WO2008057267A3 - Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations - Google Patents

Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations Download PDF

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Publication number
WO2008057267A3
WO2008057267A3 PCT/US2007/022685 US2007022685W WO2008057267A3 WO 2008057267 A3 WO2008057267 A3 WO 2008057267A3 US 2007022685 W US2007022685 W US 2007022685W WO 2008057267 A3 WO2008057267 A3 WO 2008057267A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugar alcohol
microcrystalline cellulose
excipient
tablet formulations
processed microcrystalline
Prior art date
Application number
PCT/US2007/022685
Other languages
French (fr)
Other versions
WO2008057267A2 (en
Inventor
Jian-Xin Li
Brian Carlin
Thomas Ruszkay
Original Assignee
Fmc Corp
Jian-Xin Li
Brian Carlin
Thomas Ruszkay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp, Jian-Xin Li, Brian Carlin, Thomas Ruszkay filed Critical Fmc Corp
Priority to CN200780039612.XA priority Critical patent/CN101528201B/en
Priority to JP2009534667A priority patent/JP5410290B2/en
Priority to EP07852968A priority patent/EP2076250B1/en
Priority to AT07852968T priority patent/ATE493972T1/en
Priority to DE602007011792T priority patent/DE602007011792D1/en
Publication of WO2008057267A2 publication Critical patent/WO2008057267A2/en
Publication of WO2008057267A3 publication Critical patent/WO2008057267A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.
PCT/US2007/022685 2006-10-27 2007-10-26 Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations WO2008057267A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN200780039612.XA CN101528201B (en) 2006-10-27 2007-10-26 As microcrystalline Cellulose and the sugar alcohol of the coprocessing of tablet formulations excipient
JP2009534667A JP5410290B2 (en) 2006-10-27 2007-10-26 CO-PROCESSED COMPOSITION AND PROCESS FOR PRODUCING THE SAME, TABLETABLE TABLET COMPOSITION
EP07852968A EP2076250B1 (en) 2006-10-27 2007-10-26 Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
AT07852968T ATE493972T1 (en) 2006-10-27 2007-10-26 JOINTLY PROCESSED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN EXCIPIENT FOR TABLET FORMULATIONS
DE602007011792T DE602007011792D1 (en) 2006-10-27 2007-10-26 COMMONLY PREPARED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN AUXILIARY FOR TABLET FORMULATIONS

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US85510606P 2006-10-27 2006-10-27
US85506606P 2006-10-27 2006-10-27
US60/855,106 2006-10-27
US60/855,066 2006-10-27
US92816607P 2007-05-08 2007-05-08
US60/928,166 2007-05-08

Publications (2)

Publication Number Publication Date
WO2008057267A2 WO2008057267A2 (en) 2008-05-15
WO2008057267A3 true WO2008057267A3 (en) 2008-07-24

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/022684 WO2008057266A2 (en) 2006-10-27 2007-10-26 Dry granulation binders, products, and use thereof
PCT/US2007/022685 WO2008057267A2 (en) 2006-10-27 2007-10-26 Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/022684 WO2008057266A2 (en) 2006-10-27 2007-10-26 Dry granulation binders, products, and use thereof

Country Status (7)

