WO2007085021A2 - Methods of treating or preventing peritonitis with oxidative reductive potential water solution - Google Patents
Methods of treating or preventing peritonitis with oxidative reductive potential water solution Download PDFInfo
- Publication number
- WO2007085021A2 WO2007085021A2 PCT/US2007/060860 US2007060860W WO2007085021A2 WO 2007085021 A2 WO2007085021 A2 WO 2007085021A2 US 2007060860 W US2007060860 W US 2007060860W WO 2007085021 A2 WO2007085021 A2 WO 2007085021A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- water solution
- orp water
- solution
- peritonitis
- reductive potential
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 583
- 229910001868 water Inorganic materials 0.000 title claims abstract description 574
- 238000000034 method Methods 0.000 title claims abstract description 127
- 206010034674 peritonitis Diseases 0.000 title claims abstract description 81
- 230000001590 oxidative effect Effects 0.000 title claims abstract description 49
- 230000002829 reductive effect Effects 0.000 title claims description 52
- 230000009467 reduction Effects 0.000 claims abstract description 50
- 206010034650 Peritoneal adhesions Diseases 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 13
- 206010034649 Peritoneal abscess Diseases 0.000 claims abstract description 12
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 10
- 241000894007 species Species 0.000 claims description 63
- 208000015181 infectious disease Diseases 0.000 claims description 47
- 241000700605 Viruses Species 0.000 claims description 40
- -1 hypochlorite ions Chemical class 0.000 claims description 39
- 238000002360 preparation method Methods 0.000 claims description 34
- 241000894006 Bacteria Species 0.000 claims description 31
- 244000005700 microbiome Species 0.000 claims description 31
- 238000001356 surgical procedure Methods 0.000 claims description 28
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims description 23
- 241000233866 Fungi Species 0.000 claims description 22
- 230000001771 impaired effect Effects 0.000 claims description 21
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims description 19
- 241000191967 Staphylococcus aureus Species 0.000 claims description 18
- 241000588724 Escherichia coli Species 0.000 claims description 17
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 16
- 206010020751 Hypersensitivity Diseases 0.000 claims description 15
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- 241000222122 Candida albicans Species 0.000 claims description 13
- 239000003242 anti bacterial agent Substances 0.000 claims description 13
- 229940095731 candida albicans Drugs 0.000 claims description 13
- 241000606153 Chlamydia trachomatis Species 0.000 claims description 12
- 229940038705 chlamydia trachomatis Drugs 0.000 claims description 12
- 239000005708 Sodium hypochlorite Substances 0.000 claims description 10
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 8
- 239000004599 antimicrobial Substances 0.000 claims description 8
- 208000014674 injury Diseases 0.000 claims description 8
- 230000007794 irritation Effects 0.000 claims description 8
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 8
- 230000009885 systemic effect Effects 0.000 claims description 8
- 241000191938 Micrococcus luteus Species 0.000 claims description 7
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 7
- 206010040047 Sepsis Diseases 0.000 claims description 7
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 7
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 7
- 241000222178 Candida tropicalis Species 0.000 claims description 6
- 241000194032 Enterococcus faecalis Species 0.000 claims description 6
- 206010062070 Peritonitis bacterial Diseases 0.000 claims description 6
- 241000607715 Serratia marcescens Species 0.000 claims description 6
- 241000191963 Staphylococcus epidermidis Species 0.000 claims description 6
- 229960005475 antiinfective agent Drugs 0.000 claims description 6
- 229940032049 enterococcus faecalis Drugs 0.000 claims description 6
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 241000588626 Acinetobacter baumannii Species 0.000 claims description 5
- 241000228212 Aspergillus Species 0.000 claims description 5
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 5
- 108010059993 Vancomycin Proteins 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 201000008827 tuberculosis Diseases 0.000 claims description 5
- 229960003165 vancomycin Drugs 0.000 claims description 5
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 5
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 5
- 241000589291 Acinetobacter Species 0.000 claims description 4
- 241000194029 Enterococcus hirae Species 0.000 claims description 4
- 241000606768 Haemophilus influenzae Species 0.000 claims description 4
- 241000588915 Klebsiella aerogenes Species 0.000 claims description 4
- 241000588749 Klebsiella oxytoca Species 0.000 claims description 4
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 206010033645 Pancreatitis Diseases 0.000 claims description 4
- 241000588770 Proteus mirabilis Species 0.000 claims description 4
- 241000191984 Staphylococcus haemolyticus Species 0.000 claims description 4
- 241000192087 Staphylococcus hominis Species 0.000 claims description 4
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 4
- 241001045770 Trichophyton mentagrophytes Species 0.000 claims description 4
- 208000030961 allergic reaction Diseases 0.000 claims description 4
- 229940092559 enterobacter aerogenes Drugs 0.000 claims description 4
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 4
- 208000003243 intestinal obstruction Diseases 0.000 claims description 4
- 229940037649 staphylococcus haemolyticus Drugs 0.000 claims description 4
- 230000008733 trauma Effects 0.000 claims description 4
- 208000000197 Acute Cholecystitis Diseases 0.000 claims description 3
- 206010003011 Appendicitis Diseases 0.000 claims description 3
- 241000606124 Bacteroides fragilis Species 0.000 claims description 3
- 206010008614 Cholecystitis acute Diseases 0.000 claims description 3
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 3
- 208000008469 Peptic Ulcer Diseases 0.000 claims description 3
- 241001138501 Salmonella enterica Species 0.000 claims description 3
- 206010040070 Septic Shock Diseases 0.000 claims description 3
- 241000607764 Shigella dysenteriae Species 0.000 claims description 3
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims description 3
- 201000001352 cholecystitis Diseases 0.000 claims description 3
- 208000007784 diverticulitis Diseases 0.000 claims description 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000036303 septic shock Effects 0.000 claims description 3
- 229940007046 shigella dysenteriae Drugs 0.000 claims description 3
- 206010043626 Thrombosis mesenteric vessel Diseases 0.000 claims description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 241000902235 Oides Species 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000011906 peptic ulcer disease Diseases 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 abstract description 6
- 208000031853 Peritoneal haemorrhage Diseases 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 482
- 210000004027 cell Anatomy 0.000 description 107
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 102
- 210000003630 histaminocyte Anatomy 0.000 description 62
- 210000001519 tissue Anatomy 0.000 description 61
- 238000006722 reduction reaction Methods 0.000 description 50
- 239000012266 salt solution Substances 0.000 description 48
- 239000000460 chlorine Substances 0.000 description 47
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 43
- 229910052801 chlorine Inorganic materials 0.000 description 40
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 39
- 239000007844 bleaching agent Substances 0.000 description 39
- 239000000758 substrate Substances 0.000 description 39
- 238000012360 testing method Methods 0.000 description 38
- 239000000427 antigen Substances 0.000 description 37
- 102000036639 antigens Human genes 0.000 description 36
- 108091007433 antigens Proteins 0.000 description 36
- 239000000203 mixture Substances 0.000 description 35
- 241001465754 Metazoa Species 0.000 description 31
- 208000027418 Wounds and injury Diseases 0.000 description 27
- 206010061218 Inflammation Diseases 0.000 description 26
- 108090000695 Cytokines Proteins 0.000 description 25
- 206010052428 Wound Diseases 0.000 description 25
- 238000006243 chemical reaction Methods 0.000 description 25
- 230000004054 inflammatory process Effects 0.000 description 25
- 230000028327 secretion Effects 0.000 description 25
- 238000011282 treatment Methods 0.000 description 25
- 230000000694 effects Effects 0.000 description 24
- 102000004127 Cytokines Human genes 0.000 description 22
- 230000015572 biosynthetic process Effects 0.000 description 22
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 22
- 239000000463 material Substances 0.000 description 21
- 239000011780 sodium chloride Substances 0.000 description 21
- 241000699670 Mus sp. Species 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 239000001301 oxygen Substances 0.000 description 18
- 229910052760 oxygen Inorganic materials 0.000 description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 17
- 238000005868 electrolysis reaction Methods 0.000 description 17
- 239000000725 suspension Substances 0.000 description 17
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 16
- 206010000269 abscess Diseases 0.000 description 16
- 230000000813 microbial effect Effects 0.000 description 16
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 16
- 238000004140 cleaning Methods 0.000 description 15
- 239000003085 diluting agent Substances 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 15
- 230000008569 process Effects 0.000 description 15
- 208000034486 Multi-organ failure Diseases 0.000 description 14
- 241000700159 Rattus Species 0.000 description 14
- 150000002500 ions Chemical class 0.000 description 14
- 238000004659 sterilization and disinfection Methods 0.000 description 14
- 239000013566 allergen Substances 0.000 description 13
- 230000006378 damage Effects 0.000 description 13
- 239000007789 gas Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 13
- 239000000523 sample Substances 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 13
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 12
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 12
- 239000003014 ion exchange membrane Substances 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- 239000004155 Chlorine dioxide Substances 0.000 description 11
- 230000000845 anti-microbial effect Effects 0.000 description 11
- 239000004744 fabric Substances 0.000 description 11
- 230000002401 inhibitory effect Effects 0.000 description 11
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 10
- 241000193830 Bacillus <bacterium> Species 0.000 description 10
- 230000001580 bacterial effect Effects 0.000 description 10
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 10
- 235000019398 chlorine dioxide Nutrition 0.000 description 10
- 238000010790 dilution Methods 0.000 description 10
- 239000012895 dilution Substances 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 230000002458 infectious effect Effects 0.000 description 10
- 210000003200 peritoneal cavity Anatomy 0.000 description 10
- 239000002243 precursor Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 230000004913 activation Effects 0.000 description 9
- 239000000443 aerosol Substances 0.000 description 9
- 229940088710 antibiotic agent Drugs 0.000 description 9
- 239000000872 buffer Substances 0.000 description 9
- 230000007423 decrease Effects 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 229910001415 sodium ion Inorganic materials 0.000 description 9
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 8
- 208000026935 allergic disease Diseases 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 230000006907 apoptotic process Effects 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 229960001340 histamine Drugs 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 239000013642 negative control Substances 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- 150000002978 peroxides Chemical class 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 230000000770 proinflammatory effect Effects 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 7
- 210000000683 abdominal cavity Anatomy 0.000 description 7
- 230000002411 adverse Effects 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 208000006673 asthma Diseases 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 7
- 238000011161 development Methods 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 210000003743 erythrocyte Anatomy 0.000 description 7
- 210000002950 fibroblast Anatomy 0.000 description 7
- 230000014509 gene expression Effects 0.000 description 7
- 229940098803 hibiclens Drugs 0.000 description 7
- 238000007912 intraperitoneal administration Methods 0.000 description 7
