WO2007086536A3 - Soft-gelatin capsule formulation - Google Patents

Soft-gelatin capsule formulation Download PDF

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Publication number
WO2007086536A3
WO2007086536A3 PCT/JP2007/051329 JP2007051329W WO2007086536A3 WO 2007086536 A3 WO2007086536 A3 WO 2007086536A3 JP 2007051329 W JP2007051329 W JP 2007051329W WO 2007086536 A3 WO2007086536 A3 WO 2007086536A3
Authority
WO
WIPO (PCT)
Prior art keywords
gelatin capsule
soft
capsule formulation
keto
soft gelatin
Prior art date
Application number
PCT/JP2007/051329
Other languages
French (fr)
Other versions
WO2007086536A2 (en
Inventor
Yukiko Hashitera
Ryu Hirata
Yasuhiro Harada
Original Assignee
R Tech Ueno Ltd
Yukiko Hashitera
Ryu Hirata
Yasuhiro Harada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38169220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007086536(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ570191A priority Critical patent/NZ570191A/en
Priority to ES07707560T priority patent/ES2392590T3/en
Priority to JP2007542937A priority patent/JP4783794B2/en
Priority to KR1020087020676A priority patent/KR101393944B1/en
Priority to AU2007208632A priority patent/AU2007208632B2/en
Application filed by R Tech Ueno Ltd, Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada filed Critical R Tech Ueno Ltd
Priority to MX2008009650A priority patent/MX2008009650A/en
Priority to BRPI0707334A priority patent/BRPI0707334B8/en
Priority to CA2637274A priority patent/CA2637274C/en
Priority to DK07707560.4T priority patent/DK1978944T3/en
Priority to EP07707560A priority patent/EP1978944B1/en
Publication of WO2007086536A2 publication Critical patent/WO2007086536A2/en
Publication of WO2007086536A3 publication Critical patent/WO2007086536A3/en
Priority to IL192867A priority patent/IL192867A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
PCT/JP2007/051329 2006-01-24 2007-01-23 Soft-gelatin capsule formulation WO2007086536A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP07707560A EP1978944B1 (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation
BRPI0707334A BRPI0707334B8 (en) 2006-01-24 2007-01-23 soft gelatin capsule formulation of a 15-keto-prostaglandin compound and method for stabilizing a 15-ketoprostaglandin compound
JP2007542937A JP4783794B2 (en) 2006-01-24 2007-01-23 Soft gelatin capsule formulation
KR1020087020676A KR101393944B1 (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation
AU2007208632A AU2007208632B2 (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation
NZ570191A NZ570191A (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation comprising a keto-prostaglandin compound
MX2008009650A MX2008009650A (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation.
ES07707560T ES2392590T3 (en) 2006-01-24 2007-01-23 Soft gelatin capsule formulation
CA2637274A CA2637274C (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation
DK07707560.4T DK1978944T3 (en) 2006-01-24 2007-01-23 SOFT GELATIN-CAPSULE FORMULATION
IL192867A IL192867A (en) 2006-01-24 2008-07-17 Soft-gelatin capsule formulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76136006P 2006-01-24 2006-01-24
US60/761,360 2006-01-24

Publications (2)

Publication Number Publication Date
WO2007086536A2 WO2007086536A2 (en) 2007-08-02
WO2007086536A3 true WO2007086536A3 (en) 2007-11-15

Family

ID=38169220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/051329 WO2007086536A2 (en) 2006-01-24 2007-01-23 Soft-gelatin capsule formulation

Country Status (16)

Country Link
US (4) US8026393B2 (en)
EP (1) EP1978944B1 (en)
JP (1) JP4783794B2 (en)
KR (1) KR101393944B1 (en)
CN (3) CN101410097A (en)
AU (1) AU2007208632B2 (en)
BR (1) BRPI0707334B8 (en)
CA (1) CA2637274C (en)
DK (1) DK1978944T3 (en)
ES (1) ES2392590T3 (en)
IL (1) IL192867A (en)
MX (1) MX2008009650A (en)
NZ (1) NZ570191A (en)
PT (1) PT1978944E (en)
RU (1) RU2420291C3 (en)
WO (1) WO2007086536A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1978944T3 (en) * 2006-01-24 2012-11-05 Sucampo Ag SOFT GELATIN-CAPSULE FORMULATION
KR101485212B1 (en) * 2007-07-19 2015-01-22 가부시키가이샤 아루떼꾸 우에노 Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound
CN101854920B (en) * 2007-10-19 2013-05-01 大塚制药株式会社 Pharmaceutical solid preparation
TW201118084A (en) * 2009-09-18 2011-06-01 Adolor Corp The use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders
US8940790B2 (en) 2009-11-03 2015-01-27 Bernard Charles Sherman Stable pharmaceutical formulations comprising lubiprostone
JP2014515004A (en) * 2011-04-27 2014-06-26 スキャンポ・アーゲー Regulation method of ion transporter
BR112014026614A2 (en) * 2012-04-30 2017-06-27 Dow Agrosciences Llc pesticide administration vehicles
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
CA2980165C (en) 2015-03-26 2021-06-15 Patheon Softgels Inc. Liquisoft capsules
US9808531B2 (en) 2015-09-22 2017-11-07 Graybug Vision, Inc. Compounds and compositions for the treatment of ocular disorders
CN107638403B (en) * 2016-07-22 2020-05-05 江苏威凯尔医药科技有限公司 Hard capsule preparation
US11534404B2 (en) 2016-10-06 2022-12-27 Sucampo Ag Multilayer beads for pharmaceutical use
GB201711157D0 (en) * 2017-07-11 2017-08-23 Univ Liverpool Sulfur-Doped Carbonaceous porous materials
CN108619107A (en) * 2018-05-28 2018-10-09 青海制药厂有限公司 A kind of soft capsule and preparation method thereof containing Lubiprostone 1

