WO2007103555A3 - Transdermal drug delivery compositions and topical compositions for application on the skin - Google Patents

Transdermal drug delivery compositions and topical compositions for application on the skin Download PDF

Info

Publication number
WO2007103555A3
WO2007103555A3 PCT/US2007/006037 US2007006037W WO2007103555A3 WO 2007103555 A3 WO2007103555 A3 WO 2007103555A3 US 2007006037 W US2007006037 W US 2007006037W WO 2007103555 A3 WO2007103555 A3 WO 2007103555A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
skin
transdermal delivery
topical compositions
agents
Prior art date
Application number
PCT/US2007/006037
Other languages
French (fr)
Other versions
WO2007103555A2 (en
Inventor
Bruce J Sand
Michael Babich
Ali Zendedel Haghighi
Original Assignee
Nuviance Inc
Bruce J Sand
Michael Babich
Ali Zendedel Haghighi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuviance Inc, Bruce J Sand, Michael Babich, Ali Zendedel Haghighi filed Critical Nuviance Inc
Priority to EP07752719A priority Critical patent/EP1998742A2/en
Priority to CA002645073A priority patent/CA2645073A1/en
Priority to US12/281,768 priority patent/US20090053290A1/en
Publication of WO2007103555A2 publication Critical patent/WO2007103555A2/en
Publication of WO2007103555A3 publication Critical patent/WO2007103555A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Abstract

Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio- frequency-based skin remodeling. LES/les
PCT/US2007/006037 2006-03-08 2007-03-08 Transdermal drug delivery compositions and topical compositions for application on the skin WO2007103555A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07752719A EP1998742A2 (en) 2006-03-08 2007-03-08 Transdermal drug delivery compositions and topical compositions for application on the skin
CA002645073A CA2645073A1 (en) 2006-03-08 2007-03-08 Transdermal drug delivery compositions and topical compositions for application on the skin
US12/281,768 US20090053290A1 (en) 2006-03-08 2007-03-08 Transdermal drug delivery compositions and topical compositions for application on the skin

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US78195106P 2006-03-08 2006-03-08
US78195006P 2006-03-08 2006-03-08
US78192506P 2006-03-08 2006-03-08
US78195206P 2006-03-08 2006-03-08
US60/781,950 2006-03-08
US60/781,952 2006-03-08
US60/781,951 2006-03-08
US60/781,925 2006-03-08
US79600706P 2006-04-28 2006-04-28
US60/796,007 2006-04-28
US80134906P 2006-05-18 2006-05-18
US60/801,349 2006-05-18
US87888607P 2007-01-03 2007-01-03
US60/878,886 2007-01-03

Publications (2)

Publication Number Publication Date
WO2007103555A2 WO2007103555A2 (en) 2007-09-13
WO2007103555A3 true WO2007103555A3 (en) 2008-12-04

Family

ID=38475593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006037 WO2007103555A2 (en) 2006-03-08 2007-03-08 Transdermal drug delivery compositions and topical compositions for application on the skin

Country Status (4)

Country Link
US (1) US20090053290A1 (en)
EP (1) EP1998742A2 (en)
CA (1) CA2645073A1 (en)
WO (1) WO2007103555A2 (en)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179159B2 (en) * 1999-10-22 2019-01-15 Scott Wepfer Topical anesthetic formulation
US7763663B2 (en) 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9668972B2 (en) * 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20060018937A1 (en) * 2002-10-25 2006-01-26 Foamix Ltd. Steroid kit and foamable composition and uses thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US10117812B2 (en) * 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US20080031907A1 (en) * 2002-10-25 2008-02-07 Foamix Ltd. Cosmetic and pharmaceutical foam
US20060233721A1 (en) * 2002-10-25 2006-10-19 Foamix Ltd. Foam containing unique oil globules
US20080138296A1 (en) * 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
EP1556009B2 (en) 2002-10-25 2021-07-21 Foamix Pharmaceuticals Ltd. Cosmetic and pharmaceutical foam
