WO2008017998A3 - Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis - Google Patents

Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis Download PDF

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Publication number
WO2008017998A3
WO2008017998A3 PCT/IB2007/053074 IB2007053074W WO2008017998A3 WO 2008017998 A3 WO2008017998 A3 WO 2008017998A3 IB 2007053074 W IB2007053074 W IB 2007053074W WO 2008017998 A3 WO2008017998 A3 WO 2008017998A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood clot
microbubble
ultrasound system
flow imaging
clot lysis
Prior art date
Application number
PCT/IB2007/053074
Other languages
French (fr)
Other versions
WO2008017998B1 (en
WO2008017998A2 (en
Inventor
Wendy Swan
Jeffry E Powers
Original Assignee
Koninkl Philips Electronics Nv
Wendy Swan
Jeffry E Powers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Wendy Swan, Jeffry E Powers filed Critical Koninkl Philips Electronics Nv
Priority to EP07825990A priority Critical patent/EP2051778A2/en
Priority to US12/376,321 priority patent/US8211023B2/en
Priority to CN2007800298288A priority patent/CN101500651B/en
Priority to JP2009523404A priority patent/JP5336369B2/en
Publication of WO2008017998A2 publication Critical patent/WO2008017998A2/en
Publication of WO2008017998A3 publication Critical patent/WO2008017998A3/en
Publication of WO2008017998B1 publication Critical patent/WO2008017998B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0808—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4227—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by straps, belts, cuffs or braces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/483—Diagnostic techniques involving the acquisition of a 3D volume of data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50—Supports for surgical instruments, e.g. articulated arms
    • A61B2090/502—Headgear, e.g. helmet, spectacles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
    • A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Mechanical Engineering (AREA)
  • Neurology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Surgical Instruments (AREA)

Abstract

An ultrasonic diagnostic imaging system is described which utilizes one or more transducer arrays (10a, 10b) affixed to the head of a patient to diagnose and treat stroke victims. The transducer headset (200) produces a two or three dimensional image of the vasculature (300) inside the cranium, preferably assisted by a microbubble contrast agent. A vascular flow map is produced by the system which may be diagnosed for signs of a blood clot. If a blood clot is detected, a therapeutic beam is transmitted while the contrast agent is present to break up the blood clot by the disruption of microbubbles. The headset may also be used in a monitoring application to detect the recurrence of blood clots in a stroke victim.
PCT/IB2007/053074 2006-08-11 2007-08-03 Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis WO2008017998A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07825990A EP2051778A2 (en) 2006-08-11 2007-08-03 Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis
US12/376,321 US8211023B2 (en) 2006-08-11 2007-08-03 Ultrasound system for cerebral blood flow monitoring
CN2007800298288A CN101500651B (en) 2006-08-11 2007-08-03 Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis
JP2009523404A JP5336369B2 (en) 2006-08-11 2007-08-03 Ultrasound system for cerebral blood flow imaging and microbubble improvement thrombus resolution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82210906P 2006-08-11 2006-08-11
US60/822,109 2006-08-11

Publications (3)

Publication Number Publication Date
WO2008017998A2 WO2008017998A2 (en) 2008-02-14
WO2008017998A3 true WO2008017998A3 (en) 2008-05-08
WO2008017998B1 WO2008017998B1 (en) 2008-06-19

Family

ID=39007768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/053074 WO2008017998A2 (en) 2006-08-11 2007-08-03 Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis

Country Status (5)

