WO2008015238A2 - Subcutaneous implants releasing an active principle over an extended period of time - Google Patents
Subcutaneous implants releasing an active principle over an extended period of time Download PDFInfo
- Publication number
- WO2008015238A2 WO2008015238A2 PCT/EP2007/057969 EP2007057969W WO2008015238A2 WO 2008015238 A2 WO2008015238 A2 WO 2008015238A2 EP 2007057969 W EP2007057969 W EP 2007057969W WO 2008015238 A2 WO2008015238 A2 WO 2008015238A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- subcutaneous implants
- active ingredient
- plga
- implants according
- microparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT07788137T ATE451913T1 (en) | 2006-08-02 | 2007-08-01 | SUBCUTANEOUS IMPLANTS THAT RELEASE AN ACTIVE SUBSTANCE OVER A LONGER PERIOD |
EA200900247A EA017292B1 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
CA002659441A CA2659441A1 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
US12/309,875 US20100003298A1 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extender period of time |
EP07788137A EP2054037B1 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
AU2007280397A AU2007280397A1 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
DE602007003854T DE602007003854D1 (en) | 2006-08-02 | 2007-08-01 | SUBCUTANEOUS IMPLANTS THAT RELEASE AN ACTIVE AGENT FOR A LONGER PERIOD |
BRPI0714515-2A BRPI0714515A2 (en) | 2006-08-02 | 2007-08-01 | subcutaneous active principle release implants over a prolonged period of time |
MX2009001232A MX2009001232A (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time. |
JP2009522274A JP2009545564A (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implant that releases active body over time |
PL07788137T PL2054037T3 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
HK09107201.1A HK1129835A1 (en) | 2006-08-02 | 2009-08-05 | Subcutaneous implants releasing an active principle over an extended period of time |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2006A001545 | 2006-08-02 | ||
IT001545A ITMI20061545A1 (en) | 2006-08-02 | 2006-08-02 | PARTICLES ABLE TO RELEASE THE ACTIVE PRINCIPLE FOR A PROLONGED PERIOD OF TIME |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008015238A2 true WO2008015238A2 (en) | 2008-02-07 |
WO2008015238A3 WO2008015238A3 (en) | 2008-03-20 |
WO2008015238A8 WO2008015238A8 (en) | 2008-06-05 |
Family
ID=37846057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/057969 WO2008015238A2 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
Country Status (18)
Country | Link |
---|---|
US (1) | US20100003298A1 (en) |
EP (1) | EP2054037B1 (en) |
JP (1) | JP2009545564A (en) |
KR (1) | KR20090037946A (en) |
CN (1) | CN101553212A (en) |
AT (1) | ATE451913T1 (en) |
AU (1) | AU2007280397A1 (en) |
BR (1) | BRPI0714515A2 (en) |
CA (1) | CA2659441A1 (en) |
DE (1) | DE602007003854D1 (en) |
EA (1) | EA017292B1 (en) |
ES (1) | ES2337419T3 (en) |
HK (1) | HK1129835A1 (en) |
IT (1) | ITMI20061545A1 (en) |
MX (1) | MX2009001232A (en) |
PL (1) | PL2054037T3 (en) |
PT (1) | PT2054037E (en) |
WO (1) | WO2008015238A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100075893A1 (en) * | 2008-03-20 | 2010-03-25 | N.V. Organon | Preparation of a pharmaceutical composition for increasing bone mineral density |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000033809A1 (en) * | 1998-12-10 | 2000-06-15 | Mediolanum Farmaceutici S.P.A. | Compositions containing a peptide and polylactic-glycolic acid suitable for preparing subcutaneous implants with an extended release period |
US6183781B1 (en) * | 1996-05-14 | 2001-02-06 | Alkermes Controlled Therapeutics, Inc. | Method for fabricating polymer-based controlled-release devices |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1311686C (en) * | 1986-06-25 | 1992-12-22 | John Weldon Shell | Controlled release bioerodible drug delivery system |
US5490962A (en) * | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
PT1638535E (en) * | 2003-06-26 | 2007-11-08 | Mediolanum Pharmaceuticals Ltd | Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof |
AU2005219413A1 (en) * | 2004-03-02 | 2005-09-15 | Massachusetts Institute Of Technology | Nanocell drug delivery system |
-
2006
- 2006-08-02 IT IT001545A patent/ITMI20061545A1/en unknown
-
2007
- 2007-08-01 AT AT07788137T patent/ATE451913T1/en active
- 2007-08-01 KR KR1020097003183A patent/KR20090037946A/en not_active Application Discontinuation
- 2007-08-01 BR BRPI0714515-2A patent/BRPI0714515A2/en not_active IP Right Cessation
- 2007-08-01 WO PCT/EP2007/057969 patent/WO2008015238A2/en active Application Filing
