WO2007067923A3 - Compositions and methods for detecting phosphomonoester - Google Patents

Compositions and methods for detecting phosphomonoester Download PDF

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Publication number
WO2007067923A3
WO2007067923A3 PCT/US2006/061681 US2006061681W WO2007067923A3 WO 2007067923 A3 WO2007067923 A3 WO 2007067923A3 US 2006061681 W US2006061681 W US 2006061681W WO 2007067923 A3 WO2007067923 A3 WO 2007067923A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphomonoester
compound
moiety
target compound
compositions
Prior art date
Application number
PCT/US2006/061681
Other languages
French (fr)
Other versions
WO2007067923A2 (en
Inventor
Igor Kozlov
Peter Melnyk
Chanfeng Zhao
Original Assignee
Illumina Inc
Igor Kozlov
Peter Melnyk
Chanfeng Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc, Igor Kozlov, Peter Melnyk, Chanfeng Zhao filed Critical Illumina Inc
Priority to EP06846502A priority Critical patent/EP1960781A4/en
Publication of WO2007067923A2 publication Critical patent/WO2007067923A2/en
Publication of WO2007067923A3 publication Critical patent/WO2007067923A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides

Abstract

The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of the first carbodiimide compound to the electrophilic moiety over the phosphomonoester moiety, thereby forming an electrophile-protected target compound; and (c) contacting the electrophile-protected target compound with a second carbodiimide compound and a nucleophilic compound under conditions for addition of the nucleophilic compound to the phosphomonoester.
PCT/US2006/061681 2005-12-09 2006-12-06 Compositions and methods for detecting phosphomonoester WO2007067923A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06846502A EP1960781A4 (en) 2005-12-09 2006-12-06 Compositions and methods for detecting phosphomonoester

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/298,907 US7803751B2 (en) 2005-12-09 2005-12-09 Compositions and methods for detecting phosphomonoester
US11/298,907 2005-12-09

Publications (2)

Publication Number Publication Date
WO2007067923A2 WO2007067923A2 (en) 2007-06-14
WO2007067923A3 true WO2007067923A3 (en) 2007-11-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/061681 WO2007067923A2 (en) 2005-12-09 2006-12-06 Compositions and methods for detecting phosphomonoester

Country Status (3)

Country Link
US (2) US7803751B2 (en)
EP (1) EP1960781A4 (en)
WO (1) WO2007067923A2 (en)

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US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
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US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
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EP4242325A3 (en) 2020-04-22 2023-10-04 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207A1 (en) 2020-06-10 2023-04-19 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (en) 2020-12-21 2023-01-25 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
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Citations (4)

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US5512486A (en) * 1993-05-10 1996-04-30 Northeastern University Single step signal group-imidazole labeling of organic phosphate groups under aqueous conditions
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US20050014197A1 (en) * 2002-05-03 2005-01-20 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules

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US5686310A (en) * 1995-06-06 1997-11-11 University Of Virginia Patent Foundation Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
US20020049307A1 (en) * 2000-06-12 2002-04-25 Ruedi Aebersold Selective labeling and isolation of phosphopeptides and applications to proteome analysis
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Also Published As

Publication number Publication date
WO2007067923A2 (en) 2007-06-14
US20070134723A1 (en) 2007-06-14
US20110020853A1 (en) 2011-01-27
US7803751B2 (en) 2010-09-28
US8101375B2 (en) 2012-01-24
EP1960781A2 (en) 2008-08-27
EP1960781A4 (en) 2010-08-18

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