Country Link
US (1) US8211023B2 (en)
EP (2) EP2051778A2 (en)
JP (1) JP5336369B2 (en)
CN (1) CN101500651B (en)
WO (1) WO2008017998A2 (en)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1453425B1 (en) 2001-12-03 2006-03-08 Ekos Corporation Catheter with multiple ultrasound radiating members
US20120165668A1 (en) * 2010-08-02 2012-06-28 Guided Therapy Systems, Llc Systems and methods for treating acute and/or chronic injuries in soft tissue
WO2008017997A2 (en) 2006-08-11 2008-02-14 Koninklijke Philips Electronics, N.V. Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
EP2134262B1 (en) * 2007-04-13 2019-06-12 Koninklijke Philips N.V. Quantified perfusion studies with ultrasonic thick slice imaging
CN101657736B (en) * 2007-04-13 2013-03-20 皇家飞利浦电子股份有限公司 High speed ultrasonic thick slice imaging
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
ES2651898T3 (en) 2007-11-26 2018-01-30 C.R. Bard Inc. Integrated system for intravascular catheter placement
US8465433B2 (en) 2008-05-27 2013-06-18 Volusonics Medical Imaging Ltd. Ultrasound garment
ES2736276T3 (en) 2008-07-14 2019-12-27 Arizona Board Of Regents For And On Behalf Of Arizona State Univ Cellular activity modulation devices using ultrasound
US20100210940A1 (en) * 2008-11-14 2010-08-19 Hoag Memorial Hospital Presbyterian CT-Guided Focused Ultrasound for Stroke Treatment
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
EP2496307B1 (en) * 2009-11-04 2016-01-27 Arizona Board Of Regents, For And On Behalf Of Arizona State University Ultrasonic device for modulating brain activity
EP2368494A1 (en) * 2010-03-24 2011-09-28 Brain Products GmbH Dry electrode for detecting eeg signals and attaching device for holding the dry electrode
EP2912999B1 (en) 2010-05-28 2022-06-29 C. R. Bard, Inc. Apparatus for use with needle insertion guidance system
EP4000546A1 (en) 2010-08-27 2022-05-25 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
US8603014B2 (en) * 2010-10-05 2013-12-10 Cerevast Therapeutics, Inc. Hands-free operator-independent transcranial ultrasound apparatus and methods
US8613714B2 (en) * 2010-10-05 2013-12-24 Cerevast Therapeutics, Inc. Non-invasive transcranial ultrasound apparatus
CN102711603B (en) * 2011-01-11 2017-07-18 东芝医疗系统株式会社 Image diagnosing system, image diagnosing method, medical imaging server and medical imaging store method
JP2014521462A (en) 2011-08-05 2014-08-28 シルク・ロード・メディカル・インコーポレイテッド Method and system for treating acute ischemic stroke
US9042201B2 (en) 2011-10-21 2015-05-26 Thync, Inc. Method and system for direct communication
WO2013170223A1 (en) * 2012-05-11 2013-11-14 The Regents Of The University Of California Portable device to initiate and monitor treatment of stroke victims in the field
US10194801B2 (en) * 2012-06-28 2019-02-05 Koninklijke Philips N.V. Fiber optic sensor guided navigation for vascular visualization and monitoring
WO2014036170A1 (en) 2012-08-29 2014-03-06 Thync, Inc. Systems and devices for coupling ultrasound energy to a body
US20140194740A1 (en) * 2013-01-07 2014-07-10 Cerebrosonics, Llc Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement
SG10201702432YA (en) 2013-03-14 2017-05-30 Ekos Corp Method and apparatus for drug delivery to a target site
EP3016713B1 (en) * 2013-07-03 2023-03-01 Bracco Suisse SA Devices for the ultrasound treatment of ischemic stroke
