WO2008045015A1 - Imino and amino sugar purification - Google Patents
Imino and amino sugar purification Download PDFInfo
- Publication number
- WO2008045015A1 WO2008045015A1 PCT/US2006/022756 US2006022756W WO2008045015A1 WO 2008045015 A1 WO2008045015 A1 WO 2008045015A1 US 2006022756 W US2006022756 W US 2006022756W WO 2008045015 A1 WO2008045015 A1 WO 2008045015A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sugar
- dgj
- alkali
- imino
- purified
- Prior art date
Links
- 0 *CC(CC(*)C(*)C(*)=*)=N Chemical compound *CC(CC(*)C(*)C(*)=*)=N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0613222-7A BRPI0613222A2 (en) | 2005-06-08 | 2006-06-08 | method for purifying a nitrogen-containing raw sugar and method for purifying crude d-1-deoxygalactonojirimycin (dgj) |
JP2009514248A JP5107350B2 (en) | 2005-06-08 | 2006-06-08 | Purification of imino and amino sugars |
DK06772888.1T DK2027137T3 (en) | 2005-06-08 | 2006-06-08 | Imino and aminosugar PURIFICATION |
ES06772888.1T ES2537089T3 (en) | 2005-06-08 | 2006-06-08 | Purification of imino- and amino sugars |
EP06772888.1A EP2027137B1 (en) | 2005-06-08 | 2006-06-08 | Imino and amino sugar purification |
SI200631928T SI2027137T1 (en) | 2005-06-08 | 2006-06-08 | Imino and amino sugar purification |
PL06772888T PL2027137T3 (en) | 2005-06-08 | 2006-06-08 | Imino and amino sugar purification |
CN2006800271469A CN101277969B (en) | 2005-06-08 | 2006-06-09 | Purification of imido-sugar and amino-sugar |
IL187988A IL187988A (en) | 2005-06-08 | 2007-12-06 | Method for purification of a crude d-1-deoxygalactonojirimycin or the hcl salt thereof contaminated with an alkali- or alkaline earth metal-containing compound |
HK09103054.8A HK1125111A1 (en) | 2005-06-08 | 2009-03-31 | Imino and amino sugar purification |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68913005P | 2005-06-08 | 2005-06-08 | |
US60/689,130 | 2005-06-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008045015A1 true WO2008045015A1 (en) | 2008-04-17 |
WO2008045015A8 WO2008045015A8 (en) | 2009-11-05 |
Family
ID=41256089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/022756 WO2008045015A1 (en) | 2005-06-08 | 2006-06-08 | Imino and amino sugar purification |
Country Status (13)
Country | Link |
---|---|
US (1) | US7973157B2 (en) |
EP (1) | EP2027137B1 (en) |
JP (1) | JP5107350B2 (en) |
CN (1) | CN101277969B (en) |
BR (1) | BRPI0613222A2 (en) |
DK (1) | DK2027137T3 (en) |
ES (1) | ES2537089T3 (en) |
HK (1) | HK1125111A1 (en) |
IL (1) | IL187988A (en) |
PL (1) | PL2027137T3 (en) |
PT (1) | PT2027137E (en) |
SI (1) | SI2027137T1 (en) |
WO (1) | WO2008045015A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015121488A1 (en) * | 2014-02-17 | 2015-08-20 | Glaxosmithkline Intellectual Property Development Limited | Microbiological process |
IT201700078102A1 (en) * | 2017-07-11 | 2019-01-11 | Dipharma Francis Srl | SYNTHESIS OF AN AZAZUCCHERO AND ITS INTERMEDIATES |
US10792278B2 (en) | 2017-05-30 | 2020-10-06 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10813921B2 (en) | 2008-02-12 | 2020-10-27 | Amicus Therapeutics, Inc. | Method to predict response to pharmacological chaperone treatment of diseases |
US11241422B2 (en) | 2006-05-16 | 2022-02-08 | Amicus Therapeutics, Inc. | Methods for treatment of Fabry disease |
WO2022132992A1 (en) * | 2020-12-16 | 2022-06-23 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds |
US11623916B2 (en) | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
US11833164B2 (en) | 2019-08-07 | 2023-12-05 | Amicus Therapeutics, Inc. | Methods of treating Fabry disease in patients having a mutation in the GLA gene |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103626809B (en) * | 2013-12-10 | 2016-01-20 | 安徽丰原发酵技术工程研究有限公司 | A kind of purification process of glucosamine hydrochloride mother liquid |
US11357784B2 (en) | 2018-02-06 | 2022-06-14 | Amicus Therapeutics, Inc. | Use of migalastat for treating Fabry disease in pregnant patients |
