WO2007044976A3 - Improved testosterone gel and method of use - Google Patents

Improved testosterone gel and method of use Download PDF

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Publication number
WO2007044976A3
WO2007044976A3 PCT/US2006/040481 US2006040481W WO2007044976A3 WO 2007044976 A3 WO2007044976 A3 WO 2007044976A3 US 2006040481 W US2006040481 W US 2006040481W WO 2007044976 A3 WO2007044976 A3 WO 2007044976A3
Authority
WO
WIPO (PCT)
Prior art keywords
testosterone gel
improved testosterone
improved
things
methods
Prior art date
Application number
PCT/US2006/040481
Other languages
French (fr)
Other versions
WO2007044976A2 (en
Inventor
Ramana Malladi
Original Assignee
Unimed Pharmaceuticals Inc
Ramana Malladi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37943593&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007044976(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to PL11181638T priority Critical patent/PL2450041T3/en
Priority to BRPI0617294A priority patent/BRPI0617294B8/en
Priority to EP18195634.3A priority patent/EP3456329A1/en
Priority to EP11181638.5A priority patent/EP2450041B1/en
Priority to CN2006800381261A priority patent/CN101287470B/en
Priority to ES06836341T priority patent/ES2399763T3/en
Priority to AU2006299833A priority patent/AU2006299833B2/en
Priority to EA200801049A priority patent/EA012754B1/en
Priority to NO20200014A priority patent/NO346660B1/en
Priority to DK06836341.5T priority patent/DK1937276T3/en
Priority to EP06836341A priority patent/EP1937276B1/en
Priority to CA2624788A priority patent/CA2624788C/en
Priority to SI200631518T priority patent/SI1937276T1/en
Priority to PL06836341T priority patent/PL1937276T3/en
Application filed by Unimed Pharmaceuticals Inc, Ramana Malladi filed Critical Unimed Pharmaceuticals Inc
Priority to JP2008535781A priority patent/JP5584415B2/en
Priority to RS20130059A priority patent/RS52671B/en
Priority to NZ567056A priority patent/NZ567056A/en
Publication of WO2007044976A2 publication Critical patent/WO2007044976A2/en
Publication of WO2007044976A3 publication Critical patent/WO2007044976A3/en
Priority to IL190522A priority patent/IL190522A/en
Priority to TNP2008000167A priority patent/TNSN08167A1/en
Priority to KR1020087008787A priority patent/KR101342357B1/en
Priority to NO20082170A priority patent/NO344564B1/en
Priority to HK08111228.3A priority patent/HK1117417A1/en
Priority to HRP20130071TT priority patent/HRP20130071T1/en
Priority to CY181101199T priority patent/CY1120904T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Abstract

The present invention relates to an improved transdermal hydroalcoholic testosterone gel formulation that provides, among other things, a desirable pharmacokinetic hormone profile, and methods of use.
PCT/US2006/040481 2005-10-12 2006-10-12 Improved testosterone gel and method of use WO2007044976A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
BRPI0617294A BRPI0617294B8 (en) 2005-10-12 2006-10-12 pharmaceutical composition in hydroalcoholic gel and use of testosterone
PL06836341T PL1937276T3 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
SI200631518T SI1937276T1 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
EP11181638.5A EP2450041B1 (en) 2005-10-12 2006-10-12 Improved testosterone gel for use in the treatment of hypogonadism
CN2006800381261A CN101287470B (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
ES06836341T ES2399763T3 (en) 2005-10-12 2006-10-12 Enhanced testosterone gel and method of use
AU2006299833A AU2006299833B2 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
EA200801049A EA012754B1 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
NO20200014A NO346660B1 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
DK06836341.5T DK1937276T3 (en) 2005-10-12 2006-10-12 IMPROVED TESTOSTERONGEL AND PROCEDURE TO USE THEREOF
EP06836341A EP1937276B1 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
CA2624788A CA2624788C (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
EP18195634.3A EP3456329A1 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
PL11181638T PL2450041T3 (en) 2005-10-12 2006-10-12 Improved testosterone gel for use in the treatment of hypogonadism
NZ567056A NZ567056A (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
JP2008535781A JP5584415B2 (en) 2005-10-12 2006-10-12 Improved testosterone gel formulation and method of use
RS20130059A RS52671B (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use
IL190522A IL190522A (en) 2005-10-12 2008-03-31 Hydroalcoholic testosterone gel pharmaceutical composition and the use of testosterone for the manufacture of a composition
TNP2008000167A TNSN08167A1 (en) 2005-10-12 2008-04-11 IMPROVED TESTOSTERONE GEL AND METHOD OF USE
KR1020087008787A KR101342357B1 (en) 2005-10-12 2008-04-11 Improved testosterone gel and method of use
NO20082170A NO344564B1 (en) 2005-10-12 2008-05-09 Improved testosterone gel and method of use
HK08111228.3A HK1117417A1 (en) 2005-10-12 2008-10-10 Improved testosterone gel and method of use
HRP20130071TT HRP20130071T1 (en) 2005-10-12 2013-01-28 Improved testosterone gel and method of use
