WO2008021431A3 - Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders - Google Patents

Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders Download PDF

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Publication number
WO2008021431A3
WO2008021431A3 PCT/US2007/018135 US2007018135W WO2008021431A3 WO 2008021431 A3 WO2008021431 A3 WO 2008021431A3 US 2007018135 W US2007018135 W US 2007018135W WO 2008021431 A3 WO2008021431 A3 WO 2008021431A3
Authority
WO
WIPO (PCT)
Prior art keywords
monitoring
diagnosing
immune disorders
status
transplant rejection
Prior art date
Application number
PCT/US2007/018135
Other languages
French (fr)
Other versions
WO2008021431A2 (en
Inventor
Steven Rosenberg
Kirk Fry
Bin Wu
Russell L Dedrick
Original Assignee
Xdx Inc
Steven Rosenberg
Kirk Fry
Bin Wu
Russell L Dedrick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xdx Inc, Steven Rosenberg, Kirk Fry, Bin Wu, Russell L Dedrick filed Critical Xdx Inc
Publication of WO2008021431A2 publication Critical patent/WO2008021431A2/en
Publication of WO2008021431A3 publication Critical patent/WO2008021431A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.
PCT/US2007/018135 2006-08-14 2007-08-14 Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders WO2008021431A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83769806P 2006-08-14 2006-08-14
US60/837,698 2006-08-14

Publications (2)

Publication Number Publication Date
WO2008021431A2 WO2008021431A2 (en) 2008-02-21
WO2008021431A3 true WO2008021431A3 (en) 2008-11-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018135 WO2008021431A2 (en) 2006-08-14 2007-08-14 Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders

Country Status (2)

Country Link
US (1) US7993832B2 (en)
WO (1) WO2008021431A2 (en)

Cited By (1)

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CN102300875A (en) * 2009-01-28 2011-12-28 财团法人工业技术研究院 Biomarkers associated with nephropathy

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US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20060263813A1 (en) * 2005-05-11 2006-11-23 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
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WO2008140484A2 (en) * 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
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US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
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WO2011116111A1 (en) * 2010-03-16 2011-09-22 Cedars-Sinai Medical Center Methods of using prdm1 genetic variants to prognose, diagnose and treat inflammatory bowel disease
HUE032648T2 (en) * 2011-11-16 2017-10-30 Sphingotec Gmbh Adrenomedullin assays and methods for determining mature adrenomedullin
AU2014241162A1 (en) 2013-03-27 2015-10-22 Cedars-Sinai Medical Center Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
WO2015157546A1 (en) 2014-04-09 2015-10-15 The Regents Of The University Of California Protein biomarkers for immune assessment and prediction of transplant rejection
CN109462996A (en) 2016-03-17 2019-03-12 西达-赛奈医疗中心 The method for diagnosing inflammatory bowel disease by RNASET2

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