JP2007508243A (en) * 2003-08-04 2007-04-05 フォーミックス エルティーディー． Foam carrier containing amphiphilic copolymer gelling agent
US8795693B2 (en) * 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
JP2005310310A (en) * 2004-04-23 2005-11-04 Sanyo Electric Co Ltd Tracking balance adjustment device
BRPI0613631A8 (en) 2005-07-18 2017-12-26 Univ Massachusetts Lowell nanoemulsion and method,
US20080152596A1 (en) * 2005-07-19 2008-06-26 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
PT3295955T (en) 2005-12-01 2021-07-12 Univ Massachusetts Lowell Botulinum nanoemulsions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US20080003244A1 (en) * 2006-06-28 2008-01-03 Gary Viole Inflammation and Oxidative Stress Reducing Compostion for Topical or Oral Administration
US20080260655A1 (en) * 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US20080124306A1 (en) * 2006-11-28 2008-05-29 Kiminobu Sugaya Vigor Enhancement Via Administration of Pyrimidine Derivatives
JP5292304B2 (en) 2006-12-01 2013-09-18 アンテリオス， インコーポレイテッド Peptide nanoparticles and uses thereof
BRPI0719756A2 (en) 2006-12-01 2014-01-21 Anterios Inc Amphiphilic Nanoparticles
US20080292560A1 (en) * 2007-01-12 2008-11-27 Dov Tamarkin Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent
KR100892273B1 (en) 2007-04-25 2009-04-09 (주)아모레퍼시픽 Composition of skin external application comprising kaempferol-3-O-rutinoside as active ingredient
US10016451B2 (en) 2007-05-31 2018-07-10 Anterios, Inc. Nucleic acid nanoparticles and uses therefor
JP5259710B2 (en) * 2007-07-10 2013-08-07 メディ‐トックス、インク． Pharmaceutical liquid composition with improved stability of botulinum toxin
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
EP2055309A1 (en) * 2007-10-31 2009-05-06 Pharmatex Italia Srl Vancomycin and Teicoplanin anhydrous formulations for topical use
US9439857B2 (en) * 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US9107815B2 (en) 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
ES2327201B1 (en) * 2008-04-23 2010-07-23 Ignacio Umbert Millet PERSONALIZED PHARMACEUTICAL COMPOSITION FOR THE REJUVENATION OF SKIN CONTAINING RETINOIC ACID.
US8367122B2 (en) * 2008-06-11 2013-02-05 Biochemics, Inc. Control of blood vessel physiology to treat skin disorders
CZ2008407A3 (en) * 2008-06-26 2009-08-26 Agra Group, A. S. Water-soluble composition based on flavanonol lignanes and process for preparing thereof
EP3574921A1 (en) 2008-09-10 2019-12-04 BioChemics, Inc. Ibuprofen for topical administration
MX349176B (en) 2008-09-22 2017-07-14 Biochemics Inc Transdermal drug delivery using an osmolyte and vasoactive agent.
PL2344329T3 (en) 2008-10-02 2013-05-31 Mylan Inc Method of making a multilayer adhesive laminate
US9278233B2 (en) 2008-12-04 2016-03-08 Biochemics, Inc. Methods and compositions for tattoo removal
CN102395274B (en) 2009-02-13 2014-03-12 托派卡医药股份有限公司 Anti-fungal formulation
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
US20100316728A1 (en) * 2009-06-15 2010-12-16 Rreeves William H Therapeutic mask and Method of Treatment Employing the Same
WO2011001676A1 (en) * 2009-07-02 2011-01-06 国立大学法人山口大学 Surface anesthetic agent
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9364485B2 (en) 2009-08-31 2016-06-14 Dr. Reddy's Laboratories Ltd. Topical formulations comprising a steroid
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US8871184B2 (en) 2009-10-02 2014-10-28 Foamix Ltd. Topical tetracycline compositions
KR101791277B1 (en) * 2009-10-20 2017-10-27 디스커버리 파트너스, 엘엘씨 Dermatologic and cosmetic compositions
EP2498783B1 (en) 2009-11-09 2018-08-22 Allergan, Inc. Compositions and methods for stimulating hair growth
EP2329849B1 (en) * 2009-11-18 2015-04-29 Galderma Research & Development Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder
JP5864837B2 (en) * 2010-03-24 2016-02-17 セイコーエプソン株式会社 Recording liquid containing photopolymerizable polymer micelle and method for producing photopolymerizable polymer micelle used for recording liquid