- 230000002262 irrigation Effects 0.000 description 7
- 238000003973 irrigation Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 239000007921 spray Substances 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 230000035899 viability Effects 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 108010001478 Bacitracin Proteins 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004889 Interleukin-6 Human genes 0.000 description 6
- 108090001005 Interleukin-6 Proteins 0.000 description 6
- 229960003071 bacitracin Drugs 0.000 description 6
- 229930184125 bacitracin Natural products 0.000 description 6
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 6
- 210000001185 bone marrow Anatomy 0.000 description 6
- 239000003710 calcium ionophore Substances 0.000 description 6
- 230000003833 cell viability Effects 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 239000000645 desinfectant Substances 0.000 description 6
- 210000000981 epithelium Anatomy 0.000 description 6
- CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 description 6
- 239000007928 intraperitoneal injection Substances 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 230000001603 reducing effect Effects 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 241000701161 unidentified adenovirus Species 0.000 description 6
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 5
- 108020005124 DNA Adducts Proteins 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 241001529936 Murinae Species 0.000 description 5
- 206010028851 Necrosis Diseases 0.000 description 5
- 230000005856 abnormality Effects 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000004061 bleaching Methods 0.000 description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 230000000120 cytopathologic effect Effects 0.000 description 5
- 230000000249 desinfective effect Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000002147 killing effect Effects 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 210000004962 mammalian cell Anatomy 0.000 description 5
- 230000017074 necrotic cell death Effects 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 description 4
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 4
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 208000010718 Multiple Organ Failure Diseases 0.000 description 4
- 238000011887 Necropsy Methods 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 229930182555 Penicillin Natural products 0.000 description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 4
- 108010003541 Platelet Activating Factor Proteins 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 4
- 230000003187 abdominal effect Effects 0.000 description 4
- 238000012387 aerosolization Methods 0.000 description 4
- 230000007815 allergy Effects 0.000 description 4
- 230000003266 anti-allergic effect Effects 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 238000000889 atomisation Methods 0.000 description 4
- 238000011888 autopsy Methods 0.000 description 4
- 210000003651 basophil Anatomy 0.000 description 4
- 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 description 4
- 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 230000032677 cell aging Effects 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 239000002561 chemical irritant Substances 0.000 description 4
- 239000013626 chemical specie Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 230000006735 deficit Effects 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- 230000002500 effect on skin Effects 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 208000024711 extrinsic asthma Diseases 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000005090 green fluorescent protein Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 229920001903 high density polyethylene Polymers 0.000 description 4
- 239000004700 high-density polyethylene Substances 0.000 description 4
- 208000000509 infertility Diseases 0.000 description 4
- 230000036512 infertility Effects 0.000 description 4
- 210000004969 inflammatory cell Anatomy 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000002663 nebulization Methods 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 229940049954 penicillin Drugs 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 231100000057 systemic toxicity Toxicity 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 230000035897 transcription Effects 0.000 description 4
- 230000005951 type IV hypersensitivity Effects 0.000 description 4
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 4
- 230000003253 viricidal effect Effects 0.000 description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 206010070419 Chemical peritonitis Diseases 0.000 description 3
- 241000193468 Clostridium perfringens Species 0.000 description 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 3
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 3
- 238000008157 ELISA kit Methods 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 208000001718 Immediate Hypersensitivity Diseases 0.000 description 3
- 229920000297 Rayon Polymers 0.000 description 3
- 206010039085 Rhinitis allergic Diseases 0.000 description 3
- 102100028748 Transportin-1 Human genes 0.000 description 3
- 206010045240 Type I hypersensitivity Diseases 0.000 description 3
- 201000010105 allergic rhinitis Diseases 0.000 description 3
- 208000010216 atopic IgE responsiveness Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 230000020411 cell activation Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 229960004397 cyclophosphamide Drugs 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 238000001839 endoscopy Methods 0.000 description 3
- 210000003527 eukaryotic cell Anatomy 0.000 description 3
- 229950003499 fibrin Drugs 0.000 description 3
- 230000004761 fibrosis Effects 0.000 description 3
- 238000000684 flow cytometry Methods 0.000 description 3
- UQSQSQZYBQSBJZ-UHFFFAOYSA-N fluorosulfonic acid Chemical compound OS(F)(=O)=O UQSQSQZYBQSBJZ-UHFFFAOYSA-N 0.000 description 3
- 230000002538 fungal effect Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 3
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 3
- 230000009610 hypersensitivity Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000002357 laparoscopic surgery Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 230000008789 oxidative DNA damage Effects 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 238000002271 resection Methods 0.000 description 3
- 238000003757 reverse transcription PCR Methods 0.000 description 3
- 201000003068 rheumatic fever Diseases 0.000 description 3
- 230000003248 secreting effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 230000004797 therapeutic response Effects 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 230000009959 type I hypersensitivity Effects 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- QNGVNLMMEQUVQK-UHFFFAOYSA-N 4-n,4-n-diethylbenzene-1,4-diamine Chemical compound CCN(CC)C1=CC=C(N)C=C1 QNGVNLMMEQUVQK-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 206010006482 Bronchospasm Diseases 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 206010016825 Flushing Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 102000009438 IgE Receptors Human genes 0.000 description 2
- 108010073816 IgE Receptors Proteins 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 108010002616 Interleukin-5 Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000186366 Mycobacterium bovis Species 0.000 description 2
- 229910019093 NaOCl Inorganic materials 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- 208000031848 Peritonitis sclerosing Diseases 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 102000040945 Transcription factor Human genes 0.000 description 2
- 102100027654 Transcription factor PU.1 Human genes 0.000 description 2
- 206010052779 Transplant rejections Diseases 0.000 description 2
- 102100022563 Tubulin polymerization-promoting protein Human genes 0.000 description 2
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 235000021120 animal protein Nutrition 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 210000003567 ascitic fluid Anatomy 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 102000005936 beta-Galactosidase Human genes 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 230000007885 bronchoconstriction Effects 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 235000011116 calcium hydroxide Nutrition 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000006037 cell lysis Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000002800 charge carrier Substances 0.000 description 2
- MAYPHUUCLRDEAZ-UHFFFAOYSA-N chlorine peroxide Inorganic materials ClOOCl MAYPHUUCLRDEAZ-UHFFFAOYSA-N 0.000 description 2
- TVWHTOUAJSGEKT-UHFFFAOYSA-N chlorine trioxide Chemical compound [O]Cl(=O)=O TVWHTOUAJSGEKT-UHFFFAOYSA-N 0.000 description 2
- 229960002227 clindamycin Drugs 0.000 description 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 229960000265 cromoglicic acid Drugs 0.000 description 2
- 229940109248 cromoglycate Drugs 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000016396 cytokine production Effects 0.000 description 2
- 230000003436 cytoskeletal effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 230000000617 effect on degranulation Effects 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 229920002313 fluoropolymer Polymers 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 230000003118 histopathologic effect Effects 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 229940113601 irrigation solution Drugs 0.000 description 2
- 231100001231 less toxic Toxicity 0.000 description 2
- 150000002617 leukotrienes Chemical class 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000002864 mononuclear phagocyte Anatomy 0.000 description 2
- 230000003843 mucus production Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000243 mutagenic effect Toxicity 0.000 description 2
- 230000003505 mutagenic effect Effects 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000033116 oxidation-reduction process Effects 0.000 description 2
- 230000004792 oxidative damage Effects 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 210000004303 peritoneum Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 235000021118 plant-derived protein Nutrition 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 108010008929 proto-oncogene protein Spi-1 Proteins 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000002964 rayon Substances 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 210000000574 retroperitoneal space Anatomy 0.000 description 2
- 201000000306 sarcoidosis Diseases 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 201000009890 sinusitis Diseases 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 229940072768 sodium chloride irrigation solution Drugs 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 239000012209 synthetic fiber Substances 0.000 description 2
- 239000003104 tissue culture media Substances 0.000 description 2
- 231100000041 toxicology testing Toxicity 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 239000006150 trypticase soy agar Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000008728 vascular permeability Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- MWBJRTBANFUBOX-SQYJNGITSA-N (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclot Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/O)/[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MWBJRTBANFUBOX-SQYJNGITSA-N 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 1
- 101710187886 60S ribosomal protein L30 Proteins 0.000 description 1
- 102100040768 60S ribosomal protein L32 Human genes 0.000 description 1
- YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 description 1
- 108700012813 7-aminoactinomycin D Proteins 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 241001673062 Achromobacter xylosoxidans Species 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000029483 Acquired immunodeficiency Diseases 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 108090000672 Annexin A5 Proteins 0.000 description 1
- 102000004121 Annexin A5 Human genes 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 208000000104 Arthus reaction Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 241000353754 Bacillus subtilis subsp. niger Species 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 206010051779 Bone marrow toxicity Diseases 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical class [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical class ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 108010065152 Coagulase Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- 208000031973 Conjunctivitis infective Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 102000001493 Cyclophilins Human genes 0.000 description 1
- 108010068682 Cyclophilins Proteins 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000001860 Eye Infections Diseases 0.000 description 1
