WO2008122051B1 - Methods and devices for enhanced analysis of field focused cells and particles - Google Patents
Methods and devices for enhanced analysis of field focused cells and particlesInfo
- Publication number
- WO2008122051B1 WO2008122051B1 PCT/US2008/059181 US2008059181W WO2008122051B1 WO 2008122051 B1 WO2008122051 B1 WO 2008122051B1 US 2008059181 W US2008059181 W US 2008059181W WO 2008122051 B1 WO2008122051 B1 WO 2008122051B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluid
- particles
- population
- channel
- acoustically
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract 35
- 238000000034 method Methods 0.000 title claims abstract 34
- 239000012530 fluid Substances 0.000 claims abstract 42
- 210000004027 cell Anatomy 0.000 claims 5
- 238000003556 assay Methods 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 230000005855 radiation Effects 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000013060 biological fluid Substances 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3678—Separation of cells using wave pressure; Manipulation of individual corpuscles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/12—Coulter-counters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/222—Constructional or flow details for analysing fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G01N15/1409—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
- G01N2015/1415—Control of particle position
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
- G01N2015/142—Acoustic or ultrasonic focussing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/024—Mixtures
- G01N2291/02416—Solids in liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/028—Material parameters
- G01N2291/02809—Concentration of a compound, e.g. measured by a surface mass change
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/028—Material parameters
- G01N2291/02836—Flow rate, liquid level
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25625—Dilution
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Acoustics & Sound (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
A system and method for analyzing one or more particles in a flow cell comprises focusing the one or more particles in a fluid stream with an acoustic standing wave to acoustically focus the one or more particles in a flow cell. The fluid is transited within the flow cell with a linear flow velocity ranging between about 0 meters/second and about 10 meters/second in the forward or reverse direction.
Claims
1. A method for acoustically reorienting a fluid in a channel comprising; introducing into a channel a first fluid wherein the first fluid has a first acoustic contrast relative to a second fluid; introducing into the channel the second fluid wherein the second fluid has a second acoustic contrast that is different from the first acoustic contrast; applying acoustic radiation pressure to the channel; acoustically reorienting the second fluid based upon the acoustic contrast of the second fluid.
2. The method of claim 1 further comprising moving the first fluid in a laminar flow stream.
3. The method of claim 2 further comprising moving the second fluid in a second laminar flow stream parallel to a flow stream of the first fluid.
4. The method of claim 1 wherein the second fluid comprises particles therein.
5. The method of claim 4 wherein the first fluid and the second fluid are acoustically reoriented relative to the particles.
6. The method of claim 5 further comprising assaying the particles or fluids to produce an assay,
7. An assay produced by the method of claim 6 wherein the second fluid is a biological fluid.
8. The method of claim 1 wherein the first fluid comprises particles therein.
9. The method of claim 1 wherein the first fluid or the second fluid is acoustically reoriented based upon the first acoustic contrast or the second acoustic contrast.
10. The method of claim 1 further comprising flowing the particles in the second fluid to a particle analyzer in fine with the channel.
11. The method of claim 1 wherein the first fluid or the second fluid comprises reagents.
12. A method for acoustically manipulating a particle using radial acoustic focusing comprising: introducing into a channel a first fluid having a first acoustic contrast with a population of particles suspended therein; introducing into the channel a second fluid having a second acoustic contrast that is greater than or equal to the acoustic contrast of the first fluid; applying a radial acoustic radiation pressure to the channel; and acoustically focusing at least a portion of the population of particles from the first fluid to the second fluid.
13. The method of claim 12 wherein the portion of the population of particles are acoustically focused relative to the first acoustic contrast and the second acoustic contrast.
14. The method of claim 12 further comprising moving the first fluid in a first laminar flow stream and moving the second fluid in a second laminar flow stream.
15. The method of claim 12 wherein the step of acoustically focusing comprises concentrating the population of particles into the second stream.
16. The method of claim 12 further comprising analyzing in a particle analyzer the portion of the population of particles in the second fluid.
17. The method of claim 12 further comprising imaging with an imager the portion of the population of particles in the second fluid.
18. The method of claim 12 further comprising non-dilutive sorting of the portion of the population of particles in the second fluid,
19. The method of claim 12 wherein the first fluid comprises a reagent that reacts with at least some of the population of particles.
20. The method of claim 12 wherein the second fluid is located at a center of the channel.
21. The method of claim 12 wherein the population of particles is selected from the group consisting of cells, beads, or any combination thereof.
22. The method of claim 12 further comprising flowing the particle in the first fluid or the second fluid to a particle analyzer that is in line with the channel.
23. The method of claim 22 wherein the particle analyzer is a flow cytometer.
24. The method of claim 12 wherein the population of particles are cultured cells, the first fluid is cell growth medium in which the cells are grown and the second fluid is new cell growth medium.
25. The method of claim 12 wherein the population of particles are microsphere beads.
26. The method of claim 12 wherein a negative contrast particle is within the population of particles.
27. The method of claim 26 further comprising: capturing a particle of interest from the population of particles with the negative contrast particle; and forcing the particle of interest and the negative contrast particle toward a wall of the channel away from a center of the channel.
28. The method of claim 12 wherein the population of particles is blood cells.
29. The method of claim 28 further comprising assaying the particles or fluids to produce an assay.
30. A method for imaging an acoustically manipulated rare target in an acoustic flow cytorneter comprising: introducing a fluid comprising the rare target to a flow cell; applying acoustic radiation pressure to the flow cell; acoustically focusing the rare target within the flow cell to concentrate the rare target; aligning the concentrated rare target in the flow eel); interrogating the aligned rare target at an interrogation site to obtain an optical signal from the rare target to yield population statistical data: and imaging the rare target to produce a high content image representative of the rare target.
31. The method of claim 30 further comprising correlating the population statistical data with the high content image to produce improved data content.