CY181101199T CY1120904T1 (en) 2005-10-12 2018-11-13 IMPROVED TESTOSTERONE GEL AND METHOD OF USE IN THE TREATMENT OF HYPODONGISM

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72527605P 2005-10-12 2005-10-12
US60/725,276 2005-10-12

Publications (2)

Publication Number Publication Date
WO2007044976A2 WO2007044976A2 (en) 2007-04-19
WO2007044976A3 true WO2007044976A3 (en) 2007-09-07

Family

ID=37943593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040481 WO2007044976A2 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use

Country Status (30)

Country Link
US (11) US20070237822A1 (en)
EP (3) EP1937276B1 (en)
JP (2) JP5584415B2 (en)
KR (1) KR101342357B1 (en)
CN (1) CN101287470B (en)
AU (1) AU2006299833B2 (en)
BR (1) BRPI0617294B8 (en)
CA (1) CA2624788C (en)
CY (1) CY1120904T1 (en)
DK (2) DK2450041T3 (en)
EA (1) EA012754B1 (en)
EC (1) ECSP088363A (en)
ES (2) ES2399763T3 (en)
GE (1) GEP20125432B (en)
HK (1) HK1117417A1 (en)
HR (1) HRP20130071T1 (en)
IL (1) IL190522A (en)
LT (1) LT2450041T (en)
MA (1) MA29941B1 (en)
NO (2) NO346660B1 (en)
NZ (1) NZ567056A (en)
PL (2) PL1937276T3 (en)
PT (2) PT2450041T (en)
RS (1) RS52671B (en)
SI (2) SI1937276T1 (en)
TN (1) TNSN08167A1 (en)
TR (1) TR201815853T4 (en)
UA (1) UA87627C2 (en)
WO (1) WO2007044976A2 (en)
ZA (1) ZA200803087B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125816B2 (en) 2000-08-30 2015-09-08 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
UA80964C2 (en) * 2002-03-15 2007-11-26 Unimed Pharmaceuticals Inc Method for treating depression and kit therefor
EP1634583A1 (en) * 2004-09-09 2006-03-15 Laboratoires Besins International Testosterone gels comprising propylene glycol as penetration enhancer
EA012754B1 (en) 2005-10-12 2009-12-30 Юнимед Фармасьютикалз Ллк Improved testosterone gel and method of use
CA2623477C (en) * 2007-03-23 2011-05-31 Robert E. Dudley Compositions and method for treating pediatric hypogonadism
MX2010004789A (en) * 2007-11-02 2010-07-05 Acrux Dds Pty Ltd Transdermal delivery system for hormones and steroids.
AU2010237596A1 (en) * 2009-04-01 2011-10-27 Wirra Ip Pty Ltd A multidose package, course and method of treatment for delivering predetermined multiple doses of a pharmaceutical
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
AR086400A1 (en) * 2011-05-13 2013-12-11 Trimel Pharmaceuticals Corp FORMULATIONS IN INTRANASAL GEL OF TESTOSTERONE IN DOSE OF LOWER POWER AND USE OF THE SAME FOR THE TREATMENT OF ANORGASMIA OR THE DISORDER OF HYPOACTIVE SEXUAL DESIRE
US9987213B2 (en) * 2012-06-13 2018-06-05 Edward Dunne Corboy, JR. Topical dihydrotestosterone (DHT) for promoting hair growth—containing formulations
US20140058339A1 (en) * 2012-08-22 2014-02-27 Mark L. Baum Method and apparatus for self-dosing and self-administering pharmaceutical compositions
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event
US11160751B2 (en) 2013-10-07 2021-11-02 Antares Pharma, Inc. Hematocrit modulation through needle assisted jet injection of testosterone
US8785426B1 (en) 2013-12-13 2014-07-22 Upsher-Smith Laboratories, Inc. Testosterone gel compositions and related methods
WO2015128876A2 (en) * 2014-02-25 2015-09-03 Intas Pharmaceuticals Limited Stable transdermal testosterone gel
US20170014417A1 (en) 2015-07-14 2017-01-19 Lipp Life Sciences Llc Pharmaceutical administration system for the transdermal application of vardenafil
WO2017057743A1 (en) * 2015-09-30 2017-04-06 富士フイルム株式会社 Transdermally absorbable composition
JP6838952B2 (en) * 2016-12-07 2021-03-03 川崎重工業株式会社 Robots and bags used for robots

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002017926A1 (en) * 2000-08-30 2002-03-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040072810A1 (en) * 2001-11-07 2004-04-15 Besins International Belgique Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof
WO2004037173A2 (en) * 2002-10-18 2004-05-06 Unimed Pharmaceuticals, Inc. Method for treating erectile dysfunction and increasing libido in men
US20050020552A1 (en) * 2003-07-16 2005-01-27 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery

Family Cites Families (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2155658A (en) 1936-01-08 1939-04-25 Chemische Forschungs Gmbh Surgical and medical preparations
US2232508A (en) 1938-10-21 1941-02-18 Lionel Corp Accessory control circuits for toy electric railroads and apparatus therefor
BE565269A (en) 1957-03-27
GB916778A (en) 1959-10-15 1963-01-30 Vismara Francesco Spa Oral compositions containing 3-substituted 17-ª--methyl testosterones
US3121042A (en) 1959-05-04 1964-02-11 Ercoli Alberto Oral compositions containing 3-enolethers of methyltestosterone
GB941634A (en) 1960-11-16 1963-11-13 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3218283A (en) 1962-07-26 1965-11-16 Monsanto Co Novel solutions of poly-(acrylic anhydride) and poly-(methacrylic anhydride) polymers
US3164520A (en) 1962-10-29 1965-01-05 Olin Mathieson Injectable steroid compositions containing at least 75% benzyl benzoate
GB1158283A (en) 1965-10-21 1969-07-16 Foster Milburn Company Composition to be Applied to Skin and Process for Preparing Same.
