WO2007053608A3 - Films and capsules made from modified carboxymethycellulose materials and methods of making same - Google Patents

Films and capsules made from modified carboxymethycellulose materials and methods of making same Download PDF

Info

Publication number
WO2007053608A3
WO2007053608A3 PCT/US2006/042452 US2006042452W WO2007053608A3 WO 2007053608 A3 WO2007053608 A3 WO 2007053608A3 US 2006042452 W US2006042452 W US 2006042452W WO 2007053608 A3 WO2007053608 A3 WO 2007053608A3
Authority
WO
WIPO (PCT)
Prior art keywords
capsules
films
materials
modified
edible films
Prior art date
Application number
PCT/US2006/042452
Other languages
French (fr)
Other versions
WO2007053608A2 (en
Inventor
Andries Hanzen
Hoven Henrica Wilhelmina Cornelia Vaessen-Van
Anja Maria Christina Petronella Hopman
Ross Clark
Original Assignee
Andries Hanzen
Hoven Henrica Wilhelmina Cornelia Vaessen-Van
Anja Maria Christina Petronella Hopman
Ross Clark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/264,260 external-priority patent/US20070098779A1/en
Priority claimed from US11/264,262 external-priority patent/US20070166371A1/en
Application filed by Andries Hanzen, Hoven Henrica Wilhelmina Cornelia Vaessen-Van, Anja Maria Christina Petronella Hopman, Ross Clark filed Critical Andries Hanzen
Priority to EA200801223A priority Critical patent/EA200801223A1/en
Priority to EP06827160A priority patent/EP1954250A2/en
Priority to AP2008004489A priority patent/AP2008004489A0/en
Priority to MX2008005874A priority patent/MX2008005874A/en
Priority to CA002628207A priority patent/CA2628207A1/en
Priority to AU2006310988A priority patent/AU2006310988A1/en
Publication of WO2007053608A2 publication Critical patent/WO2007053608A2/en
Publication of WO2007053608A3 publication Critical patent/WO2007053608A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
    • C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

Films and/or capsules for the delivery of and/or coating of active ingredients are provided. Such edible films and/or capsules comprise particular modified carboxymethylcellulose (CMC) materials either alone or in combination with other types of hydrocolloids or biogums. The utilization of such modified CMC products aids in the production of such films and/or capsules through the availability of larger amounts of base materials with lower amounts of water requiring evaporation therefrom. In such a manner, not only may dimensionally stable, flexible, non-tacky, salt tolerant, and quick dissolving edible films and/or capsules be produced, but the amount of time required for such manufacture is minimal when compared with traditional methods of production with cellulosic-based materials. Furthermore, such novel edible films and/or capsules exhibit excellent clarity, retention of actives, and other physical properties (such as tensile strength, elongation, and ability to be cut into various shapes and sizes, etc.) that make such ultimate products attractive for use in a variety of functions. Furthermore, such films and/or capsules also exhibit properties in dissolution that permit controlled release of actives at any particularly desired rate. The novel method of manufacture as well as the ultimate edible films and/or capsules exhibiting such physical characteristics are also encompassed within this invention.
PCT/US2006/042452 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same WO2007053608A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EA200801223A EA200801223A1 (en) 2005-11-01 2006-10-31 FILMS AND CAPSULES MADE OF MODIFIED CARBOXYMETHYL CELLULOSE MATERIALS AND METHODS OF THEIR PRODUCTION
EP06827160A EP1954250A2 (en) 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same
AP2008004489A AP2008004489A0 (en) 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same
MX2008005874A MX2008005874A (en) 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same.
CA002628207A CA2628207A1 (en) 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same
AU2006310988A AU2006310988A1 (en) 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/264,260 US20070098779A1 (en) 2005-11-01 2005-11-01 Films and capsules made from modified carboxymethylcellulose materials
US11/264,262 US20070166371A1 (en) 2005-11-01 2005-11-01 Methods of producing films and capsules made from modified carboxymethylcellulose materials
US11/264,260 2005-11-01

