WO2007081486A3 - Oral administration of defensins to treat intestinal diseases - Google Patents

Oral administration of defensins to treat intestinal diseases Download PDF

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Publication number
WO2007081486A3
WO2007081486A3 PCT/US2006/047605 US2006047605W WO2007081486A3 WO 2007081486 A3 WO2007081486 A3 WO 2007081486A3 US 2006047605 W US2006047605 W US 2006047605W WO 2007081486 A3 WO2007081486 A3 WO 2007081486A3
Authority
WO
WIPO (PCT)
Prior art keywords
defensins
oral administration
intestinal diseases
treat intestinal
disease
Prior art date
Application number
PCT/US2006/047605
Other languages
French (fr)
Other versions
WO2007081486A2 (en
Inventor
Jan Wehkamp
Ning Huang
Charles L Bevins
Eduard Stange
Original Assignee
Ventria Bioscience
Univ California
Jan Wehkamp
Ning Huang
Charles L Bevins
Eduard Stange
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventria Bioscience, Univ California, Jan Wehkamp, Ning Huang, Charles L Bevins, Eduard Stange filed Critical Ventria Bioscience
Publication of WO2007081486A2 publication Critical patent/WO2007081486A2/en
Publication of WO2007081486A3 publication Critical patent/WO2007081486A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates, generally, to oral administration of defensins for the treatment of intestinal diseases such as ulcerative colitis and Crohn's disease. The defensins are preferably human defensins, and are more preferably human α-defensins. The defensins may be provided in a dosage form that is suitable for oral administration to a patient suffering from intestinal disease.
PCT/US2006/047605 2005-12-15 2006-12-14 Oral administration of defensins to treat intestinal diseases WO2007081486A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75040305P 2005-12-15 2005-12-15
US60/750,403 2005-12-15

Publications (2)

Publication Number Publication Date
WO2007081486A2 WO2007081486A2 (en) 2007-07-19
WO2007081486A3 true WO2007081486A3 (en) 2008-04-10

Family

ID=38256784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/047605 WO2007081486A2 (en) 2005-12-15 2006-12-14 Oral administration of defensins to treat intestinal diseases

Country Status (1)

Country Link
WO (1) WO2007081486A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110015409A (en) * 2007-11-29 2011-02-15 제넨테크, 인크. Gene expression markers for inflammatory bowel disease
CA2750727A1 (en) * 2008-07-18 2010-01-21 Novozymes Adenium Biotech A/S Treatment of inflammatory bowel diseases with mammal beta defensins
CA2730666A1 (en) 2008-07-18 2010-01-21 Novozymes Adenium Biotech A/S Treatment of rheumatoid arthritis with mammal beta defensins
AR072524A1 (en) * 2008-07-18 2010-09-01 Novozymes As TREATMENT OF INFLAMMATORY DISEASES WITH BETA DEFENSES OF MAMMALS
DE102010040153A1 (en) * 2010-09-02 2012-03-08 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Combination of substances for the treatment of inflammatory or infectious diseases
EP2729159B1 (en) 2011-07-08 2017-05-24 Defensin Therapeutics ApS Oral treatment of inflammatory bowel disease
US20130052213A1 (en) 2011-08-19 2013-02-28 Novozymes A/S Novel immunomodulatory peptide
EP3908305A1 (en) * 2019-01-07 2021-11-17 Aesculus Bio ApS Defensin fragments for use in therapy or prophylaxis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148945A1 (en) * 2001-08-24 2003-08-07 Micrologix Biotech Inc. Antimicrobial and anti-inflammatory peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148945A1 (en) * 2001-08-24 2003-08-07 Micrologix Biotech Inc. Antimicrobial and anti-inflammatory peptides

Also Published As

Publication number Publication date
WO2007081486A2 (en) 2007-07-19

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