WO2008016581A3 - Imaging neuronal activity using nonlinear phase modulation as an intrinsic contrast mechanism - Google Patents

Imaging neuronal activity using nonlinear phase modulation as an intrinsic contrast mechanism Download PDF

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Publication number
WO2008016581A3
WO2008016581A3 PCT/US2007/017067 US2007017067W WO2008016581A3 WO 2008016581 A3 WO2008016581 A3 WO 2008016581A3 US 2007017067 W US2007017067 W US 2007017067W WO 2008016581 A3 WO2008016581 A3 WO 2008016581A3
Authority
WO
WIPO (PCT)
Prior art keywords
phase modulation
neuronal activity
nonlinear phase
xpm
spm
Prior art date
Application number
PCT/US2007/017067
Other languages
French (fr)
Other versions
WO2008016581A2 (en
Inventor
Martin C Fischer
S Warren Warren
Original Assignee
Univ Duke
Martin C Fischer
S Warren Warren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Martin C Fischer, S Warren Warren filed Critical Univ Duke
Publication of WO2008016581A2 publication Critical patent/WO2008016581A2/en
Publication of WO2008016581A3 publication Critical patent/WO2008016581A3/en

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B2207/00—Coding scheme for general features or characteristics of optical elements and systems of subclass G02B, but not including elements and systems which would be classified in G02B6/00 and subgroups
    • G02B2207/114—Two photon or multiphoton effect

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Measurements of two photon absorption (TPA) and/or intrinsic non-linear phase modulation such as self-phase modulation (SPM) or cross- phase modulation (XPM) can be used for neuronal imaging, with potential advantages in speed, penetration depth and molecular contrast. Nonlinear optical processes such as SPM and XPM are known to be sensitive to material structure and are significantly altered by neuronal firing. A pulse shaping technique that extracts weak non-linear phase modulation signatures can be extrapolated to high spatial and temporal resolution while retaining the noninvasive character, thus eliminating the requirement for expressed or exogenous contrast agents.
PCT/US2007/017067 2006-07-31 2007-07-31 Imaging neuronal activity using nonlinear phase modulation as an intrinsic contrast mechanism WO2008016581A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82085906P 2006-07-31 2006-07-31
US60/820,859 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008016581A2 WO2008016581A2 (en) 2008-02-07
WO2008016581A3 true WO2008016581A3 (en) 2008-11-13

Family

ID=38997667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017067 WO2008016581A2 (en) 2006-07-31 2007-07-31 Imaging neuronal activity using nonlinear phase modulation as an intrinsic contrast mechanism

Country Status (1)

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WO (1) WO2008016581A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10405750B2 (en) 2014-09-30 2019-09-10 Washington University Nonradiative voltage-sensitive dye for imaging neuronal action potential
CN104375374B (en) * 2014-11-25 2017-02-08 北京理工大学 Ultra-fast laser continuous imaging device and method based on frequency domain space-time transformation
CN111239997A (en) * 2020-03-20 2020-06-05 西北大学 Rapid focusing dark field imaging device and method based on cross phase modulation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835779A (en) * 1987-05-04 1989-05-30 American Telephone And Telegraph Company, At&T Bell Laboratories Method and apparatus for the operation of a distributed feedback laser
US20020141028A1 (en) * 1998-06-26 2002-10-03 Hagler Thomas W. Method and apparatus for spectrum analysis and encoder
US20040143190A1 (en) * 2003-01-22 2004-07-22 Schnitzer Mark J. Mapping neural and muscular electrical activity
US20040233944A1 (en) * 2001-01-30 2004-11-25 Marcos Dantus Laser system using ultra-short laser pulses
US20050057756A1 (en) * 2001-12-18 2005-03-17 Massachusetts Institute Of Technology Systems and methods for phase measurements
US20060058683A1 (en) * 1999-08-26 2006-03-16 Britton Chance Optical examination of biological tissue using non-contact irradiation and detection

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835779A (en) * 1987-05-04 1989-05-30 American Telephone And Telegraph Company, At&T Bell Laboratories Method and apparatus for the operation of a distributed feedback laser
US20020141028A1 (en) * 1998-06-26 2002-10-03 Hagler Thomas W. Method and apparatus for spectrum analysis and encoder
US20060058683A1 (en) * 1999-08-26 2006-03-16 Britton Chance Optical examination of biological tissue using non-contact irradiation and detection
US20040233944A1 (en) * 2001-01-30 2004-11-25 Marcos Dantus Laser system using ultra-short laser pulses
US20050057756A1 (en) * 2001-12-18 2005-03-17 Massachusetts Institute Of Technology Systems and methods for phase measurements
US20040143190A1 (en) * 2003-01-22 2004-07-22 Schnitzer Mark J. Mapping neural and muscular electrical activity

Also Published As

Publication number Publication date
WO2008016581A2 (en) 2008-02-07

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