WO2007143676A3 - Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms - Google Patents

Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms Download PDF

Info

Publication number
WO2007143676A3
WO2007143676A3 PCT/US2007/070460 US2007070460W WO2007143676A3 WO 2007143676 A3 WO2007143676 A3 WO 2007143676A3 US 2007070460 W US2007070460 W US 2007070460W WO 2007143676 A3 WO2007143676 A3 WO 2007143676A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage forms
lingual
buccal
sublingual
epinephrine
Prior art date
Application number
PCT/US2007/070460
Other languages
French (fr)
Other versions
WO2007143676A2 (en
Inventor
Malcolm Hill
Original Assignee
Verus Pharmaceuticals Inc
Malcolm Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verus Pharmaceuticals Inc, Malcolm Hill filed Critical Verus Pharmaceuticals Inc
Publication of WO2007143676A2 publication Critical patent/WO2007143676A2/en
Publication of WO2007143676A3 publication Critical patent/WO2007143676A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion

Abstract

The present invention relates to methods of administering a series of epinephrine doses for the treatment of allergic emergencies, including anaphylaxis, comprising buccal, lingual or sublingual epinephrine dosage forms and injectable epinephrine dosage forms. Also provided herein are kits and packaging systems useful in these methods.
PCT/US2007/070460 2006-06-05 2007-06-05 Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms WO2007143676A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US80396806P 2006-06-05 2006-06-05
US80397506P 2006-06-05 2006-06-05
US60/803,968 2006-06-05
US60/803,975 2006-06-05
US80718106P 2006-07-12 2006-07-12
US60/807,181 2006-07-12

Publications (2)

Publication Number Publication Date
WO2007143676A2 WO2007143676A2 (en) 2007-12-13
WO2007143676A3 true WO2007143676A3 (en) 2008-12-18

Family

ID=38802314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/070460 WO2007143676A2 (en) 2006-06-05 2007-06-05 Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms

Country Status (3)