- 108010040476 FITC-annexin A5 Proteins 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 102000001398 Granzyme Human genes 0.000 description 1
- 108060005986 Granzyme Proteins 0.000 description 1
- 208000003807 Graves Disease Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 101001066129 Homo sapiens Glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 241001135569 Human adenovirus 5 Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 206010058558 Hypoperfusion Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010021113 Hypothermia Diseases 0.000 description 1
- 208000024781 Immune Complex disease Diseases 0.000 description 1
- 206010065042 Immune reconstitution inflammatory syndrome Diseases 0.000 description 1
- 206010021450 Immunodeficiency congenital Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102000034655 MIF Human genes 0.000 description 1
- 108060004872 MIF Proteins 0.000 description 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 229910021380 Manganese Chloride Inorganic materials 0.000 description 1
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 1
- 241001430197 Mollicutes Species 0.000 description 1
- 206010028400 Mutagenic effect Diseases 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000005141 Otitis Diseases 0.000 description 1
- 206010033647 Pancreatitis acute Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 206010061336 Pelvic neoplasm Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 206010034668 Peritoneal infections Diseases 0.000 description 1
- 208000031845 Pernicious anaemia Diseases 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 206010035039 Piloerection Diseases 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 238000012180 RNAeasy kit Methods 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 230000010757 Reduction Activity Effects 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 208000003441 Transfusion reaction Diseases 0.000 description 1
- 206010054000 Type II hypersensitivity Diseases 0.000 description 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 229920001938 Vegetable gum Polymers 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 201000001028 acute contagious conjunctivitis Diseases 0.000 description 1
- 231100000569 acute exposure Toxicity 0.000 description 1
- 201000003229 acute pancreatitis Diseases 0.000 description 1
- 231100000899 acute systemic toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 238000011374 additional therapy Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 241001148470 aerobic bacillus Species 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229960004821 amikacin Drugs 0.000 description 1
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000003092 anti-cytokine Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 230000007503 antigenic stimulation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229960004099 azithromycin Drugs 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 231100000366 bone marrow toxicity Toxicity 0.000 description 1
- 238000013276 bronchoscopy Methods 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229960004261 cefotaxime Drugs 0.000 description 1
- AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000010094 cellular senescence Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 238000002192 cholecystectomy Methods 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000024203 complement activation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 150000001925 cycloalkenes Chemical class 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 238000003936 denaturing gel electrophoresis Methods 0.000 description 1
- 210000004262 dental pulp cavity Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000007682 dermal toxicity Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 210000001840 diploid cell Anatomy 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000019258 ear infection Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000010439 empiric antimicrobial therapy Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 208000011323 eye infectious disease Diseases 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000027950 fever generation Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 description 1
- 229960004413 flucytosine Drugs 0.000 description 1
- 229940124307 fluoroquinolone Drugs 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 210000003953 foreskin Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000001434 glomerular Effects 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000002175 goblet cell Anatomy 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 238000007489 histopathology method Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 102000047486 human GAPDH Human genes 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 230000008076 immune mechanism Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000037041 intracellular level Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 206010024378 leukocytosis Diseases 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- LWXVCCOAQYNXNX-UHFFFAOYSA-N lithium hypochlorite Chemical compound [Li+].Cl[O-] LWXVCCOAQYNXNX-UHFFFAOYSA-N 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- YZQBYALVHAANGI-UHFFFAOYSA-N magnesium;dihypochlorite Chemical compound [Mg+2].Cl[O-].Cl[O-] YZQBYALVHAANGI-UHFFFAOYSA-N 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000011565 manganese chloride Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000000479 mitotic spindle apparatus Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 238000001828 necrosectomy Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000014207 opsonization Effects 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 206010033072 otitis externa Diseases 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229930192851 perforin Natural products 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 230000005371 pilomotor reflex Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001869 rapid Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000007468 re-laparotomy Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000005067 remediation Methods 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 238000002579 sigmoidoscopy Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003330 sporicidal effect Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 208000005057 thyrotoxicosis Diseases 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000008026 type II hypersensitivity Effects 0.000 description 1
- 230000028063 type III hypersensitivity Effects 0.000 description 1
- 208000025883 type III hypersensitivity disease Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 206010047470 viral myocarditis Diseases 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2637197A CA2637197C (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
EP07717981.0A EP1993570B1 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
JP2008551573A JP2009523832A (en) | 2006-01-20 | 2007-01-22 | Method for treating or preventing peritonitis using redox potential aqueous solution |
BRPI0706676A BRPI0706676B8 (en) | 2006-01-20 | 2007-01-22 | use of an aqueous solution with redox potential |
AU2007205863A AU2007205863B2 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76064506P | 2006-01-20 | 2006-01-20 | |
US76055706P | 2006-01-20 | 2006-01-20 | |
US76056706P | 2006-01-20 | 2006-01-20 | |
US76063506P | 2006-01-20 | 2006-01-20 | |
US60/760,567 | 2006-01-20 | ||
US60/760,557 | 2006-01-20 | ||
US60/760,645 | 2006-01-20 | ||
US60/760,635 | 2006-01-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007085021A2 true WO2007085021A2 (en) | 2007-07-26 |
WO2007085021A3 WO2007085021A3 (en) | 2007-11-01 |
Family
ID=38198117
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/060854 WO2007085018A2 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing inflammation and hypersensitivity with oxidative reductive potential water solution |
PCT/US2007/060856 WO2007085019A2 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing sinusitis with oxidative reductive potential water solution |
PCT/US2007/060860 WO2007085021A2 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/060854 WO2007085018A2 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing inflammation and hypersensitivity with oxidative reductive potential water solution |
PCT/US2007/060856 WO2007085019A2 (en) | 2006-01-20 | 2007-01-22 | Methods of treating or preventing sinusitis with oxidative reductive potential water solution |
Country Status (9)
Country | Link |
---|---|
US (7) | US8147444B2 (en) |
EP (3) | EP1993572A2 (en) |
JP (3) | JP2009523832A (en) |
KR (3) | KR20080093135A (en) |
AU (3) | AU2007205863B2 (en) |
BR (3) | BRPI0706671A2 (en) |
CA (3) | CA2637175C (en) |
HK (1) | HK1130675A1 (en) |
WO (3) | WO2007085018A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008111000A (en) * | 2007-11-29 | 2008-05-15 | Mandom Corp | Antibacterial composition and deodorant agent |
US9421286B2 (en) | 2011-11-03 | 2016-08-23 | Elwha Llc | Heat-sanitization of surfaces |
US9687670B2 (en) | 2007-08-17 | 2017-06-27 | Gearbox, Llc | Systems, devices, and methods including infection-fighting and monitoring shunts |
US10426857B2 (en) | 2008-12-04 | 2019-10-01 | Gearbox, Llc | Systems, devices, and methods including implantable devices with anti-microbial properties |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6702949B2 (en) | 1997-10-24 | 2004-03-09 | Microdiffusion, Inc. | Diffuser/emulsifier for aquaculture applications |
US9168318B2 (en) * | 2003-12-30 | 2015-10-27 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and methods of using the same |
NO20043150D0 (en) * | 2004-07-23 | 2004-07-23 | Ntnu Technology Transfer As | "Heat recovery method and equipment" |
EP1863502B1 (en) | 2005-03-23 | 2018-09-12 | Sonoma Pharmaceuticals, Inc. | Method of treating skin ulcers using oxidative reductive potential water solution |
JP5907645B2 (en) * | 2005-05-02 | 2016-04-26 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Usage of redox potential aqueous solution in dental applications |
AU2006307923B2 (en) * | 2005-10-28 | 2012-02-02 | Akuatech S.R.L. | New highly stable aqueous solution, electrode with nanocoating for preparing the solution and method for making this electrode |
US8147444B2 (en) * | 2006-01-20 | 2012-04-03 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
EP1986952A4 (en) * | 2006-02-22 | 2011-03-30 | Puricore Inc | Methods of treating cystic fibrosis |
US8784897B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
WO2008115290A2 (en) | 2006-10-25 | 2008-09-25 | Revalesio Corporation | Methods of wound care and treatment |
JP5306214B2 (en) | 2006-10-25 | 2013-10-02 | リバルシオ コーポレイション | Mixing equipment |
US8445546B2 (en) | 2006-10-25 | 2013-05-21 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
US8784898B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of wound care and treatment |
US8609148B2 (en) | 2006-10-25 | 2013-12-17 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
WO2008052145A2 (en) | 2006-10-25 | 2008-05-02 | Revalesio Corporation | Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution |
US9999635B2 (en) | 2007-01-16 | 2018-06-19 | Realm Therapeutics, Inc. | Methods and compositions for treating inflammatory disorders |
WO2008089268A2 (en) * | 2007-01-16 | 2008-07-24 | Puricore, Inc. | Methods and compositions for treating conditions associated with infection and/or inflammation |
US20080288019A1 (en) * | 2007-01-31 | 2008-11-20 | Adam Heller | Electrochemical management of pain |
US8623392B2 (en) * | 2007-03-22 | 2014-01-07 | Taiko Pharmaceutical Co., Ltd. | Allergen inactivating agent |
CA2684807A1 (en) * | 2007-04-05 | 2008-10-16 | Velomedix, Inc. | Automated therapy system and method |
EP2162140B1 (en) * | 2007-04-25 | 2013-05-29 | APR Nanotechnologies S.A. | Highly stable electrolytic water with reduced nmr half line width |
JP5196864B2 (en) * | 2007-05-14 | 2013-05-15 | キヤノン株式会社 | Probe set, probe carrier and inspection method |
WO2009009540A1 (en) | 2007-07-09 | 2009-01-15 | Velomedix, Inc. | Hypothermia devices and methods |
CN105213299A (en) * | 2007-07-26 | 2016-01-06 | Azad药物股份公司 | The pharmaceutical preparation of the hypochlorite solutions containing electrochemical activation |
US8734718B2 (en) | 2007-08-17 | 2014-05-27 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component |
US8647292B2 (en) | 2007-08-17 | 2014-02-11 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having components that are actively controllable between two or more wettability states |
US20090048648A1 (en) * | 2007-08-17 | 2009-02-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Self-sterilizing device |
US8706211B2 (en) | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having self-cleaning surfaces |
US8753304B2 (en) | 2007-08-17 | 2014-06-17 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter |
US8162924B2 (en) * | 2007-08-17 | 2012-04-24 | The Invention Science Fund I, Llc | System, devices, and methods including actively-controllable superoxide water generating systems |
US8460229B2 (en) | 2007-08-17 | 2013-06-11 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states |
