WO2008014280A3 - Flourescent dyes for use in glucose sensing - Google Patents

Flourescent dyes for use in glucose sensing Download PDF

Info

Publication number
WO2008014280A3
WO2008014280A3 PCT/US2007/074255 US2007074255W WO2008014280A3 WO 2008014280 A3 WO2008014280 A3 WO 2008014280A3 US 2007074255 W US2007074255 W US 2007074255W WO 2008014280 A3 WO2008014280 A3 WO 2008014280A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucose sensing
flourescent dyes
dyes
flourescent
cys
Prior art date
Application number
PCT/US2007/074255
Other languages
French (fr)
Other versions
WO2008014280A2 (en
Inventor
Jeff T Suri
Original Assignee
Glumetrics Inc
Jeff T Suri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glumetrics Inc, Jeff T Suri filed Critical Glumetrics Inc
Priority to AU2007276777A priority Critical patent/AU2007276777A1/en
Priority to AT07799791T priority patent/ATE514755T1/en
Priority to JP2009521962A priority patent/JP5159778B2/en
Priority to CA002652025A priority patent/CA2652025A1/en
Priority to EP07799791A priority patent/EP2054476B9/en
Publication of WO2008014280A2 publication Critical patent/WO2008014280A2/en
Publication of WO2008014280A3 publication Critical patent/WO2008014280A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00Other synthetic dyes of known constitution
    • C09B57/001Pyrene dyes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • Y10T436/144444Glucose

Abstract

A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.
PCT/US2007/074255 2006-07-25 2007-07-24 Flourescent dyes for use in glucose sensing WO2008014280A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2007276777A AU2007276777A1 (en) 2006-07-25 2007-07-24 Flourescent dyes for use in glucose sensing
AT07799791T ATE514755T1 (en) 2006-07-25 2007-07-24 FLUORESCENT DYES FOR USE IN GLUCOSE DETECTION
JP2009521962A JP5159778B2 (en) 2006-07-25 2007-07-24 Fluorescent dyes for use in glucose sensing
CA002652025A CA2652025A1 (en) 2006-07-25 2007-07-24 Flourescent dyes for use in glucose sensing
EP07799791A EP2054476B9 (en) 2006-07-25 2007-07-24 Flourescent dyes for use in glucose sensing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83308106P 2006-07-25 2006-07-25
US60/833,081 2006-07-25

Publications (2)

Publication Number Publication Date
WO2008014280A2 WO2008014280A2 (en) 2008-01-31
WO2008014280A3 true WO2008014280A3 (en) 2008-09-18

Family

ID=38896105

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074255 WO2008014280A2 (en) 2006-07-25 2007-07-24 Flourescent dyes for use in glucose sensing

Country Status (7)

Country Link
US (2) US7417164B2 (en)
EP (1) EP2054476B9 (en)
JP (1) JP5159778B2 (en)
AT (1) ATE514755T1 (en)
AU (1) AU2007276777A1 (en)
CA (1) CA2652025A1 (en)
WO (1) WO2008014280A2 (en)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US7885697B2 (en) * 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
JP4708342B2 (en) 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド Oxygen augmentation membrane system for use in implantable devices
US20100168657A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US6931327B2 (en) 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP2239566B1 (en) 2003-12-05 2014-04-23 DexCom, Inc. Calibration techniques for a continuous analyte sensor
WO2005057175A2 (en) 2003-12-09 2005-06-23 Dexcom, Inc. Signal processing for continuous analyte sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7857760B2 (en) 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US20060016700A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
EP1991110B1 (en) 2006-03-09 2018-11-07 DexCom, Inc. Systems and methods for processing analyte sensor data
WO2007120381A2 (en) 2006-04-14 2007-10-25 Dexcom, Inc. Analyte sensor
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7751863B2 (en) 2007-02-06 2010-07-06 Glumetrics, Inc. Optical determination of ph and glucose
DK2989975T3 (en) 2007-02-06 2018-09-24 Medtronic Minimed Inc OPTICAL SYSTEMS AND PROCEDURES FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION
US8972196B2 (en) * 2007-02-06 2015-03-03 Medtronic Minimed, Inc. Algorithms for calibrating an analyte sensor
WO2008137604A1 (en) * 2007-05-01 2008-11-13 Glumetrics, Inc. Pyridinium boronic acid quenchers for use in analyte sensors
CA2686860A1 (en) * 2007-05-10 2008-11-20 Glumetrics, Inc. Device and methods for calibrating analyte sensors
CA2686065A1 (en) 2007-05-10 2008-11-20 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
CA2688184A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
JP2010535903A (en) * 2007-08-06 2010-11-25 グルメトリックス,インコーポレイテッド HPTS-mono and bis-Cys-MA polymerizable fluorescent dyes used in analyte sensors
US9452258B2 (en) 2007-10-09 2016-09-27 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
CA2715624A1 (en) * 2008-02-20 2009-08-27 Dexcom, Inc. Continuous medicament sensor system for in vivo use
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
WO2009129186A2 (en) * 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
US20110136929A1 (en) * 2008-07-09 2011-06-09 Pei Yong Edwin Chow Trapping glucose probe in pores of polymer
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US9801575B2 (en) 2011-04-15 2017-10-31 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
WO2011041546A1 (en) 2009-09-30 2011-04-07 Glumetrics, Inc. Sensors with thromboresistant coating
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
EP2534470B1 (en) 2010-02-08 2016-08-10 Medtronic Minimed, Inc. Antioxidant protection of a chemical sensor
EP2545373B1 (en) * 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
WO2012143370A2 (en) * 2011-04-18 2012-10-26 Noviotech B.V. Biosensor
CA2857493C (en) 2011-07-15 2019-06-11 Glumetrics, Inc. Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors
DK2760432T3 (en) 2011-09-27 2019-06-11 Medtronic Minimed Inc PROCEDURE FOR FUNCTIONALIZING A POROSE MEMBRANE COVER ON AN OPTICAL SENSOR FOR PROMOTING ANTITROMBOGENT INTERMEDIATE
CN105820810B (en) * 2016-04-27 2018-03-30 中南大学 A kind of synthesis and application for identifying cysteine and homocysteine novel fluorescence probe
CN115505280A (en) 2016-12-21 2022-12-23 普罗菲尤萨股份有限公司 Polymerizable near infrared dyes
JOP20190161A1 (en) 2016-12-27 2017-06-16 Profusa Inc Near-ir glucose sensors
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US20190120785A1 (en) 2017-10-24 2019-04-25 Dexcom, Inc. Pre-connected analyte sensors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060083688A1 (en) * 2000-12-05 2006-04-20 Bakthan Singaram Optical determination of glucose utilizing boronic acid adducts

