WO2008061157A3 - Generation of plants with altered protein, fiber, or oil content - Google Patents
Generation of plants with altered protein, fiber, or oil content Download PDFInfo
- Publication number
- WO2008061157A3 WO2008061157A3 PCT/US2007/084715 US2007084715W WO2008061157A3 WO 2008061157 A3 WO2008061157 A3 WO 2008061157A3 US 2007084715 W US2007084715 W US 2007084715W WO 2008061157 A3 WO2008061157 A3 WO 2008061157A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plants
- fiber
- generation
- oil content
- altered protein
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
- C12N15/8246—Non-starch polysaccharides, e.g. cellulose, fructans, levans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8255—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving lignin biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Abstract
The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an IMQ nucleic acid. The invention is further directed to methods of generating plants with an improved oil quantity phenotype or improved meal quality phenotype.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002669989A CA2669989A1 (en) | 2006-11-15 | 2007-11-14 | Generation of plants with altered protein, fiber, or oil content |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86605606P | 2006-11-15 | 2006-11-15 | |
US60/866,056 | 2006-11-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008061157A2 WO2008061157A2 (en) | 2008-05-22 |
WO2008061157A3 true WO2008061157A3 (en) | 2008-12-31 |
Family
ID=39402464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/084715 WO2008061157A2 (en) | 2006-11-15 | 2007-11-14 | Generation of plants with altered protein, fiber, or oil content |
Country Status (4)
Country | Link |
---|---|
US (5) | US8034993B2 (en) |
AR (1) | AR063845A1 (en) |
CA (1) | CA2669989A1 (en) |
WO (1) | WO2008061157A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2361985A1 (en) * | 2010-02-26 | 2011-08-31 | BASF Plant Science Company GmbH | Plants having enhanced yield-related traits and a method for making the same |
BR122022020015B1 (en) * | 2013-03-15 | 2023-05-16 | The Regents Of The University Of California | METHODS OF ENGINEERING A PLANT HAVING REDUCED LIGNIN CONTENT AND OBTAINING AN INCREASED AMOUNT OF SOLUBLE SUGARS FROM A PLANT IN A SACHARIFYING REACTION |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1033405A2 (en) * | 1999-02-25 | 2000-09-06 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
WO2002010210A2 (en) * | 2001-08-28 | 2002-02-07 | Bayer Cropscience Ag | Polypeptides for identifying herbicidally active compounds |
US20060107345A1 (en) * | 2003-09-30 | 2006-05-18 | Nickolai Alexandrov | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
Family Cites Families (28)
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US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US5704160A (en) | 1990-11-16 | 1998-01-06 | E. I. Du Pont De Nemours And Company | Production method for high-oil corn grain |
US6750046B2 (en) * | 1991-02-22 | 2004-06-15 | Sembiosys Genetics, Inc. | Preparation of thioredoxin and thioredoxin reductase proteins on oil bodies |
US5639790A (en) | 1991-05-21 | 1997-06-17 | Calgene, Inc. | Plant medium-chain thioesterases |
US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
CA2124673C (en) | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
AU670316B2 (en) | 1992-07-27 | 1996-07-11 | Pioneer Hi-Bred International, Inc. | An improved method of (agrobacterium)-mediated transformation of cultured soybean cells |
CA2149223C (en) | 1992-11-17 | 2007-04-24 | Jonathan Edward Lightner | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
ZA951231B (en) | 1994-02-15 | 1996-08-15 | Du Pont | Corn plants and products with improved oil composition |
US6229033B1 (en) | 1998-05-11 | 2001-05-08 | E. I. Du Pont De Nemours And Company | Fat products from high stearic soybean oil and a method for the production thereof |
US6664446B2 (en) | 1999-03-23 | 2003-12-16 | Mendel Biotechnology, Inc. | Transgenic plants comprising polynucleotides encoding transcription factors that confer disease tolerance |
US7511190B2 (en) | 1999-11-17 | 2009-03-31 | Mendel Biotechnology, Inc. | Polynucleotides and polypeptides in plants |