CN112500441A (en) * | 2020-12-20 | 2021-03-16 | 上海彩迩文生化科技有限公司 | Preparation process of high-purity glycosyl phosphate |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4634765A (en) | 1984-12-18 | 1987-01-06 | Merrell Dow Pharmaceuticals Inc. | Homodisaccharide hypoglycemic agents |
US4957926A (en) | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
US5200523A (en) * | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
US5250545A (en) | 1988-02-12 | 1993-10-05 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitor methods |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2801261A (en) * | 1954-05-28 | 1957-07-30 | Du Pont | Alkyl esters of substituted thiocyanooctanoic acids |
NO154918C (en) | 1977-08-27 | 1987-01-14 | Bayer Ag | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE DERIVATIVES OF 3,4,5-TRIHYDROXYPIPERIDINE. |
US5192772A (en) | 1987-12-09 | 1993-03-09 | Nippon Shinyaku Co. Ltd. | Therapeutic agents |
EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
US5003072A (en) | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
US5144037A (en) | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
US5043273A (en) | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
KR910007655A (en) | 1989-10-03 | 1991-05-30 | 엠. 피. 잭슨 | Therapeutic Nucleosides |
DE3936295A1 (en) | 1989-11-01 | 1991-05-02 | Bayer Ag | METHOD FOR PRODUCING INTERMEDIATE PRODUCTS AND SYNTHESISING N- (2-HYDROXYETHYL) -2-HYDROXYMETHYL-3,4,5-TRIHYDROXYPIPERIDINE |
IT1236902B (en) * | 1989-12-20 | 1993-04-26 | COMMAND DEVICE FOR PISTON NEEDLES IN CROCHET MACHINES | |
US5273981A (en) | 1990-10-18 | 1993-12-28 | Monsanto Company | Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins |
US5248779A (en) | 1991-06-17 | 1993-09-28 | Monsanto Company | Synthesis of nojirimycin derivatives |
US5206251A (en) | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
US5258518A (en) | 1992-04-01 | 1993-11-02 | G. D. Searle & Co. | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
US5268482A (en) | 1992-04-01 | 1993-12-07 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
JP2921544B2 (en) * | 1993-07-30 | 1999-07-19 | 三菱瓦斯化学株式会社 | Purification method of monoalkenylbenzenes |
AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
US5451679A (en) | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
FR2764304B1 (en) | 1997-06-06 | 1999-07-16 | Rhone Poulenc Rorer Sa | NEW CLASS OF CATIONIC NUCLEIC ACID TRANSFECTANTS |
ID27290A (en) | 1998-02-12 | 2001-03-22 | Searle & Co | USE OF 1,5-DIDEOKSI-1,5-IMINO-D-GLUSITOL-N-SUBSTITUTED N-COMPOUND IN TREATMENT OF HEPATITIC VIRUS INFECTION |
JP2003506406A (en) | 1999-08-10 | 2003-02-18 | ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード | Long-chain N-alkyl compounds and oxa derivatives thereof |
WO2001036435A1 (en) | 1999-11-16 | 2001-05-25 | Industrial Research Limited | Glucofuranoses |
WO2001074776A1 (en) | 2000-03-31 | 2001-10-11 | Michigan State University | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines |
JP2002087808A (en) * | 2000-09-14 | 2002-03-27 | Showa Denko Kk | Adsorbent for purifying perfluorocarbon, manufacturing method thereof, high purity octafluorocyclobutane, method of purifying and manufacturing the same and utilization thereof |
NZ520108A (en) * | 2002-07-10 | 2004-09-24 | Ind Res Ltd | Process for preparing kifunensine (cyclic oxamide derivative of 1-amino-mannojirimycin) intermediate and kifunensine therefrom |
-
2006
- 2006-06-08 JP JP2009514248A patent/JP5107350B2/en not_active Expired - Fee Related
- 2006-06-08 US US11/450,978 patent/US7973157B2/en not_active Expired - Fee Related
- 2006-06-08 PL PL06772888T patent/PL2027137T3/en unknown
- 2006-06-08 WO PCT/US2006/022756 patent/WO2008045015A1/en active Application Filing
- 2006-06-08 BR BRPI0613222-7A patent/BRPI0613222A2/en not_active Application Discontinuation
