WO2008036375A3 - Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents - Google Patents
Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents Download PDFInfo
- Publication number
- WO2008036375A3 WO2008036375A3 PCT/US2007/020418 US2007020418W WO2008036375A3 WO 2008036375 A3 WO2008036375 A3 WO 2008036375A3 US 2007020418 W US2007020418 W US 2007020418W WO 2008036375 A3 WO2008036375 A3 WO 2008036375A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biologically active
- active agents
- cellular response
- impedance
- exposure
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Abstract
The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07838594A EP2064644A4 (en) | 2006-09-20 | 2007-09-20 | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84606706P | 2006-09-20 | 2006-09-20 | |
US60/846,067 | 2006-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008036375A2 WO2008036375A2 (en) | 2008-03-27 |
WO2008036375A3 true WO2008036375A3 (en) | 2008-10-16 |
Family
ID=39201101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/020418 WO2008036375A2 (en) | 2006-09-20 | 2007-09-20 | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2064644A4 (en) |
WO (1) | WO2008036375A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120015846A1 (en) * | 2010-07-16 | 2012-01-19 | Ye Fang | Label-free Cellular Pharmacology For Drug Antitarget Assessment |
GB201522323D0 (en) | 2015-12-17 | 2016-02-03 | Vrije Universiteit Brussel And Katholieke Universiteit Leuven | Systems and methods for conducting electrochemical impedance spectroscopy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051422A (en) * | 1997-05-30 | 2000-04-18 | Board Of Trustees, Leland Stanford, Jr., University | Hybrid biosensors |
WO2005077104A2 (en) * | 2004-02-09 | 2005-08-25 | Xiao Xu | Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
US20060050596A1 (en) * | 2002-12-20 | 2006-03-09 | Abassi Yama A | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6377057B1 (en) * | 1999-02-18 | 2002-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential |
DE60316044T2 (en) * | 2003-07-14 | 2008-05-15 | MDS Inc., doing business as MDS Sciex, Concord | LABEL-FREE PROCESS FOR CLASSIFYING AND CHARACTERIZING CELLULENT EVENTS |
-
2007
- 2007-09-20 WO PCT/US2007/020418 patent/WO2008036375A2/en active Application Filing
- 2007-09-20 EP EP07838594A patent/EP2064644A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051422A (en) * | 1997-05-30 | 2000-04-18 | Board Of Trustees, Leland Stanford, Jr., University | Hybrid biosensors |
US20060050596A1 (en) * | 2002-12-20 | 2006-03-09 | Abassi Yama A | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
WO2005077104A2 (en) * | 2004-02-09 | 2005-08-25 | Xiao Xu | Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
Non-Patent Citations (1)
Title |
---|
XING ET AL.: "Dynamic Monitoring of Cytotoxicity on Microelectronic Sensors", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 18, 2005, pages 154 - 161, XP008104930 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008036375A2 (en) | 2008-03-27 |
EP2064644A2 (en) | 2009-06-03 |
EP2064644A4 (en) | 2010-12-29 |
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