Country Link
US (1) US20070293582A1 (en)
TW (1) TW200817049A (en)
WO (1) WO2007143676A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2475573C (en) 2002-02-11 2013-03-26 Antares Pharma, Inc. Intradermal injector
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
BRPI0614025A2 (en) 2005-01-24 2012-12-25 Antares Pharma Inc jet injectors
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
CA2718053C (en) 2008-03-10 2016-09-27 Antares Pharma, Inc. Injector safety device
JP5611208B2 (en) 2008-08-05 2014-10-22 アンタレス・ファーマ・インコーポレーテッド Multiple dose injection device
CN102202703B (en) * 2008-11-14 2014-08-27 松下健康医疗器械株式会社 Carrying case and syringe system with same
KR101597672B1 (en) 2009-03-20 2016-02-25 앤태어스 파머, 인코퍼레이티드 Hazardous agent injection system
NZ599594A (en) 2009-10-30 2014-06-27 Ix Biopharma Ltd Fast dissolving solid dosage form
US10350364B2 (en) 2009-11-11 2019-07-16 Windgap Medical, Inc. Portable Drug Mixing and Delivery Device and Associated Methods
JO3112B1 (en) 2010-03-29 2017-09-20 Ferring Bv A fast dissolving pharmaceutical composition
MX341200B (en) 2010-03-29 2016-08-11 Ferring Bv A fast dissolving pharmaceutical composition.
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
AU2012307530B2 (en) 2011-09-16 2016-12-08 Ferring B.V. A fast dissolving pharmaceutical composition
PT2822618T (en) 2012-03-06 2024-03-04 Antares Pharma Inc Prefilled syringe with breakaway force feature
CA2868500C (en) 2012-04-06 2020-04-21 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
WO2013169804A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
EP2903607B1 (en) * 2012-10-03 2017-08-16 Bioprojet A combination of adrenalin with an antidepressant for use in the treatment of shocks
AR094117A1 (en) * 2012-12-20 2015-07-08 Sanofi Aventis Deutschland PACKAGING ASSEMBLY FOR DRUG ADMINISTRATION DEVICES
ITCR20130004A1 (en) * 2013-02-05 2014-08-06 Vincenzo Vigna SALVAVITA DRUG
EP4349383A2 (en) 2013-02-11 2024-04-10 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
TW201440811A (en) * 2013-02-12 2014-11-01 Ys Pharmtech Epinephrine formulations for medicinal products
WO2014164786A1 (en) 2013-03-11 2014-10-09 Madsen Patrick Dosage injector with pinion system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US10569017B2 (en) 2013-03-15 2020-02-25 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
US9907910B2 (en) 2013-03-15 2018-03-06 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
US9199037B2 (en) 2013-03-15 2015-12-01 Windgap Medical, Inc. Portable drug mixing and delivery system and method
US20200085765A1 (en) * 2014-07-03 2020-03-19 Darren Rubin Safer and more effective methods of transmucosal, including intranasal, delivery for raising blood pressure and stimulating the body
AU2015305638B2 (en) 2014-08-18 2019-01-17 Windgap Medical, Inc Portable drug mixing and delivery device and associated methods
US11116903B2 (en) 2014-08-18 2021-09-14 Windgap Medical, Inc Compression seal for use with a liquid component storage vial of an auto-injector
US20160051494A1 (en) * 2014-08-21 2016-02-25 Mylan, Inc. Multi-dose medication kit for treating anaphylaxis
EP3268068A1 (en) 2015-04-15 2018-01-17 Windgap Medical, LLC Removable actuating cap for use with an auto-injector assembly
CN108290000B (en) 2015-08-13 2021-03-19 温德加普医疗股份有限公司 Mixing and injection device with sterility feature
US11253488B2 (en) 2017-09-06 2022-02-22 pHase Pharmaceuticals LLC Sublingual epinephrine tablets
BR112020004586A2 (en) * 2017-09-08 2020-09-08 Insignis Therapeutics, Inc. methods for using dipivephrine
KR20200060748A (en) * 2017-09-27 2020-06-01 어퀘스티브 테라퓨틱스, 아이엔씨. Enhanced delivery ephnephrine and prodrug compositions
JP6941224B2 (en) 2018-02-06 2021-09-29 イージス セラピューティクス，エルエルシー Intranasal epinephrine preparations and methods for the treatment of the disease
EP3930685A1 (en) 2019-03-01 2022-01-05 Insignis Therapeutics, Inc. Dipivefrin orally disintegrating tablet formulations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070203247A1 (en) * 2006-02-28 2007-08-30 Elaine Phillips Epinephrine dosing regimens