32. The method of claim 30 further comprising slowing the transit time of the rare target during the interrogating step.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT08733084T ATE538377T1 (en) | 2007-04-02 | 2008-04-02 | METHOD FOR IMPROVED ANALYSIS OF CELLS AND PARTICLES FOCUSED IN AN ACOUSTIC FIELD |
EP08733084A EP2156178B1 (en) | 2007-04-02 | 2008-04-02 | Methods for enhanced analysis of acoustic field focused cells and particles |
US12/239,410 US8865476B2 (en) | 2007-04-02 | 2008-09-26 | Particle switching systems and methods using acoustic radiation pressure |
US12/239,483 US8900870B2 (en) | 2007-04-02 | 2008-09-26 | Methods for fusing cells using acoustic radiation pressure |
US12/239,453 US8846408B2 (en) | 2007-04-02 | 2008-09-26 | Particle analyzing systems and methods using acoustic radiation pressure |
US12/239,390 US8227257B2 (en) | 2007-04-02 | 2008-09-26 | Medium switching systems and methods using acoustic radiation pressure |
US12/239,467 US8134705B2 (en) | 2007-04-02 | 2008-09-26 | Particle imaging systems and methods using acoustic radiation pressure |
US12/239,513 US8309408B2 (en) | 2007-04-02 | 2008-09-26 | Particle quantifying systems and methods using acoustic radiation pressure |
US12/239,501 US9457139B2 (en) | 2007-04-02 | 2008-09-26 | Kits for systems and methods using acoustic radiation pressure |
US13/365,375 US8436993B2 (en) | 2007-04-02 | 2012-02-03 | Methods and systems for controlling the flow of particles for detection |
US13/523,370 US8507293B2 (en) | 2007-04-02 | 2012-06-14 | Medium switching systems and methods using acoustic radiation pressure |
US13/614,956 US9134271B2 (en) | 2007-04-02 | 2012-09-13 | Particle quantifying systems and methods using acoustic radiation pressure |
US13/849,456 US8873051B2 (en) | 2007-04-02 | 2013-03-22 | Methods and systems for controlling the flow of particles for detection |
US14/464,763 US9476855B2 (en) | 2007-04-02 | 2014-08-21 | Particle analyzing systems and methods using acoustic radiation pressure |
US15/239,948 US10254212B2 (en) | 2007-04-02 | 2016-08-18 | Particle analyzing systems and methods using acoustic radiation pressure |
US16/282,793 US10969325B2 (en) | 2007-04-02 | 2019-02-22 | Particle analyzing systems and methods using acoustic radiation pressure |
US17/186,296 US20210364407A1 (en) | 2007-04-02 | 2021-02-26 | Particle Analyzing Systems And Methods Using Acoustic Radiation Pressure |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90970407P | 2007-04-02 | 2007-04-02 | |
US60/909,704 | 2007-04-02 | ||
US2608208P | 2008-02-04 | 2008-02-04 | |
US61/026,082 | 2008-02-04 |
Related Child Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/239,453 Continuation-In-Part US8846408B2 (en) | 2007-04-02 | 2008-09-26 | Particle analyzing systems and methods using acoustic radiation pressure |
US12/239,483 Continuation-In-Part US8900870B2 (en) | 2007-04-02 | 2008-09-26 | Methods for fusing cells using acoustic radiation pressure |
US12/239,410 Continuation-In-Part US8865476B2 (en) | 2007-04-02 | 2008-09-26 | Particle switching systems and methods using acoustic radiation pressure |
US12/239,513 Continuation-In-Part US8309408B2 (en) | 2007-04-02 | 2008-09-26 | Particle quantifying systems and methods using acoustic radiation pressure |
US12/239,390 Continuation-In-Part US8227257B2 (en) | 2007-04-02 | 2008-09-26 | Medium switching systems and methods using acoustic radiation pressure |
US12/239,467 Continuation-In-Part US8134705B2 (en) | 2007-04-02 | 2008-09-26 | Particle imaging systems and methods using acoustic radiation pressure |
US12/239,501 Continuation-In-Part US9457139B2 (en) | 2007-04-02 | 2008-09-26 | Kits for systems and methods using acoustic radiation pressure |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008122051A1 WO2008122051A1 (en) | 2008-10-09 |
WO2008122051B1 true WO2008122051B1 (en) | 2008-11-20 |
Family
ID=39808730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/059181 WO2008122051A1 (en) | 2007-04-02 | 2008-04-02 | Methods and devices for enhanced analysis of field focused cells and particles |
Country Status (4)
Country | Link |
---|---|
US (15) | US9457139B2 (en) |
EP (3) | EP2664916B1 (en) |
AT (1) | ATE538377T1 (en) |
WO (1) | WO2008122051A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9134271B2 (en) | 2007-04-02 | 2015-09-15 | Life Technologies Corporation | Particle quantifying systems and methods using acoustic radiation pressure |
Families Citing this family (241)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US7340957B2 (en) * | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US20100137163A1 (en) | 2006-01-11 | 2010-06-03 | Link Darren R | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors |
US20080003142A1 (en) | 2006-05-11 | 2008-01-03 | Link Darren R | Microfluidic devices |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US7835000B2 (en) | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8083068B2 (en) * | 2007-04-09 | 2011-12-27 | Los Alamos National Security, Llc | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
US7837040B2 (en) | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
EP2142279A2 (en) | 2007-04-16 | 2010-01-13 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Systems and methods for particle focusing in microchannels |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US8528406B2 (en) * | 2007-10-24 | 2013-09-10 | Los Alamos National Security, LLP | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8263407B2 (en) | 2007-10-24 | 2012-09-11 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8266951B2 (en) * | 2007-12-19 | 2012-09-18 | Los Alamos National Security, Llc | Particle analysis in an acoustic cytometer |
US8714014B2 (en) * | 2008-01-16 | 2014-05-06 | Life Technologies Corporation | System and method for acoustic focusing hardware and implementations |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
US7830517B2 (en) * | 2008-09-05 | 2010-11-09 | Palo Alto Research Center Incorporated | Flow schemes for enhanced light-target interaction in fluidic channels |
US8865003B2 (en) * | 2008-09-26 | 2014-10-21 | Abbott Laboratories | Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended |
CA2759392A1 (en) | 2009-04-27 | 2010-11-04 | Abbott Laboratories | Method for discriminating red blood cells from white blood cells by using forward scattering from a laser in an automated hematology analyzer |
WO2010132471A2 (en) | 2009-05-11 | 2010-11-18 | Stc.Unm | Synthesis of stable elastomeric negative acoustic contrast particles |
WO2010132053A1 (en) | 2009-05-13 | 2010-11-18 | Indevr, Inc. | Flow measurement and control for improved quantification of particles in flow cytometry |