CA2796575C (en) * 2010-04-13 2018-05-15 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
DE102010023949A1 (en) * 2010-06-16 2011-12-22 F. Holzer Gmbh In-situ lecithin microemulsion gel formulation
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
CN103179972A (en) * 2010-10-22 2013-06-26 雷迪博士实验室公司 Use of storage stable viscous phospholipid depot to treat wounds
CN103596560B (en) * 2010-11-09 2016-08-10 张洁 The transdermal drug delivery system that thin layer and liquid combine
US20120177747A1 (en) * 2011-01-09 2012-07-12 Noble Ion, Llc Compositions and Methods for Treating Lameness in Hoofed Domesticated Animals Due to Hairy Foot Warts and Foot Rot
WO2012097420A1 (en) * 2011-01-19 2012-07-26 Peixoto Eduardo Motta Alves Pharmaceutical composition for treating oxidative stress-induced pathology and use thereof
US8911782B2 (en) * 2011-04-11 2014-12-16 Specialty Pharmaceutical Products Llc Transdermal patches having ionized beam crosslinked polymers and improved release characteristics
WO2012166227A1 (en) * 2011-06-02 2012-12-06 Procertus Biopharm, Inc. Formulation of small adrenergic agonist salt forms in organic solvents
DE102011117364A1 (en) * 2011-10-29 2013-05-02 Merck Patent Gmbh Skin whitening in phototherapy
FR2984735B1 (en) * 2011-12-23 2014-01-24 Oreal MOISTURIZING COMPOSITION
NZ606177A (en) * 2012-01-30 2014-03-28 Dolorgiet Gmbh & Co Kg Compositions for the treatment of actinic keratosis
WO2013158317A1 (en) * 2012-04-16 2013-10-24 Zemtsov Enterprises, Llc Formulations and methods for treatment of inflammatory skin diseases
US9943551B2 (en) 2012-08-15 2018-04-17 Mimedx Group, Inc. Tissue grafts composed of micronized placental tissue and methods of making and using the same
EP2884944B1 (en) 2012-08-15 2020-10-07 MiMedx Group, Inc. Reinforced placental tissue grafts and methods of making and using the same
US9180145B2 (en) 2012-10-12 2015-11-10 Mimedx Group, Inc. Compositions and methods for recruiting and localizing stem cells
BR112015009002B1 (en) * 2012-10-25 2020-02-27 Société des Produits Nestlé S.A. ENCAPSULATED BITTER PEPTIDES, THEIR ENCAPSULATION METHOD, AND NUTRITIVE COMPOSITIONS
US8940684B2 (en) * 2012-11-19 2015-01-27 Mimedx Group, Inc. Cross-linked collagen comprising an antifungal agent
US9155799B2 (en) 2012-11-19 2015-10-13 Mimedx Group, Inc. Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US8936814B2 (en) * 2012-11-30 2015-01-20 Zuri A. Murrell Skin cream
WO2014110177A2 (en) * 2013-01-09 2014-07-17 International Stem Cell Corporation Small molecules that promote skin regeneration
US9662355B2 (en) 2013-01-18 2017-05-30 Mimedx Group, Inc. Methods for treating cardiac conditions
US10206977B1 (en) 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
US9289363B2 (en) * 2013-03-13 2016-03-22 Avon Products, Inc. Cosmetic use of salicylic acid derivatives
WO2014159798A1 (en) 2013-03-13 2014-10-02 Avery Dennison Corporation Improving adhesive properties
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
US10335433B2 (en) 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
US9446142B2 (en) 2013-05-28 2016-09-20 Mimedx Group, Inc. Polymer chelator conjugates
US10058455B2 (en) * 2013-06-10 2018-08-28 Ultramend, Inc. Nano-enhanced wound dressing
US9011934B2 (en) 2013-06-14 2015-04-21 SatisPharma, LLC Multi-purpose anti-itch treatment
WO2014209910A1 (en) * 2013-06-24 2014-12-31 Sand Bruce J Transepidermal composition for restoration of pre-mature aging skin
CN103405383B (en) * 2013-08-14 2015-04-22 江苏中丹制药有限公司 Clindamycin phosphate gel and preparation method thereof
US9579257B2 (en) 2013-08-20 2017-02-28 Anutra Medical, Inc. Haptic feedback and audible output syringe
EP3038630B1 (en) 2013-08-30 2020-03-18 MIMEDX Group Inc. Micronized placental compositions comprising a chelator
MX363386B (en) 2013-10-03 2019-03-20 Dow Pharmaceutical Sciences Stabilized efinaconazole compositions.