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2698822A (en) * 1951-04-28 1955-01-04 Fougera & Co Inc E Cardiac glycoside buccal composition
GB1142325A (en) * 1965-05-14 1969-02-05 Higham Stanley Russell Means for administering drugs
GB1230472A (en) * 1967-07-10 1971-05-05
US3572336A (en) * 1968-04-30 1971-03-23 Daniel R Hershberg Syringe
US3721301A (en) * 1968-09-16 1973-03-20 Tem Cole Inc Control system for a multiple row crop harvesting machine
US3870790A (en) * 1970-01-22 1975-03-11 Forest Laboratories Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose
US3882863A (en) * 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
FR2278317A1 (en) * 1974-07-19 1976-02-13 Commissariat Energie Atomique ORAL IMPLANT FOR ADMINISTERING SOLUBILIZABLE PRODUCTS
US4044933A (en) * 1974-12-11 1977-08-30 Kosgegi Leather & Vinyl Products, Inc. Article carrier with improved combination belt loop and clip
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4031893A (en) * 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4226235A (en) * 1979-01-25 1980-10-07 Survival Technology, Inc. Plural injecting device
US4229447A (en) * 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4394863A (en) * 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4723937A (en) * 1985-05-20 1988-02-09 Survival Technology, Inc. Plural dosage automatic injector with a by-pass fitment
US5622716A (en) * 1987-02-20 1997-04-22 Farmarc Nederland B.V. Process for preparing a retard product containing diltiazem for a single daily administration
US5223614A (en) * 1987-12-19 1993-06-29 Boehringer Ingelheim Gmbh New quaternary ammonium compounds, their preparation and use
GB8900763D0 (en) * 1989-01-13 1989-03-08 Kabi Vitrum Peptide Hormones A Multi-dose syringe
GB8926825D0 (en) * 1989-11-28 1990-01-17 Glaxo Group Ltd Device
US5558880A (en) * 1989-12-22 1996-09-24 Janssen Pharmaceutica Inc. Pharmaceutical and other dosage forms
US5188825A (en) * 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
DE69231281T2 (en) * 1991-12-17 2001-03-01 Biovail Tech Ltd COMPOSITION AND METHOD FOR ULCUS PREVENTION AND TREATMENT
US5654003A (en) * 1992-03-05 1997-08-05 Fuisz Technologies Ltd. Process and apparatus for making tablets and tablets made therefrom
US5540664A (en) * 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5833669A (en) * 1993-05-27 1998-11-10 Washington Biotech Corp. Medicine injection syringe constructions
US5358489A (en) * 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
ES2162867T3 (en) * 1993-07-09 2002-01-16 Scherer Corp R P METHOD OF MANUFACTURE OF DOSAGE FORMS OF LIOFILIZED PHARMACOS.
US5622719A (en) * 1993-09-10 1997-04-22 Fuisz Technologies Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5895664A (en) * 1993-09-10 1999-04-20 Fuisz Technologies Ltd. Process for forming quickly dispersing comestible unit and product therefrom
AU1994295A (en) * 1994-05-16 1995-12-05 Washington Biotech Corporation Modular automatic or manual emergency medicine injection system
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
CA2134611C (en) * 1994-10-28 2002-12-24 Richard John Yarwood Process for preparing solid pharmaceutical dosage forms
US6726928B2 (en) * 1994-10-28 2004-04-27 R.P. Scherer Technologies, Inc. Process for preparing solid dosage forms for unpalatable pharmaceuticals
GB9421836D0 (en) * 1994-10-28 1994-12-14 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
US5601839A (en) * 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US5722956A (en) * 1995-08-24 1998-03-03 The General Hospital Corporation Multi-dose syringe driver
BE1010122A3 (en) * 1996-03-19 1998-01-06 Atlas Copco Airpower Nv COMPRESSOR DEVICE.
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5976577A (en) * 1997-07-11 1999-11-02 Rp Scherer Corporation Process for preparing fast dispersing solid oral dosage form
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
US6508801B1 (en) * 1998-08-27 2003-01-21 S. Lee Fineberg Method, composition and apparatus for rapid and accurate pediatric resuscitation and emergency medical treatment
US6596298B2 (en) * 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
CA2251863A1 (en) * 1998-10-20 2000-04-20 Zoni Inc. Belt system for housing medical device
GB9908014D0 (en) * 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
EP1257307A2 (en) * 1999-09-13 2002-11-20 Vitro Diagnostics, Inc. Multi-dose syringe driver
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US20040069667A1 (en) * 2000-05-12 2004-04-15 Tomellini Dalita R. Cases for medication delivery devices
WO2001087739A1 (en) * 2000-05-12 2001-11-22 Lindon Products, Inc. Cases for medication delivery devices
US6641015B2 (en) * 2000-08-14 2003-11-04 Charles E. Huggins, Jr. Reinforced article holder
AU2001294808A1 (en) * 2000-09-29 2002-04-08 Board Of Trustees Operating Michigan State University Catecholamine pharmaceutical compositions and methods
US6833377B2 (en) * 2001-02-05 2004-12-21 Gevys Pharmaceuticals Ltd. Composition and method for potentiating drugs
US6509040B1 (en) * 2001-06-22 2003-01-21 R.P. Scherer Corporation Fast dispersing dosage forms essentially free of mammalian gelatin
US20030021841A1 (en) * 2001-07-02 2003-01-30 Matharu Amol Singh Pharmaceutical composition
US6702997B2 (en) * 2001-10-26 2004-03-09 Dey, L.P. Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
EP1455864A2 (en) * 2001-11-02 2004-09-15 Meridian Medical Technologies, Inc. A medicament container, a medicament dispensing kit for administering medication and a method for packaging the same
JP2005529151A (en) * 2002-04-19 2005-09-29 アスティオン・ディヴェロップメント・アクティーゼルスカブ Combinations of beta-2 adrenergic receptor agonists and amino sugars and their use for the treatment of immunomodulatory disorders
US20040131661A1 (en) * 2002-07-26 2004-07-08 Pfizer Inc. Process for making orally consumable dosage forms
US7329240B2 (en) * 2003-01-02 2008-02-12 Meridian Medical Technologies, Inc. Protective packaging for medicament dispenser
AU2004233744A1 (en) * 2003-05-02 2004-11-11 Warner-Lambert Company Llc Fast dissolving orally consumable films containing a modified starch for improved heat and moisture resistance
US7635348B2 (en) * 2003-11-04 2009-12-22 Meridian Medical Technologies, Inc. Container for medicament automatic injector and automatic injector adapted therefor
US7297136B2 (en) * 2004-12-06 2007-11-20 Wyrick Ronald E Medicine injection devices and methods
US20060129122A1 (en) * 2004-12-06 2006-06-15 Wyrick Ronald E Method and apparatus for delivering epinephrine
US20070031619A1 (en) * 2005-08-04 2007-02-08 Verus Pharmaceuticals, Inc. Label for a pharmaceutical container
TW200800142A (en) * 2005-09-09 2008-01-01 Univ Manitoba Fast-disintegrating epinephrine tablets for buccal or sublingual administration

