WO2007146261A3 - Biomolecule-linked biomimetic scaffolds - Google Patents

Biomolecule-linked biomimetic scaffolds Download PDF

Info

Publication number
WO2007146261A3
WO2007146261A3 PCT/US2007/013736 US2007013736W WO2007146261A3 WO 2007146261 A3 WO2007146261 A3 WO 2007146261A3 US 2007013736 W US2007013736 W US 2007013736W WO 2007146261 A3 WO2007146261 A3 WO 2007146261A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomolecule
linked
covalently
biomimetic scaffolds
nanofiber polymer
Prior art date
Application number
PCT/US2007/013736
Other languages
French (fr)
Other versions
WO2007146261A2 (en
Inventor
Craig Hashi
Song Li
Original Assignee
Univ California
Craig Hashi
Song Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2007/061253 external-priority patent/WO2007090102A2/en
Application filed by Univ California, Craig Hashi, Song Li filed Critical Univ California
Priority to JP2009514426A priority Critical patent/JP2009540878A/en
Priority to EP07795989A priority patent/EP2023852A4/en
Priority to MX2008015695A priority patent/MX2008015695A/en
Priority to RU2009100654/14A priority patent/RU2009100654A/en
Priority to CA002654840A priority patent/CA2654840A1/en
Priority to AU2007258379A priority patent/AU2007258379A1/en
Publication of WO2007146261A2 publication Critical patent/WO2007146261A2/en
Publication of WO2007146261A3 publication Critical patent/WO2007146261A3/en
Priority to IL195801A priority patent/IL195801A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Abstract

The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.
PCT/US2007/013736 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds WO2007146261A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009514426A JP2009540878A (en) 2006-06-09 2007-06-11 Biomimetic scaffolds with biomolecules attached
EP07795989A EP2023852A4 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds
MX2008015695A MX2008015695A (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds.
RU2009100654/14A RU2009100654A (en) 2006-06-09 2007-06-11 BIOMIMETIC FRAMES WITH ATTACHED BIOMOLECULES
CA002654840A CA2654840A1 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds
AU2007258379A AU2007258379A1 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds
IL195801A IL195801A0 (en) 2006-06-09 2008-12-08 Biomolecule-linked biomimetic scaffolds

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US80435006P 2006-06-09 2006-06-09
US60/804,350 2006-06-09
US86178006P 2006-11-30 2006-11-30
US60/861,780 2006-11-30
PCT/US2007/061253 WO2007090102A2 (en) 2006-01-27 2007-01-29 Biomimetic scaffolds
US11/668,448 2007-01-29
USPCT/US2007/016253 2007-01-29
US11/668,448 US20070269481A1 (en) 2006-01-27 2007-01-29 Biomimetic Scaffolds
US92492607P 2007-06-05 2007-06-05
US60/924,926 2007-06-05

Publications (2)

Publication Number Publication Date
WO2007146261A2 WO2007146261A2 (en) 2007-12-21
WO2007146261A3 true WO2007146261A3 (en) 2008-12-04

Family

ID=40243723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/013736 WO2007146261A2 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds

Country Status (9)

Country Link
EP (1) EP2023852A4 (en)
JP (1) JP2009540878A (en)
KR (1) KR20090024249A (en)
AU (1) AU2007258379A1 (en)
CA (1) CA2654840A1 (en)
IL (1) IL195801A0 (en)
MX (1) MX2008015695A (en)
RU (1) RU2009100654A (en)
WO (1) WO2007146261A2 (en)

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JP5249785B2 (en) * 2006-01-27 2013-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Biomimetic scaffold
EP2962704A1 (en) 2008-10-07 2016-01-06 Nanonerve, Inc. Multilayer fibrous polymer scaffolds, methods of production and methods of use
CN102223910B (en) 2008-11-25 2014-05-07 爱德华兹生命科学公司 Apparatus for in situ expansion of prosthetic device
WO2011127478A1 (en) 2010-04-09 2011-10-13 Nanovasc, Inc. Sleeve for graft and method
US9090863B2 (en) 2010-05-17 2015-07-28 Pall Corporation System for seeding cells onto three dimensional scaffolds
NZ603234A (en) * 2010-05-17 2014-05-30 Univ Yale System for seeding cells onto three dimensional scaffolds
EP2412798A1 (en) * 2010-07-27 2012-02-01 Gambro Lundia AB Biomimetic membrane for cell expansion
EP2646065A4 (en) 2010-12-05 2016-03-23 Nanonerve Inc Fibrous polymer scaffolds having diametrically patterned polymer fibers
EP2661243B1 (en) * 2011-01-06 2022-10-12 Humacyte, Inc. Tissue-engineered constructs
CN102698323B (en) * 2012-05-14 2014-07-23 西南交通大学 Preparation method of anticlotting materials
ES2470495B1 (en) 2012-12-19 2015-05-14 Universidad De Castilla La Mancha Materials, methods and devices to stimulate and direct the proliferation and migration of neural progenitors and axonal and dendritic growth
KR101526308B1 (en) * 2013-01-23 2015-06-09 아주대학교산학협력단 Biomaterials containing contrast agent for tracing polymer in vivo and method for preparing the same
CN106103821B (en) 2014-02-14 2018-03-02 日产化学工业株式会社 Fiber manufacture composition containing active ester groups and the cell culturing rack material using the fiber
CN104153123B (en) * 2014-07-30 2016-08-24 东华大学 A kind of flexible TiOx nano fibrous membrane and preparation method thereof
CN104153124B (en) * 2014-07-30 2016-11-02 东华大学 A kind of flexible rare-earth oxide nanofiber film and preparation method thereof
ES2919964T3 (en) * 2015-08-17 2022-07-29 Univ Johns Hopkins Composite material that is formed in situ for tissue restoration
CA2995855C (en) 2015-09-02 2024-01-30 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
WO2017062375A1 (en) * 2015-10-05 2017-04-13 The Regents Of The University Of California Thermoreversible polymers and methods of use thereof
EP3457996B1 (en) * 2016-05-16 2021-03-03 Edwards Lifesciences Corporation System and method for applying material to a stent
US10456245B2 (en) 2016-05-16 2019-10-29 Edwards Lifesciences Corporation System and method for applying material to a stent
USD846122S1 (en) 2016-12-16 2019-04-16 Edwards Lifesciences Corporation Heart valve sizer
US11337805B2 (en) 2018-01-23 2022-05-24 Edwards Lifesciences Corporation Prosthetic valve holders, systems, and methods
CN112384258A (en) 2018-05-09 2021-02-19 约翰·霍普金斯大学 Nanofiber-hydrogel composites for cell and tissue delivery
USD908874S1 (en) 2018-07-11 2021-01-26 Edwards Lifesciences Corporation Collapsible heart valve sizer
CN110548187A (en) * 2019-09-16 2019-12-10 生纳科技(上海)有限公司 Instant puncture dialysis type nanofiber artificial blood vessel

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Also Published As

Publication number Publication date
JP2009540878A (en) 2009-11-26
EP2023852A4 (en) 2012-06-27
RU2009100654A (en) 2010-07-20
IL195801A0 (en) 2009-09-01
AU2007258379A1 (en) 2007-12-21
CA2654840A1 (en) 2007-12-21
EP2023852A2 (en) 2009-02-18
KR20090024249A (en) 2009-03-06
WO2007146261A2 (en) 2007-12-21
MX2008015695A (en) 2009-02-06

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