EP2432421A4 (en) | 2009-05-19 | 2013-03-06 | Univ Rochester | Ultrasound technology to control the spatial organization of cells and proteins in engineered tissues |
EP2259065A1 (en) * | 2009-06-03 | 2010-12-08 | Erasmus University Medical Center Rotterdam | Methods, reagents and kits for flow cytometric immunophenotyping |
US8772004B2 (en) * | 2009-06-25 | 2014-07-08 | Old Dominion University Research Foundation | System and method for high-voltage pulse assisted aggregation of algae |
US20110001963A1 (en) * | 2009-07-02 | 2011-01-06 | Durack Gary P | System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system |
CN102472701A (en) * | 2009-07-06 | 2012-05-23 | 索尼公司 | Microfluidic device |
US20110003330A1 (en) * | 2009-07-06 | 2011-01-06 | Durack Gary P | Microfluidic device |
WO2011005760A1 (en) * | 2009-07-06 | 2011-01-13 | Sony Corporation | Microfluidic device having onboard tissue or cell sample handling |
WO2011005757A1 (en) | 2009-07-07 | 2011-01-13 | Sony Corporation | Microfluidic device adapted for post-centrifugation use with selective sample extraction and methods for its use |
CN102472702B (en) * | 2009-07-07 | 2014-05-21 | 索尼公司 | Method for detecting particles in samples |
WO2011005754A1 (en) * | 2009-07-08 | 2011-01-13 | Sony Corporation | Microfluidic device having a flow channel within a gain medium |
JP5047248B2 (en) * | 2009-09-30 | 2012-10-10 | 株式会社日立ハイテクノロジーズ | Flow cell, detector, and liquid chromatograph |
US8691145B2 (en) * | 2009-11-16 | 2014-04-08 | Flodesign Sonics, Inc. | Ultrasound and acoustophoresis for water purification |
HUP0900741A2 (en) * | 2009-11-27 | 2011-07-28 | 3Dhistech Kft | Assembly and procedure for digitization of moving slide |
AU2010326180B2 (en) * | 2009-12-04 | 2015-06-18 | Life Technologies Corporation | Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry |
AU2015224429B2 (en) * | 2009-12-04 | 2017-05-25 | Life Technologies Corporation | Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
AU2011222514A1 (en) * | 2010-03-04 | 2012-09-20 | University Of Utah Research Foundation | Colloidal-crystal quantum dots as tracers in underground formations |
DE102010012580A1 (en) * | 2010-03-23 | 2011-09-29 | Hochschule Niederrhein | Device for time-resolved measurement of fluorescence signals in flow-cytometric investigation of e.g. cells, has detector with measuring point comprising local displacements that are changed during operation of device |
EP2550351A4 (en) * | 2010-03-25 | 2014-07-09 | Quantalife Inc | Detection system for droplet-based assays |
US8590710B2 (en) * | 2010-06-10 | 2013-11-26 | Samsung Electronics Co., Ltd. | Target particles-separating device and method using multi-orifice flow fractionation channel |
WO2011159957A2 (en) | 2010-06-16 | 2011-12-22 | Flodesign Sonics, Inc. | Phononic crystal desalination system and method of use |
US9182353B2 (en) | 2010-07-22 | 2015-11-10 | Hach Company | Lab-on-a-chip for alkalinity analysis |
US8757871B2 (en) * | 2010-08-16 | 2014-06-24 | The Board Of Trustees Of The University Of Illinois | Particle dynamics microscopy using temperature jump and probe anticorrelation/correlation techniques |
US8679338B2 (en) | 2010-08-23 | 2014-03-25 | Flodesign Sonics, Inc. | Combined acoustic micro filtration and phononic crystal membrane particle separation |
US9421553B2 (en) | 2010-08-23 | 2016-08-23 | Flodesign Sonics, Inc. | High-volume fast separation of multi-phase components in fluid suspensions |
US20120048190A1 (en) * | 2010-08-31 | 2012-03-01 | Wirth Reinhold F | System and method for ultrasonic focused printing |
EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9170138B2 (en) * | 2010-10-01 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced microfluidic electromagnetic measurements |
US8969071B2 (en) * | 2010-10-13 | 2015-03-03 | Lawrence Livermore National Security, Llc | Passive chip-based droplet sorting |
US8460607B2 (en) | 2010-10-22 | 2013-06-11 | Abbott Laboratories | Microfluidic device having a flow channel |
US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
US8980106B2 (en) | 2010-12-15 | 2015-03-17 | Abbott Laboratories | Apparatus and method for separation of whole blood into plasma or serum and cells |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
JP5973471B2 (en) | 2011-03-03 | 2016-08-23 | ライフ テクノロジーズ コーポレーション | Sampling probe, system, apparatus and method |
WO2012129170A1 (en) * | 2011-03-18 | 2012-09-27 | Cidra Corporate Services Inc. | Acoustic standing wave particle size or distribution detection |
US8399262B2 (en) | 2011-03-23 | 2013-03-19 | Darrel A. Mazzari | Biosensor |
WO2012135667A1 (en) | 2011-04-01 | 2012-10-04 | Life Technologies Corporation | System and method for determining copies-per-unit-volume using pcr and flow control of droplets |
AU2012250179B2 (en) | 2011-04-27 | 2016-08-18 | Becton Dickinson And Company | Devices and methods for separating magnetically labeled moieties in a sample |
WO2012167142A2 (en) | 2011-06-02 | 2012-12-06 | Raindance Technolgies, Inc. | Enzyme quantification |
EP2724160A2 (en) * | 2011-06-27 | 2014-04-30 | Life Technologies Corporation | Acoustic cytometry methods and protocols |
US9291547B2 (en) * | 2011-07-15 | 2016-03-22 | Nanyang Technological University | Immersion refractometer |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US9656263B2 (en) * | 2011-09-28 | 2017-05-23 | Acousort Ab | System and method to separate cells and/or particles |
KR102038400B1 (en) * | 2012-02-04 | 2019-11-26 | 센터 포 셀룰러 앤드 멀레큘러 플랫폼즈 (씨-캠프) | A microfluidic-based flow analyzer |
US9797836B1 (en) * | 2012-02-29 | 2017-10-24 | National Technology & Engineering Solutions Of Sandia, Llc | Hyperspectral imaging flow cytometer |
US10180398B2 (en) * | 2012-02-29 | 2019-01-15 | National Technology & Engineering Solutions Of Sandia, Llc | Trajectory-based triggering system for hyperspectral imaging flow cytometer |
US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US9340435B2 (en) | 2012-03-15 | 2016-05-17 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US9422328B2 (en) | 2012-03-15 | 2016-08-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
US9272234B2 (en) | 2012-03-15 | 2016-03-01 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
US9822333B2 (en) | 2012-03-15 | 2017-11-21 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9783775B2 (en) | 2012-03-15 | 2017-10-10 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9796956B2 (en) | 2013-11-06 | 2017-10-24 | Flodesign Sonics, Inc. | Multi-stage acoustophoresis device |
