WO2008023027A2 - Process for preparing pramipexole dihydrochloride tablets with high storage stability - Google Patents
Process for preparing pramipexole dihydrochloride tablets with high storage stability Download PDFInfo
- Publication number
- WO2008023027A2 WO2008023027A2 PCT/EP2007/058696 EP2007058696W WO2008023027A2 WO 2008023027 A2 WO2008023027 A2 WO 2008023027A2 EP 2007058696 W EP2007058696 W EP 2007058696W WO 2008023027 A2 WO2008023027 A2 WO 2008023027A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pramipexole dihydrochloride
- intra
- tablets
- granular tableting
- granular
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2009001884A MX2009001884A (en) | 2006-08-24 | 2007-08-22 | Process for preparing pramipexole dihydrochloride tablets with high storage stability. |
JP2009525064A JP2010501525A (en) | 2006-08-24 | 2007-08-22 | Preparation method of pramipexole dihydrochloride tablets |
EP07788511A EP2056795A2 (en) | 2006-08-24 | 2007-08-22 | Process for preparing pramipexole dihydrochloride tablets with high storage stability |
AU2007287560A AU2007287560A1 (en) | 2006-08-24 | 2007-08-22 | Process for preparing pramipexole dihydrochloride tablets with high storage stability |
CA002661616A CA2661616A1 (en) | 2006-08-24 | 2007-08-22 | Process for preparing pramipexole dihydrochloride tablets |
BRPI0715835-1A BRPI0715835A2 (en) | 2006-08-24 | 2007-08-22 | process for preparing pramipexole dihydrochloride tablets |
IL197130A IL197130A0 (en) | 2006-08-24 | 2009-02-19 | Process for preparing pramipexole dihydrochloride tablets |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46705006A | 2006-08-24 | 2006-08-24 | |
US11/467,050 | 2006-08-24 | ||
US11/734,041 US20080254118A1 (en) | 2007-04-11 | 2007-04-11 | Process for preparing pramipexole dihydrochloride tablets |
US11/734,041 | 2007-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008023027A2 true WO2008023027A2 (en) | 2008-02-28 |
WO2008023027A3 WO2008023027A3 (en) | 2008-04-17 |
Family
ID=38963081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/058696 WO2008023027A2 (en) | 2006-08-24 | 2007-08-22 | Process for preparing pramipexole dihydrochloride tablets with high storage stability |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP2056795A2 (en) |
JP (1) | JP2010501525A (en) |
KR (1) | KR20090045943A (en) |
AR (1) | AR062509A1 (en) |
AU (1) | AU2007287560A1 (en) |
BR (1) | BRPI0715835A2 (en) |
CA (1) | CA2661616A1 (en) |
CL (1) | CL2007002477A1 (en) |
IL (1) | IL197130A0 (en) |
MX (1) | MX2009001884A (en) |
RU (1) | RU2009110253A (en) |
TW (1) | TW200816998A (en) |
WO (1) | WO2008023027A2 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008122638A2 (en) * | 2007-04-10 | 2008-10-16 | Boehringer Ingelheim International Gmbh | Process for preparing pramipexole dihydrochloride tablets |
EP2295040A1 (en) | 2009-09-11 | 2011-03-16 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical compositions of pramipexole |
US8017598B2 (en) | 2006-05-16 | 2011-09-13 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(−) pramipexole and methods of using the same |
EP2462925A1 (en) | 2010-11-12 | 2012-06-13 | Neuraxpharm Arzneimittel GmbH | Pramipexole Dihydrochloride Granulate |
US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9642840B2 (en) | 2013-08-13 | 2017-05-09 | Knopp Biosciences, Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
US9849116B2 (en) | 2008-08-19 | 2017-12-26 | Knopp Biosciences Llc | Compositions and methods of using (R)-pramipexole |
US10179774B2 (en) | 2007-03-14 | 2019-01-15 | Knopp Biosciences Llc | Synthesis of chirally purified substituted benzothiazole diamines |
US10383857B2 (en) | 2013-07-12 | 2019-08-20 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101712049B1 (en) * | 2010-11-17 | 2017-03-03 | 엘지이노텍 주식회사 | Light emitting device |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000044353A1 (en) * | 1999-01-29 | 2000-08-03 | Losan Pharma Gmbh | Pharmaceutical compositions |
WO2003053402A1 (en) * | 2001-12-20 | 2003-07-03 | Pharmacia Corporation | Zero-order sustained released dosage forms and method of making the same |
WO2004100857A2 (en) * | 2003-05-07 | 2004-11-25 | Akina, Inc. | Highly plastic granules for making fast melting tablets |
WO2006015942A1 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
WO2006015943A2 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
WO2007070843A2 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for oral administration |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0998933A1 (en) * | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Process for producing pharmaceutical compositions containing diphosphonates for oral administration |
JP4446177B2 (en) * | 2005-01-21 | 2010-04-07 | 東和薬品株式会社 | Method for producing moisture-resistant orally disintegrating tablets |
-
2007