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0415564A2 (en) * 1989-08-09 1991-03-06 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Use of prostanoic acid derivaties for the manufacture of a medicament for improvement of excretion of nonprotein nitrogen into the intestine
US5225439A (en) * 1987-01-28 1993-07-06 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
EP1362588A1 (en) * 2001-02-22 2003-11-19 Ono Pharmaceutical Co., Ltd. Medicinal compositions comprising diclofenac and ornoprostil
WO2005002588A1 (en) * 2003-07-03 2005-01-13 Sucampo Ag Enteric coated composition comprising prostaglandin analogs as chloride channel opener

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GB8305693D0 (en) * 1983-03-02 1983-04-07 Scherer Ltd R P Pharmaceutical compositions
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US5380709A (en) * 1987-01-28 1995-01-10 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
US5166174A (en) * 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
CA1322749C (en) * 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
DE3853493T2 (en) 1987-05-28 1995-07-27 Hiroshi Maeda Superoxide dismutase derivatives, process for their preparation and their use as medicines.
US5317032A (en) * 1987-10-02 1994-05-31 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Prostaglandin cathartic
US5048022A (en) * 1989-08-01 1991-09-10 Digital Equipment Corporation Memory device with transfer of ECC signals on time division multiplexed bidirectional lines
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TW224942B (en) * 1990-04-04 1994-06-11 Adka Ueno Kk
JPH07100655B2 (en) * 1990-04-04 1995-11-01 株式会社アールテック・ウエノ Cataract treatment agent
CA2041417C (en) 1990-05-01 2002-05-21 Ryuji Ueno Treatment of pancreatic disease with 15-keto-prostaglandin compounds
JPH04187637A (en) * 1990-11-21 1992-07-06 Ueno Seiyaku Oyo Kenkyusho:Kk Hypermnesic agent
CA2150287C (en) * 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
CN100337632C (en) * 1996-06-10 2007-09-19 苏坎波公司 Endothelin antagonist
US5998438A (en) * 1996-11-26 1999-12-07 Allelix Biopharmaceuticals, Inc. 5-cyclo indole compounds
US6207699B1 (en) * 1999-06-18 2001-03-27 Richard Brian Rothman Pharmaceutical combinations for treating obesity and food craving
CA2385732C (en) 1999-10-15 2009-02-10 Sucampo Ag Bicyclic compounds composition and method for stabilizing the same
TWI331920B (en) * 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
CN1257711C (en) * 2003-12-05 2006-05-31 石药集团中奇制药技术（石家庄）有限公司 Butyl benzene phthalein soft capsule and its preparation method
KR20140147142A (en) * 2006-01-24 2014-12-29 가부시키가이샤 아루떼꾸 우에노 Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
DK1978944T3 (en) * 2006-01-24 2012-11-05 Sucampo Ag SOFT GELATIN-CAPSULE FORMULATION
KR101485212B1 (en) * 2007-07-19 2015-01-22 가부시키가이샤 아루떼꾸 우에노 Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225439A (en) * 1987-01-28 1993-07-06 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
EP0415564A2 (en) * 1989-08-09 1991-03-06 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Use of prostanoic acid derivaties for the manufacture of a medicament for improvement of excretion of nonprotein nitrogen into the intestine
EP1362588A1 (en) * 2001-02-22 2003-11-19 Ono Pharmaceutical Co., Ltd. Medicinal compositions comprising diclofenac and ornoprostil
WO2005002588A1 (en) * 2003-07-03 2005-01-13 Sucampo Ag Enteric coated composition comprising prostaglandin analogs as chloride channel opener

Also Published As

Publication number Publication date
BRPI0707334B1 (en) 2021-02-23
JP4783794B2 (en) 2011-09-28
EP1978944A2 (en) 2008-10-15
RU2420291C2 (en) 2011-06-10
US8338639B2 (en) 2012-12-25
BRPI0707334A8 (en) 2018-04-10
RU2420291C3 (en) 2020-07-21
IL192867A0 (en) 2009-02-11
BRPI0707334B8 (en) 2021-05-25
US8026393B2 (en) 2011-09-27
IL192867A (en) 2015-06-30
CN101410097A (en) 2009-04-15
CA2637274A1 (en) 2007-08-02
AU2007208632B2 (en) 2012-01-19
KR20080090526A (en) 2008-10-08
CA2637274C (en) 2013-06-04
ES2392590T3 (en) 2012-12-12
BRPI0707334A2 (en) 2011-05-03
CN104983712A (en) 2015-10-21
PT1978944E (en) 2012-11-26
KR101393944B1 (en) 2014-05-12
MX2008009650A (en) 2008-11-06
CN104971056A (en) 2015-10-14
WO2007086536A2 (en) 2007-08-02
DK1978944T3 (en) 2012-11-05
RU2008134489A (en) 2010-02-27
EP1978944B1 (en) 2012-08-15
US20140287036A1 (en) 2014-09-25
US20130078303A1 (en) 2013-03-28
NZ570191A (en) 2010-09-30
AU2007208632A1 (en) 2007-08-02
US20110300211A1 (en) 2011-12-08
US20070172523A1 (en) 2007-07-26
US8779187B2 (en) 2014-07-15
JP2008534432A (en) 2008-08-28

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