WO2008091294A3 - Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter - Google Patents

Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter Download PDF

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Publication number
WO2008091294A3
WO2008091294A3 PCT/US2007/016975 US2007016975W WO2008091294A3 WO 2008091294 A3 WO2008091294 A3 WO 2008091294A3 US 2007016975 W US2007016975 W US 2007016975W WO 2008091294 A3 WO2008091294 A3 WO 2008091294A3
Authority
WO
WIPO (PCT)
Prior art keywords
force sensor
microfluidic
biocalorimeter
nems
cell
Prior art date
Application number
PCT/US2007/016975
Other languages
French (fr)
Other versions
WO2008091294A2 (en
Inventor
Michael L Roukes
Chung-Wah Fon
Wonhee Lee
Hongxing Tang
Blake W Axelrod
John Liang Tan
Original Assignee
California Inst Of Techn
Michael L Roukes
Chung-Wah Fon
Wonhee Lee
Hongxing Tang
Blake W Axelrod
John Liang Tan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Michael L Roukes, Chung-Wah Fon, Wonhee Lee, Hongxing Tang, Blake W Axelrod, John Liang Tan filed Critical California Inst Of Techn
Publication of WO2008091294A2 publication Critical patent/WO2008091294A2/en
Publication of WO2008091294A3 publication Critical patent/WO2008091294A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L1/00—Measuring force or stress, in general
    • G01L1/04—Measuring force or stress, in general by measuring elastic deformation of gauges, e.g. of springs
    • G01L1/044—Measuring force or stress, in general by measuring elastic deformation of gauges, e.g. of springs of leaf springs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5032—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/724—Devices having flexible or movable element
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/956—Of mechanical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/957—Of chemical property or presence
    • Y10S977/958—Of biomolecule property

Abstract

A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene.
PCT/US2007/016975 2006-07-28 2007-07-30 Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter WO2008091294A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83428806P 2006-07-28 2006-07-28
US83425306P 2006-07-28 2006-07-28
US83405206P 2006-07-28 2006-07-28
US60/834,288 2006-07-28
US60/834,052 2006-07-28
US60/834,253 2006-07-28

Publications (2)

Publication Number Publication Date
WO2008091294A2 WO2008091294A2 (en) 2008-07-31
WO2008091294A3 true WO2008091294A3 (en) 2009-01-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016975 WO2008091294A2 (en) 2006-07-28 2007-07-30 Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter

Country Status (2)

