WO2008035349A1 - Device and method for crossing a vascular occlusion - Google Patents
Device and method for crossing a vascular occlusion Download PDFInfo
- Publication number
- WO2008035349A1 WO2008035349A1 PCT/IL2007/001167 IL2007001167W WO2008035349A1 WO 2008035349 A1 WO2008035349 A1 WO 2008035349A1 IL 2007001167 W IL2007001167 W IL 2007001167W WO 2008035349 A1 WO2008035349 A1 WO 2008035349A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- catheter
- distal end
- guidewire
- occlusion
- lumen
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
- A61B2017/00539—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated hydraulically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
- A61B2017/22042—Details of the tip of the guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
- A61B2017/22042—Details of the tip of the guide wire
- A61B2017/22044—Details of the tip of the guide wire with a pointed tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22067—Blocking; Occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22094—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for crossing total occlusions, i.e. piercing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
Abstract
A method and system for crossing a vascular occlusion having an occlusion proximal end and an occlusion distal end, situated within a blood vessel having a blood vessel wall, the system comprising a catheter having a catheter proximal and a catheter distal end, the catheter comprising an injection lumen extending between the catheter proximal end and the catheter distal end, and an anchoring means disposed between the proximal and distal ends of the catheter for anchoring the catheter to the blood vessel wall; an injector adapted for being connected to the catheter, at least for injecting a liquid through the lumen to a space adjacent to, and surrounding, the distal end of the catheter; the catheter being free of any means for removal of the liquid from the space, allowing thereby to create a hydraulic chamber between the catheter distal end and the occlusion proximal end with the liquid therein having an elevated pressure sufficient to create a pathway between the occlusion proximal end and the occlusion distal end; and a guidewire adapted for being inserted through the catheter and being pushed through the pathway.
Description
DEVICE AND METHOD FOR CROSSING A VASCULAR OCCLUSION
FIELD OF THE INVENTION
This invention relates to medical devices for the treatment of vascular occlusions. More particularly the present invention relates to a device and method for crossing a vascular occlusion.
BACKGROUND OF THE INVENTION
Vascular occlusion is arterial vessel blockage that prevents blood flow though the arterial vessel. The occlusion my be partial or total and may be found at a great variety of sites in the arterial system including aorta, coronary and peripheral arteries.
The treatment of vascular occlusion may involve interventional methods, such as catheter-based methods. The purpose of such methods is re-canalization of the occluded vessel by first generating an initial small pathway through the occlusion (crossing the occlusion), and subsequently expanding it to a diameter essentially close to the original diameter of the vessel prior to its becoming occluded.
Interventional treatment typically involves introducing a guidewire through the occlusion using fluoroscopic means and delivering a balloon catheter over the guidewire to perform balloon angioplasty at the site of the occlusion. The guidewire may also pass through the subintimal space between the layers of the blood vessel, and not directly through the occlusion.
There are interventional devices known in the art for crossing vascular occlusions. US 2004/0230219 and US 2005/0021002 disclose examples of blunt dissection techniques. US 2005/0119676 discloses an ultrasonic probe transmitting ultrasonic vibrations for ablation of chronic total occlusions. US 2002/0143358 describes a method and apparatus for micro-dissection of vascular occlusions by two or more expansion members that rotate radially, stretching the tissue walls, thereby causing the occlusions to tear. US 2004/0230219 describes balloon anchoring and centering catheter with a hydraulic guidewire having increased pushability through the occlusion.
SUMMARY OF THE INVENTION
According to one aspect of the present invention, there is provided a system for crossing a vascular occlusion having an occlusion proximal end and an occlusion distal end, situated within a blood vessel having a blood vessel wall, the system comprising: a catheter having a catheter proximal and a catheter distal end, the catheter comprising an injection lumen extending between said catheter proximal end and said catheter distal end, and an anchoring means disposed between the proximal and distal ends of said catheter for anchoring the catheter to said blood vessel wall; an injector adapted for being connected to said catheter, at least for injecting a liquid through said lumen to a space adjacent to, and surrounding, said distal end of the catheter; said catheter being free of any means for removal of said liquid from said space, allowing thereby to create a hydraulic chamber between said catheter distal end and said occlusion proximal end with said liquid therein having an elevated pressure sufficient to create a pathway between the occlusion proximal end and the occlusion distal end; and a guidewire adapted for being inserted through said catheter and pushed through said pathway.
