WO2008079672A4 - Flowable carrier compositions for orthopedic implants and methods of use - Google Patents

Flowable carrier compositions for orthopedic implants and methods of use Download PDF

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Publication number
WO2008079672A4
WO2008079672A4 PCT/US2007/087117 US2007087117W WO2008079672A4 WO 2008079672 A4 WO2008079672 A4 WO 2008079672A4 US 2007087117 W US2007087117 W US 2007087117W WO 2008079672 A4 WO2008079672 A4 WO 2008079672A4
Authority
WO
WIPO (PCT)
Prior art keywords
phosphate
biodegradable polymer
combinations
composition
group
Prior art date
Application number
PCT/US2007/087117
Other languages
French (fr)
Other versions
WO2008079672A3 (en
WO2008079672A2 (en
Inventor
William F Mckay
Steven M Peckham
Original Assignee
Warsaw Orthopedic Inc
William F Mckay
Steven M Peckham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc, William F Mckay, Steven M Peckham filed Critical Warsaw Orthopedic Inc
Priority to EP07865523A priority Critical patent/EP2129318A2/en
Priority to JP2009543070A priority patent/JP2010512974A/en
Publication of WO2008079672A2 publication Critical patent/WO2008079672A2/en
Publication of WO2008079672A3 publication Critical patent/WO2008079672A3/en
Publication of WO2008079672A4 publication Critical patent/WO2008079672A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

Abstract

A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.

Claims

AMENDED CLAIMS received by the International Bureau on 24 December 2008 (24.12.2008)
7. The composition of claim 1, wherein the biodegradable polymer is a natural polymer selected from the group consisting of collagen, hyaluronic acid, chitosan, carboxymethylcellulose, alginate, silk, eastin, fibrin glue, bone marrow with or without thrombin, and combinations thereof.
8. The composition of claim 1, wherein the biodegradable polymer is a synthetic polymer selected from the group consisting of polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyorthoester (POE), polylactic acid (PLA), polyglycolic acid (PGA), polyactic-glycolic acid (PLGA) and combinations thereof.
9. The composition of claim 1 , wherein the calcium phosphate compound is selected from the group consisting of amorphous calcium phosphate, biphasic calcium phosphate, calcium phosphate, dicalcium phosphate, dicalciυm phosphate dihydrate, calcium hydroxyapatite, carbonated calcium hydroxyapatite, monocalcium phosphate, monocalcium phosphate monohydrate, octacalcium phosphate, tricalcium phosphate, alpha-tricalcium phosphate, beta-tricalciυm phosphate, tetracalcium phosphate, and combinations thereof.
10. A medical kit comprising: a biological factor; a biodegradable polymer, a calcium phosphate compound; and an applicator.
11. The medical kit of claim 10 further comprising a biocompatible fluid.
12. The medical kit of claim 11, wherein the applicator is adapted for applying the biological factor and a carrier slurry resulting from hydrating the biodegradable polymer and the calcium phosphate compound with the biocompatible fluid to a site of bone repair orto an orthopedic implant
13. The medical kit of claim 10, wherein the biological factor and the biocompatible fluid are contained in separate containers.
14. The kit of claim 10, wherein the biodegradable polymer is a natural polymer selected from the group consisting of collagen, hyaluronic acid, chitosan, carboxyniethylcellulose, alginate, silk, elastin, fibrin glue, bone marrow with or without thrombin, and combinations thereof.
15. The kit of claim 10, wherein the biodegradable polymer is a synthetic polymer selected from the group consisting of polyethylene glycol (PEG), polyvinyl alcohol
(PVA), polyorthoester (POE), polylactic acid (PLA), polyglycolic acid (PGA). polyacticglycolic acid (PLGA) and combinations thereof.
PCT/US2007/087117 2006-12-19 2007-12-12 Flowable carrier compositions for orthopedic implants and methods of use WO2008079672A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07865523A EP2129318A2 (en) 2006-12-19 2007-12-12 Flowable carrier compositions for orthopedic implants and methods of use
JP2009543070A JP2010512974A (en) 2006-12-19 2007-12-12 Flowable carrier composition and method of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/612,853 US8048857B2 (en) 2006-12-19 2006-12-19 Flowable carrier compositions and methods of use
US11/612,853 2006-12-19

Publications (3)

Publication Number Publication Date
WO2008079672A2 WO2008079672A2 (en) 2008-07-03
WO2008079672A3 WO2008079672A3 (en) 2008-12-24
WO2008079672A4 true WO2008079672A4 (en) 2009-02-19

Family

ID=39528417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/087117 WO2008079672A2 (en) 2006-12-19 2007-12-12 Flowable carrier compositions for orthopedic implants and methods of use

Country Status (4)

Country Link
US (1) US8048857B2 (en)
EP (1) EP2129318A2 (en)
JP (1) JP2010512974A (en)
WO (1) WO2008079672A2 (en)

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Also Published As

Publication number Publication date
JP2010512974A (en) 2010-04-30
EP2129318A2 (en) 2009-12-09
WO2008079672A3 (en) 2008-12-24
WO2008079672A2 (en) 2008-07-03
US8048857B2 (en) 2011-11-01
US20080147065A1 (en) 2008-06-19

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