US3888995A (en) 1968-07-19 1975-06-10 Syntex Corp Fatty alcohol-propylene glycol vehicle
US3887699A (en) 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3913789A (en) 1974-02-13 1975-10-21 United States Banknote Corp Fluid container of the flexible wall capsule type
US4009254A (en) 1974-05-06 1977-02-22 Colgate-Palmolive Company Topical compositions
US3939111A (en) 1974-07-01 1976-02-17 The B. F. Goodrich Company Stable polyurethane solutions
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4197316A (en) 1975-07-23 1980-04-08 Scott Eugene J Van Treatment of dry skin
NL7510104A (en) 1975-08-27 1977-03-01 Akzo Nv PROCESS FOR THE PREPARATION OF AN ORAL ACTIVE PHARMACEUTICAL PREPARATION.
US4078060A (en) 1976-05-10 1978-03-07 Richardson-Merrell Inc. Method of inducing an estrogenic response
CH625702A5 (en) 1977-01-18 1981-10-15 Delalande Sa
DE2747531A1 (en) 1977-10-22 1979-04-26 Basf Ag SUBSTITUTED 3-AMINOPYRAZOLE
US4954487A (en) 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4299826A (en) 1979-10-12 1981-11-10 The Procter & Gamble Company Anti-acne composition
CA1165240A (en) 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4442094A (en) 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4440777A (en) 1981-07-07 1984-04-03 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
US4447562A (en) 1981-07-15 1984-05-08 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
FR2515041A1 (en) 1981-10-26 1983-04-29 Besins Jean PROGESTERONE-BASED DRUG FOR THE TREATMENT OF MAMMARY DISEASES
FR2518879A1 (en) 1981-12-30 1983-07-01 Besins Jean Topical oestradiol compsns. - for treatment of disorders associated with menopause
FR2519252A1 (en) 1982-01-07 1983-07-08 Besins Jean Percutaneous gel contg. di:hydro:testosterone - for treating deficient secretion of testicular androgen
US4496556A (en) 1982-08-16 1985-01-29 Norman Orentreich Topical applications for preventing dry skin
DE3315654A1 (en) 1983-04-29 1984-10-31 Bosch Gmbh Robert POLAROGRAPHIC PROBE FOR DETERMINING THE OXYGEN CONTENT IN GASES
NL8301550A (en) 1983-05-03 1984-12-03 Gist Brocades Nv IMIDAZOLETHANOL ESTERS.
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4631188A (en) 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
DE3333240A1 (en) 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen MEDIUM FOR TRANSDERMAL APPLICATION OF MEDICINAL PRODUCTS
US4690775A (en) 1983-09-30 1987-09-01 Research Corporation Emulsion-based gel and process for preparing same
US4615697A (en) 1983-11-14 1986-10-07 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
FR2558373B1 (en) 1984-01-20 1987-07-03 Mauvais Jarvis Pierre ANTI-ESTROGEN MEDICINAL PRODUCT BASED ON 4-HYDROXYTAMOXIFENE FOR PERCUTANEOUS ADMINISTRATION
GB8508404D0 (en) 1985-03-30 1985-05-09 Baylor College Medicine Therapeutic compositions
CA1248450A (en) 1984-04-05 1989-01-10 Kazuo Kigasawa Soft patch
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4704282A (en) 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4791099A (en) 1984-10-29 1988-12-13 Chaovanee Aroonsakul Method of treatment for central nervous system diseases such as Alzheimer's's disease
GB2167408B (en) 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
EP0189861A3 (en) 1985-01-26 1988-02-17 Showa Denko Kabushiki Kaisha Percutaneous absorption accelerator for ionic water-soluble medicine
ATE77962T1 (en) 1985-02-25 1992-07-15 Univ Rutgers DOSING SYSTEM FOR TRANSDERMAL ABSORPTION OF DRUGS.
US4663157A (en) 1985-02-28 1987-05-05 The Proctor & Gamble Company Sunscreen compositions
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4994265A (en) 1985-09-06 1991-02-19 Aloe Scientific Labs Shaving composition
US4683242A (en) 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
DE3687692T2 (en) 1985-11-13 1993-05-19 Japan Res Dev Corp GENDER HORMONES FOR THE TREATMENT OF IMMUNE-DEFICIENT DISEASES.