JP6611014B2 (en) 2013-11-22 2019-11-27 ボシュ ヘルス アイルランド リミテッド Anti-infection method, anti-infection composition, and anti-infection device
US9460402B2 (en) * 2013-12-27 2016-10-04 International Business Machines Corporation Condensing hierarchical data
US9582566B2 (en) 2013-12-27 2017-02-28 International Business Machines Corporation Condensing hierarchical data
JP7464348B2 (en) 2014-01-17 2024-04-09 ミメディクス グループ インコーポレイテッド Methods for inducing angiogenesis
WO2015112100A1 (en) * 2014-01-21 2015-07-30 Metuas Medi̇kal Sağlik Hi̇zmetleri̇ Danişmanlik İhracat İthalat A.Ş Şi̇rketi̇ A diffusional patch
US20160184431A1 (en) 2014-03-11 2016-06-30 Promius Pharma Llc Topical compositions comprising a corticosteroid
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
WO2015199753A1 (en) * 2014-06-23 2015-12-30 Sand Bruce J Restoration of pre-mature aging skin
JP7099822B2 (en) 2014-08-28 2022-07-12 ミメディクス グループ インコーポレイテッド Collagen-enhanced tissue graft
US9452178B1 (en) 2014-10-22 2016-09-27 SatisPharma, LLC Acne formulations, treatments, and pressure sensitive patches for delivery of acne formulations
EP4349414A2 (en) * 2014-12-23 2024-04-10 Dyve Biosciences, Inc. Methods and formulations for transdermal administration
CN104857514B (en) * 2015-05-15 2018-01-19 东华大学 A kind of insulin liposome transdermal enhancer and preparation method thereof
ES2760520T3 (en) 2015-07-31 2020-05-14 Univ Warszawski Medyczny Antipsoriatic emulsion composition consisting of cefazolin
WO2017059447A1 (en) * 2015-10-02 2017-04-06 PACHECO, Theresa Topical silibinin formulations and uses thereofor
AU2016346203B2 (en) 2015-10-30 2021-05-27 Leo Pharma A/S Isotretinoin formulations and uses and methods thereof
CA3012194A1 (en) * 2016-01-23 2017-07-27 Ampersand Biopharmaceuticals Inc. Enhanced transdermal delivery of active agents
US10039830B2 (en) * 2016-03-04 2018-08-07 Cetylite Industries, Inc. Topical anesthetic composition
US9949939B2 (en) * 2016-07-01 2018-04-24 Transdermal Biotechnology, Inc. Systems and methods for treating vitiligo
US10086036B2 (en) 2016-08-19 2018-10-02 Adam M. Rotunda Bleomycin-based compositions and use thereof for treating loose skin and fatty tissue
MX2020012139A (en) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Compositions and methods for treating rosacea and acne.
CN117731591A (en) 2016-11-21 2024-03-22 艾里奥治疗公司 Transdermal delivery of large agents
US11040090B2 (en) * 2016-12-08 2021-06-22 Prime Bio, Inc Botulinum neurotoxin compositions
US20190365730A1 (en) * 2017-02-09 2019-12-05 Med Solutions Sweden Aktiebolag Anaesthetic composition comprising ropivacaine, prilocaine and lidocaine
MX2019012385A (en) * 2017-04-17 2022-03-15 Ampersand Biopharmaceuticals Llc Parenteral non-systemic administration of buffering agents for inhibiting metastasis of solid tumors, hyperpigmentation and gout.
