WO2008023333A3 - Process for the preparation of 4-(isobutylamino)-3-amino-quinoline - Google Patents
Process for the preparation of 4-(isobutylamino)-3-amino-quinoline Download PDFInfo
- Publication number
- WO2008023333A3 WO2008023333A3 PCT/IB2007/053334 IB2007053334W WO2008023333A3 WO 2008023333 A3 WO2008023333 A3 WO 2008023333A3 IB 2007053334 W IB2007053334 W IB 2007053334W WO 2008023333 A3 WO2008023333 A3 WO 2008023333A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- isobutylamino
- quinoline
- amino
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
Abstract
The invention relates to a process for the preparation of 4-isobutylamino-3- aminoquinoline. This compound is a useful pharmaceutical intermediate for the preparation of 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-4-amine - a compound known generically as imiquimod, an immune response modifier.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1886DE2006 | 2006-08-22 | ||
IN1886/DEL/2006 | 2006-08-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008023333A2 WO2008023333A2 (en) | 2008-02-28 |
WO2008023333A3 true WO2008023333A3 (en) | 2008-05-15 |
Family
ID=38962695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/053334 WO2008023333A2 (en) | 2006-08-22 | 2007-08-21 | Process for the preparation of 4-(isobutylamino)-3-amino-quinoline |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008023333A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4689338A (en) * | 1983-11-18 | 1987-08-25 | Riker Laboratories, Inc. | 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use |
US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
US20030055087A1 (en) * | 1998-03-26 | 2003-03-20 | Japan Tobacco Inc. | Amide derivatives and nociceptin antagonists |
-
2007
- 2007-08-21 WO PCT/IB2007/053334 patent/WO2008023333A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4689338A (en) * | 1983-11-18 | 1987-08-25 | Riker Laboratories, Inc. | 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use |
US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
US20030055087A1 (en) * | 1998-03-26 | 2003-03-20 | Japan Tobacco Inc. | Amide derivatives and nociceptin antagonists |
Non-Patent Citations (3)
Title |
---|
JOHN F. GERSTER ET AL: "Synthesis and Structure - Activity - Relationships of 1H-Imidazo[4,5-c]quinolines that Induce Interferon Production", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 3481 - 3491, XP002450996 * |
RICHARD C. LAROCK: "Comprehensive Organic Transformations", 1999, WILEY-VCH, XP002469288 * |
S. VANGAPANDU ET AL: "Ring-substituted quinolines as potential anti-tuberculosis agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 2501 - 2508, XP002469287 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008023333A2 (en) | 2008-02-28 |
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