Country Link
US (3) US7998505B2 (en)
EP (2) EP2076250B1 (en)
JP (2) JP5410290B2 (en)
AT (1) ATE493972T1 (en)
DE (1) DE602007011792D1 (en)
TW (2) TW200824721A (en)
WO (2) WO2008057266A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
DE602007011792D1 (en) * 2006-10-27 2011-02-17 Fmc Corp COMMONLY PREPARED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN AUXILIARY FOR TABLET FORMULATIONS
EP2100595A1 (en) * 2008-03-10 2009-09-16 The Procter and Gamble Company Compressed tablets
JP2010024156A (en) * 2008-07-16 2010-02-04 Ucb Pharma Sa Pharmaceutical composition comprising levetiracetam
EP2168573A1 (en) * 2008-09-30 2010-03-31 LEK Pharmaceuticals D.D. Formulations comprising ezetimibe
BRPI0921507A2 (en) * 2008-11-19 2016-01-19 Avantor Performance Mat Inc composition, method of preparation of an excipient, pharmaceutical tablet and method of preparation thereof
US9144625B2 (en) 2008-11-27 2015-09-29 Speciality Fibres And Materials Ltd. Cellulose ethylsulfonate-based absorbent material
US9221963B2 (en) 2008-11-27 2015-12-29 Speciality Fibres And Materials Ltd. Absorbent material
ES2467105T5 (en) * 2008-12-08 2017-12-05 Ratiopharm Gmbh Compacted moxifloxacin
EP2198857A1 (en) 2008-12-19 2010-06-23 Ratiopharm GmbH Oral dispersible tablet
TW201129386A (en) * 2009-11-05 2011-09-01 Fmc Corp Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
TWI461213B (en) * 2009-11-05 2014-11-21 Fmc Corp Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
EP2515682A4 (en) * 2009-12-22 2016-11-02 Fmc Corp Water-dispersible compositions for food applications
US8632819B2 (en) * 2009-12-22 2014-01-21 Fmc Corporation Microcrystalline cellulose and calcium carbonate compositions useful as recompactible pharmaceutical excipients
CN101822796B (en) * 2010-03-17 2012-01-04 山西仟源制药有限公司 Silver ice buccal tablet, and preparation method and application thereof
AT509515B1 (en) 2010-06-23 2012-10-15 Chemiefaser Lenzing Ag USE OF CELLULOSE IN TABLETS
CA2821799C (en) 2010-12-16 2020-01-14 Merck Patent Gmbh Dry granulated cell culture media
FR2970400B1 (en) 2011-01-19 2013-02-22 Eurotab PROCESS FOR MANUFACTURING MILK COMPACTS
CN103842425B (en) 2011-10-05 2017-05-24 Fmc有限公司 Stabilizer composition of microcrystalline cellulose and carboxymethylcellulose, method for making, and uses
ES2657648T3 (en) 2011-10-05 2018-03-06 Fmc Corporation Stabilizing composition of microcrystalline cellulose and co-reduced carboxymethylcellulose, method for making it and uses
PL2787837T3 (en) 2011-12-09 2017-09-29 Fmc Corporation Co-attrited stabilizer composition
WO2014087422A1 (en) * 2012-12-03 2014-06-12 Zim Laboratories Limited Chewable milk compositions and fortified powder formulations thereof
US10596261B2 (en) 2013-03-12 2020-03-24 Hercules Incorporated Coprocessed silica coated polymer composition
JP6104038B2 (en) * 2013-05-02 2017-03-29 旭化成株式会社 Composite composition of crystalline cellulose
CN105616418A (en) * 2014-11-07 2016-06-01 江苏豪森药业集团有限公司 Pharmaceutical preparation containing cyclin inhibitor, and preparation method thereof
US11059756B1 (en) 2015-09-29 2021-07-13 Intrepid Potash, Inc. Pelletized fertilizer and methods of preparing pelletized fertilizer
EP3528937B1 (en) 2016-10-24 2024-04-10 GERTEIS, Paul Methods and devices for controlling the dry granulation process
CN107063906B (en) * 2016-12-16 2020-01-07 中国农业科学院农产品加工研究所 Quantitative characterization method for moisture absorption and caking degree of powder
CN107960663A (en) * 2017-11-24 2018-04-27 南通励成生物工程有限公司 Carbonic acid calcium-nutrition intensifying agent and preparation method
CN112384494A (en) * 2018-07-12 2021-02-19 四川海思科制药有限公司 Composition of fused tricyclic gamma-amino acid derivative and preparation thereof
KR20200043618A (en) * 2018-10-18 2020-04-28 주식회사유한양행 Pharmaceutical composition for oral administration comprising an aminopyrimidine derivative or its salt
WO2020090970A1 (en) * 2018-10-31 2020-05-07 富士フイルム株式会社 Pharmaceutical composition containing antitumor agent
BR112022000899A2 (en) * 2019-07-19 2022-03-29 The Global Alliance For Tb Drug Dev Inc Pretomanida compositions
CN110973635B (en) * 2019-12-26 2022-07-29 汤臣倍健股份有限公司 Auxiliary material composition and probiotic tablet
TW202207940A (en) * 2020-04-14 2022-03-01 美商健生生物科技公司 Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof
CN113477179B (en) * 2021-06-08 2022-05-13 安徽农业大学 Multi-effect biomass particle forming machine
CN113893226B (en) * 2021-11-16 2023-03-17 烟台万润药业有限公司 Olmesartan medoxomil tablet and preparation method thereof
CN115607518B (en) * 2022-09-16 2024-02-06 四川制药制剂有限公司 Texazolamide phosphate tablet and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004862A2 (en) * 1998-07-20 2000-02-03 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
EP1226818A1 (en) * 2001-01-26 2002-07-31 Pfizer Products Inc. Pharmaceutical dosage forms with enhanced cohesive and compressibility properties
WO2005030177A2 (en) * 2003-09-29 2005-04-07 Cipla Limited Pharmaceutical formulation with improved stability
EP1681048A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Orally disintegrating composition of olanzapine or donepezil