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface
WO2019021287A1 (en) * 2017-07-25 2019-01-31 Menni Menashe Zinger Treatment of skin ailment
WO2019055884A2 (en) * 2017-09-15 2019-03-21 Ampersand Biopharmaceuticals, Inc. Inhibition of spontaneous metastasis via protein inhibitors of cysteine proteases
US20190083386A1 (en) * 2017-09-15 2019-03-21 Ampersand Biopharmaceuticals, Inc. Methods and formulations for transdermal administration of buffering agents
US11766391B2 (en) 2018-05-22 2023-09-26 HSP Technologies LLC Hair care compositions and methods of making and using same
RU2677255C1 (en) * 2018-06-07 2019-01-16 Елена Владимировна Герасимчук Method for cleansing diseased nail plates in onychomycosis
RU2698871C1 (en) * 2018-08-14 2019-08-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" Method of photochemotherapy of vitiligo
EP3870225A1 (en) * 2018-10-23 2021-09-01 Ampersand Biopharmaceuticals, Inc. Methods and formulations for transdermal administration of dermal contouring agents
EP3937816A4 (en) 2019-03-15 2022-12-21 The General Hospital Corporation Systems and methods for laser-assisted topical treatment of nail fungal infections
WO2020190376A1 (en) * 2019-03-15 2020-09-24 The General Hospital Corporation Systems and methods for laser-assisted topical treatment of nail fungal infections
US20200330380A1 (en) * 2019-04-18 2020-10-22 DePuy Synthes Products, Inc. Biocompatible organogel matrices for intraoperative preparation of a drug delivery depot
WO2021113410A1 (en) * 2019-12-02 2021-06-10 Ampersand Biopharmaceuticals, Inc. Transdermal penetrant formulations for vitamins, minerals and supplements
WO2021113411A1 (en) * 2019-12-02 2021-06-10 Ampersand Biopharmaceuticals, Inc. Transdermal penetrant formulations for vitamins, minerals and supplements
CA3189438A1 (en) 2020-07-21 2022-01-27 Chembeau LLC Diester cosmetic formulations and uses thereof
US20220079873A1 (en) * 2020-09-11 2022-03-17 Ps Therapy Ltd. Topical compositions and methods of use
US20220133705A1 (en) * 2020-11-05 2022-05-05 Physiomefit, Llc Composition for increasing skin thickness
US20220257535A1 (en) * 2021-02-16 2022-08-18 Apothecary Ink LLC Ink formulation and manufacture thereof
WO2022208544A1 (en) * 2021-03-31 2022-10-06 Council Of Scientific & Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Isoprenyl natural scaffold against mdr staphylococcus aureus and synergistic compositions thereof
WO2023154479A1 (en) * 2022-02-10 2023-08-17 Dyve Biosciences, Inc. Formulations for transdermal administration of active agents
KR20230166353A (en) 2022-05-30 2023-12-07 (주) 레비레스코 Composition comprising Ecklonia cava extract, citrus peel extract, and green tea extract for protecting cells from UV or suppressing expression of MMP-1
WO2024013711A1 (en) * 2022-07-15 2024-01-18 Universidade De Coimbra Topical composition and uses thereof
WO2024018271A1 (en) * 2022-08-30 2024-01-25 Rabiei Bahman Anti-spot, lightening and anti-wrinkle solution based on organic phase and aqueous phase
CN115429731B (en) * 2022-10-09 2023-09-12 阿基米德(广州)化妆品研究有限公司 Skin whitening and freckle removing composition containing supramolecular polymer and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
US6414028B1 (en) * 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698524A (en) * 1986-07-16 1987-10-06 Honeywell Inc. MESFET logic using integral diode level shifting
US4895727A (en) * 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
US5137530A (en) * 1985-09-27 1992-08-11 Sand Bruce J Collagen treatment apparatus
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US4976709A (en) * 1988-12-15 1990-12-11 Sand Bruce J Method for collagen treatment
US5304169A (en) * 1985-09-27 1994-04-19 Laser Biotech, Inc. Method for collagen shrinkage
US5660692A (en) * 1988-02-24 1997-08-26 Cedars-Sinai Medical Center Method of crosslinking amino acid-containing polymers using photoactivatable chemical crosslinkers
US5024742A (en) * 1988-02-24 1991-06-18 Cedars-Sinai Medical Center Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US6028105A (en) * 1989-04-06 2000-02-22 Nigra; Thomas P. Topical drug delivery composition and method
US5336692A (en) * 1990-06-28 1994-08-09 Medicis Pharmaceutical Corporation Ointment base and method of use
EP0576605A4 (en) * 1991-03-19 1994-06-08 Vithal J Rajadhyaksha Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers
ES2114569T3 (en) * 1991-10-16 1998-06-01 Richardson Vicks Inc IMPROVED SKIN PENETRATION SYSTEM FOR THE IMPROVED TOPICAL ADMINISTRATION OF PHARMACES.