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070203247A1 (en) * 2006-02-28 2007-08-30 Elaine Phillips Epinephrine dosing regimens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GU ET AL., BIOPHARMACEUTICS & DRUG DISPOSITION, BIOPHARM. DRUG DISPOS., vol. 23, 2002, pages 213 - 216 *

Also Published As

Publication number Publication date
US20070293582A1 (en) 2007-12-20
TW200817049A (en) 2008-04-16
WO2007143676A2 (en) 2007-12-13

Similar Documents

Publication Publication Date Title
WO2007143676A3 (en) Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms
WO2007143674A3 (en) Methods for buccal, lingual or sublingual dosing regimens of epinephrine for the treatment of allergic emergencies
WO2011017483A3 (en) Sublingual and buccal film compositions
WO2007103510A3 (en) Methods, dosing regimens & medications using anti-progestational agents for the treatment of disorders
TNSN07105A1 (en) Cap for drug delivery devices
WO2008148074A3 (en) Inhibitors of mtor and methods of treatment using same
WO2009065406A3 (en) Novel cyclic hydrocarbon compounds for the treatment of diseases
CA119221S (en) Blister package
IL209499A (en) Human monoclonal antibody against influenza a virus, pharmaceutical compositions comprising the same and use thereof as medicaments
HK1125040A1 (en) Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
WO2010062581A3 (en) A botanical composition for enhanced skin repair and uses thereof
WO2007142811A3 (en) Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia
CA119774S (en) Blister package
IL213112A (en) Nalmefene hydrochloride dihydrate
WO2007101710A8 (en) Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases
DK2350026T3 (en) SULFOXIMIN-SUBSTITUTED ANILINOPYRIMIDE INGREDIENTS AS CDK INHIBITORS, PREPARATION AND USE THEREOF AS A MEDICINE
EA201300151A1 (en) ANTI-MALARY PHARMACEUTICAL COMPOSITION
WO2008047061A3 (en) Cosmetic oral and/or parenteral use of glucosamine optionally in combination with at least one polyphenol compound, and corresponding composition
WO2011076367A3 (en) Synergistic antiviral composition and use thereof
WO2009068708A3 (en) Pharmaceutical composition with prolonged release of somatostatin or an analogue thereof
WO2006056695A8 (en) Bengamides with a substituted caprolactame cycle, method for the preparation thereof, compositions containing them and use thereof
WO2007079312A3 (en) Compositions and methods for treating actin-mediated medical conditions
WO2010012045A8 (en) Influenza vaccines
WO2005105135A8 (en) Il-6 for therapy or prevention of chemotherapy-induced neuropathy
WO2007115287A3 (en) Combination of organic compounds

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07784335

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 07784335

Country of ref document: EP

Kind code of ref document: A2