Any one or more of the following features may be included in the device described above:
• The guidewire may be adapted for being inserted through said injection lumen.
• The catheter may further comprise a guidewire lumen extending between a guidewire lumen inlet and said catheter distal end, for the insertion of said guidewire therethrough. • The catheter may further comprise a pressure lumen extending between a pressure lumen inlet and said catheter distal end, for measuring said elevated pressure.
• The catheter may further comprise a sealing means for preventing a backward flow of said liquid. • The anchoring means may be in a form of a cap adapted for being inflated by the elevated pressure within the hydraulic chamber.
• The anchoring means may be in a form of a balloon.
• The catheter may further comprise a balloon lumen, extending between a balloon lumen inlet and said balloon, for passing therethrough inflation fluid for the inflation of said balloon. When inflated, the balloon is adapted to have a balloon pressure of said inflation fluid therein, which is not less than said elevated pressure
• The elevated pressure may be between about 200 rnmHg and about 5000 mmHg.
• The injector may be adapted to inject said liquid in different ways and to create in said hydraulic chamber different kinds of said elevated pressure. For example, injector may be adapted to create in said hydraulic chamber a static pressure or a dynamic pulsatile pressure.
• The guidewire may comprise a tip at a guidewire distal end, having a tip surface oriented transversely to a longitudinal axis of the injection lumen.
According to another aspect of the present invention, there is provided a method for crossing a vascular occlusion having an occlusion proximal end and an occlusion distal end, situated within a blood vessel having a blood vessel wall, the method comprises: providing a catheter having a catheter proximal and a catheter distal end, the catheter comprising an injection lumen extending between said catheter proximal end and said catheter distal end, and an anchoring means disposed between the proximal and distal ends of said catheter for anchoring the catheter to said blood vessel wall; anchoring the catheter to said blood vessel wall by said anchoring means; injecting a liquid through said lumen so as to create a hydraulic chamber between said catheter distal end and said occlusion proximal end with said liquid therein having an elevated pressure sufficient to create a pathway between the occlusion proximal end and the occlusion distal end;
- providing a guidewire and inserting thereof through said catheter; and
- pushing said guidewire though said pathway.
The pathway is created due to a stretching of the blood vessel caused by the elevated pressure created within the hydraulic chamber. The occlusion at least partially tears, causing thereby the creation of the pathway. The pathaway may be created within the occlusion or outside the occlusion in a subintimal space of the vessel wall.
BRIEF DESCRIPTION OF THE DRAWINGS
In order to understand the invention and to see how it may be carried out in practice, embodiments will now be described, by way of non-limiting example only, with reference to the accompanying drawings, in which: Fig. 1 is schematic illustration of a system according to one embodiment of the present invention;
Fig. 2 is schematic illustration of a system according to another embodiment of the present invention;
Fig. 3 A is a cross-sectional view of the catheter shown in Fig. 3 B along the line Y-Y;
Fig. 3B is a cross-sectional view of the catheter shown in Fig. 3 A along the line X-X;
Figs. 4A to 4C are schematic illustrations of different embodiments of a guidewire which may be used in a system shown in Figs. 1 and 2; Fig. 5 is schematic illustration of another embodiment of the catheter according to the present invention used together with an injector; and
Fig. 6 is schematic illustration of a method of use of the system shown in Fig. 1.
DETAILED DESCRIPTION OF EMBODIMENTS
Figs. 1 and 2 schematically illustrate a system 10 for crossing a vascular occlusion 12 having an occlusion proximal end 12a and an occlusion distal end 12b. The occlusion 12 is disposed within a blood vessel B having a blood vessel wall 14.