US8702640B2 (en) | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | System, devices, and methods including catheters configured to monitor and inhibit biofilm formation |
US8114346B2 (en) * | 2007-08-17 | 2012-02-14 | The Invention Science Fund I, Llc | Event-triggered ultraviolet light sterilization of surfaces |
US8029740B2 (en) | 2008-07-11 | 2011-10-04 | The Invention Science Fund I, Llc | Event-triggered self-sterilization of article surfaces |
US9745567B2 (en) | 2008-04-28 | 2017-08-29 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US10125359B2 (en) | 2007-10-25 | 2018-11-13 | Revalesio Corporation | Compositions and methods for treating inflammation |
US9523090B2 (en) | 2007-10-25 | 2016-12-20 | Revalesio Corporation | Compositions and methods for treating inflammation |
DE102008011807A1 (en) * | 2008-02-29 | 2009-09-10 | Aquagroup Ag | Process for in-process decontamination in food processing and treatment and for reducing the germ content of cosmetics, pharmaceuticals, daily care products and animal and vegetable foods, as well as for the treatment of surfaces |
AU2009243045B2 (en) | 2008-05-01 | 2015-01-29 | Revalesio Corporation | Compositions and methods for treating digestive disorders |
US8636987B2 (en) * | 2008-07-15 | 2014-01-28 | Basf Corporation | Tooth whitening compositions and methods |
WO2010011927A1 (en) | 2008-07-25 | 2010-01-28 | Noventis, Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
WO2010025305A1 (en) * | 2008-08-27 | 2010-03-04 | Drug Enhancement Company Of America, Llc | Use of non-toxic antimicrobial, oxychlorine, hypochlorous acid and superoxidized water products |
EP2384168B1 (en) | 2008-12-04 | 2014-10-08 | Searete LLC | Actively-controllable sterilizing excitation delivery implants |
US8585627B2 (en) | 2008-12-04 | 2013-11-19 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters configured to monitor biofilm formation having biofilm spectral information configured as a data structure |
WO2010075477A2 (en) * | 2008-12-22 | 2010-07-01 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing biofilm associated infections with free available chlorine water |
US20100196512A1 (en) | 2009-02-04 | 2010-08-05 | Basf Catalyst Llc | Treatment of Non-Oral Biological Tissue with Chlorine Dioxide |
WO2010111137A2 (en) * | 2009-03-23 | 2010-09-30 | Kross-Link Laboratories, Inc. | Method for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition prepared on-site |
US8815292B2 (en) | 2009-04-27 | 2014-08-26 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
CA2761710C (en) * | 2009-05-11 | 2019-10-01 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing influenza associated illness with oxidative reductive potential water solutions |
JP6033082B2 (en) | 2009-06-15 | 2016-11-30 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Solution containing hypochlorous acid and method of using the same |
EP2954901A1 (en) * | 2009-06-17 | 2015-12-16 | APR Nanotechnologies S.A. | Methods of treating outer eye disorders using high orp acid water and compositions thereof |
EP2525802A4 (en) | 2010-01-19 | 2013-11-06 | Sinox Pharma Inc | A method of treating sinusitis, including chronic sinusitis |
EP2558107B1 (en) | 2010-04-13 | 2018-07-11 | KCI Licensing, Inc. | Compositions with reactive ingredients, and wound dressings, apparatuses, and methods |
CN102939130A (en) | 2010-04-14 | 2013-02-20 | 海波流动有限公司 | Device for preparing dilute disinfectant solution |
BR112012028540A2 (en) | 2010-05-07 | 2016-07-26 | Revalesio Corp | compositions and methods for improving physiological performance and recovery time |
US9622670B2 (en) | 2010-07-09 | 2017-04-18 | Potrero Medical, Inc. | Method and apparatus for pressure measurement |
CN104997803B (en) | 2010-07-22 | 2019-07-09 | 雷文制药有限公司 | Comprising the treatment using magnetic dipole stabilizing solutions or improves disease and enhance the method and composition of performance |
JP2013533320A (en) | 2010-08-12 | 2013-08-22 | レバレジオ コーポレイション | Compositions and methods for treating tauopathy |
US11452778B2 (en) | 2011-03-18 | 2022-09-27 | Urgo Us, Inc. | Stabilized hypohalous acid solutions |
CN107439588B (en) | 2011-03-18 | 2020-07-07 | 瑞尔姆治疗股份有限公司 | Stable hypohalous acid solutions |
US9381214B2 (en) | 2011-03-18 | 2016-07-05 | Puricore, Inc. | Methods for treating skin irritation |
ITRM20110390A1 (en) * | 2011-07-21 | 2013-01-22 | Eramo Alessandra D | PRODUCT TO STIMULATE THE ENDOGENOUS PRODUCTION OF INFLAMMATION MEDIATORS. |
KR101297712B1 (en) | 2011-11-02 | 2013-08-20 | (주)그린제약 | Biocide/disinfection agent containing hypochlorous acid water and soy protein |
US20150079039A1 (en) * | 2012-04-13 | 2015-03-19 | The Regents Of The University Of California | Sinusitis diagnostics and treatments |
US9815714B2 (en) * | 2012-12-11 | 2017-11-14 | Slate Group, Llc | Process for generating oxygenated water |
WO2014190184A1 (en) | 2013-05-22 | 2014-11-27 | Oculus Innovative Sciences, Inc. | Stabilized hypochlorous acid solution and use thereof |
WO2015061753A1 (en) * | 2013-10-24 | 2015-04-30 | Reoxcyn Discoveries Group, Inc. | Redox signaling gel formulation |
AU2014343506C1 (en) | 2013-10-29 | 2023-06-01 | Hypo-Stream Limited | Anti-inflammatory solution comprising sodium hypochlorite |
DE102014204142B4 (en) * | 2014-03-06 | 2016-05-25 | Hans-Jürgen Dörfer | Process for the preparation of aqueous chlorine dioxide solutions and use of an apparatus for carrying out the process |
US10617716B2 (en) * | 2014-12-16 | 2020-04-14 | Urgo Us, Inc. | Hypochlorous acid formulations and methods for treating skin conditions |
MX2017007852A (en) | 2014-12-16 | 2018-01-11 | Realm Therapeutics Inc | Hypochlorous acid formulations and methods for treating skin conditions. |
US10094030B2 (en) | 2015-02-03 | 2018-10-09 | Tipul Biotechnology, LLC | Devices and methods for electrolytic production of disinfectant solution from salt solution in a container |
US20190298761A1 (en) | 2016-12-15 | 2019-10-03 | Adept Water Technologies A/S | Device for producing aqueous liquid having free available chlorine (fac) |
WO2019006217A1 (en) | 2017-06-28 | 2019-01-03 | Collidion, Inc. | Compositions, methods and uses for cleaning, disinfecting and/or sterilizing |
US20190125825A1 (en) * | 2017-10-12 | 2019-05-02 | High Point University | Small-molecule adjuvants for antibiotics to address antibiotic resistance |
DE102017131104A1 (en) * | 2017-12-22 | 2019-06-27 | B. Braun Avitum Ag | Blood treatment machine with SOS generator and disinfection process |
MX2020007533A (en) | 2018-01-14 | 2021-01-15 | Collidion Inc | Compositions, kits, methods and uses for cleaning, disinfecting, sterilizing and/or treating. |
FR3088543B1 (en) * | 2018-11-21 | 2021-03-19 | Waterdiam France | Treatment of skin conditions with electrolyzed water |
CN109172601A (en) * | 2018-08-20 | 2019-01-11 | 四川建元天地环保科技有限公司 | Electrolyte is eliminating the purposes in pseudomonas aeruginosa |
US20200281969A1 (en) * | 2019-03-05 | 2020-09-10 | Wonder Spray, LLC | Inhibiting viral and bacterial activity using low concentration hypochlorous acid solutions |
US11826382B2 (en) | 2020-05-01 | 2023-11-28 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
US11642372B2 (en) | 2020-05-01 | 2023-05-09 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
DE102020113383A1 (en) * | 2020-05-18 | 2021-11-18 | Cytopharma Gmbh | Pharmaceutical preparation for use in the treatment of SIRS |
JP7385616B2 (en) | 2021-03-22 | 2023-11-22 | 株式会社日本トリム | Electrolyzed water generator |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005065383A2 (en) * | 2003-12-30 | 2005-07-21 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution, processes for producing same and methods of using the same |
WO2006102681A2 (en) * | 2005-03-23 | 2006-09-28 | Oculus Innovative Sciences, Inc. | Method of treating skin ulcers using oxidative reductive potential water solution |
Family Cites Families (415)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3066095A (en) * | 1959-09-30 | 1962-11-27 | Hagan Chemicals & Controls Inc | Water purification agents and method of using same |
US3616355A (en) | 1968-08-05 | 1971-10-26 | Kdi Chloro Guard Corp | Method of generating enhanced biocidal activity in the electroylsis of chlorine containing solutions and the resulting solutions |
GB1367067A (en) | 1970-10-06 | 1974-09-18 | Wilkinson Sword Ltd | Compositions containing a source of hypochlorite ions |
GB1422795A (en) | 1972-05-31 | 1976-01-28 | Bunyan J | Antiseptic and non-toxic substance and a method of making the same |
US3975246A (en) | 1973-06-09 | 1976-08-17 | Sachs-Systemtechnik Gmbh | Method of disinfecting water |
US3975247A (en) | 1974-01-23 | 1976-08-17 | Stralser Bernard J | Treating sewage and recovering usable water and solids |
DE2442078A1 (en) * | 1974-09-03 | 1976-03-18 | Sachs Systemtechnik Gmbh | METHOD AND DEVICE FOR THE DISINICIATION AND DETOXIFICATION OF LIQUIDS BY ANODIC OXYDATION WITH THE ADDITION OF SILVER |
US3949742A (en) | 1974-09-20 | 1976-04-13 | Frigitronics, Inc. | Medical dressing |
DE2607906A1 (en) * | 1976-02-26 | 1977-09-01 | Hans Einhell Inh Josef Thannhu | ELECTROLYSIS CELL FOR WATER TREATMENT |
US4146578A (en) | 1977-12-27 | 1979-03-27 | Olin Corporation | Hypochlorous acid process |
US4190638A (en) | 1978-06-07 | 1980-02-26 | Ppg Industries, Inc. | Production of hypochlorous acid |
US4242446A (en) | 1978-07-26 | 1980-12-30 | Coulter Electronics, Inc. | Method for determining a substance in a biological fluid and reagent combination for use in the method |
GB2047543B (en) | 1978-12-06 | 1983-04-20 | Svedman Paul | Device for treating tissues for example skin |
US4236992A (en) | 1979-08-06 | 1980-12-02 | Themy Constantinos D | High voltage electrolytic cell |
JPS5684089U (en) | 1979-11-30 | 1981-07-07 | ||
US4296103A (en) * | 1980-08-08 | 1981-10-20 | Felipe Laso | Stabilized solution of chlorine oxides |
DE3046324A1 (en) | 1980-12-09 | 1982-12-16 | Rudolf Dr.med. 6900 Heidelberg Anderson | Microbicide effective against microbes which affect the lungs - contains calcium hypochlorite and water which produce hypochlorous acid, which produces iso:hypochlorous acid which releases active oxygen |
SU1296156A1 (en) | 1985-02-14 | 1987-03-15 | Ю.Ф. Исаков, В.А. Михедьсон, С.А. Байдин, Г.А. Гинодман, А.А. Нурмухамедов, Д.Д. Казанский .А. ФатjaxoB | Method of healing wounds |
US4670252A (en) | 1985-05-24 | 1987-06-02 | The Procter & Gamble Company | Treatment of oral diseases |
US4615937A (en) * | 1985-09-05 | 1986-10-07 | The James River Corporation | Antimicrobially active, non-woven web used in a wet wiper |
US4693832A (en) | 1985-11-27 | 1987-09-15 | Quantum Technologies, Inc. | Preparation of safe drinking water |
US4970216A (en) | 1986-03-17 | 1990-11-13 | Richardson Vicks, Inc. | Skin treatment composition and method |
US4666621A (en) * | 1986-04-02 | 1987-05-19 | Sterling Drug Inc. | Pre-moistened, streak-free, lint-free hard surface wiping article |
US4781974A (en) | 1986-04-23 | 1988-11-01 | James River Corporation | Antimicrobially active wet wiper |
IT1207620B (en) | 1987-02-27 | 1989-05-25 | Castellini Spa | METHOD AND EQUIPMENT FOR COLD STELIZATION OF SURGICAL INSTRUMENTS, IN PARTICULAR FOR DENTAL INSTRUMENTS |
US5906810A (en) * | 1987-03-17 | 1999-05-25 | Turner; Robert E. | Formulations and uses thereof in the prevention and treatment of oral lesions |
US4767511A (en) * | 1987-03-18 | 1988-08-30 | Aragon Pedro J | Chlorination and pH control system |
US5388571A (en) * | 1987-07-17 | 1995-02-14 | Roberts; Josephine A. | Positive-pressure ventilator system with controlled access for nebulizer component servicing |
FI82808C (en) | 1987-12-31 | 1991-04-25 | Etelae Haemeen Keuhkovammayhdi | Ultraljudfinfördelningsanordning |
JPH0249798B2 (en) | 1988-01-28 | 1990-10-31 | Kogyo Gijutsuin | JUKIKAGOBUTSUGANJUSUINOSHORIHOHO |
JPH01218682A (en) | 1988-02-29 | 1989-08-31 | Tatsuo Okazaki | Method for regulating electrolytic water and apparatus thereof |
JPH078768B2 (en) | 1988-06-06 | 1995-02-01 | ジプコム株式会社 | Sterilized water |
JP2638611B2 (en) | 1988-06-17 | 1997-08-06 | 紀久雄 及川 | Method for producing stabilized chlorine dioxide aqueous solution |
DE3929411A1 (en) | 1988-09-22 | 1990-03-29 | Siegfried Natterer | Pharmaceutical preparation and process for its preparation |
JPH0293088A (en) | 1988-09-29 | 1990-04-03 | Permelec Electrode Ltd | Method and device for water electrolysis |
US5037627A (en) | 1988-10-31 | 1991-08-06 | Olin Corporation | Hypochlorous acid process |
JPH02149395A (en) | 1988-11-30 | 1990-06-07 | Jipukomu Kk | Apparatus and method of preparing aqueous disinfectant |
US4979938A (en) * | 1989-05-11 | 1990-12-25 | Iomed, Inc. | Method of iontophoretically treating acne, furuncles and like skin disorders |
SE466196B (en) | 1989-06-13 | 1992-01-13 | Pavel Voracek | PROCEDURE AND DEVICE FOR ELECTRICAL TREATMENT OF AN ELECTROLYTIC SOLUTION AND SOLUTION FRACTIONS PREPARED ACCORDING TO THE PROCEDURE |
US6638413B1 (en) * | 1989-10-10 | 2003-10-28 | Lectro Press, Inc. | Methods and apparatus for electrolysis of water |
