A (en) | 2019-06-21 | 2022-07-08 | 特韦斯特生物科学公司 | Barcode-based nucleic acid sequence assembly |
US20220333178A1 (en) | 2021-03-22 | 2022-10-20 | Illumina Cambridge Limited | Methods for improving nucleic acid cluster clonality |
US20230096386A1 (en) | 2021-09-30 | 2023-03-30 | Illumina Cambridge Limited | Polynucleotide sequencing |
WO2023126457A1 (en) | 2021-12-29 | 2023-07-06 | Illumina Cambridge Ltd. | Methods of nucleic acid sequencing using surface-bound primers |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6264891B1 (en) * | 1998-12-22 | 2001-07-24 | Eos Biotechnology, Inc. | Apparatus and method for concurrent chemical synthesis |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1241539A (en) * | 1913-07-08 | 1917-10-02 | Max Meirowsky | Making mica plates. |
US3586484A (en) * | 1969-05-23 | 1971-06-22 | Atomic Energy Commission | Multistation analytical photometer and method of use |
US3605829A (en) * | 1970-04-29 | 1971-09-20 | Becton Dickinson Co | Blood handling machine |
BE793544A (en) * | 1972-01-31 | 1973-04-16 | American Hospital Supply Corp | CENTRIFUGE |
DE2540969A1 (en) * | 1975-09-13 | 1977-03-17 | Bodenseewerk Perkin Elmer Co | AUTOMATIC SAMPLE PREPARATION DEVICE |
DE2810765C2 (en) * | 1978-03-13 | 1984-11-22 | Dr. Molter GmbH, 6901 Bammental | Laboratory centrifuge |
US4244694A (en) * | 1978-03-31 | 1981-01-13 | Union Carbide Corporation | Reactor/separator device for use in automated solid phase immunoassay |
US4285463A (en) * | 1979-11-01 | 1981-08-25 | American Hospital Supply Corporation | Decanting centrifuge |
US4287154A (en) * | 1980-05-07 | 1981-09-01 | Sommers Philip B | Specimen transfer rack |
FR2496268A1 (en) * | 1980-12-15 | 1982-06-18 | Guigan Jean | AUTONOMOUS SIMULTANEOUS ANALYSIS DEVICE AND METHOD FOR IMPLEMENTING SAME |
JPS61139756A (en) | 1984-12-12 | 1986-06-27 | Hitachi Koki Co Ltd | Centrifugal automatic reaction apparatus |
JPH0786509B2 (en) * | 1985-06-18 | 1995-09-20 | 株式会社東芝 | Automatic chemical analyzer |
JPH0690212B2 (en) * | 1986-02-21 | 1994-11-14 | 株式会社東芝 | Automatic chemical analyzer |
JPH0754326B2 (en) * | 1986-06-24 | 1995-06-07 | 株式会社東芝 | Automatic chemical analyzer |
US5089417A (en) * | 1987-07-01 | 1992-02-18 | Miles Inc. | Fluid separation and processing device |
JPH06103315B2 (en) * | 1987-08-14 | 1994-12-14 | 株式会社東芝 | Dispensing nozzle device of automatic chemical analyzer |
US4862932A (en) * | 1988-04-20 | 1989-09-05 | Bio-Rad Laboratories, Inc. | Fraction collector |
US5045047A (en) * | 1989-07-17 | 1991-09-03 | Zymark Corporation | Automated centrifuge |
JP2539512B2 (en) * | 1989-07-17 | 1996-10-02 | 株式会社日立製作所 | Multi-item analyzer and method for operating the analyzer |
DE3923833C2 (en) * | 1989-07-19 | 1998-07-02 | Boehringer Mannheim Gmbh | Analyzer for heterogeneous immunological tests |
CZ280777B6 (en) * | 1990-02-02 | 1996-04-17 | Ústav Organické Chemie A Biochemie Avčr | Process of multistep synthesis of peptides on planar carriers and apparatus for making the same |
US5178602A (en) * | 1990-02-07 | 1993-01-12 | Wells John R | Automatic decanting centrifuge |
US5585068A (en) * | 1990-02-20 | 1996-12-17 | Biochemical Diagnostics, Inc. | Apparatus for automatically separating a compound from a plurality of discrete liquid specimens |
US5105305A (en) * | 1991-01-10 | 1992-04-14 | At&T Bell Laboratories | Near-field scanning optical microscope using a fluorescent probe |
US5888723A (en) * | 1992-02-18 | 1999-03-30 | Johnson & Johnson Clinical Diagnostics, Inc. | Method for nucleic acid amplification and detection using adhered probes |