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512246A (en) 1989-09-21 1996-04-30 Anthony P. Russell Method and means for detecting polyhydroxyl compounds
US5137833A (en) 1989-09-21 1992-08-11 Russell Anthony P Method for detecting polyhydroxyl compounds
GB2284809B (en) 1993-11-07 1998-04-29 Japan Res Dev Corp A fluorescent phenylboronic acid suitable for use in the detection of saccharides
JP2799837B2 (en) 1995-03-03 1998-09-21 科学技術振興事業団 Boronic acid compounds having a binaphthyl group
US6002954A (en) 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
AU1058297A (en) 1995-11-22 1997-06-11 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
JP2004506069A (en) 2000-08-04 2004-02-26 センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド Analyte detection in aqueous environment
US6627177B2 (en) 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US6653141B2 (en) 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US6800451B2 (en) 2001-01-05 2004-10-05 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060083688A1 (en) * 2000-12-05 2006-04-20 Bakthan Singaram Optical determination of glucose utilizing boronic acid adducts

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D. B. CORDES ET AL.: "Topics in Fluorescence Spectroscopy; Vol. 11, Glucose Sensing", 2006, SPRINGER, ISBN: 978-0-387-29571-8, XP008081136 *
GAMSEY SOYA ET AL: "Continuous glucose detection using boronic acid-substituted viologens in fluorescent hydrogels: linker effects and extension to fiber optics", LANGMUIR, ACS, WASHINGTON, DC, US, vol. 22, no. 21, 10 October 2006 (2006-10-10), pages 9067 - 9074, XP002442273, ISSN: 0743-7463 *

Also Published As

Publication number Publication date
EP2054476B9 (en) 2012-03-14
US7767846B2 (en) 2010-08-03
JP5159778B2 (en) 2013-03-13
US7417164B2 (en) 2008-08-26
US20080027245A1 (en) 2008-01-31
EP2054476A2 (en) 2009-05-06
ATE514755T1 (en) 2011-07-15
AU2007276777A1 (en) 2008-01-31
WO2008014280A2 (en) 2008-01-31
US20080305506A1 (en) 2008-12-11
EP2054476B1 (en) 2011-06-29
JP2009544729A (en) 2009-12-17
CA2652025A1 (en) 2008-01-31

Similar Documents

Publication Publication Date Title
WO2008014280A3 (en) Flourescent dyes for use in glucose sensing
EP1954190A4 (en) Blood analyte determinations
EP1751590A4 (en) Planar-resonator based optical chemo- and biosensors
WO2005103298A3 (en) Method for detecting ncrna
EP1893084A4 (en) Analyte sensor
FI20050739A (en) Micromechanical sensor, sensor group and method
WO2007035864A3 (en) Electrophoresis standards, methods and kits
WO2007008759A3 (en) Methods for detecting and confirming minimal disease in a cancer patient
WO2009017861A3 (en) Analyte detection using autocatalytic chain reactions
ZA200802422B (en) A colorimetric bio-barcode amplification assay for analyte detection
HK1119245A1 (en) Pathogen detection biosensor
WO2008131361A3 (en) Biosensors for measuring analytes in the interstitial fluid
WO2008017074A3 (en) Dyes and precursors and conjugates thereof
WO2008106648A3 (en) Immunoassays exhibiting a reduction in prozone phenomena
GB2443694B (en) Analyte saturation assay, methods and kits and devices
EP1900321A4 (en) Needle integrating biosensor
WO2007069240A3 (en) Compositions and articles for detection of analytes exceeding a pre-set threshold
GB0711455D0 (en) Light-sensitive component with increased blue sensitivity, method for the production thereof, and operating method
AU2005259012A1 (en) Analyte detection system
EP2046998A4 (en) Molecular biosensors for detecting macromolecules and other analytes
WO2008010837A3 (en) Noncompetitive immunoassays to detect small molecules
WO2006044611A3 (en) Neurotransmitter sensors and methods of using the same
GB0617730D0 (en) Analyte detection
EP2345077A4 (en) Analyte sensors, testing apparatus and manufacturing methods
DE112004002995A5 (en) differential pressure measuring

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07799791

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2652025

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2007276777

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2007276777

Country of ref document: AU

Date of ref document: 20070724

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2009521962

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007799791

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU