WO2008023333A3 - Process for the preparation of 4-(isobutylamino)-3-amino-quinoline - Google Patents

Process for the preparation of 4-(isobutylamino)-3-amino-quinoline Download PDF

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Publication number
WO2008023333A3
WO2008023333A3 PCT/IB2007/053334 IB2007053334W WO2008023333A3 WO 2008023333 A3 WO2008023333 A3 WO 2008023333A3 IB 2007053334 W IB2007053334 W IB 2007053334W WO 2008023333 A3 WO2008023333 A3 WO 2008023333A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
isobutylamino
quinoline
amino
compound
Prior art date
Application number
PCT/IB2007/053334
Other languages
French (fr)
Other versions
WO2008023333A2 (en
Inventor
Suresh Babu Jayachandra
Jigar Bhaskarbhai Shah
Sailu Chiguru
Chandra Has Khanduri
Original Assignee
Ranbaxy Lab Ltd
Suresh Babu Jayachandra
Jigar Bhaskarbhai Shah
Sailu Chiguru
Chandra Has Khanduri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Suresh Babu Jayachandra, Jigar Bhaskarbhai Shah, Sailu Chiguru, Chandra Has Khanduri filed Critical Ranbaxy Lab Ltd
Publication of WO2008023333A2 publication Critical patent/WO2008023333A2/en
Publication of WO2008023333A3 publication Critical patent/WO2008023333A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4

Abstract

The invention relates to a process for the preparation of 4-isobutylamino-3- aminoquinoline. This compound is a useful pharmaceutical intermediate for the preparation of 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-4-amine - a compound known generically as imiquimod, an immune response modifier.
PCT/IB2007/053334 2006-08-22 2007-08-21 Process for the preparation of 4-(isobutylamino)-3-amino-quinoline WO2008023333A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1886DE2006 2006-08-22
IN1886/DEL/2006 2006-08-22

Publications (2)

Publication Number Publication Date
WO2008023333A2 WO2008023333A2 (en) 2008-02-28
WO2008023333A3 true WO2008023333A3 (en) 2008-05-15

Family

ID=38962695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/053334 WO2008023333A2 (en) 2006-08-22 2007-08-21 Process for the preparation of 4-(isobutylamino)-3-amino-quinoline

Country Status (1)

Country Link
WO (1) WO2008023333A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689338A (en) * 1983-11-18 1987-08-25 Riker Laboratories, Inc. 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US20030055087A1 (en) * 1998-03-26 2003-03-20 Japan Tobacco Inc. Amide derivatives and nociceptin antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689338A (en) * 1983-11-18 1987-08-25 Riker Laboratories, Inc. 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US20030055087A1 (en) * 1998-03-26 2003-03-20 Japan Tobacco Inc. Amide derivatives and nociceptin antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOHN F. GERSTER ET AL: "Synthesis and Structure - Activity - Relationships of 1H-Imidazo[4,5-c]quinolines that Induce Interferon Production", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 3481 - 3491, XP002450996 *
RICHARD C. LAROCK: "Comprehensive Organic Transformations", 1999, WILEY-VCH, XP002469288 *
S. VANGAPANDU ET AL: "Ring-substituted quinolines as potential anti-tuberculosis agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 2501 - 2508, XP002469287 *

Also Published As

Publication number Publication date
WO2008023333A2 (en) 2008-02-28

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