US6692962B1 (en) * | 2000-06-06 | 2004-02-17 | University Of Wyoming | Plant translation methods and compositions related thereto |
AU2003304464A1 (en) | 2002-03-15 | 2005-03-29 | Monsanto Technology Llc | Nucleic acid molecules associated with oil in plants |
EP1551983A2 (en) | 2002-10-18 | 2005-07-13 | CropDesign N.V. | Identification of e2f target genes and uses thereof |
DK1571901T3 (en) * | 2002-12-18 | 2013-03-11 | Agrigenetics Inc | Production of plants with altered oil content |
WO2004093532A2 (en) | 2003-04-22 | 2004-11-04 | Agrinomics Llc | Generation of plants with altered oil content |
WO2004093531A2 (en) | 2003-04-22 | 2004-11-04 | Agrinomics Llc | Generation of plants with altered oil content |
WO2004093528A2 (en) | 2003-04-22 | 2004-11-04 | Agrinomics Llc | Generation of plants with altered oil content |
US20060048240A1 (en) | 2004-04-01 | 2006-03-02 | Nickolai Alexandrov | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
US20060150283A1 (en) | 2004-02-13 | 2006-07-06 | Nickolai Alexandrov | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
AU2004290050A1 (en) | 2003-11-13 | 2005-05-26 | Mendel Biotechnology, Inc. | Plant transcriptional regulators |
MXPA06012634A (en) | 2004-04-30 | 2007-02-08 | Dow Agrosciences Llc | Novel herbicide resistance genes. |
WO2007023190A2 (en) * | 2005-08-26 | 2007-03-01 | Vib Vzw | Genes involved in asymmetric cell division |
NZ567807A (en) | 2005-10-28 | 2011-09-30 | Dow Agrosciences Llc | Novel herbicide (2,4-D and pyridyloxyacetate) resistance genes with aryloxyalkanoage dioxygenase activity |
-
2007
- 2007-11-14 US US11/940,274 patent/US8034993B2/en not_active Expired - Fee Related
- 2007-11-14 CA CA002669989A patent/CA2669989A1/en not_active Abandoned
- 2007-11-14 WO PCT/US2007/084715 patent/WO2008061157A2/en active Application Filing
- 2007-11-15 AR ARP070105089A patent/AR063845A1/en not_active Application Discontinuation
-
2011
- 2011-08-30 US US13/221,790 patent/US8217225B2/en not_active Expired - Fee Related
-
2012
- 2012-05-24 US US13/480,275 patent/US8916747B2/en not_active Expired - Fee Related
-
2014
- 2014-11-13 US US14/540,606 patent/US9587246B2/en not_active Expired - Fee Related
-
2017
- 2017-01-18 US US15/409,313 patent/US20170130240A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1033405A2 (en) * | 1999-02-25 | 2000-09-06 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
WO2002010210A2 (en) * | 2001-08-28 | 2002-02-07 | Bayer Cropscience Ag | Polypeptides for identifying herbicidally active compounds |
US20060107345A1 (en) * | 2003-09-30 | 2006-05-18 | Nickolai Alexandrov | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
Non-Patent Citations (5)
Title |
---|
DATABASE EMBL [online] 9 April 1999 (1999-04-09), "Arabidopsis thaliana genomic DNA, chromosome 3, P1 clone: MPN9.", XP002486264, retrieved from EBI accession no. EMBL:AB025631 Database accession no. AB025631 * |
DATABASE EPO Proteins [online] 1 March 2002 (2002-03-01), "Sequence 1582 from Patent WO0210210.", XP002486269, retrieved from EBI accession no. EPOP:AX372934 Database accession no. AX372934 * |
DATABASE Geneseq [online] 18 October 2000 (2000-10-18), "Arabidopsis thaliana protein fragment SEQ ID NO: 54598.", XP002486271, retrieved from EBI accession no. GSP:AAG43661 Database accession no. AAG43661 * |
DATABASE Geneseq [online] 28 December 2007 (2007-12-28), "Arabidopsis thaliana SDF amino acid sequence SEQ ID 11124.", XP002486270, retrieved from EBI accession no. GSP:AJG65472 Database accession no. AJG65472 * |
DATABASE UniProt [online] 1 October 2000 (2000-10-01), "Genomic DNA, chromosome 3, P1 clone: MPN9.", XP002486263, retrieved from EBI accession no. UNIPROT:Q9LT22 Database accession no. Q9LT22 * |
Also Published As
Publication number | Publication date |
---|---|
US20170130240A1 (en) | 2017-05-11 |
US8217225B2 (en) | 2012-07-10 |
AR063845A1 (en) | 2009-02-25 |
WO2008061157A2 (en) | 2008-05-22 |
CA2669989A1 (en) | 2008-05-22 |
US20110318473A1 (en) | 2011-12-29 |
US8034993B2 (en) | 2011-10-11 |
US9587246B2 (en) | 2017-03-07 |
US20150074849A1 (en) | 2015-03-12 |
US20080160162A1 (en) | 2008-07-03 |
US20120233724A1 (en) | 2012-09-13 |
US8916747B2 (en) | 2014-12-23 |
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