- 2006-06-08 PT PT67728881T patent/PT2027137E/en unknown
- 2006-06-08 EP EP06772888.1A patent/EP2027137B1/en active Active
- 2006-06-08 ES ES06772888.1T patent/ES2537089T3/en active Active
- 2006-06-08 DK DK06772888.1T patent/DK2027137T3/en active
- 2006-06-08 SI SI200631928T patent/SI2027137T1/en unknown
- 2006-06-09 CN CN2006800271469A patent/CN101277969B/en not_active Expired - Fee Related
-
2007
- 2007-12-06 IL IL187988A patent/IL187988A/en active Protection Beyond IP Right Term
-
2009
- 2009-03-31 HK HK09103054.8A patent/HK1125111A1/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4634765A (en) | 1984-12-18 | 1987-01-06 | Merrell Dow Pharmaceuticals Inc. | Homodisaccharide hypoglycemic agents |
US5250545A (en) | 1988-02-12 | 1993-10-05 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitor methods |
US4957926A (en) | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
US5200523A (en) * | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
Non-Patent Citations (24)
Title |
---|
AMAT ET AL.: "Enantioselective synthesis of 1-deoxy-D-gluonojirimycin from a phenylglycinol derived lactam", TETRAHEDRON LETTERS, vol. 45, 2004, pages 5355 - 5358, XP004518878 * |
AOYAGI ET AL., J. ORG. CHEM., vol. 56, 1991, pages 815 |
BARILI ET AL., TETRAHEDRON, 1997, pages 3407 |
BEMOTAS RC ET AL., CARBOHYDR. RES., vol. 167, 15 September 1987 (1987-09-15), pages 305 - 11 |
CHERONIS: "Purification of solids by crystallization", SEMIMICRO EXPERIMENTAL ORGANIC CHEMISTRY, 1958, pages 31 - 49, XP008135710 * |
CHIDA ET AL., J. CHEM. SOC., CHEM COMMUN., 1994, pages 1247 |
CHIDA N ET AL., CARBOHYDR. RES., vol. 237, 31 December 1992 (1992-12-31), pages 185 - 94 |
FAN ET AL., NAT. MED, vol. 5, no. 1, 1999, pages 112 - 5 |
HEIGHTMAN ET AL., HELV. CHIM. ACTA, vol. 78, 1995, pages 514 |
HUGHES AB ET AL., NAT PROD REP., vol. 11, no. 2, April 1994 (1994-04-01), pages 135 - 62 |
JOHNSON ET AL., TETRAHEDRON LETT., vol. 36, 1995, pages 653 |
KIBAYASHI ET AL., J. ORG. CHEM., 1987, pages 3337 - 3342 |
KISO, BIOORG MED CHEM., vol. 2, no. 11, November 1994 (1994-11-01), pages 1295 - 308 |
LEGLER G ET AL., CARBOHYDR. RES., vol. 155, 1 November 1986 (1986-11-01), pages 119 - 29 |
LINDEN ET AL.: "1-Deoxynojirimycin hydrochloride", ACTA CRYSTALLOGRAPHICA, vol. C50, 1994, pages 746 - 749, XP009130663 * |
MARIANO, J. ORG. CHEM., 1998, pages 841 - 859 |
MARTIN R ET AL., ORG LETT., vol. 2, no. 1, January 2000 (2000-01-01), pages 93 - 5 |
PAULSEN ET AL., CHEM. BER., vol. 113, 1980, pages 2601 |
See also references of EP2027137A4 |
SHILVOCK ET AL., SYNLETT, 1998, pages 554 |
SYNTHESIS, 1998, pages 1787 - 1792 |
TAKAHASHI ET AL., J. CARBOHYDR. CHEM., vol. 17, 1998, pages 117 |
TAKAHATA ET AL., ORG. LETT., vol. 5, no. 14, 2003, pages 2527 - 2529 |
URIEL, C.; SANTOYO-GONZALEZ, F. ET AL., SYNLETT, 1999, pages 593 - 595 |
Cited By (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11241422B2 (en) | 2006-05-16 | 2022-02-08 | Amicus Therapeutics, Inc. | Methods for treatment of Fabry disease |
US10813921B2 (en) | 2008-02-12 | 2020-10-27 | Amicus Therapeutics, Inc. | Method to predict response to pharmacological chaperone treatment of diseases |
USRE48608E1 (en) | 2008-02-12 | 2021-06-29 | Amicus Therapeutics, Inc. | Method to predict response to pharmacological chaperone treatment of diseases |
US10077458B2 (en) | 2014-02-17 | 2018-09-18 | Glaxosmithkline Intellectual Property Development Limited | Microbiological process |
WO2015121488A1 (en) * | 2014-02-17 | 2015-08-20 | Glaxosmithkline Intellectual Property Development Limited | Microbiological process |
US11304940B2 (en) | 2017-05-30 | 2022-04-19 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10792279B2 (en) | 2017-05-30 | 2020-10-06 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10806727B2 (en) | 2017-05-30 | 2020-10-20 | Amicus Therapeutics, Inc. | Methods of treating fabry patients having renal impairment |