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
AU6738487A (en) 1985-12-04 1987-06-30 Hsieh, D. Transdermal delivery of drugs
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4699779A (en) 1986-02-18 1987-10-13 Victor Palinczar Waterproof sunscreen compositions
US4820724A (en) 1986-03-31 1989-04-11 University Of Southern California Dual phase solvent carrier system
US4780320A (en) 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4863911A (en) 1986-08-04 1989-09-05 University Of Florida Method for treating male sexual dysfunction
MY102980A (en) 1986-10-31 1993-03-31 Pfizer Transdermal flux enhancing compositions
US4863970A (en) 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US4861764A (en) 1986-11-17 1989-08-29 Macro Chem. Corp. Percutaneous absorption enhancers, compositions containing same and method of use
US5326790A (en) 1986-11-19 1994-07-05 Dermatologic Research Corporation Administration of skin medications by use of dicarboxylic acids and derivatives
AU601528B2 (en) 1986-12-22 1990-09-13 Ortho-Mcneil Pharmaceutical, Inc. Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
US4981696A (en) 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
US4906169A (en) 1986-12-29 1990-03-06 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US4788062A (en) 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
BE1000381A4 (en) 1987-03-13 1988-11-16 Pharlyse Sa PHARMACEUTICAL PREPARATION BASED indomethacin.
US4855305A (en) 1987-03-23 1989-08-08 Applied Medical Research Compositions and methods of effecting contraception utilizing melatonin
JPS6479103A (en) 1987-06-09 1989-03-24 Lion Corp External preparation
US5013553A (en) 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US5256652A (en) 1987-11-12 1993-10-26 Pharmedic Co. Topical compositions and methods for treatment of male impotence
US4920203A (en) 1987-12-17 1990-04-24 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US5223261A (en) 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5719197A (en) 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IE62871B1 (en) 1988-03-08 1995-03-08 Warner Lambert Co Compositions with enhanced penetration
US5231087A (en) 1988-03-16 1993-07-27 Cellegy Pharmaceuticals, Inc. Treatment of skin diseases and tumors with esters and amides of monocarboxylic acids
US5641504A (en) 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
DE68920109T2 (en) 1988-10-11 1995-05-11 Shire Holdings Ltd Drug preparation for percutaneous absorption.
EP0370220B1 (en) 1988-10-27 1996-01-10 Schering Aktiengesellschaft Gestode composition for transdermal application
DE3836862A1 (en) 1988-10-27 1990-05-03 Schering Ag Composition for the transdermal administration of steroid hormones
US5238944A (en) 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US5332577A (en) 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
EP0386960A3 (en) 1989-03-07 1991-10-23 American Cyanamid Company Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
WO1990010462A1 (en) 1989-03-10 1990-09-20 Endorecherche Inc. Combination therapy for treatment of estrogen sensitive diseases
US4917882A (en) 1989-03-16 1990-04-17 Amway Corporation Gel-type sunscreen composition
US5053227A (en) 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
EP0399432B1 (en) 1989-05-25 1994-06-22 Takeda Chemical Industries, Ltd. Transdermal therapeutic composition
US5059603A (en) 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5122519A (en) 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
KR920703065A (en) 1989-07-07 1992-12-17 원본미기재 Treatment of Androgen-Related Diseases
US5232703A (en) 1989-07-21 1993-08-03 Izhak Blank Estradiol compositions and methods for topical application
US5116828A (en) 1989-10-26 1992-05-26 Nippon Zoki Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of osteoporosis
US5324521A (en) 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
JP2893803B2 (en) 1990-02-27 1999-05-24 日本電気株式会社 Driving method of plasma display
DE69133077T2 (en) 1990-06-01 2002-11-07 Population Council New York Preparation of pharmaceutical compositions containing ST1435 for topical use
US5250534A (en) 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
US5202125A (en) 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5152997A (en) 1990-12-11 1992-10-06 Theratech, Inc. Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
EP0491076A1 (en) 1990-12-19 1992-06-24 Theratech, Inc. Penetration enhancement with multi-component system of N-aliphatic pyrrolidones with lower alcohols
JPH04261119A (en) 1991-02-13 1992-09-17 Lintec Corp Percutaneous absorption-type pharmaceutical preparation
US5340585A (en) 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5211952A (en) 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
TW218849B (en) 1991-05-17 1994-01-11 Bristol Myers Squibb Co
US5326566A (en) 1991-05-17 1994-07-05 Bristol-Myers Squibb Company Use of dibutyl adipate and isopropyl myristate in topical and transdermal products
US5208013A (en) 1991-06-03 1993-05-04 Olympus International, Inc. Composition for skin care and protection
US5252338A (en) 1991-06-27 1993-10-12 Alza Corporation Therapy delayed
US5487898A (en) 1991-08-26 1996-01-30 Abbott Laboratories Compositions and method for the sublingual or buccal administration therapeutic agents
US5238933A (en) 1991-10-28 1993-08-24 Sri International Skin permeation enhancer compositions
JP3202777B2 (en) 1992-01-24 2001-08-27 リンテック株式会社 Transdermal absorption enhancer and tape preparation
US5629019A (en) 1992-02-27 1997-05-13 Alza Corporation Formulations with hydrophobic permeation enhancers
TW224048B (en) 1992-03-30 1994-05-21 Hoechst Roussel Pharma
JP2960832B2 (en) 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト Estradiol administration system
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5446025A (en) 1992-06-12 1995-08-29 Abbott Laboratories Formulations and method of the percutaneous administration of leuprolide
NZ254392A (en) 1992-06-19 1997-07-27 Univ California Pharmaceutical compositions comprising a sphingoid (e.g. ceramide) compound and optionally cholesterol and a fatty acid
DE4223004A1 (en) 1992-07-13 1994-01-20 Liedtke Pharmed Gmbh Single-dose semi-solid topical dosage form for transdermal therapy
US5932227A (en) 1992-07-23 1999-08-03 Hisamitsu Pharmaceutical Co., Inc. Percutaneously administrable base composition and drug composition prepared therefrom
JP3276406B2 (en) 1992-07-24 2002-04-22 富士通株式会社 Driving method of plasma display
EP0581587A3 (en) 1992-07-31 1995-05-17 Tanabe Seiyaku Co Base for transdermal administration.