US9416344B2 (en) | 2012-03-15 | 2016-08-16 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9623348B2 (en) | 2012-03-15 | 2017-04-18 | Flodesign Sonics, Inc. | Reflector for an acoustophoretic device |
US9688958B2 (en) | 2012-03-15 | 2017-06-27 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US10040011B2 (en) | 2012-03-15 | 2018-08-07 | Flodesign Sonics, Inc. | Acoustophoretic multi-component separation technology platform |
US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
US10370635B2 (en) | 2012-03-15 | 2019-08-06 | Flodesign Sonics, Inc. | Acoustic separation of T cells |
US9567559B2 (en) | 2012-03-15 | 2017-02-14 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
US11324873B2 (en) | 2012-04-20 | 2022-05-10 | Flodesign Sonics, Inc. | Acoustic blood separation processes and devices |
WO2013177560A1 (en) * | 2012-05-25 | 2013-11-28 | The Regents Of The University Of California | Microfluidic systems for particle trapping and separation |
US9746412B2 (en) | 2012-05-30 | 2017-08-29 | Iris International, Inc. | Flow cytometer |
US9180449B2 (en) | 2012-06-12 | 2015-11-10 | Hach Company | Mobile water analysis |
WO2013188770A1 (en) * | 2012-06-14 | 2013-12-19 | Bio-Rad Laboratories, Inc. | Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry |
US9544777B2 (en) | 2012-06-18 | 2017-01-10 | Microsoft Technology Licensing, Llc | White space utilization |
IN2014MN02559A (en) * | 2012-06-22 | 2015-07-24 | Univ Macquarie | |
US8709250B2 (en) | 2012-07-12 | 2014-04-29 | Heliae Development, Llc | Tubular electro-acoustic aggregation device |
US8673154B2 (en) | 2012-07-12 | 2014-03-18 | Heliae Development, Llc | Tunable electrical field for aggregating microorganisms |
US8668827B2 (en) | 2012-07-12 | 2014-03-11 | Heliae Development, Llc | Rectangular channel electro-acoustic aggregation device |
US8709258B2 (en) | 2012-07-12 | 2014-04-29 | Heliae Development, Llc | Patterned electrical pulse microorganism aggregation |
US8702991B2 (en) | 2012-07-12 | 2014-04-22 | Heliae Development, Llc | Electrical microorganism aggregation methods |
EP2877832B1 (en) | 2012-07-27 | 2020-10-28 | Engender Technologies Limited | System for microfluidic orientation and sorting of particles |
US9094834B2 (en) | 2012-09-11 | 2015-07-28 | Microsoft Technology Licensing, Llc | White space utilization |
KR101933620B1 (en) * | 2012-09-18 | 2018-12-28 | 삼성전자주식회사 | Compositions and kits for detecting a vesicle, and methods for analyzing the vesicle using the same |
US20150253226A1 (en) * | 2012-09-21 | 2015-09-10 | Acousort Ab | Method for separating cells-bead complexes |
CN110579435B (en) * | 2012-10-15 | 2023-09-26 | 纳诺赛莱克特生物医药股份有限公司 | System, apparatus and method for particle sorting |
CN104736718A (en) | 2012-10-26 | 2015-06-24 | 贝克顿·迪金森公司 | Devices and methods for manipulating components in a fluid sample |
USD768872S1 (en) | 2012-12-12 | 2016-10-11 | Hach Company | Cuvette for a water analysis instrument |
US9288682B2 (en) | 2013-02-22 | 2016-03-15 | Microsoft Technology Licensing, Llc | White space utilization |
WO2014133451A1 (en) * | 2013-02-28 | 2014-09-04 | Acousort Ab | System and method to analyze non-spherical cells |
WO2014136776A1 (en) * | 2013-03-08 | 2014-09-12 | コニカミノルタ株式会社 | Resin particles for fluorescent labels |
US9854501B2 (en) | 2013-03-14 | 2017-12-26 | Microsoft Technology Licensing, Llc | Radio spectrum utilization |
GB2525570B (en) * | 2013-03-15 | 2018-06-27 | Waters Technologies Corp | Systems and devices for refractive index detection |
ES2900530T3 (en) * | 2013-04-12 | 2022-03-17 | Becton Dickinson Co | Automated setup for cell sorting |
US9645080B2 (en) | 2013-04-16 | 2017-05-09 | University Of Washington | Systems, devices, and methods for separating, concentrating, and/or differentiating between cells from a cell sample |
US9725690B2 (en) | 2013-06-24 | 2017-08-08 | Flodesign Sonics, Inc. | Fluid dynamic sonic separator |
US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
FR3009084B1 (en) * | 2013-07-23 | 2015-08-07 | Commissariat Energie Atomique | METHOD FOR SORTING CELLS AND ASSOCIATED DEVICE |
US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US20150104845A1 (en) * | 2013-10-15 | 2015-04-16 | The Penn State Research Foundation | Acoustic manipulation process and acoustic manipulation device |
US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
US11724286B2 (en) * | 2013-11-01 | 2023-08-15 | Tomra Sorting Nv | Method and apparatus for detecting matter |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
US10098581B2 (en) * | 2014-01-17 | 2018-10-16 | Massachusetts Institute Of Technology | Integrated electrical profiling system for measuring leukocytes activation from whole blood |
WO2015124942A2 (en) * | 2014-02-20 | 2015-08-27 | Malvern Instruments Limited | Heterogeneous fluid sample characterization |
EP3134719B1 (en) * | 2014-04-21 | 2021-11-03 | Aber Instruments, Inc. | Particle sensor with interferent discrimination |
KR102450509B1 (en) | 2014-05-08 | 2022-10-04 | 프로디자인 소닉스, 인크. | Acoustophoretic device with piezoelectric transducer array |
WO2015191534A2 (en) | 2014-06-09 | 2015-12-17 | Ascent Bio-Nano Technologies, Inc. | System for manipulation and sorting of particles |
SG11201610712XA (en) | 2014-07-02 | 2017-01-27 | Flodesign Sonics Inc | Acoustophoretic device with uniform fluid flow |
US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
WO2016049378A1 (en) | 2014-09-24 | 2016-03-31 | Duke University | Disposable pipette tip and methods of use |
WO2016054192A1 (en) | 2014-09-30 | 2016-04-07 | Flodesign Sonics, Inc. | Acoustophoretic clarification of particle-laden non-flowing fluids |
SG11201702571RA (en) * | 2014-10-01 | 2017-04-27 | Water Optics Technology Pte Ltd | A sensor for particle detection in a fluid |
US10564088B2 (en) | 2014-10-09 | 2020-02-18 | Kinetic River Corp. | Particle analysis and sorting apparatus and methods |
US11965812B2 (en) | 2014-10-09 | 2024-04-23 | Kinetic River Corp. | Apparatus and methods for particle analysis and autofluorescence discrimination |
US11740174B2 (en) | 2014-10-09 | 2023-08-29 | Kinetic River Corp. | Apparatus and methods for particle analysis and autofluorescence discrimination |
US9658148B2 (en) * | 2014-10-09 | 2017-05-23 | Kinetic River Corp. | Particle analysis and sorting apparatus and methods |
BR112017008429B1 (en) | 2014-10-24 | 2022-08-09 | Life Technologies Corporation | METHOD TO PURIFY A SAMPLE IN A TWO-PHASE SYSTEM AND SAMPLE PURIFICATION SYSTEM |
FR3027672B1 (en) * | 2014-10-24 | 2018-11-23 | Biomerieux | METHOD AND DEVICES FOR TREATING BIOLOGICAL SAMPLES |
EP3237037B1 (en) * | 2014-12-22 | 2019-01-30 | Biomet Biologics, LLC | Cell washing device using a bulk acoustic wave with phantom material |