US5271943A (en) * | 1989-10-27 | 1993-12-21 | Scott Health Care | Wound gel compositions containing sodium chloride and method of using them |
JPH03236315A (en) | 1989-12-05 | 1991-10-22 | Nippon Oil & Fats Co Ltd | Antipsychotic agent |
US5152757A (en) | 1989-12-14 | 1992-10-06 | Brigham And Women's Hospital | System for diagnosis and treatment of wounds |
US5126057A (en) | 1990-01-22 | 1992-06-30 | Auburn Research Foundation | Disinfecting with N,N'-dihaloimidazolidin-4-ones |
US5084011A (en) | 1990-01-25 | 1992-01-28 | Grady Daniel J | Method for oxygen therapy using hyperbarically oxygenated liquid |
JPH03247134A (en) | 1990-02-26 | 1991-11-05 | Nec Corp | Pcm signal interface circuit |
US5334383A (en) * | 1990-05-23 | 1994-08-02 | Medical Discoveries, Inc. | Electrically hydrolyzed salines as in vivo microbicides for treatment of cardiomyopathy and multiple sclerosis |
US5622848A (en) | 1990-05-23 | 1997-04-22 | Medical Discoveries, Inc. | Electrically hydrolyzed salines as microbiocides for in vitro treatment of contaminated fluids containing blood |
US5128136A (en) | 1990-07-16 | 1992-07-07 | The Oregon Health Sciences University | Wound healing kit comprised of gelable collagen |
US5187154A (en) * | 1990-12-13 | 1993-02-16 | Board Of Regents, The University Of Texas System | Diagnosis and treatment of humans with diabetes or at risk to develop diabetes |
US5244768A (en) * | 1991-02-15 | 1993-09-14 | Fuji Xerox Co., Ltd. | Manufacturing process for an electrophotographic toner |
GB2253860B (en) | 1991-03-12 | 1995-10-11 | Kirk And Charashvili Internati | The electrochemical treatment of water and a device for electrochemically treating water |
JP3236315B2 (en) | 1991-08-27 | 2001-12-10 | 修生 澄田 | Pure water electrolysis tank with an intermediate chamber |
US5152915A (en) | 1991-09-03 | 1992-10-06 | Olin Corporation | Recovery of dichlorine monoxide from hypochlorous acid solutions |
US5636643A (en) | 1991-11-14 | 1997-06-10 | Wake Forest University | Wound treatment employing reduced pressure |
DE69218901T2 (en) * | 1991-12-10 | 1997-07-17 | Tdk Corp | Ultrasonic atomizer |
JP3247134B2 (en) | 1991-12-27 | 2002-01-15 | 修生 澄田 | Liquid in which hydrogen ion or hydroxide ion and redox substance coexist by electrolysis of pure water and method for producing the same |
JP2611080B2 (en) | 1992-02-20 | 1997-05-21 | 英雄 早川 | Water reforming method |
JP2615308B2 (en) | 1992-02-20 | 1997-05-28 | 英雄 早川 | Water reforming method |
US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
US5622725A (en) * | 1992-03-20 | 1997-04-22 | Alcide Corporation | Wound disinfection and repair |
GB2274113B (en) | 1992-04-03 | 1996-05-15 | Bakhir Vitold M | Apparatus for electrochemical treatment of water |
US5287847A (en) * | 1992-07-24 | 1994-02-22 | Vortran Medical Technology, Inc. | Universal nebulizer |
US6544502B2 (en) * | 1992-09-11 | 2003-04-08 | Wasatch Pharmaceutical Inc. | Skin treatment with a water soluble antibiotic dissolved in an electrolyzed water |
JPH06206825A (en) | 1992-12-11 | 1994-07-26 | Nippon Rooshiyon Kk | Agent for treatment of dermatosis caused by trichophyton, eczema, etc., and agent for skin disinfection and activation |
JPH06182345A (en) | 1992-12-21 | 1994-07-05 | Tonen Corp | Water purification device |
GB9227020D0 (en) | 1992-12-24 | 1993-02-17 | Solvay Interox Ltd | Microbicidual compositions |
DE69409996T2 (en) | 1993-02-22 | 1999-01-14 | Nippon Intek Co | Method and device for producing electrolytic water |
JP2623204B2 (en) | 1993-02-26 | 1997-06-25 | 英雄 早川 | Water reforming method |
JPH06312183A (en) | 1993-04-28 | 1994-11-08 | Shinko Pantec Co Ltd | Method and apparatus for producing electrolytic ion water |
DE4317174A1 (en) * | 1993-05-22 | 1994-11-24 | Bosch Gmbh Robert | Composite system with at least two inorganic ceramic layers and process for their production |
JPH06335685A (en) | 1993-05-28 | 1994-12-06 | Funai Electric Co Ltd | Ionized water generator |
JP2652609B2 (en) * | 1993-05-31 | 1997-09-10 | ミズ株式会社 | Electrolyzed water generator |
JPH0710762A (en) | 1993-06-25 | 1995-01-13 | Miura Denshi Kk | Gargle for stomatitis |
JP3325081B2 (en) | 1993-06-28 | 2002-09-17 | 英雄 早川 | Water purification method and apparatus |
DK0706352T3 (en) | 1993-06-29 | 2002-07-15 | Ponwell Entpr Ltd | Dispenser |
JP3458341B2 (en) | 1993-07-12 | 2003-10-20 | 有限会社コヒーレントテクノロジー | Method for producing washing water containing hydrogen ions or hydroxyl ions in excess of counter ions and obtained washing water |
JP3321256B2 (en) * | 1993-07-30 | 2002-09-03 | ミズ株式会社 | Water storage type electrolyzed water generator |
JP3504344B2 (en) | 1993-08-31 | 2004-03-08 | 三浦電子株式会社 | Livestock skin disease treatment water |
JPH07104221A (en) | 1993-10-01 | 1995-04-21 | Tomey Technol Corp | Method for cleaning and sterizing contact lens |
US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
JP3500173B2 (en) | 1993-12-01 | 2004-02-23 | ホシザキ電機株式会社 | Electrolyzed water production equipment |
JP3420820B2 (en) | 1994-02-05 | 2003-06-30 | ペルメレック電極株式会社 | Method and apparatus for producing electrolytic acidic water |
JP3324260B2 (en) | 1994-02-28 | 2002-09-17 | 宮▲崎▼ 浩司 | Corner building tile roofing structure |
US5599438A (en) * | 1994-03-25 | 1997-02-04 | Nec Corporation | Method for producing electrolyzed water |
JP2830733B2 (en) * | 1994-03-25 | 1998-12-02 | 日本電気株式会社 | Electrolytic water generation method and electrolysis water generation mechanism |
JP2737643B2 (en) * | 1994-03-25 | 1998-04-08 | 日本電気株式会社 | Method and apparatus for producing electrolytically activated water |
JP3468835B2 (en) | 1994-05-09 | 2003-11-17 | ホシザキ電機株式会社 | Electrolyzed water generator |
JPH07323289A (en) | 1994-05-30 | 1995-12-12 | Janome Sewing Mach Co Ltd | Superoxidized water and method therefor |
JPH07328640A (en) | 1994-06-02 | 1995-12-19 | Nippon Intec Kk | Effect judging method of electrolytic sterilization washing water and device therefor |
JP3396853B2 (en) | 1994-06-21 | 2003-04-14 | 有限会社コヒーレントテクノロジー | Water production method and obtained water |
JP2949322B2 (en) | 1994-07-19 | 1999-09-13 | 株式会社アロンワールド | Ionized water, its production method and production apparatus |
WO1996003881A1 (en) * | 1994-07-29 | 1996-02-15 | Toto Ltd. | Strongly acidic sterile water containing low-concentration hypochlorous acid, method of forming strongly acidic sterile water containing low-concentration hypochlorous acid, apparatus therefor, and apparatus for forming and delivering strongly acidic sterile water containing low-concentration hypochlorous acid |
JPH0852476A (en) | 1994-08-12 | 1996-02-27 | Janome Sewing Mach Co Ltd | Superoxidized water forming device |
JP3465367B2 (en) | 1994-08-23 | 2003-11-10 | 東陶機器株式会社 | Ion-rich water generator |
JPH0861788A (en) | 1994-08-25 | 1996-03-08 | Kozo Yamanoi | Solar heat water heater |
US6117285A (en) | 1994-08-26 | 2000-09-12 | Medical Discoveries, Inc. | System for carrying out sterilization of equipment |
US5507932A (en) * | 1994-08-26 | 1996-04-16 | Schlumberger Technology Corporation | Apparatus for electrolyzing fluids |
JP3488294B2 (en) | 1994-10-14 | 2004-01-19 | 忠正 中村 | Water treatment method and treatment device |
JP2857334B2 (en) * | 1994-10-18 | 1999-02-17 | 行正 佐藤 | Electrolytic ionic water generator |
KR100227969B1 (en) | 1994-10-20 | 1999-11-01 | 사카모토 시게토시 | Production system of electrolyzed water |
JPH08126873A (en) | 1994-10-28 | 1996-05-21 | Nec Corp | Washing and device for electronic parts and the like |
JP3181796B2 (en) * | 1994-10-28 | 2001-07-03 | 日本電気株式会社 | Electrolyzed water production equipment |
JP3181795B2 (en) * | 1994-10-28 | 2001-07-03 | オルガノ株式会社 | Electrolyzed water production equipment |
JPH08126886A (en) | 1994-10-28 | 1996-05-21 | Japan Organo Co Ltd | Production of ultrapure water and device therefor |
KR100209843B1 (en) | 1994-11-09 | 1999-07-15 | 데이비드 엠 모이어 | Cleaning tissues treated with water-in-lipid emulsion |
DK173485B1 (en) | 1994-12-02 | 2000-12-18 | Thure Barsoee Carnfeldt | Process for disinfecting or sterilizing food, feed, machinery and equipment for food and feedstuffs |
JPH08164192A (en) | 1994-12-15 | 1996-06-25 | Life Sapooto:Kk | Vegetative deodorant |
EP0800388A4 (en) | 1995-01-06 | 2001-04-04 | Australian Biomedical Company | Compounds for veterinary and medicinal applications |
JPH08252310A (en) | 1995-01-17 | 1996-10-01 | Miura Denshi Kk | Washing and disinfecting method of artificial dialyzing device using electrolytically generated acidic water, and device therefor |
EP0723936B1 (en) | 1995-01-30 | 1999-05-12 | First Ocean Co., Ltd. | A composite electrode construction for electrolysis of water |
US5876743A (en) | 1995-03-21 | 1999-03-02 | Den-Mat Corporation | Biocompatible adhesion in tissue repair |
US6007693A (en) | 1995-03-30 | 1999-12-28 | Bioquest | Spa halogen generator and method of operating |
US5578022A (en) | 1995-04-12 | 1996-11-26 | Scherson; Daniel A. | Oxygen producing bandage and method |
JP3313263B2 (en) * | 1995-04-15 | 2002-08-12 | 株式会社東芝 | Electrolytic water generation method, its generation apparatus, and semiconductor manufacturing apparatus |
HU213450B (en) | 1995-04-26 | 1997-06-30 | Ladanyi Jozsef | Gel contains gelatin and process for producing it |
JP2832171B2 (en) | 1995-04-28 | 1998-12-02 | 信越半導体株式会社 | Apparatus and method for cleaning semiconductor substrate |
US5628888A (en) | 1996-03-28 | 1997-05-13 | Rscecat, Usa, Inc. | Apparatus for electrochemical treatment of water and/or water solutions |
JPH08326124A (en) | 1995-05-31 | 1996-12-10 | Isao Ueno | Toilet with washer |
US5871623A (en) * | 1995-05-31 | 1999-02-16 | Rscecat, Usa, Inc. | Apparatus for electrochemical treatment of water and/or water solutions |
US5792090A (en) | 1995-06-15 | 1998-08-11 | Ladin; Daniel | Oxygen generating wound dressing |
JP3193295B2 (en) * | 1995-07-07 | 2001-07-30 | 株式会社日本トリム | Dialysis machine |
JPH0925236A (en) | 1995-07-12 | 1997-01-28 | Koichiro Kameyama | Alkaline electrolytic water containing zinc |
JP3153473B2 (en) | 1995-08-17 | 2001-04-09 | 株式会社カイゲン | Disinfection device for medical equipment |
FR2740335B1 (en) | 1995-10-26 | 1997-12-19 | Oreal | USE OF LANTHANIDE, LITHIUM, TIN, ZINC, MANGANESE OR YTTRIUM SALT AS A SUBSTANCE P ANTAGONIST |
JPH09157173A (en) * | 1995-11-02 | 1997-06-17 | Asahi Glass Eng Kk | Acidic water containing hydroxy free radical |
JP3312837B2 (en) * | 1995-11-30 | 2002-08-12 | アルプス電気株式会社 | Ion water production apparatus and production method, electrolytic ionic water production system and production method |
US5928491A (en) | 1996-01-23 | 1999-07-27 | Maruko & Co., Ltd. | Plant compatible electrolyte composition as well as electrolyte ionized water production device and methods |
US5858202A (en) * | 1996-01-30 | 1999-01-12 | Zenkoku-Mokko-Kikai-Kan, Inc. | Method for producing electrolytic water and apparatus for producing the same |
JP3481761B2 (en) * | 1996-01-30 | 2003-12-22 | 忠正 中村 | Method of generating electrolyzed water |
US5783052A (en) | 1996-03-11 | 1998-07-21 | Rscecat, Usa, Inc. | Electrochemical cell |
US5635040A (en) * | 1996-03-11 | 1997-06-03 | Rscecat, Usa, Inc. | Electrochemical cell |
JP3785219B2 (en) * | 1996-03-27 | 2006-06-14 | ペルメレック電極株式会社 | Method for producing acidic water and alkaline water |
US5985110A (en) * | 1996-03-28 | 1999-11-16 | Bakhir; Vitold M. | Apparatus for electrochemical treatment of water and/or water solutions |
JP3716042B2 (en) | 1996-04-24 | 2005-11-16 | ペルメレック電極株式会社 | Acid water production method and electrolytic cell |
AU725252B2 (en) | 1996-04-30 | 2000-10-12 | Procter & Gamble Company, The | Cleaning articles treated with a high internal phase inverse emulsion |
US5662625A (en) * | 1996-05-06 | 1997-09-02 | Gwr Medical, L.L.P. | Pressure controllable hyperbaric device |
JPH11169856A (en) | 1996-06-04 | 1999-06-29 | Mizu Kk | Electrolytic water producing device |
WO1997049638A1 (en) | 1996-06-26 | 1997-12-31 | Ist S.A. | Method and device for the activation of liquids |
US20040171998A1 (en) | 2000-07-21 | 2004-09-02 | Marasco Patrick V. | Isolated wound-treatment arrangement |
US6028018A (en) | 1996-07-24 | 2000-02-22 | Kimberly-Clark Worldwide, Inc. | Wet wipes with improved softness |
JPH1043764A (en) | 1996-08-06 | 1998-02-17 | First Ocean Kk | Electrode for electrolizing water and sterilizing method of water using the same |
US5728274A (en) * | 1996-08-13 | 1998-03-17 | Hoshizaki Denki Kabushiki Kaisha | Production system of electrolyzed water |
JP3408394B2 (en) * | 1996-08-27 | 2003-05-19 | 株式会社日本トリム | Method for producing electrolytic hydrogen dissolved water and apparatus for producing the same |
JPH1080686A (en) | 1996-09-09 | 1998-03-31 | Takazono Sangyo Kk | Strong acidic water generating device |
GB2316090B (en) | 1996-09-26 | 1998-12-23 | Julian Bryson | Method and apparatus for producing a sterilising solution |
US6007696A (en) | 1996-09-28 | 1999-12-28 | Kabushiki Kaisha Toshiba | Apparatus and method for manufacturing electrolytic ionic water and washing method using electroyltic ionic water |
WO1998017588A1 (en) | 1996-10-18 | 1998-04-30 | Miz Co., Ltd. | Reducing electrolytic water and method for preparing the same |