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US (2) US7966898B2 (en)
WO (1) WO2008091294A2 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7340960B2 (en) * 2004-01-30 2008-03-11 Analatom Inc. Miniature sensor
US8476005B2 (en) * 2008-02-05 2013-07-02 California Institute Of Technology Microfluidic embedded polymer NEMS force sensors
US10132303B2 (en) 2010-05-21 2018-11-20 Hewlett-Packard Development Company, L.P. Generating fluid flow in a fluidic network
US9395050B2 (en) 2010-05-21 2016-07-19 Hewlett-Packard Development Company, L.P. Microfluidic systems and networks
US9963739B2 (en) 2010-05-21 2018-05-08 Hewlett-Packard Development Company, L.P. Polymerase chain reaction systems
EP2571696B1 (en) * 2010-05-21 2019-08-07 Hewlett-Packard Development Company, L.P. Fluid ejection device with circulation pump
WO2011146149A1 (en) * 2010-05-21 2011-11-24 Hewlett-Packard Development Company, L.P. Fluid ejection device with circulation pump
US9090084B2 (en) 2010-05-21 2015-07-28 Hewlett-Packard Development Company, L.P. Fluid ejection device including recirculation system
US20120015428A1 (en) * 2010-07-16 2012-01-19 Vanderbilt University Metering rotary nanopump, method of fabricating same, and applications of same
US9289191B2 (en) 2011-10-12 2016-03-22 Seno Medical Instruments, Inc. System and method for acquiring optoacoustic data and producing parametric maps thereof
US8686335B2 (en) 2011-12-31 2014-04-01 Seno Medical Instruments, Inc. System and method for adjusting the light output of an optoacoustic imaging system
US9513240B2 (en) 2011-02-22 2016-12-06 The Trustees Of Columbia University In The City Of New York MEMS-based calorimeter, fabrication, and use thereof
US8857275B2 (en) * 2011-05-02 2014-10-14 California Institute Of Technology NEMS sensors for cell force application and measurement
DE102011050490B4 (en) * 2011-05-19 2020-08-13 Ludwig-Maximilians-Universität München Force sensor and its use for determining cell forces
US20130338475A1 (en) 2012-06-13 2013-12-19 Seno Medical Instruments, Inc. Optoacoustic imaging system with fiber optic cable
US10168292B2 (en) 2012-03-22 2019-01-01 California Institute Of Technology Nanoscale calorimeter on chip and related methods and devices
EP2877841A4 (en) 2012-07-24 2016-07-27 Univ Columbia Mems-based isothermal titration calorimetry
WO2014025881A2 (en) * 2012-08-07 2014-02-13 Old Dominion University Reasearch Foundation A polymer-based microfluidic resistive sensor for detecting distributed loads, methods, and processes for fabricating the same
US9021897B2 (en) 2012-08-30 2015-05-05 Shengyuan Yang Versatile, flexible, and robust MEMS/NEMS sensor for decoupled measuring of three-dimensional forces in air or liquids
JP6385050B2 (en) * 2012-12-17 2018-09-05 日東電工株式会社 Optical laminate manufacturing method and optical laminate
CN105408730A (en) 2013-06-05 2016-03-16 纽约市哥伦比亚大学理事会 Mems-based calorimeter, fabrication, and use thereof
US10082500B2 (en) * 2013-08-22 2018-09-25 Franz Baudenbacher Device and method for detecting a target analyte
US10166542B2 (en) * 2014-09-17 2019-01-01 Arizona Board Of Regents On Behalf Of Arizona State University Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
EP3955003B1 (en) 2014-09-26 2023-06-21 Abbott Point Of Care Inc Sensors for assaying coagulation in fluid samples
CN106999930B (en) 2014-09-26 2020-09-08 雅培医护站股份有限公司 Cartridge device with segmented jet for determining coagulation in a fluid sample
WO2016049557A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Ellagic acid formulations for use in coagulation assays
WO2016049552A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device identification for coagulation assays in fluid samples
EP3954457A3 (en) 2014-09-26 2022-05-18 Abbott Point Of Care Inc Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples
US10114031B2 (en) * 2014-09-26 2018-10-30 Abbott Point Of Care Inc. Single channel cartridge device for coagulation assays in fluid samples
WO2016049533A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
US9342638B1 (en) 2014-12-17 2016-05-17 Cadence Design Systems, Inc. Method and system to perform performance checks
US9594861B1 (en) 2014-12-17 2017-03-14 Cadence Design Systems, Inc. Method and system to perform equivalency checks
WO2016153429A1 (en) * 2015-03-24 2016-09-29 National University Of Singapore A resistive microfluidic pressure sensor
FR3042905B1 (en) * 2015-10-23 2018-11-16 Vmicro DEVICE AND MICROELECTROMECHANICAL SYSTEM WITH LOW IMPEDANCE RESISTIVE TRANSDUCER
WO2018217831A1 (en) 2017-05-22 2018-11-29 Arizona Board Of Regents On Behalf Of Arizona State University Metal electrode based 3d printed device for tuning microfluidic droplet generation frequency and synchronizing phase for serial femtosecond crystallography
US10557807B2 (en) 2017-05-22 2020-02-11 Arizona Board Of Regents On Behalf Of Arizona State University 3D printed microfluidic mixers and nozzles for crystallography
EP3431982A1 (en) * 2017-07-18 2019-01-23 Nanosurf AG Microcantilever
US11173487B2 (en) 2017-12-19 2021-11-16 Arizona Board Of Regents On Behalf Of Arizona State University Deterministic ratchet for sub-micrometer bioparticle separation
US11084215B2 (en) 2019-03-19 2021-08-10 Trustees Of Boston University Systems and methods for fabricating three-dimensional conductive electrodes
US10801827B1 (en) 2019-05-03 2020-10-13 At&T Intellectual Property I, L.P. Sensor based on smart response of two-dimensional nanomaterial and associated method
US11318487B2 (en) 2019-05-14 2022-05-03 Arizona Board Of Regents On Behalf Of Arizona State University Co-flow injection for serial crystallography
US11624718B2 (en) 2019-05-14 2023-04-11 Arizona Board Of Regents On Behalf Of Arizona State University Single piece droplet generation and injection device for serial crystallography
CN110487438B (en) * 2019-08-22 2021-05-18 中南大学 Preparation method of sandwich-shaped flexible temperature sensor
US11835529B1 (en) 2019-10-24 2023-12-05 University Of Louisville Research Foundation, Inc. Plasma thermograms for diagnosis and treatment of acute myocardial infarction
WO2021081524A2 (en) * 2019-10-24 2021-04-29 The University Of Louisville Research Foundation, Inc. Microfabricated differential scanning calorimetry system and methods of use thereof
CN111982362B (en) * 2020-08-25 2022-12-20 工科思维技术(深圳)有限公司 Method for preparing high-sensitivity flexible piezoresistive sensor based on fracture microstructure
US11485632B2 (en) 2020-10-09 2022-11-01 Arizona Board Of Regents On Behalf Of Arizona State University Modular 3-D printed devices for sample delivery and method
CN113074846B (en) * 2021-03-12 2022-07-29 电子科技大学 Micro-channel stress sensor based on structural metamaterial and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028372A1 (en) * 1993-05-25 1994-12-08 Rosemount Inc. Organic chemical sensor
WO2002012443A2 (en) * 2000-08-09 2002-02-14 California Institute Of Technology Active nems arrays for biochemical analyses
WO2003022731A1 (en) * 2001-09-07 2003-03-20 Danmarks Tekniske Universitet Flexible structure with integrated sensor/actuator
WO2003095616A2 (en) * 2002-05-07 2003-11-20 California Institute Of Technology Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
US20040211243A1 (en) * 2002-06-03 2004-10-28 Porter Timothy L Embedded piezoelectric microcantilever sensors
WO2005119233A1 (en) * 2004-06-01 2005-12-15 Cantion A/S Stress sensor with capture coating for detecting a target substance