DE4227989A1 (en) 1992-08-21 1994-06-09 Schering Ag Agent for transdermal application containing 3-keto-desogestrel
US5883115A (en) 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
US5639743A (en) 1992-11-13 1997-06-17 University Of Georgia Research Foundation Compositions and methods for treating exocrine gland atrophy
WO1994013257A1 (en) 1992-12-16 1994-06-23 Creative Products Resource Associates, Ltd. Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder
JP3441730B2 (en) 1993-01-19 2003-09-02 アンドルシェルシュ・インコーポレイテッド Dehydroepiandrosterone therapeutic applications and delivery systems
US5776923A (en) 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
US5881926A (en) 1993-03-11 1999-03-16 Taro Pharmaceutical Industries, Ltd. Pharmaceutical compositions in semisolid form and a device for administration thereof
US6010691A (en) 1993-03-19 2000-01-04 The Regents Of The University Of California Methods for enhancing permeation of a topically administered physiologically active substance
EP0696919B1 (en) 1993-04-05 2002-01-30 Competitive Technologies, Inc. Diagnosis and treatment of erectile dysfunction
ATE219946T1 (en) 1993-05-19 2002-07-15 Hisamitsu Pharmaceutical Co 3-L-MENTHOXY-PROPANE-1, 2-DIOL AS A SOLVING PROVIDER AND EXTERNAL PREPARATION CONTAINING SAME
US5648350A (en) 1993-05-25 1997-07-15 Laboratoires Besins Iscovesco Dihydrotestosterone for use in androgenotherapy
US5460820B1 (en) 1993-08-03 1999-08-03 Theratech Inc Method for providing testosterone and optionally estrogen replacement therapy to women
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
BR9408457A (en) 1993-12-27 1997-08-05 Akzo Nobel Nv Percutaneous pharmaceutical preparation
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9401090D0 (en) 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
CN1106259A (en) 1994-02-05 1995-08-09 日东制药株式会社 Antiphlogistic and analgesic gel agent for external use containing propanoic acid non steroid pharmaceutical as effective composition
FR2718372B1 (en) 1994-04-08 1996-06-28 Sofab Dispenser for fluid products.
US6395744B1 (en) 1994-04-22 2002-05-28 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction
EP0758895B1 (en) 1994-04-22 2000-01-26 Pentech Pharmaceuticals, Inc. Sublingual dosage forms containing apomorphine for use in the treatment of erectile dysfunction
US5540934A (en) 1994-06-22 1996-07-30 Touitou; Elka Compositions for applying active substances to or through the skin
ATE194281T1 (en) 1994-09-14 2000-07-15 Minnesota Mining & Mfg TRANSDERMAL ACTIVE RELEASE MATRIX
CA2208132A1 (en) 1994-12-21 1996-06-27 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
US5807568A (en) 1994-12-27 1998-09-15 Mcneil-Ppc, Inc. Enhanced delivery of topical compositions containing flurbiprofen
US6024974A (en) 1995-01-06 2000-02-15 Noven Pharmaceuticals, Inc. Composition and methods for transdermal delivery of acid labile drugs
US5629021A (en) 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
AT408067B (en) 1995-03-17 2001-08-27 Gebro Pharma Gmbh PHARMACEUTICAL COMPOSITION FOR TOPICAL APPLICATION AND METHOD FOR THE PRODUCTION THEREOF
US5844103A (en) 1995-03-24 1998-12-01 Lever Brothers Company, Division Of Conopco, Inc. Anionic glycasuccinamide sufactants and a process for their manufacture
US5654337A (en) 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
FR2732223B1 (en) 1995-03-30 1997-06-13 Sanofi Sa PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION
US5731339A (en) 1995-04-28 1998-03-24 Zonagen, Inc. Methods and formulations for modulating the human sexual response
DE19517145C2 (en) 1995-05-10 2000-02-24 Hexal Pharmaforschung Gmbh Transdermal therapeutic system (TTS) for administration of testosterone
US5882676A (en) 1995-05-26 1999-03-16 Alza Corporation Skin permeation enhancer compositions using acyl lactylates
US5876746A (en) 1995-06-07 1999-03-02 Cygnus, Inc. Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen
US5785991A (en) 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
GB9512670D0 (en) 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
US5780050A (en) 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US5906830A (en) 1995-09-08 1999-05-25 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