The system 10 comprises a catheter 11, a guidewire 13 and an anchoring means in a form of a balloon 15 (Fig. 1) or in a form of a cap 25 (Fig. 2), which will be described in more detail below. With reference to Figs. 3A and 3B, the catheter 11 comprises a catheter proximal end 1 Ia, a catheter distal end 1 Ib (shown in Figs. 1, 2 and 6) and a plurality of lumens 30, 32, 34 and 36, each having its own inlet and outlet and extending between different locations in the catheter 11. hi particular, the catheter 11 comprises a guidewire lumen 30 having a longitudinal axis A and having an inlet 31a at the center of the proximal end 11a of the catheter and an outlet 31b (not shown) at the center of the distal end 1 Ib of the catheter, an injection lumen 32 having a side inlet (not shown) and a pressure lumen 34 having a pressure side inlet 34a (shown in Fig. 5), all extending
between their inlets and the catheter distal end 1 Ib, and a balloon lumen 36, extending between a baloon side inlet 33 and an inlet of the balloon 15 (not shown).
The lumens of catheter 11 are not limited to the configuration described above. For example, the injection lumen 32 may have a central inlet 32a and the guidewire lumen 30 may have a side inlet 30a, as shown in Fig. 5. Furthermore, the catheter may have three lumens instead of four, i.e. the guidewire lumen, the pressure lumen and the balloon lumen. In the absence of the injection lumen, the guidewire lumen may have one inlet, through which the guidewire is inserted and the liquid is injected, and two outlets - one for the guidewire and another one for the liquid. The catheter 11 may include sealing means 37 (Fig. 3A), such as for example an
O-ring, for sealing the guidewire lumen 30 around the guidewire, allowing the guidewire axial (forward & backwards) movement, and at the same time preventing backward flow of the liquid through the catheter 11.
The catheter 11 may be made of polymers such as PVC, polyurethane or nylon and it may have a diameter of about 2 (0.6 mm) to about 6 Fr. (2mm).
The catheter 11 further comprises an anchoring means which may be of any appropriate type. In particular, in the presented examples, the anchoring means are in the form of an inflatable member such as a balloon 15 (Figs. 1 and 6), or an umbrella- like cap 25 (Fig. 2), which in the inflated state conforms the contour of the vessel wall 14, anchoring the catheter in place. In the latter case, the cap is open towards the catheter proximal end 11a.
The balloon 15 and the cap 25 may be made of polymers such as polyurethane, silicon, PET or other materials allowing desired flexibility of these anchoring means.
Figs. 4A to 4C illustrate different embodiments of the guidewire 13. The guidewire 13 comprises a main guidewire body 41, having a guidewire proximal end 41a, a guidewire distal end 41b and a tip 43, 45, 47 on its distal end 41b. The tip may be of a ball shape 43, a half-ball shape 45, arrow head shape 47 or any other shape having a tip surface S, oriented transversely to the longitudinal axis A of the guidewire lumen 30. The guidewire 13 may also be any standard commercial guidewire.
With reference to Fig. 5, the system 10 further comprises an injector 50 with a syringe 51, situated within a servo system 56 and pre-filled with the liquid to be injected, having a piston 53 and a pressure transducer 55, which is electrically
connected to the injector 50 and hydraulically connected to the pressure side inlet 34a of the catheter 11. The servo system 56 comprises a motor (not shown) for pushing the piston 53.
As shown in Fig. 5, the injector 50 is connected to the inlet 32a of the injection lumen 32. However, the injector 50 may also be connected to the guidewire lumen 30, in the catheter configuration shown in Figs. 3A and 3B.
In operation, the catheter 11 is first inserted into the blood vessel B, as shown in Figs. 1 and 2, with the balloon 15 in its deflated state. When the catheter 11 is brought with its distal end lib disposed adjacent to the proximal end 12a of the occlusion 12, the balloon 15 is inflated to anchor the catheter to the vessel wall 14. The inflation is performed by injecting an inflation fluid into the balloon lumen 36 until a pressure within the balloon 15 reaches a predetermined pressure Pβ.