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL113985C (en) 1957-01-28
US3145146A (en) 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
US3146168A (en) 1962-04-10 1964-08-25 Fmc Corp Manufacture of pharmaceutical preparations containing cellulose crystallite aggregates
GB1010477A (en) 1962-05-15 1965-11-17 Fmc Corp Method of making cellulose crystallite aggregates in particulate form and product of such method
US3573058A (en) 1967-01-30 1971-03-30 Swift & Co Microcrystalline cellulose compositions co-dried with hydrocolloids
US3539365A (en) 1967-02-13 1970-11-10 Fmc Corp Dispersing and stabilizing agent comprising beta-1,4 glucan and cmc and method for its preparation
US3639169A (en) 1969-04-29 1972-02-01 Sucrest Corp Direct compression vehicles and method therefor
CH604548A5 (en) 1975-12-22 1978-09-15 Nestle Sa
US4110476A (en) 1977-01-10 1978-08-29 Johnson/Rhodes Cultured Foods, Inc. Preparation of liquid and frozen yogurt products
US4263334A (en) 1978-05-31 1981-04-21 Fmc Corporation Water dispersible cellulosic powder and method of making the same
US4264637A (en) 1979-01-17 1981-04-28 Amiel Braverman Microcrystalline cellulose in freezable-gel-confection compositions
EP0047734A1 (en) 1980-03-10 1982-03-24 Edward Mendell Co., Inc. Pharmaceutical vehicle composition and process of producing same
FI71750C (en) 1981-09-10 1987-02-09 Daicel Chem Process for producing an alkali salt of carboxymethyl cellulose ether.
DE3506276C1 (en) * 1985-02-22 1986-04-24 Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring Direct tableting
CA1261261A (en) * 1985-03-08 1989-09-26 Dev K. Mehra Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
US4744987A (en) * 1985-03-08 1988-05-17 Fmc Corporation Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
US4980193A (en) * 1988-06-17 1990-12-25 Fmx Corporation Microcrystalline cellulose-based stabilizer system for dry mix instant chocolate drink
EP0458484A3 (en) 1989-05-26 1992-12-09 The Kendall Company Rubber-based adhesive tapes
US5084295A (en) 1990-02-02 1992-01-28 The Procter & Gamble Company Process for making low calorie fat-containing frozen dessert products having smooth, creamy, nongritty mouthfeel
US5082684A (en) 1990-02-05 1992-01-21 Pfizer Inc. Low-calorie fat substitute
CA2067595C (en) 1991-05-01 2002-07-30 Cheryl A. Doherty Use of hydrocolloids for formulating and processing of low fat water activity confectionery products and process
EP0537554B1 (en) 1991-09-30 1999-07-21 Asahi Kasei Kogyo Kabushiki Kaisha A water-dispersible complex and a process for the production thereof
CA2126441C (en) * 1991-12-30 1999-12-21 David F. Erkoboni Microcrystalline cellulose spheronization composition
US5272137A (en) 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5286510A (en) 1992-10-07 1994-02-15 Thomas J. Lipton Co., Division Of Conopco, Inc. Fat mimetic containing salad dressing and process therefor
TW272942B (en) * 1993-02-10 1996-03-21 Takeda Pharm Industry Co Ltd
US5366742A (en) * 1993-05-03 1994-11-22 Fmc Corporation Colloidal microcrystalline cellulose and barrier dispersant composition and method for manufacture
AU7355294A (en) 1993-07-26 1995-02-20 Fmc Corporation Fat-like agents for low calorie food compositions
FR2710637B1 (en) * 1993-09-28 1995-12-08 Roquette Freres Mannitol powder of moderate friability and its preparation process.
US5505982A (en) 1994-01-28 1996-04-09 Fmc Corporation Chocolate confection
JP3666911B2 (en) 1994-11-28 2005-06-29 旭化成ケミカルズ株式会社 Water dispersible fine cellulose composition and method for producing the same
JP3076732B2 (en) 1994-12-07 2000-08-14 株式会社ヤクルト本社 Calcium fortified beverage and method for producing the same
