WO2007085403A3 - Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof - Google Patents

Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof Download PDF

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Publication number
WO2007085403A3
WO2007085403A3 PCT/EP2007/000519 EP2007000519W WO2007085403A3 WO 2007085403 A3 WO2007085403 A3 WO 2007085403A3 EP 2007000519 W EP2007000519 W EP 2007000519W WO 2007085403 A3 WO2007085403 A3 WO 2007085403A3
Authority
WO
WIPO (PCT)
Prior art keywords
carriers
crosslinking
molecular
low
analytics
Prior art date
Application number
PCT/EP2007/000519
Other languages
German (de)
French (fr)
Other versions
WO2007085403A2 (en
Inventor
Heiko Andresen
Original Assignee
Fraunhofer Ges Forschung
Heiko Andresen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung, Heiko Andresen filed Critical Fraunhofer Ges Forschung
Publication of WO2007085403A2 publication Critical patent/WO2007085403A2/en
Publication of WO2007085403A3 publication Critical patent/WO2007085403A3/en

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Abstract

The invention relates to crosslinkable multifunctional carriers for especially low-molecular ligands, the use thereof in analytics, and methods for producing and crosslinking the same. The inventive carriers have at least two different selective coupling functions which are not complementary to each other and cannot react with the same coupling partner, one coupling function being used for coupling to a ligand, preferably a low-molecular ligand, and at least one additional coupling function that is different therefrom being used for binding to an immobilizing surface and/or crosslinking the carriers among themselves. The invention also relates to the three-dimensional structures produced by crosslinking said carriers. In a special embodiment of the invention, at least some of the crosslinkable or crosslinked carriers are also bound to an immobilizing surface.
PCT/EP2007/000519 2006-01-25 2007-01-22 Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof WO2007085403A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006003603.4 2006-01-25
DE200610003603 DE102006003603B4 (en) 2006-01-25 2006-01-25 Crosslinkable multifunctional supports for (low molecular weight) ligands and their use in analytics, as well as processes for their preparation and crosslinking

Publications (2)

Publication Number Publication Date
WO2007085403A2 WO2007085403A2 (en) 2007-08-02
WO2007085403A3 true WO2007085403A3 (en) 2008-02-28

Family

ID=38268110

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/000519 WO2007085403A2 (en) 2006-01-25 2007-01-22 Crosslinkable multifunctional carriers for (low-molecular) ligands, use thereof in analytics, and method for the production and crosslinking thereof

Country Status (2)

Country Link
DE (1) DE102006003603B4 (en)
WO (1) WO2007085403A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008010692A1 (en) * 2008-02-22 2009-08-27 Qiagen Gmbh New matrices, processes for their preparation and their use in methods of isolating biomolecules
JP6545960B2 (en) * 2014-02-27 2019-07-17 シスメックス株式会社 Reagent for detection of target substance, detection method, carrier used for detection of target substance, and method for producing the same
CN115356477B (en) * 2022-10-20 2023-02-10 苏州纳微生命科技有限公司 Streptavidin magnetic bead and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
WO2000028088A1 (en) * 1998-11-10 2000-05-18 Biocrystal Limited Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
EP1215485A1 (en) * 2000-12-12 2002-06-19 Sony International (Europe) GmbH Selective chemical sensors based on interlinked nanoparticle assemblies
US20030162215A1 (en) * 2002-02-27 2003-08-28 Hitachi Software Engineering Co., Ltd. Method for detecting biopolymers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL132966A0 (en) * 1998-12-01 2001-03-19 Yissum Res Dev Co Method and system for detecting oligonucleotides in a sample
JP2004501869A (en) * 2000-03-22 2004-01-22 ソルリンク・インコーポレイテッド Hydrazine-based and carbonyl-based bifunctional crosslinkers
ATE431854T1 (en) * 2003-06-27 2009-06-15 Nanosphere Inc DETECTION OF TARGET ANALYTES BASED ON BIO-BARCODES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
WO2000028088A1 (en) * 1998-11-10 2000-05-18 Biocrystal Limited Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
EP1215485A1 (en) * 2000-12-12 2002-06-19 Sony International (Europe) GmbH Selective chemical sensors based on interlinked nanoparticle assemblies
US20030162215A1 (en) * 2002-02-27 2003-08-28 Hitachi Software Engineering Co., Ltd. Method for detecting biopolymers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDRESEN ET AL: "Peptide microarrays with site-specifically immobilized synthetic peptides for antibody diagnostics", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 113, no. 2, 18 May 2005 (2005-05-18), pages 655 - 663, XP005279071, ISSN: 0925-4005 *
FALSEY J R ET AL: "PEPTIDE AND SMALL MOLECULE MICROARRAY FOR HIGH THROUGHPUT CELL ADHESION AND FUNCTIONAL ASSAYS", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 12, no. 3, May 2001 (2001-05-01), pages 346 - 353, XP001145929, ISSN: 1043-1802 *

Also Published As

Publication number Publication date
DE102006003603A1 (en) 2007-08-02
WO2007085403A2 (en) 2007-08-02
DE102006003603B4 (en) 2010-02-04

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