GB2316091B (en) | 1996-10-23 | 1999-06-16 | Julian Bryson | Electrolytic treatment of aqueous salt solutions |
US5728287A (en) | 1996-10-31 | 1998-03-17 | H2 O Technologies, Ltd. | Method and apparatus for generating oxygenated water |
JPH10128331A (en) | 1996-11-05 | 1998-05-19 | Coherent Technol:Kk | Method and apparatus for producing sterilized water |
JPH1157720A (en) | 1996-11-07 | 1999-03-02 | Honda Motor Co Ltd | Electrolytic functional water, its production method and device |
JP3455035B2 (en) * | 1996-11-14 | 2003-10-06 | 株式会社東芝 | Electrolytic ionic water generation device and semiconductor manufacturing device |
US5908707A (en) * | 1996-12-05 | 1999-06-01 | The Procter & Gamble Company | Cleaning articles comprising a high internal phase inverse emulsion and a carrier with controlled absorbency |
RU2119802C1 (en) | 1996-12-18 | 1998-10-10 | Стерилокс Текнолоджиз, Инк. | Device for performing electrochemical treatment of liquid media |
JP3366986B2 (en) | 1996-12-27 | 2003-01-14 | 高橋金属株式会社 | Washing water |
US5919129A (en) | 1997-01-09 | 1999-07-06 | The United States Of America As Represented By The Secretary Of The Army | Fiber optic periodontal endoscope |
US5941859A (en) | 1997-03-17 | 1999-08-24 | Lerman; Benjamin S. | Wound irrigation shield with fluid scavenging |
RU2110483C1 (en) | 1997-03-24 | 1998-05-10 | Стерилокс Текнолоджиз, Инк. | Electrochemical water treatment apparatus |
US5963435A (en) | 1997-03-25 | 1999-10-05 | Gianna Sweeney | Apparatus for coating metal with oxide |
US5759478A (en) * | 1997-03-27 | 1998-06-02 | Viskase Corporation | Mandrel structure for use in manufacture of cellulose food casing |
JPH10286571A (en) | 1997-04-16 | 1998-10-27 | Permelec Electrode Ltd | Electrolytic cell for acidic water and alkaline water preparation |
US5888528A (en) | 1997-05-19 | 1999-03-30 | Bernard Technologies, Inc. | Sustained release biocidal powders |
JPH10314740A (en) | 1997-05-19 | 1998-12-02 | Permelec Electrode Ltd | Electrolytic bath for acidic water production |
RO117540B1 (en) | 1997-06-13 | 2002-04-30 | Scchimcomplex Sa Borzesti | Disinfectant and detergent composition |
TW502130B (en) | 1997-06-17 | 2002-09-11 | Toshiba Corp | Cleaning method of substrate |
US6093292A (en) | 1997-06-17 | 2000-07-25 | Shimadzu Corporation | Electrolyte producing apparatus with monitoring device |
RU2132821C1 (en) | 1997-06-25 | 1999-07-10 | Стерилокс Текнолоджиз, Инк. | Electrolytic water treatment device |
US5964089A (en) | 1997-06-27 | 1999-10-12 | Lynntech, Inc | Diagnostics and control of an on board hydrogen generation and delivery system |
AU8168198A (en) | 1997-06-27 | 1999-01-19 | Lynntech, Inc. | Method and apparatus for injecting hydrogen into a catalytic converter |
CA2264928A1 (en) * | 1997-07-09 | 1999-01-21 | Koji Kawai | Antitussives |
US6143163A (en) | 1997-08-06 | 2000-11-07 | Permelec Electrode Ltd. | Method of water electrolysis |
US5932171A (en) * | 1997-08-13 | 1999-08-03 | Steris Corporation | Sterilization apparatus utilizing catholyte and anolyte solutions produced by electrolysis of water |
US5944978A (en) | 1997-08-21 | 1999-08-31 | Omco Co., Ltd. | Cleaning method of an electrolyzed water forming apparatus and an electrolyzed water forming apparatus having mechanism for conducting the method |
US5928488A (en) | 1997-08-26 | 1999-07-27 | David S. Newman | Electrolytic sodium sulfate salt splitter comprising a polymeric ion conductor |
CA2270199C (en) | 1997-08-27 | 2005-08-09 | Miz Co., Ltd. | Electrolytic cell and electrolyzed water generating device |
CN1293805C (en) | 1997-10-10 | 2007-01-10 | 纯生物科学公司 | Disinfectant and method of making |
US6294073B1 (en) | 1997-10-22 | 2001-09-25 | Chemicoat & Co., Ltd. | Manufacturing method and apparatus of alkaline ionized water |
US20040131695A1 (en) | 1997-10-23 | 2004-07-08 | Radical Waters Ip (Pty) Ltd. | Use of an aqueous solution in the treatment of live animals |
CN1136153C (en) * | 1997-10-23 | 2004-01-28 | 星崎电机株式会社 | Electrolyzed water production apparatus |
JPH10113664A (en) | 1997-11-13 | 1998-05-06 | Aiken Kogyo Kk | Sterilized water having high electron activity |
JP3952228B2 (en) | 1997-11-19 | 2007-08-01 | 有限会社コヒーレントテクノロジー | Electrolysis apparatus and electrolysis method |
WO1999028238A1 (en) | 1997-12-04 | 1999-06-10 | Steris Corporation | Chemical modification of electrochemically activated water |
JPH11172482A (en) | 1997-12-10 | 1999-06-29 | Shinko Plant Kensetsu Kk | Ozonized water producing device and production of ozonized water with the device |
DE69833038T2 (en) * | 1997-12-26 | 2006-08-03 | Morinaga Milk Industry Co. Ltd. | METHOD FOR STERILIZING AND PACKAGING ARTICLES |
US6171551B1 (en) * | 1998-02-06 | 2001-01-09 | Steris Corporation | Electrolytic synthesis of peracetic acid and other oxidants |
JPH11226092A (en) | 1998-02-12 | 1999-08-24 | Trp:Kk | Sterile washing method for medical implement and apparatus therefor |
JPH11239790A (en) | 1998-02-25 | 1999-09-07 | Yoshiya Okazaki | Electrolytic water-making apparatus and washing method therefor |
US5948220A (en) | 1998-02-27 | 1999-09-07 | Hoshizaki Denki Kabushiki Kaisha | Production system of electrolyzed water |
TW477833B (en) | 1998-02-27 | 2002-03-01 | Amano Corp | Apparatus for producing electrolytic water |
JP3896210B2 (en) * | 1998-03-06 | 2007-03-22 | ホシザキ電機株式会社 | Electrolyzed water generator |
JP3443310B2 (en) | 1998-03-09 | 2003-09-02 | ホシザキ電機株式会社 | Electrolyzed water generator |
JPH11269686A (en) | 1998-03-18 | 1999-10-05 | Permelec Electrode Ltd | Production of hydrogen peroxide and electrolytic cell for production of hydrogen peroxide |
US20020025921A1 (en) | 1999-07-26 | 2002-02-28 | Petito George D. | Composition and method for growing, protecting, and healing tissues and cells |
US20030089618A1 (en) | 1998-04-10 | 2003-05-15 | Miz Co., Ltd. | Reducing electrolyzed water and method for producing same |
CN1231994A (en) | 1998-04-13 | 1999-10-20 | 王守林 | Domestic ozone water and oxygen-enriched water producer |
JP3783150B2 (en) | 1998-04-24 | 2006-06-07 | 株式会社オメガ | Ice having sterilizing power and method for producing the same |
US6126810A (en) | 1998-04-27 | 2000-10-03 | Steris Corporation | Generation of active chlorine in the presence of an organic load from sodium chloride in water |
JPH11320259A (en) | 1998-05-15 | 1999-11-24 | Michiko Suzuki | Electric discharge machining method and device for performing the same |
JP2000042556A (en) | 1998-05-28 | 2000-02-15 | Shimadzu Corp | Electrolytic water production device |
RU2142917C1 (en) | 1998-06-30 | 1999-12-20 | Попов Алексей Юрьевич | Method and device for electrochemical treatment of water |
US6368592B1 (en) * | 1998-07-17 | 2002-04-09 | Massachusetts Institute Of Technology | Method of delivering oxygen to cells by electrolyzing water |
US6458109B1 (en) | 1998-08-07 | 2002-10-01 | Hill-Rom Services, Inc. | Wound treatment apparatus |
JP2000051858A (en) | 1998-08-10 | 2000-02-22 | Osamu Miyake | Electrolytic ionic water maker |
US6033539A (en) * | 1998-08-21 | 2000-03-07 | Gablenko; Viacheslav G. | Units for electro-chemical synthesis of water solution |
JP2000070171A (en) | 1998-08-26 | 2000-03-07 | Trp:Kk | Wet wiper for disinfection and its feeding device |
JP2000084559A (en) | 1998-09-09 | 2000-03-28 | Hideo Hayakawa | Water treatment |
US6342150B1 (en) * | 1998-09-09 | 2002-01-29 | Thomas Clay Sale | Redox water treatment system |
TW523547B (en) | 1998-10-05 | 2003-03-11 | Miz Co Ltd | Method of producing detergent and the apparatus thereof |
US6669391B2 (en) | 1998-11-09 | 2003-12-30 | The Procter & Gamble Company | Cleaning composition, pad, wipe, implement, and system and method of use thereof |
US6280594B1 (en) | 1998-12-01 | 2001-08-28 | Tateki Yamaoka | Device for producing ion water and partition wall for device for producing ion water |
WO2000033757A1 (en) | 1998-12-09 | 2000-06-15 | Advanced H¿2?O Inc. | A system for decontamination of dental unit waterlines using electrolyzed water |
JP2000189972A (en) | 1998-12-28 | 2000-07-11 | Nippon Intek Kk | Oxidation-reduction potential water, production device of oxidation-reduction potential water, and additive |
DE10011829C2 (en) | 1999-03-15 | 2002-08-08 | Nhk Spring Co Ltd | Actuator for a vehicle occupant restraint system |
JP4583530B2 (en) | 1999-03-19 | 2010-11-17 | オルガノ株式会社 | Heat exchange water and its supply device |
US6258225B1 (en) | 1999-03-23 | 2001-07-10 | Tateki Yamaoka | Device for producing ion water |
US6277266B1 (en) | 1999-03-23 | 2001-08-21 | Tateki Yamaoka | Device for producing ion water and partition wall for device for producing ion water |
US6436445B1 (en) | 1999-03-26 | 2002-08-20 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
US7011940B1 (en) * | 1999-04-14 | 2006-03-14 | Medical Discovery Partners Llc | Quality control for cytochemical assays |
US20020006961A1 (en) | 1999-05-14 | 2002-01-17 | Katz Stanley E. | Method and composition for treating mammalian nasal and sinus diseases caused by inflammatory response |
CA2377232A1 (en) | 1999-06-11 | 2000-12-21 | Henceforth Hibernia, Inc. | Prophylactic, therapeutic and industrial antioxidant compositions enhanced with stabilized atomic hydrogen/free electrons and methods to prepare and use such compositions |
US6462250B1 (en) | 1999-06-22 | 2002-10-08 | Canon Kabushiki Kaisha | Method for decomposing halogenated aliphatic hydrocarbon compounds having adsorption process and apparatus for decomposition having adsorption means |
US6506416B1 (en) * | 1999-06-30 | 2003-01-14 | Kao Corporation | Virucide composition and sporicide composition |
DE60040317D1 (en) | 1999-06-30 | 2008-11-06 | Kao Corp | Germicidal detergent composition |
SE9902627D0 (en) | 1999-07-08 | 1999-07-08 | Siemens Elema Ab | Medical nebulizer |
CA2315355C (en) | 1999-08-06 | 2011-12-20 | Sterilox Medical (Europe) Limited | Electrochemical treatment of an aqueous solution |
GB9918458D0 (en) | 1999-08-06 | 1999-10-06 | Sterilox Med Europ Ltd | Method and apparatus for the electrochemical processing of aqueous salt solutions |
GB2355190B (en) | 1999-08-23 | 2004-07-28 | Sterilox Medical | Improvements in or relating to sterilising preparations |
TW546257B (en) | 1999-09-01 | 2003-08-11 | Nihon Trim Co Ltd | Method and apparatus for producing electrolytic reduced water |
JP2001079548A (en) | 1999-09-16 | 2001-03-27 | Kaneko Agricult Mach Co Ltd | Ionized water and, oxidation and reduction water production device |
US6852205B1 (en) * | 1999-09-27 | 2005-02-08 | Shinko-Pantec Co., Ltd. | Water-electrolysis-device-use electrode plate, unit, solid electrolytic membrane unit and electrolytic cell |
US6592907B2 (en) | 1999-10-04 | 2003-07-15 | Hampar L. Karagoezian | Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide |
JP2001113276A (en) | 1999-10-14 | 2001-04-24 | Kaneko Agricult Mach Co Ltd | Ion water and oxidation-reduction water making apparatus |
US6333054B1 (en) | 1999-10-21 | 2001-12-25 | Amuchina S.P.A. | Topical, non-cytotoxic, antimicrobial hydrogel with thixotropic properties |
JP2001139477A (en) | 1999-11-17 | 2001-05-22 | Coherent Technology:Kk | Tissue cell growth-promoting liquid for wounded part |
US6340663B1 (en) * | 1999-11-24 | 2002-01-22 | The Clorox Company | Cleaning wipes |
US6793846B2 (en) | 1999-12-10 | 2004-09-21 | Kao Corporation | Microbicide compositions |
US20030185704A1 (en) | 2000-01-12 | 2003-10-02 | Suzanne Bernard | Physiologically balanced, ionized, acidic solution and methodology for use in wound healing |
US6426066B1 (en) | 2000-01-12 | 2002-07-30 | California Pacific Labs, Inc. | Use of physiologically balanced, ionized, acidic solution in wound healing |
JP4462513B2 (en) | 2000-01-12 | 2010-05-12 | 有限会社コヒーレントテクノロジー | Electrolyzed water manufacturing method, cleaning water, and cleaning method |
US7393522B2 (en) | 2000-01-12 | 2008-07-01 | Novabay Pharmaceuticals, Inc. | Physiologically balanced, ionized, acidic solution and methodology for use in wound healing |
EP1251878A2 (en) | 2000-02-04 | 2002-10-30 | Radical Waters IP (PTY) Ltd | Dental equipment and method of operating such equipment |
JP2004129314A (en) * | 2000-03-17 | 2004-04-22 | Soichi Sato | Cogeneration system equipped with capacitor device |
JP2001259640A (en) | 2000-03-23 | 2001-09-25 | Asahi Pretec Corp | Device and method for manufacturing and supplying electrolyzed water having bactericidal property |
JP4090665B2 (en) | 2000-04-11 | 2008-05-28 | ファースト・オーシャン株式会社 | Electrolyzed water production method |
IT1317329B1 (en) | 2000-04-13 | 2003-06-16 | Nottington Holding Bv | BREATHABLE FOOTWEAR. |
JP3888835B2 (en) | 2000-05-10 | 2007-03-07 | 花王株式会社 | Disinfection and deodorization method and disinfection and deodorization tool |
JP3602773B2 (en) | 2000-06-08 | 2004-12-15 | 株式会社ミクニ | Anode electrolyzed water and method for producing the same |
EP1162179B1 (en) | 2000-06-10 | 2004-09-15 | Degussa AG | Photocatalytic process |
CA2413141C (en) | 2000-06-14 | 2014-01-07 | Chanda Zaveri | Peptides with wound healing activity |
US20020023847A1 (en) * | 2000-06-23 | 2002-02-28 | Shinichi Natsume | Cleansing system and method using water electrolysis |