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711820A (en) * 1986-06-17 1987-12-08 Petrarch Systems Inc. Method of siliconization of surfaces with lower alkyl silanes
US4935345A (en) * 1987-04-07 1990-06-19 Arizona Board Of Regents Implantable microelectronic biochemical sensor incorporating thin film thermopile
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6540895B1 (en) * 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6575020B1 (en) * 1999-05-03 2003-06-10 Cantion A/S Transducer for microfluid handling system
GB2352283A (en) * 1999-06-28 2001-01-24 California Inst Of Techn Microfabricated valves, pumps, mirror array and refracting structure
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20050158845A1 (en) * 2001-08-06 2005-07-21 Wikswo John P. Device and methods for measuring the response of a least one cell to a medium
US7495302B2 (en) * 2004-03-03 2009-02-24 Robert Bosch Gmbh Micromechanical component having a diaphragm
WO2006073426A2 (en) * 2004-04-20 2006-07-13 California Institute Of Technology Microscale calorimeters
CA2631476C (en) * 2004-12-10 2012-06-19 Simon Fraser University Microfluidic microarray assemblies and methods of manufacturing and using same
US8343755B2 (en) * 2005-08-01 2013-01-01 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
EP2141490B1 (en) * 2008-07-02 2015-04-01 Stichting IMEC Nederland Chemical sensing microbeam device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028372A1 (en) * 1993-05-25 1994-12-08 Rosemount Inc. Organic chemical sensor
WO2002012443A2 (en) * 2000-08-09 2002-02-14 California Institute Of Technology Active nems arrays for biochemical analyses
WO2003022731A1 (en) * 2001-09-07 2003-03-20 Danmarks Tekniske Universitet Flexible structure with integrated sensor/actuator
WO2003095616A2 (en) * 2002-05-07 2003-11-20 California Institute Of Technology Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
US20040211243A1 (en) * 2002-06-03 2004-10-28 Porter Timothy L Embedded piezoelectric microcantilever sensors
WO2005119233A1 (en) * 2004-06-01 2005-12-15 Cantion A/S Stress sensor with capture coating for detecting a target substance

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KNOTTER D M ET AL: "Etching mechanism of silicon nitride in HF-based solutions", JOURNAL OF THE ELECTROCHEMICAL SOCIETY ELECTROCHEM. SOC USA, vol. 148, no. 3, March 2001 (2001-03-01), pages F43 - F46, XP002492347, ISSN: 0013-4651 *
MRKSICH M ET AL: "Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 93, no. 20, 1 October 1996 (1996-10-01), pages 10775 - 10778, XP002228112, ISSN: 0027-8424 *

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US20100024572A1 (en) 2010-02-04
WO2008091294A2 (en) 2008-07-31
US20110216804A1 (en) 2011-09-08
US8827548B2 (en) 2014-09-09
US7966898B2 (en) 2011-06-28

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