US5902603A (en) 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US6251436B1 (en) 1995-09-29 2001-06-26 L.A.M. Pharmaceutical Corporation Drug preparations for treating sexual dysfunction
US6036977A (en) 1995-09-29 2000-03-14 L.A.M. Pharmaceutical Corp. Drug preparations for treating sexual dysfunction
US5849729A (en) 1995-12-26 1998-12-15 Hershey Foods Corporation Use of hydrolyzed cocoa butter for percutaneous absorption
US5643587A (en) 1996-02-15 1997-07-01 Avon Products, Inc. Composition and method for under-eye skin lightening
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US5898038A (en) 1996-03-19 1999-04-27 Board Of Regents, The University Of Texas System Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
DE19619045C1 (en) 1996-05-02 1997-11-13 Jenapharm Gmbh Use of combination products for the treatment of hypogonadal men and men with pituitary disorders
IT1283102B1 (en) 1996-06-06 1998-04-07 Permatec Nv THERAPEUTIC COMPOSITION FOR THE TRANSDERMAL ADMINISTRATION OF AN ESTROGENIC OR PROGESTINIC ACTIVE SUBSTANCE OR OF THEIR MIXTURES
US5730987A (en) 1996-06-10 1998-03-24 Omar; Lotfy Ismail Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba
US5708038A (en) 1996-06-13 1998-01-13 Univera Pharmaceuticals, Inc. Method of using aloe vera as a biological vehicle
US6007837A (en) 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US6139873A (en) 1996-07-10 2000-10-31 Cedars-Sinai Medical Center Combined pharmaceutical estrogen-androgen-progestin
US5770226A (en) 1996-07-10 1998-06-23 Wake Forest University Combined pharmaceutical estrogen-androgen-progestin oral contraceptive
RU2122396C1 (en) 1996-07-12 1998-11-27 Валентина Александровна Андрюшина Bioactive addition to cosmetics
US6228852B1 (en) 1996-07-12 2001-05-08 Carolyn V. Shaak Transdermal application of naturally occurring steroid hormones
US5783208A (en) 1996-07-19 1998-07-21 Theratech, Inc. Transdermal drug delivery matrix for coadministering estradiol and another steroid
US5837289A (en) 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
US6225299B1 (en) 1996-09-16 2001-05-01 Jenapharm Gmbh & Co. Kg Hormonal agent for skin treatment
US5760096A (en) 1996-10-18 1998-06-02 Thornfeldt; Carl R. Potent penetration enhancers
EP0971662A1 (en) 1996-10-30 2000-01-19 TheraTech, Inc. Fatty acid esters of glycolic acid and its salts as permeation enhancers
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US6019988A (en) 1996-11-18 2000-02-01 Bristol-Myers Squibb Company Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
US5855920A (en) 1996-12-13 1999-01-05 Chein; Edmund Y. M. Total hormone replacement therapy
US5807957A (en) 1996-12-23 1998-09-15 Macrochem Corporation Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin
US5908619A (en) 1997-01-09 1999-06-01 Minnesota Mining And Manufacturing Company Hydroalcoholic compositions thickened using surfactant/polymer complexes
US6019997A (en) 1997-01-09 2000-02-01 Minnesota Mining And Manufacturing Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents
DE19701949A1 (en) 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermal therapeutic system
GB9700878D0 (en) 1997-01-17 1997-03-05 Scherer Ltd R P Dosage forms and method for ameliorating male erectile dysfunction
US20010023261A1 (en) 1997-01-27 2001-09-20 Lg Chemical Limited. Novel composition for the transdermal administration of drugs
ATE293960T1 (en) 1997-02-28 2005-05-15 Minnesota Mining & Mfg TRANSDERMAL DEVICE FOR ADMINISTRATION OF TESTOSTERONE
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
US5968919A (en) 1997-10-16 1999-10-19 Macrochem Corporation Hormone replacement therapy drug formulations for topical application to the skin
US20020013304A1 (en) 1997-10-28 2002-01-31 Wilson Leland F. As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness
CA2306837C (en) 1997-10-28 2007-05-08 Asivi, Llc. Treatment of female sexual dysfunction
US5877216A (en) 1997-10-28 1999-03-02 Vivus, Incorporated Treatment of female sexual dysfunction
US6037346A (en) 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6127363A (en) 1997-10-28 2000-10-03 Vivus, Inc. Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6156753A (en) 1997-10-28 2000-12-05 Vivus, Inc. Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6046244A (en) 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
