WO2007075912A3 - A system and method of administering a therapeutic material to brain tissue - Google Patents

A system and method of administering a therapeutic material to brain tissue Download PDF

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Publication number
WO2007075912A3
WO2007075912A3 PCT/US2006/048829 US2006048829W WO2007075912A3 WO 2007075912 A3 WO2007075912 A3 WO 2007075912A3 US 2006048829 W US2006048829 W US 2006048829W WO 2007075912 A3 WO2007075912 A3 WO 2007075912A3
Authority
WO
WIPO (PCT)
Prior art keywords
pressure
pump
brain tissue
treatment material
interstitial space
Prior art date
Application number
PCT/US2006/048829
Other languages
French (fr)
Other versions
WO2007075912A2 (en
Inventor
David Jack Croteau
Amy Y Grahn
Sandeep Kunwar
Jeffrey Wayne Sherman
Original Assignee
Neopharm Inc
David Jack Croteau
Amy Y Grahn
Sandeep Kunwar
Jeffrey Wayne Sherman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neopharm Inc, David Jack Croteau, Amy Y Grahn, Sandeep Kunwar, Jeffrey Wayne Sherman filed Critical Neopharm Inc
Publication of WO2007075912A2 publication Critical patent/WO2007075912A2/en
Publication of WO2007075912A3 publication Critical patent/WO2007075912A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14224—Diaphragm type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14232—Roller pumps

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

A system and method employing intraparenchymal pressure-driven delivery of a treatment material into brain tissue at risk for infiltrating tumor cells is provided. The system and method employ bulk flow as a driving force, by creating a positive pressure gradient using a pump. The pump is connected to an infusion catheter placed directly into brain parenchyma to be treated. The positive pressure is transmitted through this delivery system into the interstitial space of the brain parenchyma. Catheter positioning relative to anatomic landmarks and structures in the targeted tissue region plays a key role in optimizing the pressure-driven delivery of treatment material into the interstitial space.
PCT/US2006/048829 2005-12-22 2006-12-22 A system and method of administering a therapeutic material to brain tissue WO2007075912A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75296605P 2005-12-22 2005-12-22
US60/752,966 2005-12-22

Publications (2)

Publication Number Publication Date
WO2007075912A2 WO2007075912A2 (en) 2007-07-05
WO2007075912A3 true WO2007075912A3 (en) 2008-11-20

Family

ID=38218625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048829 WO2007075912A2 (en) 2005-12-22 2006-12-22 A system and method of administering a therapeutic material to brain tissue

Country Status (1)

Country Link
WO (1) WO2007075912A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537241B1 (en) * 1997-08-08 2003-03-25 Twin Star Medical, Inc. System and method for site specific therapy
US20040138551A1 (en) * 2002-09-12 2004-07-15 Andreas Hartlep Determining distribution for planning an infusion
US20050002918A1 (en) * 2001-11-09 2005-01-06 Neopharm, Inc. Selective treatment of IL-13 expressing tumors
US20050148859A1 (en) * 2003-09-08 2005-07-07 Vanderbilt University Apparatus and methods of cortical surface registration and deformation tracking for patient-to-image alignment in relation to image-guided surgery

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537241B1 (en) * 1997-08-08 2003-03-25 Twin Star Medical, Inc. System and method for site specific therapy
US20050002918A1 (en) * 2001-11-09 2005-01-06 Neopharm, Inc. Selective treatment of IL-13 expressing tumors
US20040138551A1 (en) * 2002-09-12 2004-07-15 Andreas Hartlep Determining distribution for planning an infusion
US20050148859A1 (en) * 2003-09-08 2005-07-07 Vanderbilt University Apparatus and methods of cortical surface registration and deformation tracking for patient-to-image alignment in relation to image-guided surgery

Also Published As

Publication number Publication date
WO2007075912A2 (en) 2007-07-05

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