WO2008057253A3 - Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles - Google Patents
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles Download PDFInfo
- Publication number
- WO2008057253A3 WO2008057253A3 PCT/US2007/022649 US2007022649W WO2008057253A3 WO 2008057253 A3 WO2008057253 A3 WO 2008057253A3 US 2007022649 W US2007022649 W US 2007022649W WO 2008057253 A3 WO2008057253 A3 WO 2008057253A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diindolylmethane
- related indoles
- parasitic
- methods
- compositions utilizing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0717753-4A BRPI0717753B1 (en) | 2006-10-27 | 2007-10-26 | Use of a composition comprising 50-250 mg of one or more dim-related indoles and one or more anti-protozoal agents, and, composition |
US12/447,307 US8586621B2 (en) | 2006-10-27 | 2007-10-26 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
US14/051,248 US9353058B2 (en) | 2006-10-27 | 2013-10-10 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
US14/975,118 US9663462B2 (en) | 2006-10-27 | 2015-12-18 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85483006P | 2006-10-27 | 2006-10-27 | |
US60/854,830 | 2006-10-27 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/447,307 A-371-Of-International US8586621B2 (en) | 2006-10-27 | 2007-10-26 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
US14/051,248 Division US9353058B2 (en) | 2006-10-27 | 2013-10-10 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008057253A2 WO2008057253A2 (en) | 2008-05-15 |
WO2008057253A3 true WO2008057253A3 (en) | 2008-11-27 |
Family
ID=39364993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/022649 WO2008057253A2 (en) | 2006-10-27 | 2007-10-26 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
Country Status (5)
Country | Link |
---|---|
US (3) | US8586621B2 (en) |
BR (1) | BRPI0717753B1 (en) |
CO (1) | CO6190514A2 (en) |
EC (1) | ECSP099364A (en) |
WO (1) | WO2008057253A2 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008057253A2 (en) | 2006-10-27 | 2008-05-15 | Bioresponse, L.L.C. | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
CN101623255B (en) * | 2008-07-08 | 2010-12-29 | 中国农业科学院兰州畜牧与兽药研究所 | Artesunate nanoemulsion drug composition and preparation method thereof |
JP5477731B2 (en) * | 2008-07-10 | 2014-04-23 | 日本ゼトック株式会社 | Melanin inhibitor, whitening agent, collagenase inhibitor, skin preparation, oral composition and food |
EP2326327B1 (en) | 2008-09-17 | 2016-03-23 | SRI International | Analogs of indole-3-carbinol and their use as agents against infection |
TWI384995B (en) * | 2008-12-05 | 2013-02-11 | Univ Taipei Medical | Type i topoisomerase inhibitor |
FR2958118B1 (en) * | 2010-04-01 | 2012-06-15 | Pancosma Sa Pour L Ind Des Produits Biochimiques | USE OF AT LEAST ONE DIALKYL THIOSULFINATE OR THIOSULFONATE FOR REDUCING THE NUMBER OF APICOMPLEXES IN A MONOGASTRIC ANIMAL |
CN102552458A (en) * | 2010-12-16 | 2012-07-11 | 天津中敖生物科技有限公司 | Chinese medicine composition for treating chicken coccidiosis and preparation method thereof |
ES2388963B1 (en) * | 2011-03-24 | 2013-09-13 | Univ Navarra | DEVELOPMENT AND USE OF LIPID NANOPARTICLES CONTAINING EDELPHOSINE AND OTHER ETHERS OF PHOSPHOLIPIDS IN ANTITUMORAL AND ANTIPARASITARY THERAPY |
GB201105050D0 (en) * | 2011-03-25 | 2011-05-11 | Iiaa Ltd | Pharmaceutical agent |
EP2561868A1 (en) * | 2011-08-24 | 2013-02-27 | Anton Bernhard Van Oosten | Pharmaceutical compositions comprising hydroxychloroquine (HCQ), Curcumin, Piperine/BioPerine and uses thereof in the medical field |