DK1510213T3 (en) * 1997-11-10 2009-03-23 Strakan Int Ltd Penetration-enhancing and irritation-reducing systems including testosterone
CA2309855A1 (en) 1997-11-24 1999-06-03 Katherine D. Gordon Testosterone inhibitors and use for the protection of neurons
WO1999032153A1 (en) 1997-12-22 1999-07-01 Alza Corporation Monoglyceride and ethyl palmitate permeation enhancer compositions
AU1689999A (en) 1997-12-25 1999-07-19 Daiichi Pharmaceutical Co., Ltd. Medicinal composition for percutaneous administration
US5935949A (en) 1998-03-20 1999-08-10 Trustees Of Dartmouth College Use of androgen therapy in fibromyalgia and chronic fatigue syndrome
CN1644201A (en) 1998-04-17 2005-07-27 奥索-麦克尼尔药品公司 Application of folic acid-containing pharmaceutical compositions
FR2777784B1 (en) 1998-04-27 2004-03-19 Arepa PHARMACEUTICAL COMPOSITION BASED ON ESTROGEN AND PROGESTERONE
US6124461A (en) 1998-05-26 2000-09-26 Saint Louis University, Health Services Center, Research Administration Compounds, compositions, and methods for treating erectile dysfunction
US5847128A (en) 1998-05-29 1998-12-08 Virginia Commonwealth University Water soluble derivatives of cannabinoids
US6277884B1 (en) 1998-06-01 2001-08-21 Nitromed, Inc. Treatment of sexual dysfunction with N-hydroxyguanidine compounds
US6087368A (en) 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
DE19825856A1 (en) 1998-06-10 1999-12-16 Labtec Gmbh New topical formulation which includes active agent as liquid lipid nanoparticles in an oil-in-water emulsion
US5942545A (en) 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
AU4696499A (en) 1998-06-19 2000-01-05 Genetronics, Inc. Electrically assisted transdermal method and apparatus for the treatment of erectile dysfunction
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
US5880117A (en) 1998-07-13 1999-03-09 Arnold; Patrick Use of 4-androstenediol to increase testosterone levels in humans
US6207694B1 (en) 1998-07-27 2001-03-27 Howard Murad Pharmaceutical compositions and methods for managing scalp conditions
US6284234B1 (en) 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
US6436950B1 (en) 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
ES2220109T3 (en) 1998-09-04 2004-12-01 Ortho-Mcneil Pharmaceutical, Inc. 5-HETEROCICLILPIRAZOLO (4,3-D) PIRIMIDIN-7-ONAS FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION.
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
EP1005831A3 (en) 1998-12-04 2001-05-30 Eisai Co., Ltd. A method for measurement of a penile diameter
US6224573B1 (en) 1999-01-15 2001-05-01 Nexmed Holdings, Inc. Medicament dispenser
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
JP2000212080A (en) 1999-01-26 2000-08-02 Hiroshi Azuma Erection dysfunction remedy
DE19903087A1 (en) 1999-01-27 2000-08-10 Forssmann Wolf Georg Treatment of erectile dysfunction with C-type natriuretic polypeptide (CNP) as monotherapy or in combination with phosphodiesterase inhibitors
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6087362A (en) 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6187750B1 (en) 1999-08-25 2001-02-13 Everyoung Technologies, Inc. Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
US6075028A (en) 1999-09-23 2000-06-13 Graham; Richard Method of treating Tourette's syndrome and related CNS disorders
US6980566B2 (en) 2000-03-10 2005-12-27 Lightwaves Systems, Inc. Method for routing data packets using an IP address based in GEO position
US6582724B2 (en) 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US6562370B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers
US6562369B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
US20020004065A1 (en) 2000-01-20 2002-01-10 David Kanios Compositions and methods to effect the release profile in the transdermal administration of active agents
JP3596464B2 (en) * 2000-02-10 2004-12-02 セイコーエプソン株式会社 Timing device and control method of timing device
DE10015783C2 (en) 2000-03-30 2003-12-04 Lohmann Therapie Syst Lts Transdermal therapeutic system for delivery of lerisetron and its use
CA2405419A1 (en) 2000-04-07 2001-10-18 Tap Pharmaceutical Products Inc. Apomorphine derivatives and methods for their use
ES2341090T3 (en) 2000-08-30 2010-06-15 Unimed Pharmaceuticals, Llc PROCEDURE TO TREAT ERECTILE DYSFUNCTION AND INCREASE THE LIBIDO IN MEN.