AU2001272036A1 (en) * | 2000-07-07 | 2002-01-21 | Radical Waters Ip (Pty) Ltd. | Method of and equipment for washing, disinfecting and/or sterilizing health caredevices |
WO2003066070A1 (en) | 2002-02-06 | 2003-08-14 | H2O Technologies, Ltd. | Method and apparatus for treating water for use in improving the intestinal flora of livestock and poultry |
DE10038457B4 (en) | 2000-08-07 | 2008-09-25 | Cognis Ip Management Gmbh | Process for the production of sterols and tocopherols |
JP4607296B2 (en) | 2000-08-08 | 2011-01-05 | ジャパンマテックス株式会社 | Reduced water production equipment |
US6531158B1 (en) | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
US6358395B1 (en) * | 2000-08-11 | 2002-03-19 | H20 Technologies Ltd. | Under the counter water treatment system |
US20030019764A1 (en) | 2000-08-11 | 2003-01-30 | H20 Technologies, Ltd. | Under the counter water treatment system |
JP3299250B2 (en) | 2000-08-21 | 2002-07-08 | 修生 澄田 | Pure water electrolysis tank with an intermediate chamber |
KR100389917B1 (en) * | 2000-09-06 | 2003-07-04 | 삼성전자주식회사 | Wet process for fabrication of semiconductor device using electrolytically ionized anode water and/or cathod water and electrolytically ionized anode water and/or cathode water used therein |
JP2002079248A (en) * | 2000-09-06 | 2002-03-19 | Tominaga Oil Pump Mfg Co Ltd | Electrolytic water making apparatus |
US6638364B2 (en) | 2000-09-08 | 2003-10-28 | Electric Aquagenics Unlimited | System to clean and disinfect carpets, fabrics, and hard surfaces using electrolyzed alkaline water produced from a solution of NaCl |
US20020032141A1 (en) | 2000-09-08 | 2002-03-14 | Gene Harkins | System and method to clean and disinfect hard surfaces using electrolyzed acidic water produced from a solution of NaCl |
JP2004510312A (en) | 2000-09-28 | 2004-04-02 | プロトン エネルギー システムズ,インク. | Regenerative electrochemical cell system and operating method thereof |
US20020090428A1 (en) | 2000-10-12 | 2002-07-11 | Warf C. Cayce | Treatment fluid application apparatus for foodstuffs and methods related thereto |
JP2002145787A (en) * | 2000-11-02 | 2002-05-22 | Kanebo Ltd | External preparation |
DK1342462T3 (en) * | 2000-11-22 | 2007-08-06 | Otsuka Pharma Co Ltd | Oil / water emulsion composition and process for preparation thereof |
JP2002165868A (en) * | 2000-12-05 | 2002-06-11 | Kanebo Ltd | Aerosol product |
JP3805621B2 (en) * | 2000-12-19 | 2006-08-02 | 株式会社富永製作所 | Electrolyzed water generator |
US7122018B2 (en) | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
US6432077B1 (en) | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
JP2002201296A (en) | 2000-12-28 | 2002-07-19 | Yunippu:Kk | Method for modifying surface of plastic base material |
US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
US6855307B2 (en) | 2001-01-16 | 2005-02-15 | Tomco2 Equipment Company | Pressurized solution feed system for introducing hypochlorous acid to a fluid stream |
US6620315B2 (en) | 2001-02-09 | 2003-09-16 | United States Filter Corporation | System for optimized control of multiple oxidizer feedstreams |
US6844026B2 (en) | 2001-02-12 | 2005-01-18 | Rhodia Chimie | Preparation of particles by hydrolysis of a metal cation in the presence of a polymer |
US7011739B2 (en) | 2001-03-22 | 2006-03-14 | Gene Harkins | Method for sanitizing shells of eggs using electrolyzed oxidizing water |
US6921743B2 (en) | 2001-04-02 | 2005-07-26 | The Procter & Gamble Company | Automatic dishwashing compositions containing a halogen dioxide salt and methods for use with electrochemical cells and/or electrolytic devices |
US6866756B2 (en) | 2002-10-22 | 2005-03-15 | Dennis Klein | Hydrogen generator for uses in a vehicle fuel system |
JPWO2002081808A1 (en) | 2001-04-05 | 2004-07-29 | 三洋電機株式会社 | Electric washing machine |
US6767342B1 (en) | 2001-04-23 | 2004-07-27 | Evelyna D. Cantwell | Oxygen bandage system |
GB2374819B (en) | 2001-04-27 | 2004-12-01 | Sterilox Tech Int Ltd | Oxidation-resistant coatings |
JP2002338498A (en) | 2001-05-17 | 2002-11-27 | Takeda Chem Ind Ltd | Internal liquid medicine |
JP2002363017A (en) | 2001-06-01 | 2002-12-18 | Tadashi Inoue | Disinfection liquid |
TWI320713B (en) * | 2001-06-01 | 2010-02-21 | Neochemir Inc | |
JP3338435B2 (en) | 2001-06-04 | 2002-10-28 | 修生 澄田 | Method for producing liquid in which hydrogen ion or hydroxide ion and redox substance coexist by electrolysis of pure water |
WO2003000957A1 (en) | 2001-06-21 | 2003-01-03 | Sanyo Electric Co., Ltd. | Electrolyzing electrode and production method therefor and electrolysis method using electrolyzing electrode and electrolysis solution producing device |
KR20070041639A (en) | 2001-06-29 | 2007-04-18 | 미즈 가부시키가이샤 | Method for antioxidation and antioxidative functional water |
KR20030005777A (en) * | 2001-07-10 | 2003-01-23 | 삼성전자 주식회사 | Semiconductor cleaning process using electrolytic ionized water and diluted HF solution at the same time |
JP2003093479A (en) | 2001-07-18 | 2003-04-02 | Sanyo Electric Co Ltd | Sterilizing method and electrolyzed water producing device |
US6656334B2 (en) | 2001-07-23 | 2003-12-02 | Skydon Corp. | Modified electrolysis cell and a housing for the same |
WO2003010094A1 (en) * | 2001-07-26 | 2003-02-06 | H20 Technologies, Ltd. | Apparatus and methods for cleaning and controlling bacteria growth in fluid supply lines |
JP5140218B2 (en) | 2001-09-14 | 2013-02-06 | 有限会社コヒーレントテクノロジー | Electrolyzer for producing charged anode water suitable for surface cleaning and surface treatment, method for producing the same, and method of use |
DE60227547D1 (en) | 2001-09-15 | 2008-08-21 | Icf Technologies Inc | KITS AND METHOD FOR DETERMINING THE EFFECTIVENESS OF STERILIZATION OR DISINFECTION PROCEDURES |
US6833206B2 (en) | 2001-09-28 | 2004-12-21 | Daimlerchrysler Ag | Auxiliary power supply for a vehicle with a combustion engine and method for operating same |
US20040171701A1 (en) | 2001-11-02 | 2004-09-02 | Technology Convergence Inc. | Methanol production process |
CN1272020C (en) | 2001-10-01 | 2006-08-30 | 阿奎拉布西股份有限公司 | Composition of hypochlorous acid and its applications |
US6756142B2 (en) | 2001-10-31 | 2004-06-29 | Motorola, Inc. | Fuel cell using non-linear positive temperature coefficient material |
JP2003144001A (en) * | 2001-11-08 | 2003-05-20 | Hoshizaki Electric Co Ltd | Raising water for marine organism, method and apparatus for producing raising water |
US6833207B2 (en) | 2001-11-09 | 2004-12-21 | Hydrogenics Corporation | Unitized regenerative fuel cell with bifunctional fuel cell humidifier and water electrolyzer |
EP1444169A2 (en) | 2001-11-13 | 2004-08-11 | Radical Waters (Proprietary) Limited | An electrochemical activation system suitable for producing electrochemically-activated solutions through use of an electrolytic cell exchange module |
JP2003145153A (en) | 2001-11-13 | 2003-05-20 | Sugano Minoru | Method and apparatus for producing electrolyzed water |
EP1314699B1 (en) | 2001-11-23 | 2007-06-06 | Hoshizaki Denki Kabushiki Kaisha | Method for cleaning an electrolyzed water production apparatus |
US6624135B2 (en) | 2001-11-26 | 2003-09-23 | S.C. Johnson & Son, Inc. | Cleaning sheet |
ES2377945T3 (en) | 2001-12-05 | 2012-04-03 | Oculus Innovative Sciences, Inc. | Method and apparatus for producing water with negative and positive oxidation and reduction (ORP) potential |
CN1298309C (en) | 2001-12-11 | 2007-02-07 | 王小兵 | Acidifying of buffering agent to dental plaque |
TW562673B (en) | 2001-12-14 | 2003-11-21 | Sanyo Electric Co | Foot warming bath device |
US20050178920A1 (en) | 2002-01-22 | 2005-08-18 | Wilson Thomas R. | Spacecraft propulsion system |
EP1473386A4 (en) | 2002-01-29 | 2005-04-06 | Mitsubishi Corp | High-pressure hydrogen producing apparatus and producing method |
JP3848882B2 (en) * | 2002-02-13 | 2006-11-22 | ニッポン高度紙工業株式会社 | High ion conductive solid electrolyte and electrochemical system using the solid electrolyte |
JP2003236315A (en) | 2002-02-14 | 2003-08-26 | Daiki Kogyo Kk | Cleaning apparatus for rotation type drum screen |
JP2003236543A (en) | 2002-02-14 | 2003-08-26 | Hideo Hayakawa | Alternating current electrolysis method and apparatus for liquid |
JP2003247134A (en) | 2002-02-21 | 2003-09-05 | Toray Textile Inc | Slitted film yarn for magnetic recording |
EP1579037A4 (en) | 2002-03-06 | 2008-02-13 | Univ Georgia Res Found | Method and apparatus for electrolyzing water |
US6733435B2 (en) | 2002-03-08 | 2004-05-11 | Canedo Luis | Electromagnetic method of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection |
JP2003299250A (en) | 2002-03-29 | 2003-10-17 | Hitachi Ltd | Power supply unit and elevator apparatus |
JP2003311270A (en) | 2002-04-18 | 2003-11-05 | First Ocean Kk | Liquid distributor |
JPWO2003095102A1 (en) | 2002-05-08 | 2005-09-08 | 株式会社ミクニ | Electrolyzed water spray device |
JP2003338435A (en) | 2002-05-21 | 2003-11-28 | Meidensha Corp | Electric double layered capacitor |
KR100479627B1 (en) | 2002-05-25 | 2005-04-06 | 유니셈 주식회사 | Wet pre-treatment apparatus and method for treating an effluent gas |
AU2003243534A1 (en) | 2002-06-10 | 2003-12-22 | Map Technologies Llc | Methods and devices for electrosurgical electrolysis |
US6899903B2 (en) * | 2002-06-25 | 2005-05-31 | Patrick Quillin | Composition for cleansing the sinuses |
JP2004047827A (en) | 2002-07-12 | 2004-02-12 | Mec Kk | Method for manufacturing printed circuit board |
JP3954458B2 (en) | 2002-07-16 | 2007-08-08 | 株式会社コスモス.エンタープライズ | Water purification pot and water purification method using the same |
JP2004058006A (en) | 2002-07-31 | 2004-02-26 | First Ocean Kk | Method of manufacturing electrolytic water |
US20040081705A1 (en) | 2002-09-18 | 2004-04-29 | Mana Gotou | Digestion promoter for ruminant animal and breeding method of ruminant animal |
US20040055896A1 (en) | 2002-09-20 | 2004-03-25 | Sterilox Technologies, Inc. | Biocidal solution |
US6843448B2 (en) * | 2002-09-30 | 2005-01-18 | Daniel W. Parmley | Lighter-than-air twin hull hybrid airship |
JP2004121607A (en) | 2002-10-03 | 2004-04-22 | Harasawa Pharmaceutical Co Ltd | Bactericidal and deodorant agent composition |
DE10250926A1 (en) | 2002-10-31 | 2004-05-19 | Microlas Lasersystem Gmbh | Laser system which combines beams of two or more lasers, has beams directed onto beam splitter and mirror, so that reflected radiation passes through beam splitter and back to resonator |
US6855233B2 (en) | 2002-11-15 | 2005-02-15 | Kinji Sawada | Apparatus for production of strong alkali and acid electrolytic solution |
JP2004173628A (en) | 2002-11-28 | 2004-06-24 | Fuso Pharmaceutical Industries Ltd | Probe for detecting haemophilus influenzae and detection method using the same |
JP3891120B2 (en) | 2003-01-17 | 2007-03-14 | 松下電工株式会社 | Electrolyzed water generator |
JP3891118B2 (en) | 2003-01-17 | 2007-03-14 | 松下電工株式会社 | Electrolyzed water generator |
JP3891119B2 (en) | 2003-01-17 | 2007-03-14 | 松下電工株式会社 | Electrolyzed water generator |
JP3849644B2 (en) | 2003-01-17 | 2006-11-22 | 松下電工株式会社 | Electrolyzed water generator |
JP4244645B2 (en) | 2003-01-31 | 2009-03-25 | パナソニック電工株式会社 | Electrolyzed water generator |
CN1751139B (en) | 2003-02-21 | 2010-12-08 | 阿维伦斯有限责任公司 | Electrolyzer apparatus and method for hydrogen production |
US20040168909A1 (en) | 2003-02-28 | 2004-09-02 | Larson Arden L. | Three-dimensional flow-through electrode and electrochemical cell |
JP2006513849A (en) | 2003-03-04 | 2006-04-27 | エフアールエス ウォーターウェア インコーポレイテッド | Water as a free radical solution |
EP1613793A4 (en) | 2003-03-04 | 2007-08-08 | Frs Waterware Inc D B A Waterw | High electric field electrolysis cell |
JP2004267956A (en) * | 2003-03-11 | 2004-09-30 | Mikuni Corp | Method for producing mixed electrolytic water |
JP2004273961A (en) | 2003-03-12 | 2004-09-30 | Ebara Corp | Cleaning device of metal wiring forming substrate |
NZ541969A (en) | 2003-03-13 | 2008-01-31 | Glaxosmithkline Biolog Sa | Purifying pneumolysin from Streptococcus pneumoniae in a single chromatographic step by binding it to a hydrophobic interaction column in the presence of detergent and high salt |
US7923030B2 (en) | 2003-03-14 | 2011-04-12 | Sol-Gel Technologies, Inc. | Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same |
US7014932B2 (en) | 2003-03-19 | 2006-03-21 | Proton Energy Systems, Inc. | Drainage system and process for operating a regenerative electrochemical cell system |
AU2003901316A0 (en) | 2003-03-21 | 2003-04-03 | The Royal Alexandra Hospital For Children | Regulation of cell surface proteins |
JP4041422B2 (en) | 2003-03-26 | 2008-01-30 | ニッポン高度紙工業株式会社 | Solid electrolyte and electrochemical system using the solid electrolyte |
GB2400611B (en) | 2003-04-15 | 2006-03-15 | Empower Corp H | An integrated renewable energy system |
US8912174B2 (en) * | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
JP4040028B2 (en) | 2003-04-16 | 2008-01-30 | 三洋電機株式会社 | Method and system for treating water to be treated containing organic matter and nitrogen compound |
WO2005009336A2 (en) | 2003-05-01 | 2005-02-03 | Replidyne, Inc. | Antibacterial methods and compositions |
US20040226894A1 (en) | 2003-05-12 | 2004-11-18 | Tatsuo Okazaki | Method of preparing a sterile water containing hypochlorous or chlorous acid, package of sterile source materials, and sterile water preparation kit |