US6461622B2 (en) * 1994-09-07 2002-10-08 Johnson & Johnson Consumer Companies, Inc. Topical compositions
US5591157A (en) * 1994-09-07 1997-01-07 Hennings; David R. Method and apparatus for tympanic membrane shrinkage
US5976555A (en) * 1994-09-07 1999-11-02 Johnson & Johnson Consumer Products, Inc. Topical oil-in-water emulsions containing retinoids
US5639740A (en) * 1995-03-10 1997-06-17 Crandall; Wilson Trafton Topical moisturizing composition and method
US5945409A (en) * 1995-03-10 1999-08-31 Wilson T. Crandall Topical moisturizing composition and method
AU718944B2 (en) * 1995-05-26 2000-05-04 Unilever Plc Treatment regime for skin
US5948416A (en) * 1995-06-29 1999-09-07 The Procter & Gamble Company Stable topical compositions
WO1997002041A1 (en) * 1995-07-03 1997-01-23 Crandall Wilson T Transdermal and oral treatment of androgenic alopecia
US6387407B1 (en) * 1995-09-29 2002-05-14 L.A.M. Pharmaceutical Corporation Topical drug preparations
US5648389A (en) * 1995-10-27 1997-07-15 Medicis Pharmaceutical, Inc. Compositions for the treatment of dermatological disorders and methods for their use
US6531116B1 (en) * 1996-06-25 2003-03-11 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Treatment regime for skin
US5837289A (en) * 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US5976123A (en) * 1996-07-30 1999-11-02 Laser Aesthetics, Inc. Heart stabilization
US6562326B1 (en) * 1996-08-12 2003-05-13 Bruce W. Miller Topical composition for burn healing
US6497860B1 (en) * 1996-11-04 2002-12-24 Children's Hospital Medical Center Skin lightening compositions
US6019988A (en) * 1996-11-18 2000-02-01 Bristol-Myers Squibb Company Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
US6050990A (en) * 1996-12-05 2000-04-18 Thermolase Corporation Methods and devices for inhibiting hair growth and related skin treatments
US5830208A (en) * 1997-01-31 1998-11-03 Laserlite, Llc Peltier cooled apparatus and methods for dermatological treatment
US6235015B1 (en) * 1997-05-14 2001-05-22 Applied Optronics Corporation Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
US5968034A (en) * 1997-06-24 1999-10-19 Laser Aesthetics, Inc. Pulsed filament lamp for dermatological treatment
US5885274A (en) * 1997-06-24 1999-03-23 New Star Lasers, Inc. Filament lamp for dermatological treatment
US5932612A (en) * 1997-08-05 1999-08-03 Medicis Pharmaceutical Corp. Compositions and systems for the treatment of hyperpigmentation
US6264649B1 (en) * 1998-04-09 2001-07-24 Ian Andrew Whitcroft Laser treatment cooling head
US6103266A (en) * 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
US6106877A (en) * 1998-05-01 2000-08-22 Fresh Roast Systems, Inc. Method of terminating roasting of bulk materials in real time on basis of objectively determined color of materials
US6579283B1 (en) * 1998-05-22 2003-06-17 Edward L. Tobinick Apparatus and method employing a single laser for removal of hair, veins and capillaries
US5935994A (en) * 1998-05-29 1999-08-10 Nimni; Marcel E. Nutritionally balanced dermal composition and method
US6284234B1 (en) * 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
DE19852948C2 (en) * 1998-11-12 2002-07-18 Asclepion Meditec Ag Dermatological handpiece
US6402739B1 (en) * 1998-12-08 2002-06-11 Y-Beam Technologies, Inc. Energy application with cooling
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6383176B1 (en) * 1999-03-15 2002-05-07 Altus Medical, Inc. Hair removal device and method
US6762158B2 (en) * 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
