WO2008045410A3 - Alcohol free formulation of argatroban - Google Patents

Alcohol free formulation of argatroban Download PDF

Info

Publication number
WO2008045410A3
WO2008045410A3 PCT/US2007/021533 US2007021533W WO2008045410A3 WO 2008045410 A3 WO2008045410 A3 WO 2008045410A3 US 2007021533 W US2007021533 W US 2007021533W WO 2008045410 A3 WO2008045410 A3 WO 2008045410A3
Authority
WO
WIPO (PCT)
Prior art keywords
argatroban
alcohol free
free formulation
free
totally
Prior art date
Application number
PCT/US2007/021533
Other languages
French (fr)
Other versions
WO2008045410A2 (en
Inventor
Nageswara R Palepu
Original Assignee
Scidose Llc
Nageswara R Palepu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/904,067 external-priority patent/US7589106B2/en
Application filed by Scidose Llc, Nageswara R Palepu filed Critical Scidose Llc
Priority to US12/442,975 priority Critical patent/US20100076019A1/en
Publication of WO2008045410A2 publication Critical patent/WO2008045410A2/en
Publication of WO2008045410A3 publication Critical patent/WO2008045410A3/en
Priority to US13/618,532 priority patent/US20130023559A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

An aqueous formulation of argatroban and of related compounds is disclosed along with a reconstitutable formulation, each of which is substantially, if not totally alcohol free. The formulations are also substantially free, if not totally free, of mono-, di-, and oligo- saccharides. An especially preferred embodiment is a ready-to-use 1 mg/ml injectable dosage form having argatroban, lactobionic acid, and methionine.
PCT/US2007/021533 2006-09-27 2007-10-09 Alcohol free formulation of argatroban WO2008045410A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/442,975 US20100076019A1 (en) 2006-10-11 2007-10-09 Alcohol free formulation of argatroban
US13/618,532 US20130023559A1 (en) 2006-09-27 2012-09-14 Alcohol free formulation of argatroban

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US85072506P 2006-10-11 2006-10-11
US60/850,725 2006-10-11
US11/904,067 2007-09-26
USPCT/US07/20725 2007-09-26
US11/904,067 US7589106B2 (en) 2006-09-27 2007-09-26 Alcohol free formulation of argatroban
PCT/US2007/020725 WO2008039473A2 (en) 2006-09-27 2007-09-26 Alcohol free formulation of argatroban

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020725 Continuation-In-Part WO2008039473A2 (en) 2006-09-27 2007-09-26 Alcohol free formulation of argatroban

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/618,532 Continuation US20130023559A1 (en) 2006-09-27 2012-09-14 Alcohol free formulation of argatroban

Publications (2)

Publication Number Publication Date
WO2008045410A2 WO2008045410A2 (en) 2008-04-17
WO2008045410A3 true WO2008045410A3 (en) 2008-06-12

Family

ID=39283418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021533 WO2008045410A2 (en) 2006-09-27 2007-10-09 Alcohol free formulation of argatroban

Country Status (1)

Country Link
WO (1) WO2008045410A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2598148A4 (en) * 2010-07-28 2014-05-28 Eagle Pharmaceuticals Inc Pharmaceutical compositions containing pemetrexed having extended storage stability
US20170239250A1 (en) 2016-02-19 2017-08-24 Eagle Pharmaceuticals, Inc. Pemetrexed formulations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232315B1 (en) * 1998-09-28 2001-05-15 Merck & Co., Inc. Method for treating inflammatory diseases by administering a thrombin inhibitor
WO2004026252A2 (en) * 2002-09-23 2004-04-01 The Regents Of The University Of Michigan Glioma treatments
US20040242585A1 (en) * 2003-05-20 2004-12-02 Rawson Thomas E. Acylsulfamide inhibitors of factor VIIa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232315B1 (en) * 1998-09-28 2001-05-15 Merck & Co., Inc. Method for treating inflammatory diseases by administering a thrombin inhibitor
WO2004026252A2 (en) * 2002-09-23 2004-04-01 The Regents Of The University Of Michigan Glioma treatments
US20040242585A1 (en) * 2003-05-20 2004-12-02 Rawson Thomas E. Acylsulfamide inhibitors of factor VIIa

Also Published As

Publication number Publication date
WO2008045410A2 (en) 2008-04-17

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