WO2007095235A3 - Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources - Google Patents

Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources Download PDF

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Publication number
WO2007095235A3
WO2007095235A3 PCT/US2007/003804 US2007003804W WO2007095235A3 WO 2007095235 A3 WO2007095235 A3 WO 2007095235A3 US 2007003804 W US2007003804 W US 2007003804W WO 2007095235 A3 WO2007095235 A3 WO 2007095235A3
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WO
WIPO (PCT)
Prior art keywords
systems
methods
time monitoring
signals
arrays
Prior art date
Application number
PCT/US2007/003804
Other languages
French (fr)
Other versions
WO2007095235A2 (en
Inventor
Paul Lundquist
Denis Zaccarin
Yves Lacroix
Stephen Turner
John Dixon
Original Assignee
Pacific Biosciences California
Paul Lundquist
Denis Zaccarin
Yves Lacroix
Stephen Turner
John Dixon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California, Paul Lundquist, Denis Zaccarin, Yves Lacroix, Stephen Turner, John Dixon filed Critical Pacific Biosciences California
Priority to CN2007800132507A priority Critical patent/CN101421598B/en
Priority to AU2007215173A priority patent/AU2007215173B2/en
Priority to EP07750629.3A priority patent/EP1984712B1/en
Priority to JP2008555310A priority patent/JP2009526997A/en
Priority to CA002642261A priority patent/CA2642261A1/en
Publication of WO2007095235A2 publication Critical patent/WO2007095235A2/en
Publication of WO2007095235A3 publication Critical patent/WO2007095235A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0224—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using polarising or depolarising elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J3/14—Generating the spectrum; Monochromators using refracting elements, e.g. prisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Optical Communication System (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
PCT/US2007/003804 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources WO2007095235A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2007800132507A CN101421598B (en) 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
AU2007215173A AU2007215173B2 (en) 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
EP07750629.3A EP1984712B1 (en) 2006-02-13 2007-02-09 System for simultaneous real-time monitoring of optical signals from multiple sources
JP2008555310A JP2009526997A (en) 2006-02-13 2007-02-09 Method and system for simultaneously monitoring optical signals from multiple sources in real time
CA002642261A CA2642261A1 (en) 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77290806P 2006-02-13 2006-02-13
US60/772,908 2006-02-13
US11/483,413 2006-07-07
US11/483,413 US7692783B2 (en) 2006-02-13 2006-07-07 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources

Publications (2)

Publication Number Publication Date
WO2007095235A2 WO2007095235A2 (en) 2007-08-23
WO2007095235A3 true WO2007095235A3 (en) 2008-06-19

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PCT/US2007/003804 WO2007095235A2 (en) 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
PCT/US2007/003570 WO2007095119A2 (en) 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources

Family Applications After (1)

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PCT/US2007/003570 WO2007095119A2 (en) 2006-02-13 2007-02-09 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources

Country Status (7)

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US (1) US7692783B2 (en)
EP (2) EP1984670B1 (en)
JP (1) JP2009526997A (en)
CN (1) CN101421598B (en)
AU (2) AU2007215242B2 (en)
CA (2) CA2642258C (en)
WO (2) WO2007095235A2 (en)

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