JP6413616B2 (en) * 2013-11-06 2018-10-31 コニカミノルタ株式会社 Ultrasonic diagnostic apparatus, controller for ultrasonic diagnostic apparatus, and control method for ultrasonic diagnostic apparatus
US9265512B2 (en) 2013-12-23 2016-02-23 Silk Road Medical, Inc. Transcarotid neurovascular catheter
KR101674095B1 (en) * 2014-02-28 2016-11-09 주식회사 엠에스피 Helmet type stimulating system using low intensity ultrasonic focused
CN106456995A (en) * 2014-02-28 2017-02-22 Msp有限公司 Helmet-type low-intensity focused ultrasound stimulation device and system
KR101572888B1 (en) * 2014-02-28 2015-11-30 주식회사 엠에스피 Helmet type stimulating system using low intensity ultrasonic focused
CN103860201B (en) * 2014-03-06 2015-08-05 西安交通大学 A kind of based on broad beam contrast imaging and the method extracting infusion time intensity curve
JP6799537B2 (en) * 2014-12-09 2020-12-16 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Single modality-based visual identification of medical intervention devices from the organization
US10426497B2 (en) 2015-07-24 2019-10-01 Route 92 Medical, Inc. Anchoring delivery system and methods
US11065019B1 (en) 2015-02-04 2021-07-20 Route 92 Medical, Inc. Aspiration catheter systems and methods of use
AU2016215229B2 (en) 2015-02-04 2020-05-07 Route 92 Medical, Inc. Rapid aspiration thrombectomy system and method
EP3282921B1 (en) 2015-04-16 2022-02-16 Gentuity LLC Micro-optic probes for neurology
EP3307388B1 (en) 2015-06-10 2022-06-22 Ekos Corporation Ultrasound catheter
CN107635472A (en) 2015-06-19 2018-01-26 神经系统分析公司 Transcranial doppler detector
JP6981967B2 (en) 2015-08-31 2021-12-17 ジェンテュイティ・リミテッド・ライアビリティ・カンパニーGentuity, LLC Imaging system including imaging probe and delivery device
US20190069875A1 (en) 2015-10-14 2019-03-07 Koninklijke Philips N.V. Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis
JP2018538056A (en) 2015-12-09 2018-12-27 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Interleaved beam pattern for ultrasonic thrombolysis and other treatments via vascular acoustic resonator
US11589836B2 (en) * 2016-01-05 2023-02-28 Novasignal Corp. Systems and methods for detecting neurological conditions
JP2019504670A (en) 2016-01-05 2019-02-21 ニューラル アナリティクス、インコーポレイテッド System and method for determining clinical indicators
JP2019500155A (en) 2016-01-05 2019-01-10 ニューラル アナリティクス、インコーポレイテッド Integrated probe structure
EP4252992A3 (en) 2016-02-24 2024-01-10 Incept, LLC Enhanced flexibility neurovascular catheter
US11020563B2 (en) 2016-07-14 2021-06-01 C. R. Bard, Inc. Automated catheter-to-vessel size comparison tool and related methods
CN106236138A (en) * 2016-08-19 2016-12-21 西南医科大学 Intracranial pressure noninvasive monitor based on R wave
US10589129B2 (en) * 2016-09-14 2020-03-17 Insightec, Ltd. Therapeutic ultrasound with reduced interference from microbubbles
US20190329075A1 (en) 2016-12-07 2019-10-31 Koninklijke Philips N.V. Ultrasonic sonothrombolysis treatment planning
US20200107811A1 (en) * 2016-12-19 2020-04-09 Koninklijke Philips N.V. Ultrasonic transducer array monitoring during transcranial ultrasound procedures
US10653426B2 (en) 2017-01-06 2020-05-19 Incept, Llc Thromboresistant coatings for aneurysm treatment devices
CN114984407A (en) 2017-01-10 2022-09-02 92号医疗公司 System, catheter and catheter advancement device for performing medical procedures in intracranial vessels
CA3057631A1 (en) 2017-03-24 2018-09-27 BURL Concepts, Inc. Portable ultrasound device
