WO2008021795A3 - Flowable carrier matrix - Google Patents

Flowable carrier matrix Download PDF

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Publication number
WO2008021795A3
WO2008021795A3 PCT/US2007/075303 US2007075303W WO2008021795A3 WO 2008021795 A3 WO2008021795 A3 WO 2008021795A3 US 2007075303 W US2007075303 W US 2007075303W WO 2008021795 A3 WO2008021795 A3 WO 2008021795A3
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WO
WIPO (PCT)
Prior art keywords
pieces
carrier matrix
cannula
patient
wetted
Prior art date
Application number
PCT/US2007/075303
Other languages
French (fr)
Other versions
WO2008021795A2 (en
Inventor
Neil B Beals
Jeffrey L Scifert Ph D
Scott D Boden
Original Assignee
Warsaw Orthopedic Inc
Neil B Beals
Jeffrey L Scifert Ph D
Scott D Boden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc, Neil B Beals, Jeffrey L Scifert Ph D, Scott D Boden filed Critical Warsaw Orthopedic Inc
Priority to EP07840711A priority Critical patent/EP2054032A2/en
Priority to JP2009524731A priority patent/JP2010500904A/en
Publication of WO2008021795A2 publication Critical patent/WO2008021795A2/en
Publication of WO2008021795A3 publication Critical patent/WO2008021795A3/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or educed-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
PCT/US2007/075303 2006-08-14 2007-08-07 Flowable carrier matrix WO2008021795A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07840711A EP2054032A2 (en) 2006-08-14 2007-08-07 Flowable carrier matrix
JP2009524731A JP2010500904A (en) 2006-08-14 2007-08-07 Flowable carrier substrate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/504,363 US7671014B2 (en) 2006-08-14 2006-08-14 Flowable carrier matrix and methods for delivering to a patient
US11/504,363 2006-08-14

Publications (2)

Publication Number Publication Date
WO2008021795A2 WO2008021795A2 (en) 2008-02-21
WO2008021795A3 true WO2008021795A3 (en) 2008-05-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/075303 WO2008021795A2 (en) 2006-08-14 2007-08-07 Flowable carrier matrix

Country Status (5)

Country Link
US (6) US7671014B2 (en)
EP (1) EP2054032A2 (en)
JP (1) JP2010500904A (en)
CN (1) CN101505722A (en)
WO (1) WO2008021795A2 (en)

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US7993679B2 (en) * 2007-09-25 2011-08-09 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
US20090110637A1 (en) * 2007-10-26 2009-04-30 Warsaw Orthopedic, Inc. LMP and Regulation of Tissue Growth
US8088163B1 (en) 2008-02-06 2012-01-03 Kleiner Jeffrey B Tools and methods for spinal fusion
US8557273B2 (en) * 2008-04-18 2013-10-15 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US20090264489A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Method for Treating Acute Pain with a Formulated Drug Depot in Combination with a Liquid Formulation
US8366748B2 (en) 2008-12-05 2013-02-05 Kleiner Jeffrey Apparatus and method of spinal implant and fusion
US9247943B1 (en) 2009-02-06 2016-02-02 Kleiner Intellectual Property, Llc Devices and methods for preparing an intervertebral workspace
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
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US20110092953A1 (en) 2011-04-21
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