WO2008008330B1 - Deuterated ocular solutions for ltk and other surgical eye procedures - Google Patents

Deuterated ocular solutions for ltk and other surgical eye procedures

Info

Publication number
WO2008008330B1
WO2008008330B1 PCT/US2007/015718 US2007015718W WO2008008330B1 WO 2008008330 B1 WO2008008330 B1 WO 2008008330B1 US 2007015718 W US2007015718 W US 2007015718W WO 2008008330 B1 WO2008008330 B1 WO 2008008330B1
Authority
WO
WIPO (PCT)
Prior art keywords
cornea
deuterated
window
ocular
corneal epithelium
Prior art date
Application number
PCT/US2007/015718
Other languages
French (fr)
Other versions
WO2008008330A2 (en
WO2008008330A3 (en
Inventor
Michael J Berry
Original Assignee
Ntk Entpr Inc
Michael J Berry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ntk Entpr Inc, Michael J Berry filed Critical Ntk Entpr Inc
Publication of WO2008008330A2 publication Critical patent/WO2008008330A2/en
Publication of WO2008008330A3 publication Critical patent/WO2008008330A3/en
Publication of WO2008008330B1 publication Critical patent/WO2008008330B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00853—Laser thermal keratoplasty or radial keratotomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/009—Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses

Abstract

A deuterated ocular solution is applied (1204) to an eye. The deuterated ocular solution includes deuterated water and one or more ocular drugs (such as proparacaine). A protective corneal device (102) is applied (1206) to a cornea of the eye. The device (102) includes a window (210) configured to contact at least a portion of the cornea. At least part of the cornea is irradiated (1208) using light energy that passes through the window (210) during a cornea reshaping procedure, where the window (210) is substantially transparent to the light energy. The window (210) of the protective corneal device (102) and the deuterated ocular solution may prevent clinically significant damage to a corneal epithelium of the cornea during the cornea reshaping procedure, such as by preventing a temperature of the corneal epithelium from exceeding approximately 70°C during the cornea reshaping procedure. This may help to avoid a wound healing response in the eye and an associated regression of refractive correction.