Publications (2)

Publication Number Publication Date
WO2007053608A2 WO2007053608A2 (en) 2007-05-10
WO2007053608A3 true WO2007053608A3 (en) 2009-01-22

Family

ID=38006458

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/042456 WO2007053612A2 (en) 2005-11-01 2006-10-31 High viscosity diutan gums and methods of producing
PCT/US2006/042452 WO2007053608A2 (en) 2005-11-01 2006-10-31 Films and capsules made from modified carboxymethycellulose materials and methods of making same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042456 WO2007053612A2 (en) 2005-11-01 2006-10-31 High viscosity diutan gums and methods of producing

Country Status (11)

Country Link
EP (1) EP1954250A2 (en)
JP (1) JP5364377B2 (en)
KR (2) KR101372110B1 (en)
CN (2) CN101558165B (en)
AP (2) AP2008004489A0 (en)
AU (2) AU2006308904B9 (en)
CA (1) CA2628207A1 (en)
EA (2) EA200801223A1 (en)
MX (3) MX2008005874A (en)
WO (2) WO2007053612A2 (en)
ZA (1) ZA200804213B (en)

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US20110027838A1 (en) * 2009-07-31 2011-02-03 Harding Nancy E Sphingomonas Strains Producing Greatly Increased Yield Of PHB-Deficient Sphingan (Diutan)
EP3332788A1 (en) 2006-02-03 2018-06-13 Opko Renal, LLC Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
EP2032180B1 (en) 2006-06-15 2017-03-15 Biothera, Inc. Glucan preparations
ES2670029T3 (en) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Therapy using vitamin D replenishment agent and vitamin D hormone replacement agent
KR101691876B1 (en) 2007-04-25 2017-01-02 사이토크로마 인코포레이티드 Oral controlled release compositions comprising vitamin d compound and waxy carrier
CA2683514C (en) 2007-04-25 2019-07-09 Proventiv Therapeutics, Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
US11752158B2 (en) 2007-04-25 2023-09-12 Eirgen Pharma Ltd. Method of treating vitamin D insufficiency and deficiency
US20080274182A1 (en) * 2007-05-03 2008-11-06 Regina Helena Alida Boekema Tablet coatings made from modified carboxymethylcellulose materials
CA2704262A1 (en) * 2007-10-31 2009-05-07 Paladin Labs Inc. Ingestible film composition
EP3112476B1 (en) 2008-04-02 2023-08-02 EirGen Pharma Ltd. Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders
HUE048464T2 (en) 2010-03-29 2020-07-28 Opko Ireland Global Holdings Ltd Methods and compositions for reducing parathyroid levels
US9296939B2 (en) 2010-05-05 2016-03-29 Halliburton Energy Services, Inc. Compositions for modifying rheological properties of cement systems
US9296943B2 (en) 2012-05-22 2016-03-29 Schlumberger Technology Corporation Subterranean treatment fluid composition and method of treatment
KR20140072716A (en) * 2012-12-05 2014-06-13 삼성정밀화학 주식회사 Film having improved haze
KR101847947B1 (en) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 Stabilized modified release vitamin d formulation
KR102199596B1 (en) * 2013-12-31 2021-01-07 롯데정밀화학 주식회사 Aqueous composition for hard capsule and hard capsule prepared thereof
KR102161001B1 (en) * 2013-12-31 2020-09-29 롯데정밀화학 주식회사 Aqueous composition for hard capsuleand hard capsule prepared thereof
KR102199595B1 (en) * 2013-12-31 2021-01-07 롯데정밀화학 주식회사 Aqueous composition for hard capsule and hard capsule prepared thereof
EP3851111A1 (en) 2014-07-10 2021-07-21 Biothera, Inc. Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment
SG10201911274TA (en) 2014-08-07 2020-02-27 Opko Ireland Global Holdings Ltd Adjunctive therapy with 25-hydroxyvitamin d
JP6887378B2 (en) 2014-11-06 2021-06-16 バイオセラ，インク． Beta-glucan methods and compositions that affect the intratumoral microenvironment
TWI747893B (en) 2016-03-28 2021-12-01 愛爾蘭商歐科愛爾蘭全球控股股份有限公司 Methods of vitamin d treatment
US11815435B2 (en) 2017-02-24 2023-11-14 Hibercell, Inc. Beta glucan immunopharmacodynamics
CN106977618B (en) * 2017-04-13 2022-07-01 张星昊 Method for extracting diutan from diutan fermentation liquor
KR102065953B1 (en) * 2018-02-07 2020-02-11 충남대학교산학협력단 Composition for the preparation of carboxymethylnanocellulose composite film, film and production thereof
WO2020006073A1 (en) 2018-06-28 2020-01-02 Arx, Llc Dispensing method for producing dissolvable unit dose film constructs
CN111807785B (en) * 2020-07-17 2022-02-15 中铁建工集团有限公司 Large-volume self-compacting concrete and preparation method thereof
CN112680435B (en) * 2021-01-25 2022-03-25 中国石油大学(华东) Preparation method of sphingosine gum lyase and enzymatic sphingosine gum

