WO2007059007A3 - Markers of definitive endoderm - Google Patents
Markers of definitive endoderm Download PDFInfo
- Publication number
- WO2007059007A3 WO2007059007A3 PCT/US2006/043932 US2006043932W WO2007059007A3 WO 2007059007 A3 WO2007059007 A3 WO 2007059007A3 US 2006043932 W US2006043932 W US 2006043932W WO 2007059007 A3 WO2007059007 A3 WO 2007059007A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- definitive endoderm
- markers
- disclosed
- endoderm cells
- enriching
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0617—Thyroid and parathyroid glands
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
- C12N5/068—Stem cells; Progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
Abstract
Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/093,590 US8586357B2 (en) | 2003-12-23 | 2006-11-13 | Markers of definitive endoderm |
US14/066,441 US9605243B2 (en) | 2003-12-23 | 2013-10-29 | Markers of definitive endoderm |
US15/427,876 US20170216365A1 (en) | 2003-12-23 | 2017-02-08 | Markers of definitive endoderm |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73659805P | 2005-11-14 | 2005-11-14 | |
US60/736,598 | 2005-11-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/021,618 Continuation-In-Part US7510876B2 (en) | 2003-12-23 | 2004-12-23 | Definitive endoderm |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/093,590 A-371-Of-International US8586357B2 (en) | 2003-12-23 | 2006-11-13 | Markers of definitive endoderm |
US14/066,441 Continuation US9605243B2 (en) | 2003-12-23 | 2013-10-29 | Markers of definitive endoderm |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007059007A2 WO2007059007A2 (en) | 2007-05-24 |
WO2007059007A3 true WO2007059007A3 (en) | 2007-08-30 |
Family
ID=37762579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/043932 WO2007059007A2 (en) | 2003-12-23 | 2006-11-13 | Markers of definitive endoderm |
Country Status (2)
Country | Link |
---|---|
US (3) | US8586357B2 (en) |
WO (1) | WO2007059007A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691217B2 (en) | 2005-12-29 | 2014-04-08 | Anthrogenesis Corporation | Placental stem cell populations |
US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
Families Citing this family (36)
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US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
US8586357B2 (en) | 2003-12-23 | 2013-11-19 | Viacyte, Inc. | Markers of definitive endoderm |
CN103898047B (en) | 2003-12-23 | 2020-03-03 | 维亚希特公司 | Definitive endoderm |
WO2007051038A2 (en) | 2005-10-27 | 2007-05-03 | Cythera, Inc. | Pdx1-expressing dorsal and ventral foregut endoderm |
DK2420565T3 (en) | 2006-02-23 | 2017-12-04 | Viacyte Inc | APPLICABLE COMPOSITIONS AND METHODS FOR CULTIVATING DIFFERENTIBLE CELLS |
DK1999253T3 (en) | 2006-03-02 | 2019-08-12 | Viacyte Inc | ENDOCRINE PRECURSOR CELLS, PANCREATIC HORMON-EXPRESSING CELLS AND PROCEDURES FOR MANUFACTURING |
US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
US8008075B2 (en) * | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
EP2356227B1 (en) | 2008-11-14 | 2018-03-28 | Viacyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
WO2012115619A1 (en) | 2011-02-21 | 2012-08-30 | Viacyte, Inc. | Loading system for an encapsulation device |
US9040035B2 (en) | 2011-06-01 | 2015-05-26 | Anthrogenesis Corporation | Treatment of pain using placental stem cells |
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JP6804438B2 (en) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | An in vivo model of the human small intestine using pluripotent stem cells, and methods for making and using it. |
CN107614678B (en) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | Method for producing stem cell-derived beta cells and method for using same |
US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
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US20200080107A1 (en) | 2018-09-07 | 2020-03-12 | Crispr Therapeutics Ag | Universal donor cells |
JP2022547053A (en) | 2019-09-05 | 2022-11-10 | クリスパー セラピューティクス アクチェンゲゼルシャフト | universal donor cells |
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-
2006
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- 2006-11-13 WO PCT/US2006/043932 patent/WO2007059007A2/en active Application Filing
-
2013
- 2013-10-29 US US14/066,441 patent/US9605243B2/en not_active Expired - Fee Related
-
2017
- 2017-02-08 US US15/427,876 patent/US20170216365A1/en not_active Abandoned
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Non-Patent Citations (2)
Title |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691217B2 (en) | 2005-12-29 | 2014-04-08 | Anthrogenesis Corporation | Placental stem cell populations |
US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
Also Published As
Publication number | Publication date |
---|---|
US20170216365A1 (en) | 2017-08-03 |
US20090220959A1 (en) | 2009-09-03 |
US8586357B2 (en) | 2013-11-19 |
US9605243B2 (en) | 2017-03-28 |
US20140134726A1 (en) | 2014-05-15 |
WO2007059007A2 (en) | 2007-05-24 |
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