- 2007-08-01 CN CNA2007800365047A patent/CN101553212A/en active Pending
- 2007-08-01 PT PT07788137T patent/PT2054037E/en unknown
- 2007-08-01 EP EP07788137A patent/EP2054037B1/en not_active Not-in-force
- 2007-08-01 JP JP2009522274A patent/JP2009545564A/en active Pending
- 2007-08-01 EA EA200900247A patent/EA017292B1/en not_active IP Right Cessation
- 2007-08-01 US US12/309,875 patent/US20100003298A1/en not_active Abandoned
- 2007-08-01 ES ES07788137T patent/ES2337419T3/en active Active
- 2007-08-01 AU AU2007280397A patent/AU2007280397A1/en not_active Abandoned
- 2007-08-01 PL PL07788137T patent/PL2054037T3/en unknown
- 2007-08-01 DE DE602007003854T patent/DE602007003854D1/en active Active
- 2007-08-01 MX MX2009001232A patent/MX2009001232A/en active IP Right Grant
- 2007-08-01 CA CA002659441A patent/CA2659441A1/en not_active Abandoned
-
2009
- 2009-08-05 HK HK09107201.1A patent/HK1129835A1/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6183781B1 (en) * | 1996-05-14 | 2001-02-06 | Alkermes Controlled Therapeutics, Inc. | Method for fabricating polymer-based controlled-release devices |
WO2000033809A1 (en) * | 1998-12-10 | 2000-06-15 | Mediolanum Farmaceutici S.P.A. | Compositions containing a peptide and polylactic-glycolic acid suitable for preparing subcutaneous implants with an extended release period |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100075893A1 (en) * | 2008-03-20 | 2010-03-25 | N.V. Organon | Preparation of a pharmaceutical composition for increasing bone mineral density |
JP2011515363A (en) * | 2008-03-20 | 2011-05-19 | ナームローゼ・フエンノートチヤツプ・オルガノン | Manufacture of a pharmaceutical composition for increasing bone density |
Also Published As
Publication number | Publication date |
---|---|
AU2007280397A1 (en) | 2008-02-07 |
BRPI0714515A2 (en) | 2013-04-24 |
EA017292B1 (en) | 2012-11-30 |
US20100003298A1 (en) | 2010-01-07 |
PT2054037E (en) | 2010-03-24 |
DE602007003854D1 (en) | 2010-01-28 |
EA200900247A1 (en) | 2009-06-30 |
CA2659441A1 (en) | 2008-02-07 |
EP2054037B1 (en) | 2009-12-16 |
ATE451913T1 (en) | 2010-01-15 |
ES2337419T3 (en) | 2010-04-23 |
EP2054037A2 (en) | 2009-05-06 |
KR20090037946A (en) | 2009-04-16 |
WO2008015238A8 (en) | 2008-06-05 |
MX2009001232A (en) | 2009-04-28 |
HK1129835A1 (en) | 2009-12-11 |
PL2054037T3 (en) | 2010-05-31 |
JP2009545564A (en) | 2009-12-24 |
CN101553212A (en) | 2009-10-07 |
WO2008015238A3 (en) | 2008-03-20 |
ITMI20061545A1 (en) | 2008-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10406160B2 (en) | Sustained release small molecule drug formulation | |
EP2054029B1 (en) | Subcutaneous implants releasing an active principle over an extended period of time | |
RU2355385C2 (en) | Compositions of prolongedaction with controlled release | |
EP1638535B1 (en) | Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof | |
JPH10502673A (en) | Formulations and methods for providing sustained local anesthesia | |
SK287528B6 (en) | Flowable composition suitable for use in implant, use thereof and solid implant | |
JP2003517014A (en) | Pharmaceutical implant containing immediate release and sustained release components and administration method | |
JP2006525306A (en) | Methods and compositions using gonadotropin hormone-releasing hormone | |
EP2054028B1 (en) | Subcutaneous implants releasing an active principle over an extended period of time | |
CA2253377A1 (en) | Pharmaceutical compositions for the sustained release of insoluble active principles | |
WO2008015238A2 (en) | Subcutaneous implants releasing an active principle over an extended period of time | |
AU2013202598A1 (en) | Sustained release small molecule drug formulation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200780036504.7 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07788137 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12309875 Country of ref document: US Ref document number: 2659441 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2009/001232 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009522274 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020097003183 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007280397 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007788137 Country of ref document: EP Ref document number: 200900247 Country of ref document: EA |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1182/CHENP/2009 Country of ref document: IN |
|
ENP | Entry into the national phase |
Ref document number: PI0714515 Country of ref document: BR Kind code of ref document: A2 Effective date: 20090202 |