- 2007-08-22 CA CA002661616A patent/CA2661616A1/en not_active Abandoned
- 2007-08-22 BR BRPI0715835-1A patent/BRPI0715835A2/en not_active IP Right Cessation
- 2007-08-22 EP EP07788511A patent/EP2056795A2/en not_active Withdrawn
- 2007-08-22 AU AU2007287560A patent/AU2007287560A1/en not_active Abandoned
- 2007-08-22 MX MX2009001884A patent/MX2009001884A/en not_active Application Discontinuation
- 2007-08-22 RU RU2009110253/15A patent/RU2009110253A/en not_active Application Discontinuation
- 2007-08-22 KR KR1020097006052A patent/KR20090045943A/en not_active Application Discontinuation
- 2007-08-22 JP JP2009525064A patent/JP2010501525A/en active Pending
- 2007-08-22 WO PCT/EP2007/058696 patent/WO2008023027A2/en active Application Filing
- 2007-08-23 CL CL200702477A patent/CL2007002477A1/en unknown
- 2007-08-23 TW TW096131278A patent/TW200816998A/en unknown
- 2007-08-24 AR ARP070103757A patent/AR062509A1/en unknown
-
2009
- 2009-02-19 IL IL197130A patent/IL197130A0/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000044353A1 (en) * | 1999-01-29 | 2000-08-03 | Losan Pharma Gmbh | Pharmaceutical compositions |
WO2003053402A1 (en) * | 2001-12-20 | 2003-07-03 | Pharmacia Corporation | Zero-order sustained released dosage forms and method of making the same |
WO2004100857A2 (en) * | 2003-05-07 | 2004-11-25 | Akina, Inc. | Highly plastic granules for making fast melting tablets |
WO2006015942A1 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
WO2006015943A2 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
WO2007070843A2 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for oral administration |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
US8017598B2 (en) | 2006-05-16 | 2011-09-13 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(−) pramipexole and methods of using the same |
US8445474B2 (en) | 2006-05-16 | 2013-05-21 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(−) pramipexole and methods of using the same |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US10179774B2 (en) | 2007-03-14 | 2019-01-15 | Knopp Biosciences Llc | Synthesis of chirally purified substituted benzothiazole diamines |
WO2008122638A3 (en) * | 2007-04-10 | 2008-12-04 | Boehringer Ingelheim Int | Process for preparing pramipexole dihydrochloride tablets |
WO2008122638A2 (en) * | 2007-04-10 | 2008-10-16 | Boehringer Ingelheim International Gmbh | Process for preparing pramipexole dihydrochloride tablets |
US9849116B2 (en) | 2008-08-19 | 2017-12-26 | Knopp Biosciences Llc | Compositions and methods of using (R)-pramipexole |
EP2295040A1 (en) | 2009-09-11 | 2011-03-16 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical compositions of pramipexole |
TR200906997A1 (en) * | 2009-09-11 | 2011-03-21 | Sanovel �La� San. Ve T�C. A. �. | Pramipexole pharmaceutical compositions. |
EP2462925A1 (en) | 2010-11-12 | 2012-06-13 | Neuraxpharm Arzneimittel GmbH | Pramipexole Dihydrochloride Granulate |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US10208003B2 (en) | 2011-12-22 | 2019-02-19 | Knopp Biosciences Llc | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9956206B2 (en) | 2013-02-28 | 2018-05-01 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US10285981B2 (en) | 2013-02-28 | 2019-05-14 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
US10980783B2 (en) | 2013-07-12 | 2021-04-20 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
US11026928B2 (en) | 2013-07-12 | 2021-06-08 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
US10828284B2 (en) | 2013-07-12 | 2020-11-10 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
US11612589B2 (en) | 2013-07-12 | 2023-03-28 | Areteia Therapeutics, Inc. | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
US10383857B2 (en) | 2013-07-12 | 2019-08-20 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
US10383856B2 (en) | 2013-07-12 | 2019-08-20 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
US10195183B2 (en) | 2013-08-13 | 2019-02-05 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
US10456381B2 (en) | 2013-08-13 | 2019-10-29 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
US10028940B2 (en) | 2013-08-13 | 2018-07-24 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
US9642840B2 (en) | 2013-08-13 | 2017-05-09 | Knopp Biosciences, Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
Also Published As
Publication number | Publication date |
---|---|
WO2008023027A3 (en) | 2008-04-17 |
TW200816998A (en) | 2008-04-16 |
EP2056795A2 (en) | 2009-05-13 |
BRPI0715835A2 (en) | 2013-07-23 |
RU2009110253A (en) | 2010-09-27 |
MX2009001884A (en) | 2009-03-06 |
CL2007002477A1 (en) | 2008-04-18 |
JP2010501525A (en) | 2010-01-21 |
AR062509A1 (en) | 2008-11-12 |
AU2007287560A1 (en) | 2008-02-28 |
KR20090045943A (en) | 2009-05-08 |
IL197130A0 (en) | 2009-11-18 |
CA2661616A1 (en) | 2008-02-28 |
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