WO2007104057A3 - Microarray imaging system and associated methodology - Google Patents

Microarray imaging system and associated methodology Download PDF

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Publication number
WO2007104057A3
WO2007104057A3 PCT/US2007/063721 US2007063721W WO2007104057A3 WO 2007104057 A3 WO2007104057 A3 WO 2007104057A3 US 2007063721 W US2007063721 W US 2007063721W WO 2007104057 A3 WO2007104057 A3 WO 2007104057A3
Authority
WO
WIPO (PCT)
Prior art keywords
microarray
filter
electromagnetic energy
apparatus includes
frequency band
Prior art date
Application number
PCT/US2007/063721
Other languages
French (fr)
Other versions
WO2007104057A2 (en
Inventor
Clark Tibbetts
Original Assignee
Clark Tibbetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clark Tibbetts filed Critical Clark Tibbetts
Priority to JP2008558558A priority Critical patent/JP2009529681A/en
Priority to CA002645104A priority patent/CA2645104A1/en
Priority to EP07758283A priority patent/EP1996909A4/en
Priority to CN200780008502.7A priority patent/CN101400974B/en
Priority to AU2007222986A priority patent/AU2007222986B2/en
Publication of WO2007104057A2 publication Critical patent/WO2007104057A2/en
Publication of WO2007104057A3 publication Critical patent/WO2007104057A3/en
Priority to NO20084245A priority patent/NO20084245L/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0229—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using masks, aperture plates, spatial light modulators or spatial filters, e.g. reflective filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2846—Investigating the spectrum using modulation grid; Grid spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0626—Use of several LED's for spatial resolution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0631—Homogeneising elements

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CC having an Imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire microarray.
PCT/US2007/063721 2006-03-09 2007-03-09 Microarray imaging system and associated methodology WO2007104057A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008558558A JP2009529681A (en) 2006-03-09 2007-03-09 Microarray imaging system and related methods
CA002645104A CA2645104A1 (en) 2006-03-09 2007-03-09 Microarray imaging system and associated methodology
EP07758283A EP1996909A4 (en) 2006-03-09 2007-03-09 Microarray imaging system and associated methodology
CN200780008502.7A CN101400974B (en) 2006-03-09 2007-03-09 Microarray imaging system and associated methodology
AU2007222986A AU2007222986B2 (en) 2006-03-09 2007-03-09 Microarray imaging system and associated methodology
NO20084245A NO20084245L (en) 2006-03-09 2008-10-09 Microarray based imaging system and method of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78061606P 2006-03-09 2006-03-09
US60/780,616 2006-03-09

Publications (2)

Publication Number Publication Date
WO2007104057A2 WO2007104057A2 (en) 2007-09-13
WO2007104057A3 true WO2007104057A3 (en) 2008-04-24

Family

ID=38475885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/063721 WO2007104057A2 (en) 2006-03-09 2007-03-09 Microarray imaging system and associated methodology

Country Status (9)

Country Link
US (1) US7961323B2 (en)
EP (1) EP1996909A4 (en)
JP (1) JP2009529681A (en)
KR (1) KR20090004925A (en)
CN (1) CN101400974B (en)
AU (1) AU2007222986B2 (en)
CA (1) CA2645104A1 (en)
NO (1) NO20084245L (en)
WO (1) WO2007104057A2 (en)

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US8558182B2 (en) * 2009-10-09 2013-10-15 University Of Rochester Optical element, device, method, and applications
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US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
ITMI20110838A1 (en) * 2011-05-13 2012-11-14 Andrea Benedetti ASSISTIVE DEVICE FOR CLEANING THE SENSOR OF A DIGITAL CAMERA WITH INTERCHANGEABLE OBJECTIVES
CN102973245B (en) * 2012-11-30 2014-08-06 广州市盛光微电子有限公司 Short-range imaging device
US9048141B2 (en) 2013-02-28 2015-06-02 Robert Bosch Gmbh Method for aligning a biochip
CN104015358B (en) * 2014-06-03 2016-10-12 中国科学院高能物理研究所 A kind of manufacture method encoding collimator
FR3028951B1 (en) * 2014-11-21 2017-01-06 Commissariat Energie Atomique LENS-FREE IMAGING SYSTEM COMPRISING DIODE, DIAPHRAGM AND DIFFUSER BETWEEN DIODE AND DIAPHRAGM
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US10502830B2 (en) * 2016-10-13 2019-12-10 Waymo Llc Limitation of noise on light detectors using an aperture
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JP6924163B2 (en) * 2018-03-27 2021-08-25 株式会社日立製作所 Imaging device, imaging module and imaging method
CN109215604B (en) * 2018-11-07 2021-01-26 京东方科技集团股份有限公司 Display device and grain identification method thereof, product for realizing method and grain identification device
CN111310513A (en) * 2018-12-11 2020-06-19 上海耕岩智能科技有限公司 Biological feature recognition structure, system and method under coding mask type screen
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Also Published As

Publication number Publication date
WO2007104057A2 (en) 2007-09-13
CN101400974A (en) 2009-04-01
CN101400974B (en) 2014-04-16
US20070263914A1 (en) 2007-11-15
EP1996909A2 (en) 2008-12-03
US7961323B2 (en) 2011-06-14
JP2009529681A (en) 2009-08-20
EP1996909A4 (en) 2013-01-23
NO20084245L (en) 2008-12-05
CA2645104A1 (en) 2007-09-13
KR20090004925A (en) 2009-01-12
AU2007222986B2 (en) 2012-01-12
AU2007222986A1 (en) 2007-09-13

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