WO2008088588A3 - Biocompatible scaffold for sensing proteins - Google Patents

Biocompatible scaffold for sensing proteins Download PDF

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Publication number
WO2008088588A3
WO2008088588A3 PCT/US2007/078634 US2007078634W WO2008088588A3 WO 2008088588 A3 WO2008088588 A3 WO 2008088588A3 US 2007078634 W US2007078634 W US 2007078634W WO 2008088588 A3 WO2008088588 A3 WO 2008088588A3
Authority
WO
WIPO (PCT)
Prior art keywords
biocompatible scaffold
conductive layer
containing nanowires
thetav
nanofibers
Prior art date
Application number
PCT/US2007/078634
Other languages
French (fr)
Other versions
WO2008088588A2 (en
Inventor
Z Ryan Tian
Original Assignee
Univ Arkansas Technology Dev F
Z Ryan Tian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/653,189 external-priority patent/US8883115B2/en
Application filed by Univ Arkansas Technology Dev F, Z Ryan Tian filed Critical Univ Arkansas Technology Dev F
Priority to EP07814882A priority Critical patent/EP2101687A2/en
Priority to CN2007800497563A priority patent/CN101646401B/en
Publication of WO2008088588A2 publication Critical patent/WO2008088588A2/en
Publication of WO2008088588A3 publication Critical patent/WO2008088588A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated

Abstract

This invention related to a biocompatible scaffold that can detect redox-active chemicals and biomolecules electrochemically. In one embodiment, the biocompatible scaffold includes a substrate, and a conductive layer of Tiϑ2-containing nanowires or nano fibers formed on the substrate, wherein the conductive layer of Tiϑ2-containing nanowires or nanofibers is formed with a pore structure, and wherein when the biocompatible scaffold is in contact with a biological analyte, one or more proteins of the biological analyte are immobilized on a surface of the conductive layer Of TiO2- containing nanowires or nanofibers so as to generate a measurable faradic current signal.
PCT/US2007/078634 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins WO2008088588A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07814882A EP2101687A2 (en) 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins
CN2007800497563A CN101646401B (en) 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/653,189 2007-01-12
US11/653,189 US8883115B2 (en) 2006-01-12 2007-01-12 TiO2 nanostructures, membranes and films, and methods of making same
US11/653,192 2007-01-12
US11/653,192 US7931812B2 (en) 2006-01-12 2007-01-12 TiO2 nanostructures, membranes and films, and applications of same

Publications (2)

Publication Number Publication Date
WO2008088588A2 WO2008088588A2 (en) 2008-07-24
WO2008088588A3 true WO2008088588A3 (en) 2008-12-04

Family

ID=39636534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/078634 WO2008088588A2 (en) 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins

Country Status (2)

Country Link
EP (1) EP2101687A2 (en)
WO (1) WO2008088588A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503831B2 (en) * 1997-10-14 2003-01-07 Patterning Technologies Limited Method of forming an electronic device
US6914279B2 (en) * 2002-06-06 2005-07-05 Rutgers, The State University Of New Jersey Multifunctional biosensor based on ZnO nanostructures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503831B2 (en) * 1997-10-14 2003-01-07 Patterning Technologies Limited Method of forming an electronic device
US6914279B2 (en) * 2002-06-06 2005-07-05 Rutgers, The State University Of New Jersey Multifunctional biosensor based on ZnO nanostructures

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAVYKIN D. ET AL.: "A Novel Cation Binding TiO2 Nanotube Substrate for Electro- and Bioelectro-catalysis", ELECTROCHEMISTRY COMMUNICATIONS, vol. 7, no. 10, 2005, pages 1050 - 1058, XP005082477 *
TOPOGLIDIS E. ET AL.: "Direct Electrochemistry and Nitric oxide Interaction of Heme Proteins Absorbed on Nanocrystalline Tin Oxide Electrodes", LANGMUIR, vol. 19, no. 17, 2003, pages 6894 - 6900, XP008111088 *
WEBSTER T.J. ET AL.: "Increased Osteoblast Function on PLGA Composites Containing Nanophase Titania", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 74A, no. 4, PART A, 2005, pages 677 - 686, XP008111089 *

Also Published As

Publication number Publication date
EP2101687A2 (en) 2009-09-23
WO2008088588A2 (en) 2008-07-24

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