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US6106865A (en) 1995-01-09 2000-08-22 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5709896A (en) * 1996-06-18 1998-01-20 Fmc Corporation Reduced-fat food dispersions and method of preparing
US5605712A (en) * 1995-09-29 1997-02-25 Fmc Corporation Stabilizer compositions, frozen desserts containing the same and stabilizing method
US5789004A (en) * 1995-12-15 1998-08-04 Fmc Corporation Coprocessed microcrystalline cellulose stabilizer compositions, foods containing the same and stabilization method
JP3706454B2 (en) 1996-02-02 2005-10-12 ダイセル化学工業株式会社 Acid milk beverage stabilizer and acid milk beverage
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
TR199802079T2 (en) * 1996-04-16 1999-02-22 Bayer Aktiengesellschaft D-Mannitol go do 'rlanmas'.
US6025007A (en) 1996-05-28 2000-02-15 Fmc Corporation Cellulose composition, its preparation and its use in foods
JP3497666B2 (en) 1996-08-19 2004-02-16 旭化成ケミカルズ株式会社 Acidic milk beverage containing fine cellulose
CN1098644C (en) 1996-10-21 2003-01-15 旭化成株式会社 Stabilizer for meat products and meat product composition
US5747067A (en) 1996-12-06 1998-05-05 Fmc Corporation Co-processed products
JPH10237220A (en) 1996-12-24 1998-09-08 Asahi Chem Ind Co Ltd Aqueous suspension composition and water-dispersible dry composition
US5769934A (en) 1997-01-15 1998-06-23 Fmc Corporation Method for producing microcrystalline cellulose
AU5828098A (en) 1997-01-31 1998-08-25 Fmc Corporation Texture and stabilizer composition
US6037380A (en) 1997-04-11 2000-03-14 Fmc Corporation Ultra-fine microcrystalline cellulose compositions and process
US6079630A (en) 1997-04-11 2000-06-27 Schroeder; Rick A. Railway grade crossing apparatus and method of installation
ATE212039T1 (en) 1997-06-12 2002-02-15 Fmc Corp ULTRAFINE MICROCRYSTALLINE CELLULOSE COMPOSITIONS AND METHODS FOR THE PRODUCTION THEREOF
JPH1146723A (en) 1997-07-30 1999-02-23 Asahi Chem Ind Co Ltd Stabilizer for meat product and meat product composition
JPH11199517A (en) * 1997-10-31 1999-07-27 Meiji Seika Kaisha Ltd Intraoral fast disintegrable tablet
JPH11299435A (en) 1998-04-23 1999-11-02 Japan Organo Co Ltd Composition for emulsion stabilizer and foods
US6475539B1 (en) 1998-05-07 2002-11-05 Abbott Laboratories Nutritionally complete low pH enteral formula
US6391368B1 (en) 1998-09-25 2002-05-21 Fmc Corporation Rapidly peptizable microcrystalline cellulose-based stabilizing agents
JP2000184853A (en) 1998-12-22 2000-07-04 Yakult Honsha Co Ltd Milk fat-containing acidic milk beverage
US6723342B1 (en) 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
US6432448B1 (en) 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
NL1011901C2 (en) 1999-04-27 2000-10-30 Cargill Bv Method for the removal of fibrous shells from grain kernels.
US6548093B1 (en) 1999-04-29 2003-04-15 J. R. Simplot Company Process for preparing storage stable low moisture parfried potato strips
WO2001019348A1 (en) 1999-09-17 2001-03-22 Mylan Pharmaceuticals Inc. Stabilization of enalapril maleate with maleic acid
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
JP3400777B2 (en) 1999-10-27 2003-04-28 カルピス株式会社 Low-calorie milk-containing acidic beverage
BR0014966A (en) 1999-10-29 2002-07-02 Fmc Corp Ready-to-release, curable and edible coating composition
US6500462B1 (en) 1999-10-29 2002-12-31 Fmc Corporation Edible MCC/PGA coating composition
AU2001273496A1 (en) * 2000-07-24 2002-02-05 Boehringer Ingelheim Pharmaceuticals Inc. Apparatus and method for predicting the suitability of a substance for dry granulation by roller compaction using small sample sizes