CN107088066A (en) * 2017-06-20 2017-08-25 美合实业（苏州）有限公司 A kind of brain conductance connection of helmet-type anaesthesia depth monitor
CN107296627B (en) * 2017-07-14 2020-05-26 深圳市德力凯医疗设备股份有限公司 Output method of cerebral blood flow automatic regulation index, storage medium and ultrasonic equipment
JP7160935B2 (en) 2017-11-28 2022-10-25 ジェンテュイティ・リミテッド・ライアビリティ・カンパニー Imaging system
EP3742979B1 (en) * 2018-01-24 2022-10-19 Koninklijke Philips N.V. Guided-transcranial ultrasound imaging using neural networks and associated devices, systems, and methods
CA3095844A1 (en) 2018-05-01 2019-11-07 Incept, Llc Devices and methods for removing obstructive material from an intravascular site
US11395665B2 (en) 2018-05-01 2022-07-26 Incept, Llc Devices and methods for removing obstructive material, from an intravascular site
EP3793660A2 (en) 2018-05-17 2021-03-24 Route 92 Medical, Inc. Aspiration catheter systems and methods of use
US11517335B2 (en) 2018-07-06 2022-12-06 Incept, Llc Sealed neurovascular extendable catheter
US11471582B2 (en) 2018-07-06 2022-10-18 Incept, Llc Vacuum transfer tool for extendable catheter
WO2020081373A1 (en) 2018-10-16 2020-04-23 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
US11766539B2 (en) 2019-03-29 2023-09-26 Incept, Llc Enhanced flexibility neurovascular catheter
JP7325544B2 (en) * 2019-05-31 2023-08-14 コーニンクレッカ フィリップス エヌ ヴェ Method and system for guiding the acquisition of cranial ultrasound data
CA3152545A1 (en) 2019-09-20 2021-03-25 Bard Access Systems, Inc. Automatic vessel detection tools and methods
AU2020366348A1 (en) 2019-10-15 2022-05-12 Imperative Care, Inc. Systems and methods for multivariate stroke detection
CN113365687A (en) 2019-12-18 2021-09-07 因普瑞缇夫护理公司 Method and system for treating venous thromboembolic disorders
US11638637B2 (en) 2019-12-18 2023-05-02 Imperative Care, Inc. Method of removing embolic material with thrombus engagement tool
US20210315598A1 (en) 2019-12-18 2021-10-14 Imperative Care, Inc. Methods of placing large bore aspiration catheters
EP4117762A1 (en) 2020-03-10 2023-01-18 Imperative Care, Inc. Enhanced flexibility neurovascular catheter
JP2023523789A (en) * 2020-04-29 2023-06-07 ジェンテュイティ・リミテッド・ライアビリティ・カンパニー imaging system
WO2022020351A1 (en) 2020-07-21 2022-01-27 Bard Access Systems, Inc. System, method and apparatus for magnetic tracking of ultrasound probe and generation of 3d visualization thereof
US11207497B1 (en) 2020-08-11 2021-12-28 Imperative Care, Inc. Catheter with enhanced tensile strength
WO2022051657A1 (en) 2020-09-03 2022-03-10 Bard Access Systems, Inc. Portable ultrasound systems and methods
US11925505B2 (en) 2020-09-25 2024-03-12 Bard Access Systems, Inc. Minimum catheter length tool
CN113476032B (en) * 2021-08-13 2023-03-03 电子科技大学 Brain structure and function coupling method based on directed graph harmonic analysis
WO2023222845A1 (en) 2022-05-20 2023-11-23 Koninklijke Philips N.V. Multi-modality image visualization for stroke detection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040049134A1 (en) * 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
US20050015009A1 (en) * 2000-11-28 2005-01-20 Allez Physionix , Inc. Systems and methods for determining intracranial pressure non-invasively and acoustic transducer assemblies for use in such systems
EP1591073A1 (en) * 2003-01-31 2005-11-02 Hitachi Medical Corporation Ultrasonic probe and ultrasonic device