Once the catheter 11 is anchored to the vessel wall 14, the liquid is injected through the injection lumen 32 of the catheter 11 by the injector 50, thereby creating a hydraulic chamber 60 (shown in Figs. 1,2 and 6) between the catheter distal end l ib and the occlusion proximal end 12a.
As the liquid is injected, a pressure P within the chamber 60 is raised until it causes the occlusion 12 to tear, thereby creating of a pathway 61 within the occlusion 60, as shown in Fig. 6. The pathway 61 may also be created between the occlusion 12 and the vessel wall 14 or within a subintimal space (not shown) in the vessel wall 14. The pressure P is constantly measured by the pressure transducer 55. The pressure lumen 34, to which the transducer 55 is connected as previously explained, is completely filled with the liquid that also fills the injection lumen and has the same pressure P as the pressure in the hydraulic chamber 60. The measurement of the pressure P is performed in a closed loop. Therefore, in case of a leak of the liquid from the hydraulic chamber 60, the injector 50 will inject more liquid until the desired pressure P is achieved.
The pressure P cannot exceed the balloon pressure PB, i.e. P ≤PB, otherwise the balloon 15 may loose its sealing effect and the liquid from the hydraulic chamber will leak to the arterial system. The pressure P may be between about 200mmHg and 5000mmHg.
When the sufficient pressure P within the hydraulic chamber 60 is achieved and the pathway 61 is created, the guidewire 13 is inserted through the guidewire lumen 30,
with the guidewire distal end 41b directed towards the occlusion 12. It is pushed through the catheter 11 and then navigated to pass through the previously created pathway 61, from the occlusion proximal end 12a to the occlusion distal end 12b. The tip of the guidewire 43, 45, 47 facilitates the introduction of the guidewire 13, since the pressure P within the chamber 60 is applied on the surface S of the tip 43, 45, 47, thereby increasing the pushing force.
The method described above may be performed in the same way with the system shown in Fig. 2, where the anchoring means is in the form of the umbrella-like cap 25 (Fig. 2). However, in this case no special means are needed to inflate the cap since the inflation may be performed by the liquid filling the hydraulic chamber 60 as explained above. The liquid applies pressure on the interior surface of the cap 25, and thereby causes its inflation.
Those skilled in the art to which this invention pertains will readily appreciate that numerous changes, variations, and modifications can be made without departing from the scope of the invention, mutatis mutandis.
Claims
1. A system for crossing a vascular occlusion having an occlusion proximal end and an occlusion distal end, situated within a blood vessel having a blood vessel wall, the system comprising a catheter having a catheter proximal and a catheter distal end, the catheter comprising an injection lumen extending between said catheter proximal end and said catheter distal end, and an anchoring means disposed between the proximal and distal ends of said catheter for anchoring the catheter to said blood vessel wall; an injector adapted for being connected to said catheter, at least for injecting a liquid through said lumen to a space adjacent to, and surrounding, said distal end of the catheter; said catheter being free of any means for removal of said liquid from said space, allowing thereby to create a hydraulic chamber between said catheter distal end and said occlusion proximal end with said liquid therein having an elevated pressure sufficient to create a pathway between the occlusion proximal end and the occlusion distal end; and a guidewire adapted for being inserted through said catheter and being pushed through said pathway.
2. A system according to Claim 1, wherein the guidewire is adapted for being inserted through said injection lumen.
3. A system according to Claim 1, wherein the catheter further comprises a guidewire lumen extending between a guidewire lumen inlet and said catheter distal end, for the insertion of said guidewire therethrough.
4. A system according to Claim 1, wherein said catheter further comprises a pressure lumen extending between a pressure lumen inlet and said catheter distal end, for measuring said elevated pressure.
5. A system according to Claim 1, wherein the catheter further comprises a sealing means for preventing a backward flow of said liquid.
