WO2007035940A3 - Transdermal norelgestromin delivery system - Google Patents

Transdermal norelgestromin delivery system Download PDF

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Publication number
WO2007035940A3
WO2007035940A3 PCT/US2006/037342 US2006037342W WO2007035940A3 WO 2007035940 A3 WO2007035940 A3 WO 2007035940A3 US 2006037342 W US2006037342 W US 2006037342W WO 2007035940 A3 WO2007035940 A3 WO 2007035940A3
Authority
WO
WIPO (PCT)
Prior art keywords
ngmn
norelgestromin
transdermal
delivery system
permeation enhancers
Prior art date
Application number
PCT/US2006/037342
Other languages
French (fr)
Other versions
WO2007035940A2 (en
Inventor
Tyler D Westcott
Jane Stepic
Delphine C Imbert
Jay Audett
Jianye Wen
Allison Luciano
Eric N Silverberg
Paul B Foreman
Original Assignee
Alza Corp
Tyler D Westcott
Jane Stepic
Delphine C Imbert
Jay Audett
Jianye Wen
Allison Luciano
Eric N Silverberg
Paul B Foreman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Tyler D Westcott, Jane Stepic, Delphine C Imbert, Jay Audett, Jianye Wen, Allison Luciano, Eric N Silverberg, Paul B Foreman filed Critical Alza Corp
Publication of WO2007035940A2 publication Critical patent/WO2007035940A2/en
Publication of WO2007035940A3 publication Critical patent/WO2007035940A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J7/00—Adhesives in the form of films or foils
    • C09J7/20—Adhesives in the form of films or foils characterised by their carriers
    • C09J7/22—Plastics; Metallised plastics
    • C09J7/25—Plastics; Metallised plastics based on macromolecular compounds obtained otherwise than by reactions involving only carbon-to-carbon unsaturated bonds
    • C09J7/255—Polyesters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J7/00—Adhesives in the form of films or foils
    • C09J7/30—Adhesives in the form of films or foils characterised by the adhesive composition
    • C09J7/38—Pressure-sensitive adhesives [PSA]
    • C09J7/381—Pressure-sensitive adhesives [PSA] based on macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C09J7/385—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J2467/00—Presence of polyester
    • C09J2467/006—Presence of polyester in the substrate

Abstract

A system for transdermal delivery of norelgestromin (NGMN) to an individual. The system has a high NGMN loading with suitable permeation enhancers to effect therapeutic flux rate. Polyacrylate drug reservoir with the NGMN and high loading of one or more of permeation enhancers and NGMN dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties. Estrogen can be delivered with the NGMN.
PCT/US2006/037342 2005-09-23 2006-09-22 Transdermal norelgestromin delivery system WO2007035940A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72020005P 2005-09-23 2005-09-23
US60/720,200 2005-09-23

Publications (2)

Publication Number Publication Date
WO2007035940A2 WO2007035940A2 (en) 2007-03-29
WO2007035940A3 true WO2007035940A3 (en) 2007-05-10

Family

ID=37770404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/037342 WO2007035940A2 (en) 2005-09-23 2006-09-22 Transdermal norelgestromin delivery system

Country Status (2)

Country Link
US (3) US9056061B2 (en)
WO (1) WO2007035940A2 (en)

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US8263680B2 (en) * 2005-09-23 2012-09-11 Henkel Ag & Co. Kgaa Acrylic polymer-based adhesives
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US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
CA2906274A1 (en) 2012-03-14 2013-09-19 Medipacs, Inc. Smart polymer materials with excess reactive molecules
RU2700032C2 (en) * 2014-08-25 2019-09-12 ХЕНКЕЛЬ АйПи ЭНД ХОЛДИНГ ГМБХ Acrylic polymers and use thereof in transdermal drug delivery
MX2018001571A (en) 2015-08-05 2018-09-06 Childrens Medical Center Compositions with permeation enhancers for drug delivery.
CA3036696A1 (en) * 2016-09-14 2018-03-22 Children's Medical Center Corporation Compositions with permeation enhancers for drug delivery

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Also Published As

Publication number Publication date
WO2007035940A2 (en) 2007-03-29
US20070098772A1 (en) 2007-05-03
US9056061B2 (en) 2015-06-16
US20070082038A1 (en) 2007-04-12
US20160374955A1 (en) 2016-12-29

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