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948248A (en) 1974-09-05 1976-04-06 Zuckerman Joel L Method of measuring ocular pulse
US4237901A (en) 1978-08-30 1980-12-09 Picker Corporation Low and constant pressure transducer probe for ultrasonic diagnostic system
CA1237482A (en) 1984-03-09 1988-05-31 Frank B. Stiles Catheter for effecting removal of obstructions from a biological duct
US5477858A (en) 1986-07-30 1995-12-26 Siemens Medical Systems, Inc. Ultrasound blood flow/tissue imaging system
US5247938A (en) 1990-01-11 1993-09-28 University Of Washington Method and apparatus for determining the motility of a region in the human body
US5957882A (en) 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
GB9109881D0 (en) 1991-05-08 1991-07-03 Advanced Tech Lab Transesophageal echocardiography scanner with rotating image plane
US5181514A (en) 1991-05-21 1993-01-26 Hewlett-Packard Company Transducer positioning system
NO302409B1 (en) 1991-10-11 1998-03-02 Sodap Slightly tearable seal
US5388583A (en) 1993-09-01 1995-02-14 Uab Vittamed Method and apparatus for non-invasively deriving and indicating of dynamic characteristics of the human and animal intracranial media
US5509896A (en) 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
US5503152A (en) 1994-09-28 1996-04-02 Tetrad Corporation Ultrasonic transducer assembly and method for three-dimensional imaging
US5474073A (en) 1994-11-22 1995-12-12 Advanced Technology Laboratories, Inc. Ultrasonic diagnostic scanning for three dimensional display
US6019724A (en) 1995-02-22 2000-02-01 Gronningsaeter; Aage Method for ultrasound guidance during clinical procedures
US5690117A (en) 1995-03-20 1997-11-25 Gilbert; John W. Ultrasonic-fiberoptic imaging ventricular catheter
US6027460A (en) 1995-09-14 2000-02-22 Shturman Cardiology Systems, Inc. Rotatable intravascular apparatus
US5648098A (en) 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5720291A (en) 1996-03-22 1998-02-24 Advanced Technology Laboratories, Inc. Three dimensional medical ultrasonic diagnostic image of tissue texture and vasculature
US6066097A (en) 1997-10-22 2000-05-23 Florida Atlantic University Two dimensional ultrasonic scanning system and method
US5919144A (en) 1997-05-06 1999-07-06 Active Signal Technologies, Inc. Apparatus and method for measurement of intracranial pressure with lower frequencies of acoustic signal
US5951477A (en) 1997-09-11 1999-09-14 Uab Vittamed Method and apparatus for determining the pressure inside the brain
US5951476A (en) * 1997-11-14 1999-09-14 Beach; Kirk Watson Method for detecting brain microhemorrhage
US6013032A (en) * 1998-03-13 2000-01-11 Hewlett-Packard Company Beamforming methods and apparatus for three-dimensional ultrasound imaging using two-dimensional transducer array
EP1067970A2 (en) * 1998-03-31 2001-01-17 Nycomed Imaging As Diagnostic imaging of vascular abnormalities using vasomodification
US5997479A (en) * 1998-05-28 1999-12-07 Hewlett-Packard Company Phased array acoustic systems with intra-group processors
US6524249B2 (en) * 1998-11-11 2003-02-25 Spentech, Inc. Doppler ultrasound method and apparatus for monitoring blood flow and detecting emboli
US6196972B1 (en) * 1998-11-11 2001-03-06 Spentech, Inc. Doppler ultrasound method and apparatus for monitoring blood flow
US6113547A (en) * 1998-11-20 2000-09-05 Atl Ultrasound, Inc. Ultrasonic diagnostic imaging with cordless scanhead transmission system
US6398772B1 (en) 1999-03-26 2002-06-04 Coraje, Inc. Method and apparatus for emergency treatment of patients experiencing a thrombotic vascular occlusion
US6171246B1 (en) 1999-04-29 2001-01-09 Michalakis Averkiou Realtime ultrasonic imaging of perfusion using ultrasonic contrast agents
IL146692A0 (en) * 1999-05-28 2002-07-25 Vuesonix Sensors Inc Device and method for mapping and tracking blood flow and determining parameters of blood flow
US7399279B2 (en) * 1999-05-28 2008-07-15 Physiosonics, Inc Transmitter patterns for multi beam reception
US7534209B2 (en) * 2000-05-26 2009-05-19 Physiosonics, Inc. Device and method for mapping and tracking blood flow and determining parameters of blood flow
US7238158B2 (en) * 1999-05-28 2007-07-03 Allez Physionix, Ltd. Pulse interleaving in doppler ultrasound imaging
US6682483B1 (en) * 1999-05-28 2004-01-27 Vuesonix Sensors, Inc. Device and method for mapping and tracking blood flow and determining parameters of blood flow
US6442289B1 (en) 1999-06-30 2002-08-27 Koninklijke Philips Electronics N.V. Extended field of view ultrasonic diagnostic imaging
US6887199B2 (en) * 1999-09-23 2005-05-03 Active Signal Technologies, Inc. Brain assessment monitor
US6733451B2 (en) 1999-10-05 2004-05-11 Omnisonics Medical Technologies, Inc. Apparatus and method for an ultrasonic probe used with a pharmacological agent
US7037267B1 (en) * 1999-11-10 2006-05-02 David Lipson Medical diagnostic methods, systems, and related equipment