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US5366755A (en) * 1989-02-10 1994-11-22 Maritta Timonen Foodstuffs containing novel degraded cellulose derivatives
US5550189A (en) * 1992-04-17 1996-08-27 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
US6599523B2 (en) * 2000-02-29 2003-07-29 Virginia Commonwealth University Preparation of peroxide-oxidized, sulfonated, and phosphorylated cotton
US20050203278A1 (en) * 2004-03-11 2005-09-15 Mccreight Kevin W. Aqueous dispersions of carboxylated cellulose esters, and methods of making them

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US5366755A (en) * 1989-02-10 1994-11-22 Maritta Timonen Foodstuffs containing novel degraded cellulose derivatives
US5550189A (en) * 1992-04-17 1996-08-27 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
US6599523B2 (en) * 2000-02-29 2003-07-29 Virginia Commonwealth University Preparation of peroxide-oxidized, sulfonated, and phosphorylated cotton
US20050203278A1 (en) * 2004-03-11 2005-09-15 Mccreight Kevin W. Aqueous dispersions of carboxylated cellulose esters, and methods of making them

Also Published As

Publication number Publication date
EA200801223A1 (en) 2009-06-30
CN103772520A (en) 2014-05-07
AP2008004489A0 (en) 2008-06-30
AP2008004491A0 (en) 2008-06-30
EA200801224A1 (en) 2009-04-28
CN103772520B (en) 2018-04-10
CA2628207A1 (en) 2007-05-10
ZA200804213B (en) 2022-03-30
KR20080106160A (en) 2008-12-04
AU2006308904B2 (en) 2012-12-06
AP2878A (en) 2014-03-31
EA015170B1 (en) 2011-06-30
AU2006308904B9 (en) 2013-01-10
MX2008005874A (en) 2008-11-27
JP2009515512A (en) 2009-04-16
MX2008005643A (en) 2008-12-09
WO2007053612A3 (en) 2007-12-06
CN101558165B (en) 2013-07-03
WO2007053612A2 (en) 2007-05-10
MX348439B (en) 2017-06-13
JP5364377B2 (en) 2013-12-11
EP1954250A2 (en) 2008-08-13
KR101372110B1 (en) 2014-03-14
KR20090016655A (en) 2009-02-17
CN101558165A (en) 2009-10-14
AU2006310988A1 (en) 2007-05-10
AU2006308904A1 (en) 2007-05-10
WO2007053608A2 (en) 2007-05-10

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Free format text: PEDIDO CONSIDERADO RETIRADO EM RELACAO AO BRASIL E ARQUIVADO POR NAO ATENDER O DISPOSTO NO ITEM 29 E SUBITENS, DO ATO NORMATIVO NO128/1997.