US9316591B1 (en) * | 2015-02-09 | 2016-04-19 | University Of Guelph | Biosensor for detection of subclinical ketosis |
CN105987870A (en) * | 2015-02-10 | 2016-10-05 | 博奥生物集团有限公司 | Flow cell sorting system and its focusing detection method and fluidic chip |
DE102015202574A1 (en) * | 2015-02-12 | 2016-08-18 | Albert-Ludwigs-Universität Freiburg | Apparatus and method for dispensing particles aligned using an acoustic field in free-flying drops |
CA2978906A1 (en) * | 2015-02-16 | 2016-08-25 | Flodesign Sonics Inc. | Acoustic microreactor and methods of use thereof |
JP6438319B2 (en) * | 2015-02-18 | 2018-12-12 | アズビル株式会社 | Particle detector |
JP6557022B2 (en) * | 2015-02-18 | 2019-08-07 | アズビル株式会社 | Particle detector |
WO2016132222A2 (en) | 2015-02-19 | 2016-08-25 | Premium Genetics (Uk) Ltd. | Scanning infrared measurement system |
US10697010B2 (en) * | 2015-02-19 | 2020-06-30 | Becton, Dickinson And Company | High-throughput single-cell analysis combining proteomic and genomic information |
US10370653B2 (en) * | 2015-02-22 | 2019-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Micro-screening apparatus, process, and products |
US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
WO2016161109A1 (en) * | 2015-03-31 | 2016-10-06 | The Regents Of The University Of California | System and method for tunable patterning and assembly of particles via acoustophoresis |
US9855382B2 (en) * | 2015-03-31 | 2018-01-02 | Biomet Biologics, Llc | Cell washing device using standing acoustic waves and a phantom material |
US10737012B2 (en) | 2015-03-31 | 2020-08-11 | Biomet Biologics, Inc. | Cell washing using acoustic waves |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
EP3288660A1 (en) | 2015-04-29 | 2018-03-07 | Flodesign Sonics Inc. | Acoustophoretic device for angled wave particle deflection |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
EP3296014B1 (en) * | 2015-05-13 | 2023-11-15 | Airex Co., Ltd. | Particle control method |
US9550134B2 (en) | 2015-05-20 | 2017-01-24 | Flodesign Sonics, Inc. | Acoustic manipulation of particles in standing wave fields |
US10161926B2 (en) | 2015-06-11 | 2018-12-25 | Flodesign Sonics, Inc. | Acoustic methods for separation of cells and pathogens |
US10634602B2 (en) * | 2015-06-12 | 2020-04-28 | Cytochip Inc. | Fluidic cartridge for cytometry and additional analysis |
US9663756B1 (en) | 2016-02-25 | 2017-05-30 | Flodesign Sonics, Inc. | Acoustic separation of cellular supporting materials from cultured cells |
EP3319739B1 (en) | 2015-07-09 | 2021-03-31 | Flodesign Sonics Inc. | Non-planar and non-symmetrical piezolectric crystals and reflectors |
US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
US20170089881A1 (en) * | 2015-09-29 | 2017-03-30 | The Board Of Trustees Of The University Of Illinois | System and method for high-throughput, optomechanical flow cytometry |
EP3957996A1 (en) * | 2015-10-05 | 2022-02-23 | The University of North Carolina at Chapel Hill | Fluidic devices, kits, and solid supports for decoding methods for multiplexing assays |
US9862941B2 (en) | 2015-10-14 | 2018-01-09 | Pioneer Hi-Bred International, Inc. | Single cell microfluidic device |
US10245821B2 (en) | 2015-12-04 | 2019-04-02 | At&T Intellectual Property I, L.P. | Reusable networked 3-D printing |
US10648900B2 (en) * | 2015-12-23 | 2020-05-12 | Becton, Dickinson And Company | Multi-color flow cytometric analysis of samples with low cell numbers |
WO2017108129A1 (en) * | 2015-12-23 | 2017-06-29 | Siemens Healthcare Gmbh | Flow cell for analyzing particles in a liquid to be examined |
WO2017132419A1 (en) * | 2016-01-26 | 2017-08-03 | Flodesign Sonics, Inc. | Acoustic separation of t cells |
KR101807256B1 (en) * | 2016-01-26 | 2017-12-08 | 한양대학교 에리카산학협력단 | Particle separator and method for separating particle |
JP6554045B2 (en) | 2016-02-25 | 2019-07-31 | 東芝メモリ株式会社 | Dust collector and substrate processing system |
FR3049346A1 (en) * | 2016-03-23 | 2017-09-29 | Anaquant | SOLUBLE BALLS FOR THE PREPARATION OF SOLUTIONS |
US10710006B2 (en) | 2016-04-25 | 2020-07-14 | Flodesign Sonics, Inc. | Piezoelectric transducer for generation of an acoustic standing wave |
EP3481361A1 (en) | 2016-05-03 | 2019-05-15 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US9968943B2 (en) * | 2016-06-30 | 2018-05-15 | United Arab Emirates University | Magnetic particle separator |
EP3479097B1 (en) * | 2016-07-01 | 2023-07-12 | Life Technologies Corporation | Devices for concentration of particles |
US11291756B2 (en) * | 2016-07-28 | 2022-04-05 | The Charles Stark Draper Laboratory, Inc. | Acoustic separation for bioprocessing |
EP3525933A1 (en) | 2016-10-11 | 2019-08-21 | The Regents of the University of California | Systems and methods to encapsulate and preserve organic matter for analysis |
EP3529347A1 (en) | 2016-10-19 | 2019-08-28 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
WO2018085678A1 (en) * | 2016-11-07 | 2018-05-11 | Cytochip Inc. | Fluidic cartridge for cytometry and additional analysis |
EP3581917A4 (en) * | 2017-02-10 | 2020-10-14 | Tosoh Corporation | Particle detection device and particle detection method |
EP3595817A4 (en) * | 2017-03-13 | 2021-06-23 | New Mexico Technical Research Foundation | Separation of nanoparticles via acoustofluidic flow relocation |
JP6640781B2 (en) * | 2017-03-23 | 2020-02-05 | キオクシア株式会社 | Semiconductor manufacturing equipment |
WO2018183939A1 (en) * | 2017-03-31 | 2018-10-04 | Life Technologies Corporation | Apparatuses, systems and methods for imaging flow cytometry |
JP7078034B2 (en) * | 2017-03-31 | 2022-05-31 | ソニーグループ株式会社 | Channel unit and fine particle analyzer |
CA3057505A1 (en) | 2017-03-31 | 2018-10-04 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling |
WO2018185672A1 (en) | 2017-04-06 | 2018-10-11 | Magbiosense Inc. | Bio-assay capture surfaces with bleached autofluorescence |
KR102331147B1 (en) * | 2017-04-20 | 2021-11-26 | 엘지이노텍 주식회사 | Apparatus for sensing particle |
US10677709B2 (en) * | 2017-04-28 | 2020-06-09 | Becton, Dickinson And Company | Particle detection cartridges, systems thereof and methods for using the same |
US10914723B2 (en) | 2017-04-28 | 2021-02-09 | The Charles Stark Draper Laboratory, Inc. | Acoustic separation of particles for bioprocessing |
US10780438B2 (en) | 2017-06-09 | 2020-09-22 | The Regents Of The University Of California | High-efficiency encapsulation in droplets based on hydrodynamic vortices control |
US11517901B2 (en) | 2017-06-09 | 2022-12-06 | The Regents Of The University Of California | High-efficiency particle encapsulation in droplets with particle spacing and downstream droplet sorting |