US6635017B1 (en) * 2000-02-09 2003-10-21 Spentech, Inc. Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis
US6530885B1 (en) 2000-03-17 2003-03-11 Atl Ultrasound, Inc. Spatially compounded three dimensional ultrasonic images
US6468219B1 (en) * 2000-04-24 2002-10-22 Philip Chidi Njemanze Implantable telemetric transcranial doppler device
US6328694B1 (en) 2000-05-26 2001-12-11 Inta-Medics, Ltd Ultrasound apparatus and method for tissue resonance analysis
US6503202B1 (en) * 2000-06-29 2003-01-07 Acuson Corp. Medical diagnostic ultrasound system and method for flow analysis
US6468216B1 (en) * 2000-08-24 2002-10-22 Kininklijke Philips Electronics N.V. Ultrasonic diagnostic imaging of the coronary arteries
US7604599B2 (en) * 2000-09-29 2009-10-20 New Health Sciences, Inc. Systems and methods for using dynamic vascular assessment to improve vascular stent placement, application, design and marketing
US20070016046A1 (en) * 2000-09-29 2007-01-18 New Health Sciences, Inc. Systems and methods for using dynamic vascular assessment to distinguish among vascular states and for investigating intracranial pressure
US20030013960A1 (en) * 2001-05-29 2003-01-16 Makin Inder Raj. S. Guiding ultrasound end effector for medical treatment
JP3350531B2 (en) * 2001-06-19 2002-11-25 株式会社東芝 Stone crushing equipment
US6390979B1 (en) * 2001-08-24 2002-05-21 Philip Chidi Njemanze Noninvasive transcranial Doppler ultrasound computerized mental performance testing system
JP2003070787A (en) * 2001-08-31 2003-03-11 Toshiyuki Saito Detector monitor for pulmonary thromboembolism
JP2003111755A (en) * 2001-10-03 2003-04-15 Toshiyuki Saito Transesophageal monitor for detecting pulmonary thrombosis and embolism
US6589176B2 (en) 2001-12-05 2003-07-08 Koninklijke Philips Electronics N.V. Ultrasonic image stabilization system and method
US6572549B1 (en) 2001-12-18 2003-06-03 Koninklijke Philips Electronics Nv High frame rate extended field of view ultrasound imaging system and method
US6723050B2 (en) 2001-12-19 2004-04-20 Koninklijke Philips Electronics N.V. Volume rendered three dimensional ultrasonic images with polar coordinates
US6985771B2 (en) 2002-01-22 2006-01-10 Angel Medical Systems, Inc. Rapid response system for the detection and treatment of cardiac events
JP2003214516A (en) * 2002-01-24 2003-07-30 Honda Motor Co Ltd Toroidal speed change mechanism
US20040220474A1 (en) * 2002-03-20 2004-11-04 Kenneth Abend Determining the power of an ultrasound reflection using an autocorrelation technique
JP2003275207A (en) * 2002-03-25 2003-09-30 Junichi Ninomiya Remote diagnostic treatment method due ultrasonic wave and remote diagnostic treatment system
CN100356895C (en) * 2003-01-31 2007-12-26 株式会社日立医药 Ultrasonic probe and ultrasonic device
US20120165675A1 (en) * 2003-05-21 2012-06-28 Paul David Syme Method For Diagnosis And Treatment Of Vessel Occulsion
EP1633234A4 (en) * 2003-06-03 2009-05-13 Physiosonics Inc Systems and methods for determining intracranial pressure non-invasively and acoustic transducer assemblies for use in such systems
US7128713B2 (en) * 2003-07-10 2006-10-31 Spentech, Inc. Doppler ultrasound method and apparatus for monitoring blood flow and hemodynamics
ES2474160T3 (en) * 2003-09-08 2014-07-08 The Board Of Trustees Of The University Of Arkansas Ultrasonic apparatus and method for increased clot lysis
JP4567967B2 (en) * 2003-12-25 2010-10-27 株式会社東芝 Ultrasonic diagnostic equipment
WO2005074805A1 (en) 2004-02-05 2005-08-18 Koninklijke Philips Electronics N.V. Ultrasonic imaging of perfusion and blood flow with harmonic contrast agents
JP4677199B2 (en) * 2004-04-14 2011-04-27 株式会社日立メディコ Ultrasonic diagnostic equipment
JP4942477B2 (en) * 2004-06-03 2012-05-30 株式会社日立メディコ Image diagnosis support method and image diagnosis support device
JP4612379B2 (en) * 2004-09-22 2011-01-12 株式会社東芝 Medical image diagnosis support system, medical image diagnosis support device, medical image diagnosis support method, computer-readable storage medium, and computer program
US20060122513A1 (en) * 2004-12-06 2006-06-08 Taylor William G Doppler helmet
US7857763B2 (en) * 2005-02-08 2010-12-28 Alan Chi-Chung Tai Automatic signal-optimizing transducer assembly for blood flow measurement
US8162837B2 (en) * 2005-06-13 2012-04-24 Spentech, Inc. Medical doppler ultrasound system for locating and tracking blood flow
US20080262350A1 (en) * 2005-11-18 2008-10-23 Imarx Therapeutics, Inc. Ultrasound Apparatus and Method to Treat an Ischemic Stroke

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050015009A1 (en) * 2000-11-28 2005-01-20 Allez Physionix , Inc. Systems and methods for determining intracranial pressure non-invasively and acoustic transducer assemblies for use in such systems
US20040049134A1 (en) * 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
EP1591073A1 (en) * 2003-01-31 2005-11-02 Hitachi Medical Corporation Ultrasonic probe and ultrasonic device

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