Claims

AMENDED CLAIMS received by the International Bureau on 08 October 2008 (08.10.2008).
1 . A method comprising : applying a deuterated ocular solution to an eye, the eye comprising a cornea, the deuterated ocular solution comprising deuterated water and one or more ocular drugs, the one or more ocular drugs causing swelling of a corneal epithelium in the cornea; applying a device to the cornea of the eye, the device comprising a window configured to contact at least a portion of the cornea; and irradiating at least part of the cornea to modify a stroma in the cornea using light energy that passes through the window and through the corneal epithelium during a cornea reshaping procedure, the window substantially transparent to the light energy.
2. The method of Claim 1, wherein the one or more ocular drugs comprise proparacaine .
3. The method of Claim 1, wherein a mixture of deuterated water, monodeuterated water, and protonated water forms in the corneal epithelium, the mixture having a lower absorption coefficient compared to protonated water such that an affect of the swelling on a dosimetry of the light energy is reduced.
4. The method of Claim 1, further comprising: preventing, using the window and the deuterated ocular solution, clinically significant damage to the corneal epithelium of the cornea during the cornea reshaping procedure.
5. The method of Claim 4, wherein preventing
AMENDED SHEET (ARTICLE 19)
67 clinically significant damage to the corneal epithelium comprises preventing a temperature of the corneal epithelium from exceeding approximately 7O0C during the cornea reshaping procedure.
6. The method of Claim 1, further comprising: maintaining at least a portion of the cornea at a desired initial temperature prior to irradiation of the cornea.
7. The method of Claim 1, further comprising: causing at least a portion of the cornea to have a desired shape using the window prior to irradiation of the cornea.
8. The method of Claim 7, wherein the desired shape is substantially equal to at least one desired final radius of curvature of the cornea.
9. The method of Claim 1, further comprising: coupling the device to a fiber optic holder, the device comprising a first magnet configured to attract a second magnet in the fiber optic holder.
10. The method of Claim 1, further comprising: generating the light energy using a continuous wave laser.
11. An apparatus comprising: a suction ring configured to attach the apparatus to an eye, the eye comprising a cornea; a window configured to contact at least a portion of the cornea, the window substantially transparent to light
AMENDED SHEET (ARTICLE 19)
68 energy that irradiates the cornea to modify a stroma in the cornea during a cornea reshaping procedure, the window also configured to cool at least a portion of a corneal epithelium in the cornea during the cornea reshaping procedure; and a reservoir holding a deuterated ocular solution, the deuterated ocular solution comprising deuterated water and one or more ocular drugs, the deuterated ocular solution for application to the eye before the cornea reshaping procedure, the one or more ocular drugs causing swelling of the corneal epithelium when applied to the cornea.
12. The apparatus of Claim 11, further comprising: a valve configured to release the deuterated ocular solution from the reservoir; and a nozzle configured to spray the released deuterated ocular solution onto the eye.
13. The apparatus of Claim 11, wherein the window and the deuterated ocular solution prevent clinically significant damage to the corneal epithelium during the cornea reshaping procedure.
14. The apparatus of Claim 13, wherein the window is configured to prevent a temperature of the corneal epithelium from exceeding approximately 7O0C during the cornea reshaping procedure.
15. The apparatus of Claim 11, wherein the window is configured to maintain at least a portion of the cornea at a desired initial temperature prior to irradiation of the cornea.
AMENDED SHEET (ARTICLE 19)
69
16. The apparatus of Claim 11, wherein the window is configured to cause at least a portion of the cornea to have a desired shape prior to irradiation of the cornea.
17. The apparatus of Claim 16, wherein the desired shape is substantially equal to at least one desired final radius of curvature of the cornea.
18. The apparatus of Claim 11, further comprising: a first magnet configured to attach to a second magnet in a fiber optic holder, the fiber optic holder configured to hold a plurality of fiber optic cables, the fiber optic cables configured to provide the light energy.
19. The apparatus of Claim 11, further comprising: an array of microlenses on the window, the microlenses configured to change a spatial distribution of the light energy.
20. The apparatus of Claim 11, wherein the light energy comprises light energy from a continuous wave laser.
21. A system comprising: a light source configured to generate light energy for a cornea reshaping procedure; a device configured to be applied to an eye comprising a cornea, the device comprising a window configured to contact at least a portion of the cornea, the window substantially transparent to the light energy that irradiates the cornea to modify a stroma in the cornea during the cornea reshaping procedure, the window also configured to cool at least a portion of a corneal epithelium in the cornea during the cornea reshaping
AMENDED SHEET (ARTICLE 19)
70 procedure; and a container holding a deuterated ocular solution, the deuterated ocular solution comprising deuterated water and one or more ocular drugs, the deuterated ocular solution for application to the eye before the cornea reshaping procedure, the one or more ocular drugs causing swelling of the corneal epithelium when applied to the cornea.
22. The system of Claim 21, wherein the window and the deuterated ocular solution prevent clinically significant damage to the corneal epithelium during the cornea reshaping procedure.
AMENDED SHEET (ARTICLE 19)
71
PCT/US2007/015718 2006-07-12 2007-07-10 Deuterated ocular solutions for ltk and other surgical eye procedures WO2008008330A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83029206P 2006-07-12 2006-07-12
US60/830,292 2006-07-12
US11/825,816 2007-07-09
US11/825,816 US7691099B2 (en) 2006-07-12 2007-07-09 Deuterated ocular solutions for LTK and other surgical eye procedures

Publications (3)

Publication Number Publication Date
WO2008008330A2 WO2008008330A2 (en) 2008-01-17
WO2008008330A3 WO2008008330A3 (en) 2008-10-23
WO2008008330B1 true WO2008008330B1 (en) 2008-12-18

Family

ID=38923829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/015718 WO2008008330A2 (en) 2006-07-12 2007-07-10 Deuterated ocular solutions for ltk and other surgical eye procedures

Country Status (2)

Country Link
US (1) US7691099B2 (en)
WO (1) WO2008008330A2 (en)

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Also Published As

Publication number Publication date
WO2008008330A2 (en) 2008-01-17
US20080027418A1 (en) 2008-01-31
US7691099B2 (en) 2010-04-06
WO2008008330A3 (en) 2008-10-23

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