EP3421975A1 (en) * | 2017-06-30 | 2019-01-02 | Centre National De La Recherche Scientifique | Methods and device for manipulating objects |
US11331668B2 (en) * | 2017-08-31 | 2022-05-17 | Acousort Ab | Methods and devices for acoustophoretic operations in polymer chips |
WO2019075409A1 (en) | 2017-10-12 | 2019-04-18 | The Regents Of The University Of California | Microfluidic label-free isolation and identification of cells using fluorescence lifetime imaging (flim) |
US11499127B2 (en) | 2017-10-20 | 2022-11-15 | The Regents Of The University Of California | Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks |
WO2019079787A1 (en) | 2017-10-20 | 2019-04-25 | The Regents Of The University Of California | Microfluidic systems and methods for lipoplex-mediated cell transfection |
EP3727564A1 (en) * | 2017-10-23 | 2020-10-28 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for electroporation of acoustically-aligned cells |
DE102017220792A1 (en) * | 2017-11-21 | 2019-05-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method and apparatus for sorting particles of a material stream |
US20200276756A1 (en) * | 2017-11-24 | 2020-09-03 | Nanyang Technological University | Apparatus and method for three dimensional printing of an ink |
SG11202003907WA (en) | 2017-12-14 | 2020-05-28 | Flodesign Sonics Inc | Acoustic transducer drive and controller |
US11131627B2 (en) * | 2018-02-07 | 2021-09-28 | Artium Technologies, Inc. | Fuel contamination monitor |
US20190270084A1 (en) | 2018-03-03 | 2019-09-05 | Yuchen Zhou | Methods and apparatus to separate biological entities |
US11571696B2 (en) | 2018-03-03 | 2023-02-07 | Applied Cells Inc. | Biological entity separation device and method of use |
EP3796998A1 (en) | 2018-05-23 | 2021-03-31 | ABS Global, Inc. | Systems and methods for particle focusing in microchannels |
CN109157692A (en) * | 2018-06-15 | 2019-01-08 | 翁炳焕 | People-people's cell merges the preparation of female tire blood group incompatibility treatment hybrid strain |
US10983044B2 (en) | 2018-06-26 | 2021-04-20 | Arometrix, Inc. | Device, system and method for in-situ optical monitoring and control of extraction and purification of plant materials |
US11698364B2 (en) * | 2018-06-27 | 2023-07-11 | University Of Washington | Real-time cell-surface marker detection |
AU2019331113A1 (en) | 2018-08-31 | 2021-03-18 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for high throughput high efficiency transfection of cells |
CN113167723A (en) | 2018-10-02 | 2021-07-23 | 仪器实验室公司 | Disposable hemolysis sensor |
WO2020091720A1 (en) * | 2018-10-29 | 2020-05-07 | University Of Wyoming | Enhancement of fountain flow cytometry by reducing background light intensity |
CN109331996A (en) * | 2018-11-06 | 2019-02-15 | 中南大学 | A kind of single side tooth plate medium, two-sided tooth plate medium, tooth plate cartridge and Horizontal ring high intensity magnetic separator |
KR102465271B1 (en) * | 2018-12-13 | 2022-11-11 | 한국전자통신연구원 | Fluorescence sensor for measuring microalgea and method of operation the same |
US11137337B2 (en) | 2019-01-21 | 2021-10-05 | Essen Instruments, Inc. | Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation |
JP7466563B2 (en) * | 2019-03-29 | 2024-04-15 | ベクトン・ディキンソン・アンド・カンパニー | Parameters to use for particle discrimination |
EP4245140A3 (en) | 2019-04-18 | 2024-01-17 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
US11193916B2 (en) * | 2019-05-02 | 2021-12-07 | SciLogica Corp. | Calibration of a gas sensor |
CN110465339B (en) * | 2019-09-03 | 2021-02-09 | 浙江大学 | Method for positioning particles in fluid-solid two-phase transportation |
CN110734412B (en) * | 2019-11-08 | 2021-08-13 | 扬州工业职业技术学院 | Benzothiazole derivative, synthesis method thereof and application of benzothiazole derivative as antibacterial drug |
US11004315B1 (en) * | 2019-11-21 | 2021-05-11 | SmartBAR Corp. | Methods and apparatus for smart distribution of restaurant items and notification of order readiness |
US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
US11709116B2 (en) | 2020-02-04 | 2023-07-25 | Sartorius Bioanalytical Instruments, Inc. | Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods |
EP3978097A4 (en) * | 2020-08-04 | 2022-07-06 | Beihang University | Device for separating submicron particles in air |
CN112014366B (en) * | 2020-08-11 | 2024-01-02 | 国联汽车动力电池研究院有限责任公司 | Method for identifying stability of positive electrode material |
JP2024515972A (en) | 2021-04-27 | 2024-04-11 | ライフ テクノロジーズ コーポレーション | Sample Stream Centering |
US20230096558A1 (en) * | 2021-09-29 | 2023-03-30 | Charles Stark Draper Laboratory, Inc. | Cell separation particles for and/not operations or multiple targets |
WO2023234130A1 (en) * | 2022-05-30 | 2023-12-07 | 国立大学法人信州大学 | Particle two-dimensional acoustic focusing device, and acoustic concentration device using same |
Family Cites Families (163)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US477823A (en) * | 1892-06-28 | Ernst richter and adam schaefer | ||
US757066A (en) * | 1902-10-29 | 1904-04-12 | Maximilian Soblik | Pneumatic type-writer with open-pipe system. |
US955282A (en) * | 1908-10-12 | 1910-04-19 | Henry Pocock | Adjustable concrete-mold. |
GB500271A (en) | 1936-05-04 | 1939-02-06 | Metallgesellschaft Ag | Process of and apparatus for clarifying liquids |
US3882732A (en) * | 1973-08-31 | 1975-05-13 | Nasa | Material suspension within an acoustically excited resonant chamber |
US4055491A (en) | 1976-06-02 | 1977-10-25 | Porath Furedi Asher | Apparatus and method for removing fine particles from a liquid medium by ultrasonic waves |
US4079959A (en) * | 1976-06-17 | 1978-03-21 | Vance Charles E | Tractor and semi-trailer safety device |
DE2738509A1 (en) * | 1977-08-26 | 1979-03-08 | Bayer Ag | RESPONSE COPY |
CA1142466A (en) | 1979-01-09 | 1983-03-08 | Cesar Milstein | Cell lines |
US4265124A (en) | 1979-06-04 | 1981-05-05 | Rockwell International Corporation | Remote acoustic wave sensors |
US4285810A (en) | 1980-02-29 | 1981-08-25 | E. I. Du Pont De Nemours And Company | Method and apparatus for field flow fractionation |
DE3027433A1 (en) | 1980-07-19 | 1982-02-18 | Messerschmitt-Bölkow-Blohm GmbH, 8000 München | Pressure diffusion sepn. method for mixts. - uses perpendicular identical frequency wave fields with differing phases |
US4523982A (en) * | 1981-03-05 | 1985-06-18 | The Dow Chemical Company | Electron rich aromatics as cure promoters for radiation curable compositions |
US4434230A (en) * | 1981-08-12 | 1984-02-28 | Research Corporation | Human nonsecretory plasmacytoid cell line |
US4523682A (en) | 1982-05-19 | 1985-06-18 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Acoustic particle separation |