6. A system according to Claim 1, wherein the anchoring means is in a form of a cap adapted for being inflated by the elevated pressure within the hydraulic chamber.
7. A system according to Claim 1, wherein the anchoring means is in a form of a balloon.
8. A system according to Claim 7, wherein the catheter comprises a balloon lumen, extending between a balloon lumen inlet and said balloon, for passing therethrough inflation fluid for the inflation of said balloon.
9. A system according to Claim 7, wherein said balloon when inflated is adapted to have a balloon pressure therein which is not less than said elevated pressure.
10. A system according to Claim 1, wherein said elevated the pressure is between about 200 mmHg and about 5000 mniHg.
11. A system according to Claim 1, wherein said injector is adapted to create in said hydraulic chamber said elevated pressure in the form selected from a group consisting of a static pressure or a dynamic pulsatile pressure.
12. A system according to Claim 1, wherein the guidewire comprises a tip at a guidewire distal end, having a tip surface oriented transversely to a longitudinal axis of the injection lumen.
13. A method for crossing a vascular occlusion having an occlusion proximal end and an occlusion distal end, situated within a blood vessel having a blood vessel wall, the method comprises:
- providing a catheter having a catheter proximal and a catheter distal end, the catheter comprising an injection lumen extending between said catheter proximal end and said catheter distal end, and an anchoring means disposed between the proximal and distal ends of said catheter for anchoring the catheter to said blood vessel wall;
- anchoring the catheter to said blood vessel wall by said anchoring means; - injecting a liquid through said lumen so as to create a hydraulic chamber between said catheter distal end and said occlusion proximal end with said liquid therein having an elevated pressure sufficient to create a pathway between the occlusion proximal end and the occlusion distal end;
- providing a guidewire and inserting thereof through said catheter; and - pushing said guidewire though said pathway.
14. A method according to Claim 13, further comprising inserting the guidewire through said injection lumen.
15. A method according to Claim 13, further comprising inserting the guidewire through a guidewire lumen within the catheter, said guidewire lumen extending between a guidewire lumen inlet and said catheter distal end.
16. A method according to Claim 13, further comprising measuring said elevated pressure using a pressure lumen within the catheter, said pressure lumen extending between a pressure lumen inlet and said catheter distal end.
17. A method according to Claim 13, further comprising preventing a backward flow of said liquid by a sealing means of the catheter.
18. A method according to Claim 13, wherein the anchoring means is in a form of a cap adapted inflated by the elevated pressure within the hydraulic chamber.
19. A method according to Claim 13, wherein the anchoring means is in a form of a balloon.
20. A method according to Claim 19, wherein said balloon is inflated by an inflation fluid passing through a balloon lumen within the catheter, said balloon lumen extending between a balloon lumen inlet and said balloon.
21. A method according to Claim 19, wherein said balloon when inflated has a balloon pressure therein which is not less than said elevated pressure.
22. A method according to Claim 13, wherein said elevated the pressure is between about 200 mmHg and about 5000 mmHg.
23. A method according to Claim 13, wherein said injector creates in said hydraulic chamber said elevated pressure in the form selected from a group consisting of a static pressure or a dynamic pulsatile pressure.