BRPI0410758A (en) | 2003-05-19 | 2006-06-27 | Procter & Gamble | compositions, devices and methods for stabilizing halogen dioxide and increasing its effectiveness |
US20040244537A1 (en) | 2003-06-05 | 2004-12-09 | Runyon Dale Leroy | Processing coal combustion products (CCP), ore, or other material using functionally electrolyzed water (FEW) |
US6856916B2 (en) * | 2003-06-13 | 2005-02-15 | Wen-Shing Shyu | Locating system of oxidation/reduction potential of electrolysis water and the constant output method of calibration and compensation thereof |
US7453164B2 (en) | 2003-06-16 | 2008-11-18 | Polestar, Ltd. | Wind power system |
US7445800B2 (en) | 2003-06-25 | 2008-11-04 | Eau Technologies, Inc. | Method for remediating mold and mildew using acidic electrolyzed water |
JP2005013520A (en) | 2003-06-26 | 2005-01-20 | Spring:Kk | Bathtub apparatus and method of operating bathtub |
KR100412258B1 (en) | 2003-07-01 | 2003-12-31 | 주식회사 에스에프에이 | The process for cleaning a glass surface in manufacturing lcd |
ITPD20030166A1 (en) | 2003-07-22 | 2005-01-23 | Geox Spa | BREATHABLE AND WATERPROOF SOLE FOR FOOTWEAR, PARTICULARLY BUT NOT ONLY FOR OPEN-SHOE FOOTWEAR SUCH AS SANDALS, SABO 'AND SIMILAR AND SHOE MADE WITH SUCH SOLE |
JP2005058848A (en) * | 2003-08-08 | 2005-03-10 | Spring:Kk | Production method for water used for washing, disinfecting, and wound healing, its production apparatus, and water used for washing, disinfecting, and wound healing |
US7462361B2 (en) | 2003-08-18 | 2008-12-09 | Novabay Pharmaceuticals, Inc. | N,N-dihalogenated amino acids and derivatives |
US20050064259A1 (en) | 2003-09-24 | 2005-03-24 | Protonetics International, Inc. | Hydrogen diffusion electrode for protonic ceramic fuel cell |
US20050067300A1 (en) * | 2003-09-25 | 2005-03-31 | The Procter & Gamble Company | Electrolysis device for treating a reservoir of water |
DE10349158A1 (en) | 2003-10-22 | 2005-06-16 | Airbus Deutschland Gmbh | Device for water supply in aircraft |
JP4653945B2 (en) | 2003-10-24 | 2011-03-16 | ミズ株式会社 | Pharmacologically functional water and its use |
GB0518826D0 (en) | 2005-09-15 | 2005-10-26 | Smith & Nephew | Apparatus with actives from tissue - exudialysis |
JP4353772B2 (en) | 2003-11-07 | 2009-10-28 | 三洋電機株式会社 | Electrolyzed water generator |
US20050101838A1 (en) * | 2003-11-12 | 2005-05-12 | Camillocci Philip L. | Endoscope cover |
US7592300B2 (en) | 2003-11-24 | 2009-09-22 | The Dial Corporation | Antimicrobial compositions containing an aromatic carboxylic acid and a hydric solvent |
GB0328124D0 (en) | 2003-12-04 | 2004-01-07 | Daly James | Membrane electrolyser with a two part end design |
KR100542895B1 (en) | 2003-12-22 | 2006-01-11 | 재단법인 포항산업과학연구원 | Method for controlling ballast water using effect of NaOCl produced electrolysis of natural seawater and an apparatus for the same |
US9168318B2 (en) * | 2003-12-30 | 2015-10-27 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and methods of using the same |
US20050139808A1 (en) | 2003-12-30 | 2005-06-30 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and process for producing same |
US20050196462A1 (en) | 2003-12-30 | 2005-09-08 | Oculus Innovative Sciences, Inc. | Topical formulation containing oxidative reductive potential water solution and method for using same |
US7374655B2 (en) | 2004-01-12 | 2008-05-20 | Novastron | Electrochemical water purifier |
EP1753829B1 (en) | 2004-02-03 | 2008-03-12 | Akzo Nobel Coatings International BV | Antifouling compositions comprising a polymer with salt groups |
CN102091090A (en) | 2004-02-10 | 2011-06-15 | 综合植物学技术有限公司 | Methods and compositions for the treatment of inflammation |
US20050178349A1 (en) | 2004-02-17 | 2005-08-18 | Tse Kwong W. | Multi-fueled internal combustion engine |
US7510640B2 (en) | 2004-02-18 | 2009-03-31 | General Motors Corporation | Method and apparatus for hydrogen generation |
US20080038299A1 (en) | 2004-02-19 | 2008-02-14 | Reckitt & Colman (Overseas) Limited | Skincare Compositions Comprising Salicylic Acid |
FI20040279A (en) | 2004-02-23 | 2005-08-24 | Pohjoisen Kantaperuna Oy | Method and apparatus for washing and disinfecting root vegetables |
US7238272B2 (en) | 2004-02-27 | 2007-07-03 | Yoichi Sano | Production of electrolytic water |
US7000395B2 (en) | 2004-03-11 | 2006-02-21 | Yuan Ze University | Hybrid clean-energy power-supply framework |
US20050209518A1 (en) | 2004-03-17 | 2005-09-22 | Therafuse, Inc. | Self-calibrating body analyte monitoring system |
WO2005094439A2 (en) | 2004-03-23 | 2005-10-13 | The Clorox Company | Method for diluting hypochlorite |
US7157412B2 (en) | 2004-04-07 | 2007-01-02 | Advanced Medical Optics, Inc. | Alkylamine as an antimicrobial agent in ophthalmic compositions |
US7758807B2 (en) | 2004-04-20 | 2010-07-20 | The Clorox Company | Microbial control with reduced chlorine |
WO2005117914A2 (en) | 2004-06-04 | 2005-12-15 | Sterilox Technologies, Inc. | Biocidal solution |
US20060008908A1 (en) * | 2004-07-08 | 2006-01-12 | Giles Brian C | Method and composition for longevity assurance |
US20060086622A1 (en) | 2004-10-21 | 2006-04-27 | Trust Sterile Services Ltd. | Apparatus and method for electrolytic cleaning |
DE102004056456A1 (en) | 2004-11-23 | 2006-05-24 | Eugen Malamutmann | Treatment device for wounds |
US7749370B2 (en) * | 2005-02-03 | 2010-07-06 | Osao Sumita | Manufacturing method of oxidative water to be employed for sterilization |
WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
CN101163492B (en) | 2005-03-23 | 2013-01-30 | 奥古露丝创新科学公司 | Method of treating skin ulcers using oxidative reductive potential water solution |
US20060241002A1 (en) | 2005-04-26 | 2006-10-26 | Rogozinski Wallace J | Sodium hypochlorite gel composition |
JP5907645B2 (en) * | 2005-05-02 | 2016-04-26 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Usage of redox potential aqueous solution in dental applications |
US20060263240A1 (en) | 2005-05-06 | 2006-11-23 | Electric Aquagenics Unlimited | Electrolyzed water treatment for face and hands |
US20060275387A1 (en) | 2005-06-03 | 2006-12-07 | BAGLEY David | Processed water and therapeutic uses thereof |
WO2007025244A2 (en) | 2005-08-25 | 2007-03-01 | Houle Philip R | Treatment systems for delivery of sensitizer solutions |
DK2010245T3 (en) | 2005-11-21 | 2016-01-18 | Joshua David Smith | WOUND CARE SYSTEM |
US8147444B2 (en) | 2006-01-20 | 2012-04-03 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
US7779625B2 (en) | 2006-05-11 | 2010-08-24 | Kalypto Medical, Inc. | Device and method for wound therapy |
US20080243096A1 (en) | 2006-10-05 | 2008-10-02 | Paul Svedman | Device For Active Treatment and Regeneration of Tissues Such as Wounds |
US8273747B2 (en) | 2006-11-02 | 2012-09-25 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
WO2008089268A2 (en) | 2007-01-16 | 2008-07-24 | Puricore, Inc. | Methods and compositions for treating conditions associated with infection and/or inflammation |
CA2678151C (en) | 2007-02-16 | 2015-06-16 | Taiko Pharmaceutical Co., Ltd. | Broad-spectrum antiviral composition with excellent preservation stability |
EP2136819A1 (en) | 2007-03-13 | 2009-12-30 | Oculus Innovative Sciences, Inc. | Antimicrobial solutions containing dichlorine monoxide and methods of making and using the same |
EP2337544A2 (en) | 2007-04-30 | 2011-06-29 | Living Proof, Inc. | Use of matrix metalloproteinase inhibitors in skin care |
WO2009149208A1 (en) * | 2008-06-03 | 2009-12-10 | Oculus Innovative Sciences, Inc. | Method and apparatus for treating a wound |
WO2010075477A2 (en) * | 2008-12-22 | 2010-07-01 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing biofilm associated infections with free available chlorine water |
JP6033082B2 (en) | 2009-06-15 | 2016-11-30 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Solution containing hypochlorous acid and method of using the same |
WO2011014809A1 (en) | 2009-07-30 | 2011-02-03 | Oculus Innovative Sciences, Inc. | Hydrogel formulation comprising oxidative reductive potential water |
WO2014190184A1 (en) | 2013-05-22 | 2014-11-27 | Oculus Innovative Sciences, Inc. | Stabilized hypochlorous acid solution and use thereof |
-
2007
- 2007-01-22 US US11/656,328 patent/US8147444B2/en active Active
- 2007-01-22 CA CA2637175A patent/CA2637175C/en not_active Expired - Fee Related
- 2007-01-22 KR KR1020087020291A patent/KR20080093135A/en not_active Application Discontinuation
- 2007-01-22 AU AU2007205863A patent/AU2007205863B2/en not_active Ceased
- 2007-01-22 CA CA2637178A patent/CA2637178C/en not_active Expired - Fee Related
- 2007-01-22 BR BRPI0706671-6A patent/BRPI0706671A2/en not_active Application Discontinuation
- 2007-01-22 JP JP2008551573A patent/JP2009523832A/en active Pending
- 2007-01-22 AU AU2007205860A patent/AU2007205860B2/en not_active Ceased
- 2007-01-22 EP EP07718192A patent/EP1993572A2/en not_active Withdrawn
- 2007-01-22 BR BRPI0706676A patent/BRPI0706676B8/en active IP Right Grant
- 2007-01-22 JP JP2008551571A patent/JP5723084B2/en active Active
- 2007-01-22 EP EP07717981.0A patent/EP1993570B1/en not_active Not-in-force
- 2007-01-22 KR KR1020087020289A patent/KR101499822B1/en active IP Right Grant
- 2007-01-22 US US11/656,087 patent/US20070196357A1/en not_active Abandoned
- 2007-01-22 CA CA2637197A patent/CA2637197C/en not_active Expired - Fee Related
- 2007-01-22 WO PCT/US2007/060854 patent/WO2007085018A2/en active Application Filing
- 2007-01-22 EP EP07718160.0A patent/EP1993571B1/en active Active
- 2007-01-22 KR KR1020087020287A patent/KR101499824B1/en active IP Right Grant
- 2007-01-22 BR BRPI0706677-5A patent/BRPI0706677A2/en not_active Application Discontinuation
- 2007-01-22 AU AU2007205861A patent/AU2007205861B2/en not_active Ceased
- 2007-01-22 US US11/656,088 patent/US20070196434A1/en not_active Abandoned
- 2007-01-22 WO PCT/US2007/060856 patent/WO2007085019A2/en active Application Filing
- 2007-01-22 JP JP2008551570A patent/JP5449780B2/en not_active Expired - Fee Related
- 2007-01-22 WO PCT/US2007/060860 patent/WO2007085021A2/en active Application Filing
-
2009
- 2009-09-25 HK HK09108800.4A patent/HK1130675A1/en unknown
- 2009-12-21 US US12/643,191 patent/US9072726B2/en active Active
-
2012
- 2012-03-30 US US13/436,288 patent/US8834445B2/en active Active
-
2015
- 2015-07-07 US US14/793,649 patent/US9782434B2/en active Active
-
2017
- 2017-10-10 US US15/729,138 patent/US20180028562A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005065383A2 (en) * | 2003-12-30 | 2005-07-21 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution, processes for producing same and methods of using the same |
WO2006102681A2 (en) * | 2005-03-23 | 2006-09-28 | Oculus Innovative Sciences, Inc. | Method of treating skin ulcers using oxidative reductive potential water solution |
Non-Patent Citations (1)
Title |
---|
KUBOTA A ET AL: "EFFECTIVENESS OF ACIDIC OXIDATIVE POTENTIAL WATER IN PERITONEAL LAVAGE FOR PERFORATED APPENDICITIS" ASIAN JOURNAL OF SURGERY, DEPARTMENT OF SURGERY, UNIVERSITY OF HONGKONG, HONG KONG, HK, vol. 22, no. 3, July 1999 (1999-07), pages 282-284, XP009060233 ISSN: 1015-9584 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9687670B2 (en) | 2007-08-17 | 2017-06-27 | Gearbox, Llc | Systems, devices, and methods including infection-fighting and monitoring shunts |
JP2008111000A (en) * | 2007-11-29 | 2008-05-15 | Mandom Corp | Antibacterial composition and deodorant agent |
US10426857B2 (en) | 2008-12-04 | 2019-10-01 | Gearbox, Llc | Systems, devices, and methods including implantable devices with anti-microbial properties |
US9421286B2 (en) | 2011-11-03 | 2016-08-23 | Elwha Llc | Heat-sanitization of surfaces |
US10179181B2 (en) | 2011-11-03 | 2019-01-15 | Elwha Llc | Heat-sanitization of surfaces |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8834445B2 (en) | Methods of treating or preventing peritonitis with oxidative reductive potential water solution | |
US10016455B2 (en) | Method of preventing or treating influenza with oxidative reductive potential water solution | |
EP2330081A2 (en) | Oxidative reductive potential water solution, processes for producing same and methods of using the same | |
EP3205358A1 (en) | Oxidative reductive potential water solution and method of using the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 2007205863 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2637197 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/a/2008/009302 Country of ref document: MX Ref document number: 2008551573 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2007205863 Country of ref document: AU Date of ref document: 20070122 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007717981 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 7025/DELNP/2008 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200780009873.7 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07717981 Country of ref document: EP Kind code of ref document: A2 |
|
ENP | Entry into the national phase |
Ref document number: PI0706676 Country of ref document: BR Kind code of ref document: A2 Effective date: 20080721 |