US4492752A (en) * | 1982-09-03 | 1985-01-08 | Ortho Diagnostics Systems Inc. | Method for discriminating between unstained and absorbing dye stained cells |
EP0147032B1 (en) | 1983-10-31 | 1990-02-07 | National Research Development Corporation | manipulation of particles |
GB8417240D0 (en) * | 1984-07-06 | 1984-08-08 | Unilever Plc | Particle separation |
US4604542A (en) * | 1984-07-25 | 1986-08-05 | Gould Inc. | Broadband radial vibrator transducer with multiple resonant frequencies |
US5800861A (en) | 1985-08-15 | 1998-09-01 | The Sherwin-Williams Company | High solid infrared absorbing compositions |
US4759775A (en) * | 1986-02-21 | 1988-07-26 | Utah Bioresearch, Inc. | Methods and apparatus for moving and separating materials exhibiting different physical properties |
US4983189A (en) * | 1986-02-21 | 1991-01-08 | Technical Research Associates, Inc. | Methods and apparatus for moving and separating materials exhibiting different physical properties |
GB8612759D0 (en) | 1986-05-27 | 1986-07-02 | Unilever Plc | Manipulating particulate matter |
JPS63139231A (en) | 1986-07-18 | 1988-06-11 | Akira Mizuno | Method for measuring fine particles in liquid |
US5346670A (en) | 1986-12-24 | 1994-09-13 | British Technology Group U.S.A. Inc. | Phthalocyanine and tetrabenztriazaporphyrin reagents |
JPS63139231U (en) | 1987-03-04 | 1988-09-13 | ||
AT389235B (en) | 1987-05-19 | 1989-11-10 | Stuckart Wolfgang | METHOD FOR CLEANING LIQUIDS BY MEANS OF ULTRASOUND AND DEVICES FOR CARRYING OUT THIS METHOD |
US4913883A (en) | 1987-07-20 | 1990-04-03 | Hitachi, Ltd. | Particle agglutination immunoassay apparatus |
JPH01112161A (en) | 1987-07-20 | 1989-04-28 | Hitachi Ltd | Immune agglutination determining device |
US4777823A (en) | 1987-08-20 | 1988-10-18 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Controlled sample orientation and rotation in an acoustic levitator |
GB8724067D0 (en) | 1987-10-14 | 1987-11-18 | Unilever Plc | Manipulating particles |
US4845025A (en) | 1987-11-10 | 1989-07-04 | Coulter Corporation | Biological sample mixing apparatus and method |
US5040890A (en) * | 1987-11-25 | 1991-08-20 | Becton, Dickinson And Company | Sheathed particle flow controlled by differential pressure |
US4987086A (en) | 1987-11-30 | 1991-01-22 | Becton, Dickinson And Company | Method for analysis of subpopulations of cells |
US4867559A (en) | 1988-01-06 | 1989-09-19 | Amoco Corporation | Liquid/liquid fiber-optic fluorescence detector and absorbance analyzer |
JPH0718785B2 (en) | 1988-09-19 | 1995-03-06 | 株式会社日立製作所 | Flow cell device |
EP0703296B1 (en) | 1988-09-29 | 1998-07-22 | Chiron Corporation | Polynucleotide determination by displacement of a strand on a capture probe |
AT390739B (en) * | 1988-11-03 | 1990-06-25 | Ewald Dipl Ing Dr Benes | METHOD AND DEVICE FOR SEPARATING PARTICLES DISPERSED IN A DISPERSION AGENT |
US4964303A (en) | 1988-11-15 | 1990-10-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Acoustic positioning and orientation prediction |
US5032381A (en) * | 1988-12-20 | 1991-07-16 | Tropix, Inc. | Chemiluminescence-based static and flow cytometry |
US4979824A (en) | 1989-05-26 | 1990-12-25 | Board Of Trustees Of The Leland Stanford Junior University | High sensitivity fluorescent single particle and single molecule detection apparatus and method |
US5030002A (en) | 1989-08-11 | 1991-07-09 | Becton, Dickinson And Company | Method and apparatus for sorting particles with a moving catcher tube |
US5085783A (en) | 1990-08-16 | 1992-02-04 | Case Western Reserve University | Acoustically driven particle separation method and apparatus |
US5504337A (en) * | 1990-10-10 | 1996-04-02 | Joseph R. Lakowicz | Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry |
US5376551A (en) | 1991-03-12 | 1994-12-27 | University Of Utah Research Foundation | Apparatus for using fluorescently labeled ligands in studying interaction of a native ligand and its receptor |
US5264906A (en) | 1992-07-08 | 1993-11-23 | The United States Of America As Represented By The Secretary Of The Navy | Bioluminescence bathyphotometer |
US5674698A (en) | 1992-09-14 | 1997-10-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US6216538B1 (en) * | 1992-12-02 | 2001-04-17 | Hitachi, Ltd. | Particle handling apparatus for handling particles in fluid by acoustic radiation pressure |
US5395588A (en) | 1992-12-14 | 1995-03-07 | Becton Dickinson And Company | Control of flow cytometer having vacuum fluidics |
US5430541A (en) * | 1993-01-12 | 1995-07-04 | Applied Biosystems Inc. | High efficiency fluorescence flow cell for capillary liquid chromatography or capillary electrophoresis |
JP3205413B2 (en) * | 1993-02-15 | 2001-09-04 | 株式会社日立製作所 | Particle measuring device and particle measuring method |
US5547849A (en) * | 1993-02-17 | 1996-08-20 | Biometric Imaging, Inc. | Apparatus and method for volumetric capillary cytometry |
US5355688A (en) * | 1993-03-23 | 1994-10-18 | Shape, Inc. | Heat pump and air conditioning system incorporating thermal storage |
AT398707B (en) | 1993-05-11 | 1995-01-25 | Trampler Felix | MULTILAYER PIEZOELECTRIC RESONATOR FOR THE SEPARATION OF SUSPENDED PARTICLES |
BR9406396A (en) * | 1993-05-11 | 1996-02-27 | Sonosep Biotech Inc | Multi-layer piezoelectric resonator for the separation of suspended particles |
NO932088L (en) | 1993-06-08 | 1995-01-05 | Oddbjoern Gjelsnes | Device for use in liquid flow cytometry |
US5626767A (en) | 1993-07-02 | 1997-05-06 | Sonosep Biotech Inc. | Acoustic filter for separating and recycling suspended particles |
US5491344A (en) * | 1993-12-01 | 1996-02-13 | Tufts University | Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy |
JPH07286953A (en) * | 1994-04-19 | 1995-10-31 | Toa Medical Electronics Co Ltd | Imaging flow sight meter |
JPH08266891A (en) | 1995-04-03 | 1996-10-15 | Hitachi Ltd | Fine particle handling device |
US5528045A (en) | 1995-04-06 | 1996-06-18 | Becton Dickinson And Company | Particle analyzer with spatially split wavelength filter |
AU6542196A (en) | 1995-06-30 | 1997-02-05 | Biometric Imaging, Inc. | Volumetric cell quantification method and system |
US5798222A (en) | 1995-07-17 | 1998-08-25 | Guava Technologies, Inc. | Apparatus for monitoring substances in organisms |
US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
JP3487699B2 (en) | 1995-11-08 | 2004-01-19 | 株式会社日立製作所 | Ultrasonic treatment method and apparatus |
JP2700058B2 (en) | 1996-01-23 | 1998-01-19 | 工業技術院長 | Non-contact micromanipulation method using ultrasonic waves |
US5688406A (en) | 1996-02-28 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for separating particulate from a flowing fluid |