JP2004507511A (en) 2000-08-30 2004-03-11 ユニメッド・ファーマシューティカルズ・インコーポレーテッド Methods for increasing testosterone and related steroid levels in women
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
JP5039252B2 (en) 2000-08-31 2012-10-03 ユニメッド ファーマシューティカルズ，リミティド ライアビリティ カンパニー Pharmaceutical compositions and methods for treating sexual dysfunction
FR2814074B1 (en) 2000-09-15 2003-03-07 Theramex NOVEL TOPICAL ESTRO-PROGESTIVE COMPOSITIONS WITH SYSTEMIC EFFECT
CA2432534C (en) 2000-12-22 2009-09-22 Dr. August Wolff Gmbh & C0. Gel composition and trans-scrotal application of a composition for the treatment of hypogonadism
JP2002212105A (en) 2001-01-22 2002-07-31 Lion Corp Aqueous skin care composition
US20030018085A1 (en) 2001-05-11 2003-01-23 Raoof Araz A. Isostearic acid salts as permeation enhancers
US20030027804A1 (en) 2001-06-27 2003-02-06 Van Der Hoop Roland Gerritsen Therapeutic combinations for the treatment of hormone deficiencies
US20030175329A1 (en) 2001-10-04 2003-09-18 Cellegy Pharmaceuticals, Inc. Semisolid topical hormonal compositions and methods for treatment
ES2330188T3 (en) 2001-12-07 2009-12-07 Besins Manufacturing Belgium PHARMACEUTICAL COMPOSITION IN THE FORM OF A GEL OR A SOLUTION BASED ON DIHYDROTESTOTERONE, ITS PREPARATION PROCEDURE AND ITS USES.
WO2003066130A2 (en) 2002-02-07 2003-08-14 Massachusetts Institute Of Technology Transdermal drug delivery systems
UA80964C2 (en) 2002-03-15 2007-11-26 Unimed Pharmaceuticals Inc Method for treating depression and kit therefor
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
CN1470239A (en) 2002-07-28 2004-01-28 王怀秀 Testosterone intradermic sustained preparation
FR2848112B1 (en) 2002-12-10 2007-02-16 Besins Int Belgique PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL OR TRANSMUCTIVE DELIVERY COMPRISING AT LEAST ONE PROGESTATIVE AND / OR AT LEAST ONE OESTROGEN, PREPARATION METHOD AND USES THEREOF
FR2851470B1 (en) 2003-02-20 2007-11-16 Besins Int Belgique PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL OR TRANSMUCTIVE DELIVERY
US20050042268A1 (en) 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050025833A1 (en) 2003-07-16 2005-02-03 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US7968532B2 (en) 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
RU2275930C2 (en) 2004-04-26 2006-05-10 ООО "РусГен" Composition for correction of human endocrine system age-related changes (variants) and method for production of pharmaceutical formulation based on the same
US20070190124A1 (en) 2004-06-07 2007-08-16 Jie Zhang Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs
US20070196453A1 (en) 2004-06-07 2007-08-23 Jie Zhang Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US20070196323A1 (en) 2004-06-07 2007-08-23 Jie Zhang Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs
US20070189977A1 (en) 2004-06-07 2007-08-16 Jie Zhang Spray-on formulations and methods for dermal delivery of drugs
EP1634583A1 (en) * 2004-09-09 2006-03-15 Laboratoires Besins International Testosterone gels comprising propylene glycol as penetration enhancer
US20070082039A1 (en) 2004-10-18 2007-04-12 Jones Gerald S Jr Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids
US20070088012A1 (en) * 2005-04-08 2007-04-19 Woun Seo Method of treating or preventing type-2 diabetes
EA012246B1 (en) 2005-04-12 2009-08-28 Юнимед Фармасьютикалз, Инк. Method of treating or preventing bone deterioration of osteoporosis
JP2008536851A (en) 2005-04-13 2008-09-11 ユニメド ファーマスーティカルズ インク How to increase testosterone and related steroid levels in women
RU2429850C2 (en) 2005-04-15 2011-09-27 Кларус Терапьютикс, Инк. Pharmaceutical delivery systems for hydrophobic therapeutic agents and compositions containing it
CN102091079B (en) 2005-06-03 2014-03-12 艾克若克斯Dds有限公司 Method and composition for transdermal drug delivery
US20070065494A1 (en) 2005-08-03 2007-03-22 Watson Laboratories, Inc. Formulations and Methods for Enhancing the Transdermal Penetration of a Drug
EA012754B1 (en) * 2005-10-12 2009-12-30 Юнимед Фармасьютикалз Ллк Improved testosterone gel and method of use
US20070254036A1 (en) 2006-04-13 2007-11-01 Besins Healthcare Sa Treatment of menopause associated symptoms
US20080220068A1 (en) 2006-07-31 2008-09-11 Laboratories Besins International Treatment and prevention of excessive scarring
ATE545412T1 (en) 2006-09-11 2012-03-15 Sekisui Chemical Co Ltd ADHESIVE PREPARATION WITH DESGLYMIDODRINE
US20080261937A1 (en) 2007-03-23 2008-10-23 Dudley Robert E Pharmaceutical compositions and method for treating pediatric hypogonadism

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002017926A1 (en) * 2000-08-30 2002-03-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20050113353A1 (en) * 2000-08-30 2005-05-26 Dudley Robert E. Pharmaceutical composition and method for treating hypogonadism
US20040072810A1 (en) * 2001-11-07 2004-04-15 Besins International Belgique Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof
WO2004037173A2 (en) * 2002-10-18 2004-05-06 Unimed Pharmaceuticals, Inc. Method for treating erectile dysfunction and increasing libido in men
US20050020552A1 (en) * 2003-07-16 2005-01-27 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125816B2 (en) 2000-08-30 2015-09-08 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism
US9132089B2 (en) 2000-08-30 2015-09-15 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism

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