GB2533381A (en) * | 2014-12-18 | 2016-06-22 | Nordic Labs Ltd | Novel treatment of STIs |
FR3034095A1 (en) * | 2015-03-26 | 2016-09-30 | Agronomique Inst Nat Rech | PREVENTING AND / OR TREATING PARASITOSES INDUCED BY PARASITES BELONGING TO THE PHYLUM OF APICOMPLEXES |
GB2542106A (en) * | 2015-04-01 | 2017-03-15 | Nordic Labs Ltd | Novel treatment of STIs |
AU2016245984B2 (en) | 2015-04-10 | 2021-03-25 | Bioresponse, L.L.C. | Self-emulsifying formulations of DIM-related indoles |
CN105311007B (en) * | 2015-11-12 | 2017-10-10 | 广东省农业科学院动物卫生研究所 | Application of the naganol in anticoccidial drugs thing is prepared |
US20200179337A1 (en) * | 2016-05-16 | 2020-06-11 | Aktsionernoe Obschestvo "Veles Farma" | Means for treating sexually transmitted infections |
CN106309459A (en) * | 2016-08-18 | 2017-01-11 | 天承南运(天津)科技有限公司 | Application of paromomycin sulfate in preparation of neutrophil inhibitor |
CN110446505A (en) * | 2017-01-20 | 2019-11-12 | 皮肤科技生命科学有限公司 | For treating dermopathic conjoint therapy |
CN110496121A (en) * | 2019-08-23 | 2019-11-26 | 西南大学 | Dihydroqinghaosu resists the application in leishmanial drug in preparation |
WO2023215819A2 (en) * | 2022-05-06 | 2023-11-09 | Whitehead Institute For Biomedical Research | Antiparasitic agents and methods |
WO2024073473A1 (en) | 2022-09-30 | 2024-04-04 | Boulder Bioscience Llc | Compositions comprising 3,3'-diindolylmethane for treating non-hemorrhagic closed head injury |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060100264A1 (en) * | 2004-11-06 | 2006-05-11 | Bjeldanes Leonard F | 3,3'-Diindolylmethane immune activating compositions |
WO2006053160A2 (en) * | 2004-11-12 | 2006-05-18 | Celgene Corporation | Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5718921A (en) * | 1987-03-13 | 1998-02-17 | Massachusetts Institute Of Technology | Microspheres comprising polymer and drug dispersed there within |
FR2676927B1 (en) * | 1991-05-29 | 1995-06-23 | Ibf | MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM. |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
AU683838B2 (en) * | 1992-05-19 | 1997-11-27 | Novogen Research Pty Ltd | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
WO1996030347A1 (en) | 1995-03-30 | 1996-10-03 | Pfizer Inc. | Quinazoline derivatives |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
CZ1598A3 (en) | 1995-07-06 | 1998-04-15 | Novartis Ag | Pyrrolopyrimidines and process for preparing thereof |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
CN100503580C (en) | 1996-04-12 | 2009-06-24 | 沃尼尔·朗伯公司 | Irreversible inhibitor of tyrosine kinase |
US5948808A (en) * | 1997-03-07 | 1999-09-07 | The Texas A&M University System | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens |
AU6564798A (en) * | 1997-03-18 | 1998-10-12 | Brigham And Women's Hospital | Methods and kits for treating and diagnosing leiomyomas |
US6150395A (en) * | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
US5895787A (en) * | 1997-10-08 | 1999-04-20 | Designed Nutritional Products, Inc. | Treatment of fibromyalgia and related disorders |
US6086915A (en) * | 1998-04-01 | 2000-07-11 | Bioresponse L.L.C. | Compositions and methods of adjusting steroid hormone metabolism through phytochemicals |
BR9910025A (en) | 1998-04-29 | 2000-12-26 | Pfizer Prod Inc | N- (3-Ethinylphenylamino) -6,7-bis (2-methoxyethoxy) -4-quinazo linamine dehydrated and monohydrated mesylate |
DE69920455T2 (en) | 1998-07-08 | 2005-01-20 | Harbor Branch Oceanographic Institution Inc., Fort Pierce | BIS-INDOLEDERIVATE AND ITS USE AS AN INFLAMMATORY AGENT |
