WO2007136696A3 - Use of substituted azetidinone compounds with cetp inhibitors for the treatment of sitosterolemia - Google Patents

Use of substituted azetidinone compounds with cetp inhibitors for the treatment of sitosterolemia Download PDF

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Publication number
WO2007136696A3
WO2007136696A3 PCT/US2007/011825 US2007011825W WO2007136696A3 WO 2007136696 A3 WO2007136696 A3 WO 2007136696A3 US 2007011825 W US2007011825 W US 2007011825W WO 2007136696 A3 WO2007136696 A3 WO 2007136696A3
Authority
WO
WIPO (PCT)
Prior art keywords
sitosterolemia
treatment
cetp inhibitors
substituted azetidinone
azetidinone compounds
Prior art date
Application number
PCT/US2007/011825
Other languages
French (fr)
Other versions
WO2007136696A2 (en
Inventor
Harry R Davis Jr
Original Assignee
Schering Corp
Harry R Davis Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Harry R Davis Jr filed Critical Schering Corp
Publication of WO2007136696A2 publication Critical patent/WO2007136696A2/en
Publication of WO2007136696A3 publication Critical patent/WO2007136696A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

The present invention is directed to pharmaceutical compositions comprising a sterol absorption inhibitor, a CETP inhibitor, which may further comprise an HMG-CoA reductase inhibitor as well as methods for treating sitosterolemia, hypercholesterolemia, hyperlipidemia, atherosclerosis, mixed dyslopidemia, vascular events prevention and related disorders in a mammal in need thereof by administering said pharmaceutical compositions to the mammal.
PCT/US2007/011825 2006-05-19 2007-05-17 Use of substituted azetidinone compounds with cetp inhibitors for the treatment of sitosterolemia WO2007136696A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/437,454 2006-05-19
US11/437,454 US20060287254A1 (en) 2001-01-26 2006-05-19 Use of substituted azetidinone compounds for the treatment of sitosterolemia

Publications (2)

Publication Number Publication Date
WO2007136696A2 WO2007136696A2 (en) 2007-11-29
WO2007136696A3 true WO2007136696A3 (en) 2008-03-20

Family

ID=38566853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/011825 WO2007136696A2 (en) 2006-05-19 2007-05-17 Use of substituted azetidinone compounds with cetp inhibitors for the treatment of sitosterolemia

Country Status (2)

Country Link
US (1) US20060287254A1 (en)
WO (1) WO2007136696A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112227A1 (en) * 2007-03-12 2008-09-18 Reliant Pharmaceuticals, Inc. Treatment with nicorandil and omega-3 fatty acids, and a combination product thereof

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WO2000017165A1 (en) * 1998-09-17 2000-03-30 Pfizer Products Inc. 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors
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Also Published As

Publication number Publication date
WO2007136696A2 (en) 2007-11-29
US20060287254A1 (en) 2006-12-21

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