WO2007149481A3 - Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment - Google Patents

Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment Download PDF

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Publication number
WO2007149481A3
WO2007149481A3 PCT/US2007/014373 US2007014373W WO2007149481A3 WO 2007149481 A3 WO2007149481 A3 WO 2007149481A3 US 2007014373 W US2007014373 W US 2007014373W WO 2007149481 A3 WO2007149481 A3 WO 2007149481A3
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WO
WIPO (PCT)
Prior art keywords
tetrahydro
protein kinase
cancer treatment
acid based
based protein
Prior art date
Application number
PCT/US2007/014373
Other languages
French (fr)
Other versions
WO2007149481A2 (en
Inventor
Matthew L Tripp
John G Babish
Jeffrey Bland
Amy Jennae Hall
Veera Konda
Linda Pacioretty
Anu Desai
Original Assignee
Metaproteomics Llc
Matthew L Tripp
John G Babish
Jeffrey Bland
Amy Jennae Hall
Veera Konda
Linda Pacioretty
Anu Desai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metaproteomics Llc, Matthew L Tripp, John G Babish, Jeffrey Bland, Amy Jennae Hall, Veera Konda, Linda Pacioretty, Anu Desai filed Critical Metaproteomics Llc
Priority to EP07809709A priority Critical patent/EP2046353A4/en
Priority to CA002655043A priority patent/CA2655043A1/en
Priority to AU2007261400A priority patent/AU2007261400A1/en
Priority to JP2009516558A priority patent/JP2009541325A/en
Publication of WO2007149481A2 publication Critical patent/WO2007149481A2/en
Publication of WO2007149481A3 publication Critical patent/WO2007149481A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Abstract

Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on tetrahydro-isoalpha acids, commonly found in hops.
PCT/US2007/014373 2006-06-20 2007-06-20 Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment WO2007149481A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07809709A EP2046353A4 (en) 2006-06-20 2007-06-20 Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
CA002655043A CA2655043A1 (en) 2006-06-20 2007-06-20 Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
AU2007261400A AU2007261400A1 (en) 2006-06-20 2007-06-20 Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
JP2009516558A JP2009541325A (en) 2006-06-20 2007-06-20 Protein kinase-regulated cancer therapy based on tetrahydro-isoalpha acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81506406P 2006-06-20 2006-06-20
US60/815,064 2006-06-20

Publications (2)

Publication Number Publication Date
WO2007149481A2 WO2007149481A2 (en) 2007-12-27
WO2007149481A3 true WO2007149481A3 (en) 2008-11-27

Family

ID=38833737

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/US2007/014374 WO2007149482A2 (en) 2006-06-20 2007-06-20 Xanthohumol based protein kinase modulation cancer treatment
PCT/US2007/014413 WO2007149504A2 (en) 2006-06-20 2007-06-20 Isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014380 WO2007149485A1 (en) 2006-06-20 2007-06-20 Acacia based protein kinase modulation cancer treatment
PCT/US2007/014450 WO2007149523A2 (en) 2006-06-20 2007-06-20 Hexahydro-isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014412 WO2007149503A2 (en) 2006-06-20 2007-06-20 Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014373 WO2007149481A2 (en) 2006-06-20 2007-06-20 Tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014372 WO2007149480A2 (en) 2006-06-20 2007-06-20 Reduced isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014414 WO2007149505A2 (en) 2006-06-20 2007-06-20 Beta acid based protein kinase modulation cancer treatment

Family Applications Before (5)

Application Number Title Priority Date Filing Date
PCT/US2007/014374 WO2007149482A2 (en) 2006-06-20 2007-06-20 Xanthohumol based protein kinase modulation cancer treatment
PCT/US2007/014413 WO2007149504A2 (en) 2006-06-20 2007-06-20 Isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014380 WO2007149485A1 (en) 2006-06-20 2007-06-20 Acacia based protein kinase modulation cancer treatment
PCT/US2007/014450 WO2007149523A2 (en) 2006-06-20 2007-06-20 Hexahydro-isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014412 WO2007149503A2 (en) 2006-06-20 2007-06-20 Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2007/014372 WO2007149480A2 (en) 2006-06-20 2007-06-20 Reduced isoalpha acid based protein kinase modulation cancer treatment
PCT/US2007/014414 WO2007149505A2 (en) 2006-06-20 2007-06-20 Beta acid based protein kinase modulation cancer treatment

Country Status (9)

Country Link
US (6) US20080033056A1 (en)
EP (4) EP2046353A4 (en)
JP (4) JP2009541324A (en)
KR (4) KR20090023722A (en)
CN (4) CN101573128A (en)
AU (4) AU2007261399A1 (en)
CA (4) CA2654964A1 (en)
TW (8) TW200819120A (en)
WO (8) WO2007149482A2 (en)

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