WO2007085403A3 - Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof - Google Patents
Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof Download PDFInfo
- Publication number
- WO2007085403A3 WO2007085403A3 PCT/EP2007/000519 EP2007000519W WO2007085403A3 WO 2007085403 A3 WO2007085403 A3 WO 2007085403A3 EP 2007000519 W EP2007000519 W EP 2007000519W WO 2007085403 A3 WO2007085403 A3 WO 2007085403A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carriers
- crosslinking
- molecular
- low
- analytics
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
Abstract
The invention relates to crosslinkable multifunctional carriers for especially low-molecular ligands, the use thereof in analytics, and methods for producing and crosslinking the same. The inventive carriers have at least two different selective coupling functions which are not complementary to each other and cannot react with the same coupling partner, one coupling function being used for coupling to a ligand, preferably a low-molecular ligand, and at least one additional coupling function that is different therefrom being used for binding to an immobilizing surface and/or crosslinking the carriers among themselves. The invention also relates to the three-dimensional structures produced by crosslinking said carriers. In a special embodiment of the invention, at least some of the crosslinkable or crosslinked carriers are also bound to an immobilizing surface.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006003603.4 | 2006-01-25 | ||
DE200610003603 DE102006003603B4 (en) | 2006-01-25 | 2006-01-25 | Crosslinkable multifunctional supports for (low molecular weight) ligands and their use in analytics, as well as processes for their preparation and crosslinking |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007085403A2 WO2007085403A2 (en) | 2007-08-02 |
WO2007085403A3 true WO2007085403A3 (en) | 2008-02-28 |
Family
ID=38268110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/000519 WO2007085403A2 (en) | 2006-01-25 | 2007-01-22 | Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE102006003603B4 (en) |
WO (1) | WO2007085403A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008010692A1 (en) * | 2008-02-22 | 2009-08-27 | Qiagen Gmbh | New matrices, processes for their preparation and their use in methods of isolating biomolecules |
JP6545960B2 (en) * | 2014-02-27 | 2019-07-17 | シスメックス株式会社 | Reagent for detection of target substance, detection method, carrier used for detection of target substance, and method for producing the same |
CN115356477B (en) * | 2022-10-20 | 2023-02-10 | 苏州纳微生命科技有限公司 | Streptavidin magnetic bead and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
WO2000028088A1 (en) * | 1998-11-10 | 2000-05-18 | Biocrystal Limited | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
EP1215485A1 (en) * | 2000-12-12 | 2002-06-19 | Sony International (Europe) GmbH | Selective chemical sensors based on interlinked nanoparticle assemblies |
US20030162215A1 (en) * | 2002-02-27 | 2003-08-28 | Hitachi Software Engineering Co., Ltd. | Method for detecting biopolymers |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL132966A0 (en) * | 1998-12-01 | 2001-03-19 | Yissum Res Dev Co | Method and system for detecting oligonucleotides in a sample |
JP2004501869A (en) * | 2000-03-22 | 2004-01-22 | ソルリンク・インコーポレイテッド | Hydrazine-based and carbonyl-based bifunctional crosslinkers |
ATE431854T1 (en) * | 2003-06-27 | 2009-06-15 | Nanosphere Inc | DETECTION OF TARGET ANALYTES BASED ON BIO-BARCODES |
-
2006
- 2006-01-25 DE DE200610003603 patent/DE102006003603B4/en not_active Expired - Fee Related
-
2007
- 2007-01-22 WO PCT/EP2007/000519 patent/WO2007085403A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
WO2000028088A1 (en) * | 1998-11-10 | 2000-05-18 | Biocrystal Limited | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
EP1215485A1 (en) * | 2000-12-12 | 2002-06-19 | Sony International (Europe) GmbH | Selective chemical sensors based on interlinked nanoparticle assemblies |
US20030162215A1 (en) * | 2002-02-27 | 2003-08-28 | Hitachi Software Engineering Co., Ltd. | Method for detecting biopolymers |
Non-Patent Citations (2)
Title |
---|
ANDRESEN ET AL: "Peptide microarrays with site-specifically immobilized synthetic peptides for antibody diagnostics", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 113, no. 2, 18 May 2005 (2005-05-18), pages 655 - 663, XP005279071, ISSN: 0925-4005 * |
FALSEY J R ET AL: "PEPTIDE AND SMALL MOLECULE MICROARRAY FOR HIGH THROUGHPUT CELL ADHESION AND FUNCTIONAL ASSAYS", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 12, no. 3, May 2001 (2001-05-01), pages 346 - 353, XP001145929, ISSN: 1043-1802 * |
Also Published As
Publication number | Publication date |
---|---|
DE102006003603A1 (en) | 2007-08-02 |
WO2007085403A2 (en) | 2007-08-02 |
DE102006003603B4 (en) | 2010-02-04 |
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