GEP20032997B (en) | 1998-11-19 | 2003-06-25 | Warner Lambert Co | N-[4-(3-Chloro-4-Fluoro-Phenylamino)-7-(3-Morpholin-4-Yl-Propoxy)-Quinazolin-6-Yl]-crylamide, as an Irreversible Inhibitor of Tyrosine Kinases |
US6875584B1 (en) * | 1999-03-02 | 2005-04-05 | University Of Georgia Research Foundation, Inc. | Prophylactic and therapeutic immunization against protozoan infection and disease |
US6613792B1 (en) * | 1999-08-02 | 2003-09-02 | Designed Nutritional Products, Inc. | Treatment of premenstrual syndrome and menopause |
US7384971B2 (en) * | 1999-09-23 | 2008-06-10 | Bioresponse L.L.C. | Phytochemicals for the treatment of cervical dysplasia |
US6534085B1 (en) * | 1999-09-23 | 2003-03-18 | Bioresponse L.L.C. | Phytochemicals for promoting weight loss |
US6689387B1 (en) * | 1999-09-23 | 2004-02-10 | Bioresponse Llc | Phytochemicals for treatment of mastalgia and endometriosis |
JP4871476B2 (en) * | 2000-03-13 | 2012-02-08 | バイオコンパティブルズ ユーケー リミテッド | Embolization composition |
US6399645B1 (en) * | 2000-03-20 | 2002-06-04 | Maria Bell | Chemoprevention and treatment of cervical or vaginal neoplasia |
WO2001072281A2 (en) * | 2000-03-24 | 2001-10-04 | Biosphere Medical Inc. | Microspheres for active embolization |
US6477229B1 (en) * | 2000-05-12 | 2002-11-05 | Siemens Medical Solutions Usa, Inc. | Radiation therapy planning |
US7709520B2 (en) * | 2000-10-06 | 2010-05-04 | The Texas A&M University System | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers |
US20020147155A1 (en) * | 2001-04-06 | 2002-10-10 | Foster Warren G. | Prevention and treatment of endometriosis with aryl hydrocarbon receptor binding ligands |
ATE354355T1 (en) * | 2001-04-27 | 2007-03-15 | Ajinomoto Kk | A DISPERSION OF HIGHLY FINE PARTICLES CONTAINING BETA-GLUCAN, A CORRESPONDING PRODUCTION PROCESS AND THE USE OF THE DISPERSION |
US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
US7348352B2 (en) * | 2001-10-23 | 2008-03-25 | Bioresponse L.L.C. | Diindolylmethane for the treatment of HPV infection |
CA2480128A1 (en) * | 2002-03-26 | 2003-10-09 | Immunex Corporation | Methods of using flt3-ligand in immunization protocols |
US20030220377A1 (en) * | 2002-05-08 | 2003-11-27 | Richard Chesworth | Indole compounds and their use as estrogen agonists/antagonists |
US6800655B2 (en) * | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
US9668972B2 (en) * | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
WO2004071425A2 (en) | 2003-02-06 | 2004-08-26 | Bioresponse, Llc | The combined use of cruciferous indoles and chelators for the treatment of papillomavirus-related conditions |
WO2005003160A1 (en) * | 2003-07-01 | 2005-01-13 | Vib Vzw | Actin mutants |
CA2565721C (en) | 2004-05-06 | 2015-10-06 | Bioresponse, L.L.C. | Diindolymethane formulations for the treatment of leiomyomas |
US20060111423A1 (en) | 2004-10-26 | 2006-05-25 | Zeligs Michael A | Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus-associated disease |
WO2006083458A2 (en) * | 2004-12-30 | 2006-08-10 | Bioresponse Llc | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions |
US20060229355A1 (en) * | 2005-04-08 | 2006-10-12 | The Regents Of The University Of California | 3.3'-Diindolylmethane compositions inhibit angiogenesis |
WO2008057253A2 (en) | 2006-10-27 | 2008-05-15 | Bioresponse, L.L.C. | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles |
-
2007
- 2007-10-26 WO PCT/US2007/022649 patent/WO2008057253A2/en active Application Filing
- 2007-10-26 US US12/447,307 patent/US8586621B2/en active Active
- 2007-10-26 BR BRPI0717753-4A patent/BRPI0717753B1/en active IP Right Grant
-
2009
- 2009-05-27 EC EC2009009364A patent/ECSP099364A/en unknown
