WO2008091378A3 - High throughput ligand binding assays and reagents - Google Patents

High throughput ligand binding assays and reagents Download PDF

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Publication number
WO2008091378A3
WO2008091378A3 PCT/US2007/074322 US2007074322W WO2008091378A3 WO 2008091378 A3 WO2008091378 A3 WO 2008091378A3 US 2007074322 W US2007074322 W US 2007074322W WO 2008091378 A3 WO2008091378 A3 WO 2008091378A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand binding
reagents
high throughput
binding assays
throughput ligand
Prior art date
Application number
PCT/US2007/074322
Other languages
French (fr)
Other versions
WO2008091378A2 (en
Inventor
Neal Woodbury
Original Assignee
Univ Arizona
Neal Woodbury
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona, Neal Woodbury filed Critical Univ Arizona
Publication of WO2008091378A2 publication Critical patent/WO2008091378A2/en
Publication of WO2008091378A3 publication Critical patent/WO2008091378A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/08—Direct analysis of the library members per se by physical methods, e.g. spectroscopy
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/04—Integrated apparatus specially adapted for both screening libraries and identifying library members
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports

Abstract

The present invention provides methods, compositions, and computer readable storage media for multiplex detection of ligand binding.
PCT/US2007/074322 2006-07-25 2007-07-25 High throughput ligand binding assays and reagents WO2008091378A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83301906P 2006-07-25 2006-07-25
US60/833,019 2006-07-25

Publications (2)

Publication Number Publication Date
WO2008091378A2 WO2008091378A2 (en) 2008-07-31
WO2008091378A3 true WO2008091378A3 (en) 2008-10-09

Family

ID=39645016

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074322 WO2008091378A2 (en) 2006-07-25 2007-07-25 High throughput ligand binding assays and reagents

Country Status (1)

Country Link
WO (1) WO2008091378A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11205139B2 (en) 2018-08-06 2021-12-21 Arizona Board Of Regents On Behalf Of Arizona State University Computational analysis to predict molecular recognition space of monoclonal antibodies through random-sequence peptide arrays

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031468A1 (en) * 2000-02-08 2001-10-18 Alex Chenchik Analyte assays employing universal arrays
US20040014045A1 (en) * 2002-07-17 2004-01-22 Signature Bioscience Inc. A Corporation Of California Detection of ligand/antiligand complex formation by electromagnetically detectable bulk property measurement

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031468A1 (en) * 2000-02-08 2001-10-18 Alex Chenchik Analyte assays employing universal arrays
US20040014045A1 (en) * 2002-07-17 2004-01-22 Signature Bioscience Inc. A Corporation Of California Detection of ligand/antiligand complex formation by electromagnetically detectable bulk property measurement

Also Published As

Publication number Publication date
WO2008091378A2 (en) 2008-07-31

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