24. A method according to Claim 13, wherein the pathway is created within occlusion.
25. A method according to Claim 13, wherein the pathway is created within the vessel wall.
26. A method according to Claim 13, wherein the guidewire comprises a tip at a guidewire distal end, having a tip surface oriented transversely to a longitudinal axis of the injection lumen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84596106P | 2006-09-21 | 2006-09-21 | |
| US60/845,961 | 2006-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2008035349A1 true WO2008035349A1 (en) | 2008-03-27 |
Family
ID=38955193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IL2007/001167 WO2008035349A1 (en) | 2006-09-21 | 2007-09-23 | Device and method for crossing a vascular occlusion |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2008035349A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2359764A1 (en) | 2010-02-24 | 2011-08-24 | Safepass Vascular Ltd | Probe with electrodes for disrupting an occlusion |
| US9162038B2 (en) | 2011-04-11 | 2015-10-20 | The Spectranetics Corporation | Needle and guidewire holder |
| US9168049B2 (en) | 2002-03-12 | 2015-10-27 | Vladimir Chemenko | Method for intracorporeal lithotripsy fragmentation and apparatus for its implementation |
| US9283039B2 (en) | 2006-04-04 | 2016-03-15 | The Spectranetics Corporation | Laser-assisted guidewire having a variable stiffness shaft |
| US9498237B2 (en) | 2010-02-24 | 2016-11-22 | Lithotech Medical Ltd | Method and system for destroying of undesirable formations in mammalian body |
| US11083870B2 (en) | 2011-04-11 | 2021-08-10 | The Spectranetics Corporation | Hypotube based support catheter |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059178A (en) * | 1988-08-03 | 1991-10-22 | Ya Wang D | Method of percutaneously removing a thrombus from a blood vessel by using catheters and system for removing a thrombus from a blood vessel by using catheters |
| US20020044907A1 (en) * | 1999-08-27 | 2002-04-18 | Brent R. Constantz | Catheter systems and methods for their use in the treatment of calcified vascular occlusions |
| US20040054347A1 (en) * | 1999-03-16 | 2004-03-18 | Gholam-Reza Zadno-Azizi | Method for containing and removing occlusions in the carotid arteries |
| US20060041228A1 (en) * | 1998-05-13 | 2006-02-23 | Vo Hung V | Catheter having a funnel-shaped occlusion balloon of uniform thickness and methods of manufacture |
-
2007
- 2007-09-23 WO PCT/IL2007/001167 patent/WO2008035349A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059178A (en) * | 1988-08-03 | 1991-10-22 | Ya Wang D | Method of percutaneously removing a thrombus from a blood vessel by using catheters and system for removing a thrombus from a blood vessel by using catheters |
| US20060041228A1 (en) * | 1998-05-13 | 2006-02-23 | Vo Hung V | Catheter having a funnel-shaped occlusion balloon of uniform thickness and methods of manufacture |
| US20040054347A1 (en) * | 1999-03-16 | 2004-03-18 | Gholam-Reza Zadno-Azizi | Method for containing and removing occlusions in the carotid arteries |
| US20020044907A1 (en) * | 1999-08-27 | 2002-04-18 | Brent R. Constantz | Catheter systems and methods for their use in the treatment of calcified vascular occlusions |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9168049B2 (en) | 2002-03-12 | 2015-10-27 | Vladimir Chemenko | Method for intracorporeal lithotripsy fragmentation and apparatus for its implementation |
| US9283039B2 (en) | 2006-04-04 | 2016-03-15 | The Spectranetics Corporation | Laser-assisted guidewire having a variable stiffness shaft |
| US11445892B2 (en) | 2006-04-04 | 2022-09-20 | The Spectranetics Corporation | Laser-assisted guidewire having a variable stiffness shaft |
| EP2359764A1 (en) | 2010-02-24 | 2011-08-24 | Safepass Vascular Ltd | Probe with electrodes for disrupting an occlusion |
| US9498237B2 (en) | 2010-02-24 | 2016-11-22 | Lithotech Medical Ltd | Method and system for destroying of undesirable formations in mammalian body |
| US9743980B2 (en) | 2010-02-24 | 2017-08-29 | Safepass Vascular Ltd | Method and system for assisting a wire guide to cross occluded ducts |
| US9162038B2 (en) | 2011-04-11 | 2015-10-20 | The Spectranetics Corporation | Needle and guidewire holder |
| US9668766B2 (en) | 2011-04-11 | 2017-06-06 | The Spectranetics Corporation | Needle and guidewire holder |
| US10292727B2 (en) | 2011-04-11 | 2019-05-21 | The Spectranetics Corporation | Needle and guidewire holder |
| US11083870B2 (en) | 2011-04-11 | 2021-08-10 | The Spectranetics Corporation | Hypotube based support catheter |
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