EP0569115A3 (en) | 1992-05-05 | 1994-01-05 | General Atomics | High throughput DNA preparation system |
US5472672A (en) * | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
US5514789A (en) * | 1994-04-21 | 1996-05-07 | Barrskogen, Inc. | Recovery of oligonucleotides by gas phase cleavage |
US5614608A (en) * | 1995-01-20 | 1997-03-25 | Selectide Corporation | Apparatus and method for multiple synthesis of organic compounds on polymer support |
US5707331A (en) * | 1995-05-05 | 1998-01-13 | John R. Wells | Automatic multiple-decanting centrifuge |
US5633972A (en) * | 1995-11-29 | 1997-05-27 | Trustees Of Tufts College | Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy |
US6045760A (en) * | 1995-12-05 | 2000-04-04 | Hitachi Koki Co., Ltd. | Micro-plate adapter |
US6045755A (en) * | 1997-03-10 | 2000-04-04 | Trega Biosciences,, Inc. | Apparatus and method for combinatorial chemistry synthesis |
US6071748A (en) | 1997-07-16 | 2000-06-06 | Ljl Biosystems, Inc. | Light detection device |
US6121054A (en) * | 1997-11-19 | 2000-09-19 | Trega Biosciences, Inc. | Method for separation of liquid and solid phases for solid phase organic syntheses |
ID23862A (en) * | 1998-02-20 | 2000-05-25 | Scil Diagnotics Gmbh | ANALYSIS SYSTEM |
US6130046A (en) * | 1998-05-04 | 2000-10-10 | Affymetrix, Inc. | Techniques for synthesis integrity evaluation utilizing cycle fidelity probes |
US6270730B1 (en) * | 1998-06-16 | 2001-08-07 | Northwest Engineering Inc. | Multi-well rotary synthesizer |
US6846460B1 (en) * | 1999-01-29 | 2005-01-25 | Illumina, Inc. | Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses |
AU771720B2 (en) | 1999-01-29 | 2004-04-01 | Illumina, Inc. | Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses |
DE19919607A1 (en) * | 1999-04-29 | 2000-11-16 | Mets Ion Gmbh Ges Fuer Angewan | Parallel synthesis of multiple oligonucleotides comprises using plug-in modules rotating between stations for performing different operations |
US6357907B1 (en) * | 1999-06-15 | 2002-03-19 | V & P Scientific, Inc. | Magnetic levitation stirring devices and machines for mixing in vessels |
US6558623B1 (en) | 2000-07-06 | 2003-05-06 | Robodesign International, Inc. | Microarray dispensing with real-time verification and inspection |
US7390459B2 (en) * | 1999-12-13 | 2008-06-24 | Illumina, Inc. | Oligonucleotide synthesizer |
ATE527053T1 (en) * | 1999-12-13 | 2011-10-15 | Illumina Inc | SYNTHESIS DEVICE FOR OLIGONUCLEOTIDES USING CENTRIFLY FORCE |
US6587579B1 (en) | 2000-01-26 | 2003-07-01 | Agilent Technologies Inc. | Feature quality in array fabrication |
US6692972B1 (en) | 2000-08-24 | 2004-02-17 | University Of Chicago | Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules |
US7887752B2 (en) * | 2003-01-21 | 2011-02-15 | Illumina, Inc. | Chemical reaction monitor |
-
2006
- 2006-09-11 JP JP2008531251A patent/JP5055282B2/en active Active
- 2006-09-11 EP EP06814519A patent/EP1937400A4/en not_active Withdrawn
- 2006-09-11 CN CNA2006800357239A patent/CN101277758A/en active Pending
- 2006-09-11 WO PCT/US2006/035491 patent/WO2007033176A2/en active Search and Examination
- 2006-09-13 US US11/521,574 patent/US20070117178A1/en not_active Abandoned
- 2006-09-13 US US11/521,573 patent/US7914739B2/en active Active
-
2011
- 2011-02-16 US US13/029,071 patent/US8731721B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6264891B1 (en) * | 1998-12-22 | 2001-07-24 | Eos Biotechnology, Inc. | Apparatus and method for concurrent chemical synthesis |
Also Published As
Publication number | Publication date |
