WO2008070521A8 - Methods and systems for treating tissue sites using electroporation - Google Patents

Methods and systems for treating tissue sites using electroporation

Info

Publication number
WO2008070521A8
WO2008070521A8 PCT/US2007/085880 US2007085880W WO2008070521A8 WO 2008070521 A8 WO2008070521 A8 WO 2008070521A8 US 2007085880 W US2007085880 W US 2007085880W WO 2008070521 A8 WO2008070521 A8 WO 2008070521A8
Authority
WO
WIPO (PCT)
Prior art keywords
tissue site
systems
methods
electroporation
mono
Prior art date
Application number
PCT/US2007/085880
Other languages
French (fr)
Other versions
WO2008070521A9 (en
WO2008070521A3 (en
WO2008070521A2 (en
Inventor
Boris Rubinsky
Gary Onik
Paul Mikus
Original Assignee
Oncobionic Inc
Boris Rubinsky
Gary Onik
Paul Mikus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/945,781 external-priority patent/US20080132885A1/en
Application filed by Oncobionic Inc, Boris Rubinsky, Gary Onik, Paul Mikus filed Critical Oncobionic Inc
Priority to EP07864877A priority Critical patent/EP2094180A4/en
Publication of WO2008070521A2 publication Critical patent/WO2008070521A2/en
Publication of WO2008070521A9 publication Critical patent/WO2008070521A9/en
Publication of WO2008070521A8 publication Critical patent/WO2008070521A8/en
Publication of WO2008070521A3 publication Critical patent/WO2008070521A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1477—Needle-like probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle
    • A61B2018/143—Needle multiple needles

Abstract

Systems and methods for treating a tissue site. At least first and second mono-polar electrodes are configured to be introduced at or near a tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tissue site, to create necrosis of cells of the tissue site, but insufficient to create a thermal damaging effect to a majority of the tissue site.
PCT/US2007/085880 2006-12-01 2007-11-29 Methods and systems for treating tissue sites using electroporation WO2008070521A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07864877A EP2094180A4 (en) 2006-12-01 2007-11-29 Methods and systems for treating tissue sites using electroporation

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US86822606P 2006-12-01 2006-12-01
US60/868,226 2006-12-01
US11/945,781 US20080132885A1 (en) 2006-12-01 2007-11-27 Methods for treating tissue sites using electroporation
US11/945,781 2007-11-27
US11/945,772 2007-11-27
US11/945,772 US20080132884A1 (en) 2006-12-01 2007-11-27 Systems for treating tissue sites using electroporation

Publications (4)

Publication Number Publication Date
WO2008070521A2 WO2008070521A2 (en) 2008-06-12
WO2008070521A9 WO2008070521A9 (en) 2008-08-07
WO2008070521A8 true WO2008070521A8 (en) 2008-08-28
WO2008070521A3 WO2008070521A3 (en) 2008-10-09

Family

ID=39476728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/085880 WO2008070521A2 (en) 2006-12-01 2007-11-29 Methods and systems for treating tissue sites using electroporation

Country Status (2)

Country Link
US (2) US20080132884A1 (en)
WO (1) WO2008070521A2 (en)

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US20120071872A1 (en) 2012-03-22
US20080132884A1 (en) 2008-06-05
WO2008070521A3 (en) 2008-10-09
WO2008070521A2 (en) 2008-06-12

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