US11357761B2 (en) | 2017-05-30 | 2022-06-14 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10849889B2 (en) | 2017-05-30 | 2020-12-01 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10849890B2 (en) | 2017-05-30 | 2020-12-01 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10857141B2 (en) | 2017-05-30 | 2020-12-08 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10857142B2 (en) | 2017-05-30 | 2020-12-08 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10874655B2 (en) | 2017-05-30 | 2020-12-29 | Amicus Therapeutics, Inc. | Methods of treating fabry patients having renal impairment |
US10874656B2 (en) | 2017-05-30 | 2020-12-29 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11357762B2 (en) | 2017-05-30 | 2022-06-14 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10792278B2 (en) | 2017-05-30 | 2020-10-06 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11357765B1 (en) | 2017-05-30 | 2022-06-14 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11903938B2 (en) | 2017-05-30 | 2024-02-20 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11278538B2 (en) | 2017-05-30 | 2022-03-22 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11278539B2 (en) | 2017-05-30 | 2022-03-22 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11278537B2 (en) | 2017-05-30 | 2022-03-22 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11278536B2 (en) | 2017-05-30 | 2022-03-22 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11278540B2 (en) | 2017-05-30 | 2022-03-22 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11826360B2 (en) | 2017-05-30 | 2023-11-28 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10874657B2 (en) | 2017-05-30 | 2020-12-29 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US10799491B2 (en) | 2017-05-30 | 2020-10-13 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11813255B2 (en) | 2017-05-30 | 2023-11-14 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11357764B1 (en) | 2017-05-30 | 2022-06-14 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11357763B2 (en) | 2017-05-30 | 2022-06-14 | Amicus Therapeutics, Inc. | Methods of treating fabry patients having renal impairment |
US11786516B2 (en) | 2017-05-30 | 2023-10-17 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11376244B2 (en) | 2017-05-30 | 2022-07-05 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11389436B2 (en) | 2017-05-30 | 2022-07-19 | Amicus Therapeutics, Inc. | Methods of treating fabry patients having renal impairment |
US11389437B2 (en) | 2017-05-30 | 2022-07-19 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11426396B2 (en) | 2017-05-30 | 2022-08-30 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11458128B2 (en) | 2017-05-30 | 2022-10-04 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11612594B2 (en) | 2017-05-30 | 2023-03-28 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11612593B2 (en) | 2017-05-30 | 2023-03-28 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11666564B2 (en) | 2017-05-30 | 2023-06-06 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11622962B2 (en) | 2017-05-30 | 2023-04-11 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11633387B2 (en) | 2017-05-30 | 2023-04-25 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11633388B2 (en) | 2017-05-30 | 2023-04-25 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11642334B2 (en) | 2017-05-30 | 2023-05-09 | Amicus Therapeutics, Inc. | Methods of treating Fabry patients having renal impairment |
US11180454B2 (en) * | 2017-07-11 | 2021-11-23 | Dipharma Sa | Synthesis of an azasugar and intermediates thereof |
IT201700078102A1 (en) * | 2017-07-11 | 2019-01-11 | Dipharma Francis Srl | SYNTHESIS OF AN AZAZUCCHERO AND ITS INTERMEDIATES |
WO2019020362A1 (en) * | 2017-07-11 | 2019-01-31 | Dipharma Francis S.R.L. | Synthesis of an azasugar and intermediates thereof |
US11833164B2 (en) | 2019-08-07 | 2023-12-05 | Amicus Therapeutics, Inc. | Methods of treating Fabry disease in patients having a mutation in the GLA gene |
