WO2007134271A3 - Method and apparatus for reducing injury from acute myocardial infarction - Google Patents

Method and apparatus for reducing injury from acute myocardial infarction Download PDF

Info

Publication number
WO2007134271A3
WO2007134271A3 PCT/US2007/068839 US2007068839W WO2007134271A3 WO 2007134271 A3 WO2007134271 A3 WO 2007134271A3 US 2007068839 W US2007068839 W US 2007068839W WO 2007134271 A3 WO2007134271 A3 WO 2007134271A3
Authority
WO
WIPO (PCT)
Prior art keywords
myocardial tissue
adenosine
agonists
combinations
pde inhibitor
Prior art date
Application number
PCT/US2007/068839
Other languages
French (fr)
Other versions
WO2007134271A2 (en
Inventor
Diane Mai Huong Dang
Frank Litvack
Andrew Sheung-King Luk
John F Shanley
Theodore L Parker
Original Assignee
Innovational Holdings Llc
Diane Mai Huong Dang
Frank Litvack
Andrew Sheung-King Luk
John F Shanley
Theodore L Parker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovational Holdings Llc, Diane Mai Huong Dang, Frank Litvack, Andrew Sheung-King Luk, John F Shanley, Theodore L Parker filed Critical Innovational Holdings Llc
Publication of WO2007134271A2 publication Critical patent/WO2007134271A2/en
Publication of WO2007134271A3 publication Critical patent/WO2007134271A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/436—Inhibitors, antagonists of receptors

Abstract

A method and apparatus for the local delivery of therapeutic agents reduces myocardial tissue damage due to ischemia. A local delivery device is used for delivery of the therapeutic agents into a coronary artery which feeds the ischemic reperfused myocardial tissue. According to one example, an implantable medical device for delivering adenosine, agonists thereof, a PDE inhibitor, or combinations thereof locally to myocardial tissue includes a therapeutic dosage of adenosine, agonists thereof, a PDE inhibitor, or combinations thereof in a biocompatible polymer affixed to a stent. The therapeutic dosage of adenosine, agonists thereof, a PDE inhibitor, or combinations thereof is released from the stent at a therapeutic dosage and over an administration period effective to reduce ischemic and reperfusion injury of the myocardial tissue.
PCT/US2007/068839 2006-05-15 2007-05-14 Method and apparatus for reducing injury from acute myocardial infarction WO2007134271A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80050806P 2006-05-15 2006-05-15
US60/800,508 2006-05-15

Publications (2)

Publication Number Publication Date
WO2007134271A2 WO2007134271A2 (en) 2007-11-22
WO2007134271A3 true WO2007134271A3 (en) 2008-10-16

Family

ID=38694756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/068839 WO2007134271A2 (en) 2006-05-15 2007-05-14 Method and apparatus for reducing injury from acute myocardial infarction

Country Status (1)

Country Link
WO (1) WO2007134271A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009061516A1 (en) * 2007-11-08 2009-05-14 New York University School Of Medicine Medical implants containing adenosine receptor agonists and methods for inhibiting medical implant loosening
US20120130481A1 (en) * 2010-11-18 2012-05-24 Robert Falotico Local vascular delivery of adenosine a2a receptor agonists in combination with other agents to reduce myocardial injury
US20120130480A1 (en) * 2010-11-18 2012-05-24 Robert Falotico Local vascular delivery of adenosine a2a receptor agonists to reduce myocardial injury
CA3060706A1 (en) 2017-04-27 2018-11-01 University Of South Alabama Combined administration of cysteine-aspartic protease inhibitors with p2y12 receptor antagonists protects the heart against myocardial infarction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033236A1 (en) * 2003-02-10 2005-02-10 Bandula Wijay Local drug delivery catheter
US20050271697A1 (en) * 2004-06-07 2005-12-08 Conor Medsystems, Inc. Local delivery of growth factors for stem cell transplantation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033236A1 (en) * 2003-02-10 2005-02-10 Bandula Wijay Local drug delivery catheter
US20050271697A1 (en) * 2004-06-07 2005-12-08 Conor Medsystems, Inc. Local delivery of growth factors for stem cell transplantation

Also Published As

Publication number Publication date
WO2007134271A2 (en) 2007-11-22

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