- 2009-05-27 CO CO09054148A patent/CO6190514A2/en not_active Application Discontinuation
-
2013
- 2013-10-10 US US14/051,248 patent/US9353058B2/en active Active
-
2015
- 2015-12-18 US US14/975,118 patent/US9663462B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060100264A1 (en) * | 2004-11-06 | 2006-05-11 | Bjeldanes Leonard F | 3,3'-Diindolylmethane immune activating compositions |
WO2006053160A2 (en) * | 2004-11-12 | 2006-05-18 | Celgene Corporation | Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases |
Also Published As
Publication number | Publication date |
---|---|
US20160101083A1 (en) | 2016-04-14 |
US9663462B2 (en) | 2017-05-30 |
ECSP099364A (en) | 2009-07-31 |
BRPI0717753B1 (en) | 2022-04-12 |
US9353058B2 (en) | 2016-05-31 |
US8586621B2 (en) | 2013-11-19 |
US20100055201A1 (en) | 2010-03-04 |
CO6190514A2 (en) | 2010-08-19 |
BRPI0717753A2 (en) | 2013-10-22 |
US20140037577A1 (en) | 2014-02-06 |
WO2008057253A2 (en) | 2008-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008057253A3 (en) | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles | |
WO2010042163A3 (en) | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and sirt1, and methods of treating disorders | |
EA200901032A1 (en) | COMPOUNDS AND COMPOSITIONS AS GPR119 ACTIVITY MODULATORS | |
MX2009007944A (en) | Compounds and compositions as kinase inhibitors. | |
MY186986A (en) | Compositions and methods of use of phorbol esters | |
WO2008033562A3 (en) | Kinase inhibitor compounds | |
MA32393B1 (en) | Compounds and compounds that act as kinase inhibitors | |
EA201391720A1 (en) | SUBSTITUTED DIOXOPIPERIDINYL-PHTHALIMIDE DERIVATIVES | |
TN2010000122A1 (en) | Compounds and compositions as modulators of gpr119 activity | |
PL2134704T3 (en) | Compounds and compositions as modulators of gpr119 activity | |
MY157860A (en) | Prevention and treatment of secondary infections following viral infection | |
MX2020004099A (en) | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same. | |
WO2015070224A3 (en) | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers | |
GEP20135925B (en) | Inhibitors of hedgehog pathway | |
EA201290191A1 (en) | N1-PYRAZOLOSPIROKETONE INHIBITORS ACETYL-KoA-CARBOXYLASE | |
EA200700909A1 (en) | AZAINDOLKARBOXAMIDES | |
EA201170834A1 (en) | CONNECTIONS SUITABLE FOR INHIBITING CHK1 | |
EA201170963A1 (en) | POLY INHIBITORS (ADP-Ribose) POLYMERASE (PARP) | |
EA201001847A1 (en) | COMPOUNDS AND COMPOSITIONS APPLICABLE FOR THE TREATMENT OF MALARIA | |
WO2007092065A3 (en) | Compounds and compositions as lxr modulators | |
EA201100138A1 (en) | 4-PHENOXYMETHYL-PIPERIDINES AS MODEL ACTIVITY GPR119 | |
EA201071231A1 (en) | CARBOXAMIDE CONNECTIONS FOR THE TREATMENT OF METABOLIC DEVICES | |
EA201400358A1 (en) | SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL] -2-AZABICYCLO [2.2.1] HEPTAN-3-CARBOXAMIDE INHIBITORS KATEPSIN C | |
WO2007095050A3 (en) | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase | |
EA201390353A1 (en) | DERIVATIVE PYRAZOLOHINOLINA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07839788 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12447307 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2804/CHENP/2009 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09054148 Country of ref document: CO |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07839788 Country of ref document: EP Kind code of ref document: A2 |
|
ENP | Entry into the national phase |
Ref document number: PI0717753 Country of ref document: BR Kind code of ref document: A2 Effective date: 20090427 |