WO2007038411A3 - Method and apparatus for a liquid chemical concentration analysis system - Google Patents

Method and apparatus for a liquid chemical concentration analysis system Download PDF

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Publication number
WO2007038411A3
WO2007038411A3 PCT/US2006/037223 US2006037223W WO2007038411A3 WO 2007038411 A3 WO2007038411 A3 WO 2007038411A3 US 2006037223 W US2006037223 W US 2006037223W WO 2007038411 A3 WO2007038411 A3 WO 2007038411A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical
liquid
ref
analysis system
liquid chemical
Prior art date
Application number
PCT/US2006/037223
Other languages
French (fr)
Other versions
WO2007038411A2 (en
Inventor
Ronald P Chiarello
Charles Eric Boyd
Duncan A Mcphee
Original Assignee
Jetalon Solutions Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/235,622 external-priority patent/US7319523B2/en
Application filed by Jetalon Solutions Inc filed Critical Jetalon Solutions Inc
Publication of WO2007038411A2 publication Critical patent/WO2007038411A2/en
Publication of WO2007038411A3 publication Critical patent/WO2007038411A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/4133—Refractometers, e.g. differential
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/4133—Refractometers, e.g. differential
    • G01N2021/4153—Measuring the deflection of light in refractometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/09—Cuvette constructions adapted to resist hostile environments or corrosive or abrasive materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0624—Compensating variation in output of LED source

Abstract

An apparatus utilizes optical reflectivity (REF) to measure concentrations in liquids. The REF optical system is packaged in a compact and cost-effective form factor. An electronic circuit drives the optical system. The miniaturized REF sensor is situated in an optical-fluidic cell or an optical-fluidic manifold with an optical window in contact with the liquid. Changes in a total internal reflection (TIR) signal are sensitive to temperature and concentration of the liquid. These changes in the TIR signal are used to accurately determine the concentration in the liquid. The liquids may be either static or dynamic.
PCT/US2006/037223 2005-09-26 2006-09-25 Method and apparatus for a liquid chemical concentration analysis system WO2007038411A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11/235,622 2005-09-26
US11/235,622 US7319523B2 (en) 2005-09-26 2005-09-26 Apparatus for a liquid chemical concentration analysis system
US11/491,110 2006-07-21
US11/490,575 2006-07-21
US11/490,575 US7397547B2 (en) 2005-09-26 2006-07-21 Method and apparatus for a liquid chemical concentration analysis system
US11/491,110 US7268864B2 (en) 2005-09-26 2006-07-21 Method for a liquid chemical concentration analysis system

Publications (2)

Publication Number Publication Date
WO2007038411A2 WO2007038411A2 (en) 2007-04-05
WO2007038411A3 true WO2007038411A3 (en) 2009-04-09

Family

ID=37900350

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/037223 WO2007038411A2 (en) 2005-09-26 2006-09-25 Method and apparatus for a liquid chemical concentration analysis system

Country Status (1)

Country Link
WO (1) WO2007038411A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9024252B2 (en) * 2012-02-21 2015-05-05 Entegris-Jetalon Solutions, Inc. Optical sensor apparatus to detect light based on the refractive index of a sample
EP3452808A1 (en) * 2016-05-03 2019-03-13 Ventana Medical Systems, Inc. System and method for monitoring reagent concentrations
CN107228839B (en) * 2017-05-31 2021-03-26 华中科技大学 High-flux refractive index measurement chip, device and method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565978A (en) * 1993-04-15 1996-10-15 Japan Energy Corporation Total-reflection type refractive index sensor
US6549276B1 (en) * 1998-10-30 2003-04-15 Research Foundation Of State University Of New York Method and apparatus for optical measurement of concentration and temperature of liquids
US20050046853A1 (en) * 2003-09-02 2005-03-03 Fuji Photo Film Co., Ltd. Measuring apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565978A (en) * 1993-04-15 1996-10-15 Japan Energy Corporation Total-reflection type refractive index sensor
US6549276B1 (en) * 1998-10-30 2003-04-15 Research Foundation Of State University Of New York Method and apparatus for optical measurement of concentration and temperature of liquids
US20050046853A1 (en) * 2003-09-02 2005-03-03 Fuji Photo Film Co., Ltd. Measuring apparatus

Also Published As

Publication number Publication date
WO2007038411A2 (en) 2007-04-05

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