FR2798078B1 (en) * 1999-09-06 2001-10-12 Oreal ORGANOGEL, COMPRISING AN OXIDATION-SENSITIVE HYDROPHILIC COMPOUND AND ITS IN PARTICULAR COSMETIC USES
US6708822B1 (en) * 1999-11-30 2004-03-23 Cutispharma, Inc. Compositions and kits for compounding pharmaceuticals
US20040191276A1 (en) * 1999-11-30 2004-09-30 Cutispharma, Inc. Compositions and kits for compounding pharmaceuticals
US6469227B1 (en) * 1999-12-10 2002-10-22 Lectec Corporation Antipruritic patch
US20030072724A1 (en) * 1999-12-16 2003-04-17 Maibach Howard I. Topical pharmaceutical composition to treat hyperpigmentation of the skin
US6673363B2 (en) * 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
US6582724B2 (en) * 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
US6531141B1 (en) * 2000-03-07 2003-03-11 Ortho-Mcneil Pharmaceutical, Inc. Oil-in-water emulsion containing tretinoin
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US6387383B1 (en) * 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
JP2002165893A (en) * 2000-12-01 2002-06-11 Nidek Co Ltd Laser treatment device
US7044945B2 (en) * 2001-03-30 2006-05-16 Sand Bruce J Prevention of regression in thermal ciliary muscle tendinoplasty
US7094252B2 (en) * 2001-08-21 2006-08-22 Cooltouch Incorporated Enhanced noninvasive collagen remodeling
US6565884B2 (en) * 2001-09-10 2003-05-20 Interpore Cross International Bone graft material incorporating demineralized bone matrix and lipids
US20030059450A1 (en) * 2001-09-24 2003-03-27 Maibach Howard I. Method and topical formulation for treating skin conditions associated with aging
US6737068B2 (en) * 2001-10-01 2004-05-18 Playtex Products, Inc. Wipe formulation
US6641824B2 (en) * 2001-11-09 2003-11-04 Avon Products, Inc. Skin treatment using a new retinoid
US6765001B2 (en) * 2001-12-21 2004-07-20 Medicis Pharmaceutical Corporation Compositions and methods for enhancing corticosteroid delivery
US20030165546A1 (en) * 2002-03-04 2003-09-04 The Procter & Gamble Company Stable personal care compositions containing a retinoid
US20030215493A1 (en) * 2002-04-30 2003-11-20 Patel Pravin M. Composition and method for dermatological treatment
US20030229029A1 (en) * 2002-06-06 2003-12-11 Charles Laudadio Cardiac glycosides for treating muscle pain and spasm
US20030235543A1 (en) * 2002-06-21 2003-12-25 Maibach Howard I. Topical administration of pharmacologically active bases for skin lightening
US20030235542A1 (en) * 2002-06-21 2003-12-25 Maibach Howard I. Topical administration of pharmacologically active bases for skin lightening
US20050031650A1 (en) * 2002-08-26 2005-02-10 Ethypharm Composition with gelling properties for the sustained delivery of bioactive substances
US7166641B2 (en) * 2002-10-02 2007-01-23 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
US20050025833A1 (en) * 2003-07-16 2005-02-03 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050020552A1 (en) * 2003-07-16 2005-01-27 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050042268A1 (en) * 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050232980A1 (en) * 2004-04-15 2005-10-20 Chen Andrew L Transdermal chondroitin and glucosamine delivery system and method of use
US20060120997A1 (en) * 2004-10-29 2006-06-08 Biomune, Inc. Cancer therapeutic compositions
WO2006065870A2 (en) * 2004-12-13 2006-06-22 Prodermrx, Inc. Topical numbing composition for laser therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
US6414028B1 (en) * 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain

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