JP4284017B2 (en) * 2000-10-06 2009-06-24 武田薬品工業株式会社 Solid preparation
JP2002125587A (en) 2000-10-27 2002-05-08 Ina Food Ind Co Ltd Acidic protein-stabilizing agent and acidic protein food containing it
WO2002049451A2 (en) 2000-12-18 2002-06-27 Societe Des Produits Nestle S.A. Stabilizer based on microcrystalline cellulose for drink and dressing formulations
CA2440365A1 (en) 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co., Ltd. Use of a spray-dried powder comprising a sugar alcohol
ATE438309T1 (en) 2001-03-09 2009-08-15 Unilever Nv FROMED FROZEN PRODUCT
US6753107B2 (en) * 2001-04-27 2004-06-22 Plug Power Inc. Integrated fuel cell system
JP2002345401A (en) 2001-05-24 2002-12-03 Sanei Gen Ffi Inc Acidic milk beverage containing insoluble solid
EP1269854A1 (en) 2001-06-29 2003-01-02 Camoina Melkunic B.V. Clear dairy drink and method for producing same
US6753017B2 (en) 2001-11-07 2004-06-22 Jrs Pharma Lp Process for preparing dry extracts
US7247333B2 (en) 2003-03-19 2007-07-24 Pepsico Inc. Stabilized milk product containing fruit and fruit juice
US7241467B2 (en) 2002-01-23 2007-07-10 Pepsico, Inc. Stabilized milk product containing juice
TW200403994A (en) * 2002-04-04 2004-03-16 Bristol Myers Squibb Co Oral administration of EPOTHILONES
US20030203097A1 (en) 2002-04-24 2003-10-30 The Procter & Gamble Company Acidic compositions comprising protein and fiber and processes of their preparation
WO2003096976A2 (en) 2002-05-14 2003-11-27 Fmc Corporation Microcrystalline cewllulose compositions
GB0211620D0 (en) * 2002-05-21 2002-07-03 Bioprogress Technology Ltd Powder compaction and enrobing
ES2199061B1 (en) * 2002-06-10 2005-02-16 Laboratorios Vita, S.A. TROUBLE-BASED TABLETS AND PROCEDURE FOR OBTAINING.
GB2395413A (en) 2002-11-21 2004-05-26 Danisco Stabilised fluid composition comprising suspended particulates
US7230420B2 (en) 2003-04-17 2007-06-12 Infinitum Solutions, Inc. Magnetoresistive element lifecycle tester with temperature control
GB0322358D0 (en) * 2003-09-24 2003-10-22 Bioprogress Technology Ltd Improvements in powder compaction and enrobing
JP4249059B2 (en) 2004-03-01 2009-04-02 三栄源エフ・エフ・アイ株式会社 Acidic milk beverage and method for producing the same
CN101720965A (en) 2004-04-05 2010-06-09 Fmc有限公司 MCC/hydrocolloid stabilizers and edible compositions comprising the same
US7101585B2 (en) 2004-04-15 2006-09-05 Solae, Llc Ultra high pressure homogenization process for making a stable protein based acid beverage
EP1791527A2 (en) 2004-09-23 2007-06-06 Fmc Corporation Coating composition
EP1889853A4 (en) 2005-06-07 2010-03-24 San Ei Gen Ffi Inc Method for modification of pectin and application thereof
US7879382B2 (en) 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
DE602007011792D1 (en) * 2006-10-27 2011-02-17 Fmc Corp COMMONLY PREPARED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN AUXILIARY FOR TABLET FORMULATIONS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004862A2 (en) * 1998-07-20 2000-02-03 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
EP1226818A1 (en) * 2001-01-26 2002-07-31 Pfizer Products Inc. Pharmaceutical dosage forms with enhanced cohesive and compressibility properties
WO2005030177A2 (en) * 2003-09-29 2005-04-07 Cipla Limited Pharmaceutical formulation with improved stability
EP1681048A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Orally disintegrating composition of olanzapine or donepezil

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JP5410290B2 (en) 2014-02-05
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EP2076249A2 (en) 2009-07-08
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