US11623916B2 (en) | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
WO2022132992A1 (en) * | 2020-12-16 | 2022-06-23 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds |
Also Published As
Publication number | Publication date |
---|---|
US7973157B2 (en) | 2011-07-05 |
JP5107350B2 (en) | 2012-12-26 |
EP2027137A1 (en) | 2009-02-25 |
PT2027137E (en) | 2015-06-09 |
ES2537089T3 (en) | 2015-06-02 |
DK2027137T3 (en) | 2015-05-18 |
PL2027137T3 (en) | 2015-08-31 |
CN101277969B (en) | 2012-12-19 |
IL187988A0 (en) | 2009-02-11 |
SI2027137T1 (en) | 2015-06-30 |
IL187988A (en) | 2014-11-30 |
WO2008045015A8 (en) | 2009-11-05 |
BRPI0613222A2 (en) | 2010-12-28 |
EP2027137B1 (en) | 2015-02-18 |
CN101277969A (en) | 2008-10-01 |
EP2027137A4 (en) | 2010-04-14 |
HK1125111A1 (en) | 2009-07-31 |
US20060293515A1 (en) | 2006-12-28 |
JP2009539834A (en) | 2009-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7973157B2 (en) | Imino and amino sugar purification | |
JP2009539834A6 (en) | Purification of imino and amino sugars | |
KR20100017879A (en) | New method for preparing isofagomine and its derivatives | |
US9079856B2 (en) | Synthesis of a glycosyltransferase inhibitor | |
US7626016B2 (en) | Process for preparing sucrose-6-ester | |
EP2818476A1 (en) | Method for preparing 3-o-benzyl-1,2-o-isopropylidene- -l-furan idose | |
US20060293508A1 (en) | Stabilization of triflated compounds | |
Limberg et al. | Deoxyiminoalditols from Aldonic Acids VI. Preparation of the Four Stereoisomeric 4-Amino-3-hydroxypyrrolidines from Bromodeoxytetronic Acids. Discovery of a New α-Mannosidase Inhibitor | |
US20060293250A1 (en) | Crystalline sugar compositions and method of making | |
ITMI20130083A1 (en) | IMMINOZUCCHERO IN CRISTALLINA SHAPE | |
Spreitz et al. | Golgi endomannosidase inhibitor, α-d-glucopyranosyl-(1→ 3)-1-deoxymannojirimycin: a five-step synthesis from maltulose and examples of N-modified derivatives | |
Ágoston et al. | Synthesis of lactosamine from lactulose: scalable approach for the Heyns rearrangement | |
US11912647B2 (en) | Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation | |
Huang et al. | 19 Phenyl | |
Laventine | Hetero-annulation of Carbohydrates | |
Andreassen et al. | A new chemical synthesis of Ascopyrone P from 1, 5-anhydro-d-fructose | |
WO2023178017A1 (en) | Deacylation of carbohydrate compounds | |
JP5155577B2 (en) | Preparation of benzylated fructofuranose derivatives and benzylated aldose derivatives by acid hydrolysis of perbenzylated sucrose oligosaccharides | |
Wang et al. | A Novel Method for Synthesizing Aldonophenylhydrazono-lactones | |
Rao et al. | 11 Selective Anomeric S-Deacetylation Using Aqueous Sodium Methanethiolate | |
Turský et al. | Synthesis of a New Type of d-Mannosamine Glycosyl Donor and Acceptor and their Use for the Preparation of Oligosaccharides Consisting of d-Mannosamine Units Linked by α (1→ 4)-Glycosidic Bonds | |
JACOBSEN et al. | Dioxolanylium Ions Derived from Carbohydrates. VIII. Nucleophilic trans-Opening with Sulfur-and Nitrogen-containing Neighbouring Groups | |
WO2014096331A1 (en) | Method for making n-substituted mannosamine derivatives | |
WO2014128660A1 (en) | Synthesis of deoxyamino sugars | |
EP1397376A1 (en) | Method for producing perbenzylated 1-o-glycosides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200680027146.9 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 187988 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009514248 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 9806/DELNP/2007 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006772888 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 06772888 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
ENP | Entry into the national phase |
Ref document number: PI0613222 Country of ref document: BR Kind code of ref document: A2 Effective date: 20071207 |