WO2008003748A3 - Cd300lg polypeptides and their use in treating autoimmune diseases - Google Patents

Cd300lg polypeptides and their use in treating autoimmune diseases Download PDF

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Publication number
WO2008003748A3
WO2008003748A3 PCT/EP2007/056815 EP2007056815W WO2008003748A3 WO 2008003748 A3 WO2008003748 A3 WO 2008003748A3 EP 2007056815 W EP2007056815 W EP 2007056815W WO 2008003748 A3 WO2008003748 A3 WO 2008003748A3
Authority
WO
WIPO (PCT)
Prior art keywords
cd300lg
polypeptides
autoimmune diseases
treating autoimmune
disorders
Prior art date
Application number
PCT/EP2007/056815
Other languages
French (fr)
Other versions
WO2008003748A2 (en
Inventor
Tatjana Albrektsen
Kresten Skak
Jan Fleckner
Katja Brandt
Rene Ruckert
Original Assignee
Novo Nordisk As
Tatjana Albrektsen
Kresten Skak
Jan Fleckner
Katja Brandt
Rene Ruckert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Tatjana Albrektsen, Kresten Skak, Jan Fleckner, Katja Brandt, Rene Ruckert filed Critical Novo Nordisk As
Publication of WO2008003748A2 publication Critical patent/WO2008003748A2/en
Publication of WO2008003748A3 publication Critical patent/WO2008003748A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relatates to novel CD300LG polypeptides, more specifically soluble forms thereof and provides use thereof and methods for preventing and/or treating diseases and/or disorders such as inflammatory diseases, including various inflammatory autoimmune disorders, allergic hypersensitivity, allograft rejection and/or syndromes associated with increased CD300LG-FL polypeptide function on dendritic cells.
PCT/EP2007/056815 2006-07-07 2007-07-05 Cd300lg polypeptides and their use in treating autoimmune diseases WO2008003748A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116778 2006-07-07
EP06116778.9 2006-07-07

Publications (2)

Publication Number Publication Date
WO2008003748A2 WO2008003748A2 (en) 2008-01-10
WO2008003748A3 true WO2008003748A3 (en) 2008-04-17

Family

ID=37027862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/056815 WO2008003748A2 (en) 2006-07-07 2007-07-05 Cd300lg polypeptides and their use in treating autoimmune diseases

Country Status (1)

Country Link
WO (1) WO2008003748A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101233073B1 (en) 2011-01-13 2013-02-14 강원대학교산학협력단 Pharmaceutical composition comprising peptide having inhibitory activities against transendothelial migration of leucocytes and metastasis of cancer cells
KR101291764B1 (en) 2011-03-04 2013-08-01 경북대학교 산학협력단 CD300a synthetic peptides and compositions for regulation of immune response comprising thereof
EP3412770A4 (en) * 2016-02-03 2019-08-07 Japan as represented by Director General of Agency of National Institute of Infectious Deseases Cultured transgenic cell allowing growth of norovirus, and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2003080667A2 (en) * 2002-03-22 2003-10-02 Bioxell S.P.A. A novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
WO2005056597A1 (en) * 2003-12-09 2005-06-23 Riken IMMUNOGLOBULIN Fc RECEPTOR PROTEIN

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2003080667A2 (en) * 2002-03-22 2003-10-02 Bioxell S.P.A. A novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
WO2005056597A1 (en) * 2003-12-09 2005-06-23 Riken IMMUNOGLOBULIN Fc RECEPTOR PROTEIN

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CARSON M J ET AL: "Differential expression of the triggering receptors expressed on myeloid cells (TREMs) family of receptors by CNS microglia and PE", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 96, no. suppl 1, March 2006 (2006-03-01), pages 37, XP009096349, ISSN: 0022-3042 *
CHUNG D-H ET AL: "CMRF-35-like-molecular-1, a novel mouse myeloid receptor, can inhibit osteoclast formation", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 171, 2003, pages 6541 - 6548, XP002997904, ISSN: 0022-1767 *
DATABASE Geneseq [online] 20 January 2003 (2003-01-20), "Human polypeptide SEQ ID NO 1170.", XP002470025, retrieved from EBI accession no. GSP:ABP69123 Database accession no. ABP69123 *
DATABASE Geneseq [online] 22 September 2005 (2005-09-22), "Cancer cell diagnosis method-related human protein - SEQ ID 386.", XP002409457, retrieved from EBI accession no. GSN:AEB14103 Database accession no. AEB14103 *
DATABASE Geneseq [online] 25 August 2005 (2005-08-25), "Human h-eIgR-L.", XP002409456, retrieved from EBI accession no. GSN:AEA49996 Database accession no. AEA49996 *
DATABASE Geneseq [online] 25 August 2005 (2005-08-25), "Human h-eIgR-Salpha.", XP002470023, retrieved from EBI accession no. GSP:AEA50000 Database accession no. AEA50000 *
DATABASE Geneseq [online] 25 August 2005 (2005-08-25), "Human h-eIgR-Sbeta.", XP002470024, retrieved from EBI accession no. GSP:AEA50002 Database accession no. AEA50002 *
DATABASE Geneseq [online] 29 July 2004 (2004-07-29), "Human genome derived single exon protein #682.", XP002409455, retrieved from EBI accession no. GSN:ABO54448 Database accession no. ABO54448 *
DATABASE Geneseq [online] 4 December 2003 (2003-12-04), "Human immune response associated protein IRAP-6 SEQ ID NO:6.", XP002470026, retrieved from EBI accession no. GSP:ADB36335 Database accession no. ADB36335 *
TAKATSU ET AL: "CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 348, no. 1, 15 September 2006 (2006-09-15), pages 183 - 191, XP005593049, ISSN: 0006-291X *
UMEMOTO EIJI ET AL: "Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow.", THE JOURNAL OF EXPERIMENTAL MEDICINE 12 JUN 2006, vol. 203, no. 6, 12 June 2006 (2006-06-12), pages 1603 - 1614, XP002470021, ISSN: 0022-1007 *
VIERTLBOECK B C ET AL: "The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L", IMMUNOGENETICS 2006 GERMANY, vol. 58, no. 2-3, February 2006 (2006-02-01), pages 180 - 190, XP002470022, ISSN: 0093-7711 *

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Publication number Publication date
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