---|---|
US20070117178A1 (en) | 2007-05-24 |
EP1937400A4 (en) | 2011-02-23 |
EP1937400A2 (en) | 2008-07-02 |
US20070110638A1 (en) | 2007-05-17 |
US7914739B2 (en) | 2011-03-29 |
WO2007033176A2 (en) | 2007-03-22 |
US20110136696A1 (en) | 2011-06-09 |
JP5055282B2 (en) | 2012-10-24 |
US8731721B2 (en) | 2014-05-20 |
CN101277758A (en) | 2008-10-01 |
JP2009514796A (en) | 2009-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007033176A3 (en) | Continuous polymer synthesizer | |
EP1857500A4 (en) | Process for producing solar cell sealing material | |
WO2009116819A3 (en) | Preamble generation method for random access in a wireless communication system | |
EP1742283A4 (en) | Method for producing catalyst for fuel cell | |
WO2002016023A3 (en) | Method and apparatus for in situ synthesis on a solid support | |
EP1775759A4 (en) | Electrode material, solar cell and process for producing solar cell | |
DE502006007901D1 (en) | ACOUSTIC CONCENTRATION METHOD, CONCENTRATING DEVICE AND REACTION PROCESS | |
WO2006113382A3 (en) | Bioreactor system and method of enhancing functionality of muscle cultured in vitro | |
ZA200901184B (en) | Acrylic acid based on renewable raw materials,water-absorbing polymer structures,and method for the production thereof by means of dehydration | |
EP1879249A4 (en) | Hydrophobic catalyst layer for solid polymer fuel cell, method for producing same, solid polymer fuel cell and method for manufacturing same | |
EP1719790A4 (en) | Polyester polymerization catalyst, polyester produced therewith and process for producing the polyester | |
EP1950197A4 (en) | Process for producing pentaerythritol mercaptocarboxylic acid ester, pentaerythritol mercaptocarboxylic acid ester obtained by the same, and use thereof | |
EP1949960A4 (en) | Catalyst for hydrogen production, process for producing the same, fuel reformer, and fuel cell | |
EP1734602A4 (en) | Powder catalyst material, method for producing same and electrode for solid polymer fuel cell using same | |
WO2004113490A3 (en) | Directed selective solid-phase culturing of stable microbial mixed populations for the continuous preparation of defined enzyme and metabolite mixture and bioreactor | |
EP1826221A4 (en) | Method for producing norbornene based addition (co)polymer | |
BRPI0720482B8 (en) | process to produce water-absorbent polymeric particles, water-absorbent polymeric particles, use of polymeric particles, and, sanitary article | |
EP1947719A4 (en) | Electrode catalyst for fuel cell and method for producing same | |
IL177608A0 (en) | Continuous culture apparatus with mobile vessel, allowing selection of fitter cell variants | |
IL202831A (en) | Process for performing an endothermic reaction, reactors for performing the process and their uses | |
WO2007005771A3 (en) | Systems and methods for organic material conversion and use | |
WO2008025563A3 (en) | Polymer matrix, method for its production, and its use | |
AU2003293990A8 (en) | Gas diffuser substrate containing catalysts for fuel cells, in addition to a method for the production thereof | |
EP1845571A3 (en) | Deposition processes for manufacturing electrochemical cell parts | |
WO2009040646A3 (en) | Hydrogen production method, hydrogen production system, and fuel cell system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200680035723.9 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2008531251 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006814519 Country of ref document: EP |
|
DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) |