US5747349A (en) | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
US6221258B1 (en) | 1996-06-14 | 2001-04-24 | Case Western Reserve University | Method and apparatus for acoustically driven media filtration |
DK0925494T3 (en) | 1996-09-04 | 2002-07-01 | Scandinavian Micro Biodevices | Microfluidic system for particle separation and analysis |
US6055859A (en) | 1996-10-01 | 2000-05-02 | Agency Of Industrial Science And Technology | Non-contact micromanipulation method and apparatus |
US5915925A (en) * | 1997-01-07 | 1999-06-29 | North, Jr.; Howard L. | Pulseless liquid supply system for flow cytometry |
GB9708984D0 (en) | 1997-05-03 | 1997-06-25 | Univ Cardiff | Particle manipulation |
US5994089A (en) | 1997-05-16 | 1999-11-30 | Coulter International Corp. | Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry |
US6710871B1 (en) | 1997-06-09 | 2004-03-23 | Guava Technologies, Inc. | Method and apparatus for detecting microparticles in fluid samples |
ZA984976B (en) | 1997-06-11 | 1999-04-19 | Nalco Chemical Co | Solid-state fluorometer and methods of use therefore |
JPH1114533A (en) | 1997-06-19 | 1999-01-22 | Hitachi Ltd | Particulate shape measuring instrument |
US6074879A (en) * | 1997-06-23 | 2000-06-13 | Bayer Corporation | Synthetic polymer particles for use as standards and calibrators in flow cytometry |
US6003388A (en) | 1997-09-17 | 1999-12-21 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | System for manipulating drops and bubbles using acoustic radiation pressure |
US6049380A (en) | 1997-11-12 | 2000-04-11 | Regents Of The University Of California | Single molecule identification using selected fluorescence characteristics |
KR20010041113A (en) | 1998-02-20 | 2001-05-15 | 헤릭호프, 리사 | A vibratory system for a sorting flow cytometer |
US6248590B1 (en) | 1998-02-27 | 2001-06-19 | Cytomation, Inc. | Method and apparatus for flow cytometry |
US6090295A (en) | 1998-08-11 | 2000-07-18 | University Technology Corporation | Method and apparatus for acoustically demixing aqueous solutions |
US6197593B1 (en) * | 1998-10-20 | 2001-03-06 | Coulter International Corp. | Method for enumerating blood cells |
US20010006416A1 (en) | 1999-01-11 | 2001-07-05 | Johnson Paul E. | Ribbon flow cytometry apparatus and methods |
AU1995800A (en) | 1999-01-15 | 2000-08-01 | University College Cardiff Consultants Limited | Particle manipulation |
US6565727B1 (en) | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
US6975400B2 (en) * | 1999-01-25 | 2005-12-13 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
CN1181337C (en) | 2000-08-08 | 2004-12-22 | 清华大学 | Solid molecule operating method in microfluid system |
US6592821B1 (en) | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
US6309886B1 (en) | 1999-06-04 | 2001-10-30 | The Regents Of The University Of California | High throughput analysis of samples in flowing liquid |
DE60040603D1 (en) | 1999-08-17 | 2008-12-04 | Luminex Corp | METHOD FOR ANALYZING A MULTIPLE OF SAMPLES OF VARIOUS ORIGIN ON AN ANALYTE |
US6348687B1 (en) * | 1999-09-10 | 2002-02-19 | Sandia Corporation | Aerodynamic beam generator for large particles |
US6449563B1 (en) | 1999-10-12 | 2002-09-10 | Dispersion Technology, Inc | Method and device for determining particle size distribution and zeta potential in concentrated dispersions |
US6813017B1 (en) | 1999-10-20 | 2004-11-02 | Becton, Dickinson And Company | Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer |
US6263745B1 (en) | 1999-12-03 | 2001-07-24 | Xy, Inc. | Flow cytometer nozzle and flow cytometer sample handling methods |
US6373567B1 (en) * | 1999-12-17 | 2002-04-16 | Micron Optical Systems | Dispersive near-IR Raman spectrometer |
US6549275B1 (en) * | 2000-08-02 | 2003-04-15 | Honeywell International Inc. | Optical detection system for flow cytometry |
US7262838B2 (en) | 2001-06-29 | 2007-08-28 | Honeywell International Inc. | Optical detection system for flow cytometry |
US6784981B1 (en) * | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
CN100495030C (en) * | 2000-09-30 | 2009-06-03 | 清华大学 | Multi-force operator and use thereof |
DE10054382A1 (en) * | 2000-10-27 | 2002-05-08 | Attomol Gmbh Molekulare Diagno | Method and test kit for the detection of analytes in a sample |
DK200001860A (en) * | 2000-12-12 | 2002-06-13 | Ingenioer Et Lytzen As Fa | Apparatus for heat treatment of elongated items |
US6736904B2 (en) | 2001-03-02 | 2004-05-18 | Paper Quality Management Associates | Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid |
SE0103013D0 (en) | 2001-03-09 | 2001-09-12 | Erysave Ab Ideon | System and method of treatment of whole blood |
DE10111392A1 (en) * | 2001-03-09 | 2002-09-12 | Chromeon Gmbh | Bioanalytical measurement method using oxidases |
SE522801C2 (en) | 2001-03-09 | 2004-03-09 | Erysave Ab | Apparatus for separating suspended particles from an ultrasonic fluid and method for such separation |
SE0100820D0 (en) | 2001-03-09 | 2001-03-09 | Erysave Ab Ideon | Particle separation using an acoustic filter |
US6467350B1 (en) | 2001-03-15 | 2002-10-22 | The Regents Of The University Of California | Cylindrical acoustic levitator/concentrator |
DE60218074T2 (en) | 2001-03-29 | 2008-02-07 | Sysmex Corp. | flow cytometer |
US6683314B2 (en) * | 2001-08-28 | 2004-01-27 | Becton, Dickinson And Company | Fluorescence detection instrument with reflective transfer legs for color decimation |
WO2003027027A1 (en) * | 2001-09-25 | 2003-04-03 | P.M.G. Medica Ltd. | System and method for sterilization of a liquid |
US20030059850A1 (en) * | 2001-09-26 | 2003-03-27 | Psychiatric Genomics, Inc. | Fluorescence proximity assay |
US7166443B2 (en) * | 2001-10-11 | 2007-01-23 | Aviva Biosciences Corporation | Methods, compositions, and automated systems for separating rare cells from fluid samples |
DE60237531D1 (en) * | 2001-10-11 | 2010-10-14 | Aviva Biosciences Corp | METHOD FOR DISCONNECTING RARE CELLS FROM FLUID SAMPLES |
US6773556B1 (en) | 2001-10-18 | 2004-08-10 | Seagate Technology Llc | Method for energy barrier equalization of magnetic recording media and media obtained thereby |
US6831279B2 (en) | 2001-11-27 | 2004-12-14 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Laser diode-excited biological particle detection system |
US7018819B2 (en) * | 2001-11-30 | 2006-03-28 | Cellectricon Ab | Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof |
JP4113361B2 (en) | 2002-02-05 | 2008-07-09 | 日立ソフトウエアエンジニアリング株式会社 | Method for producing multilayer semiconductor nanoparticles |
SE0200860D0 (en) | 2002-03-20 | 2002-03-20 | Monica Almqvist | Microfluidic cell and method for sample handling |
WO2004003510A2 (en) | 2002-07-01 | 2004-01-08 | Guava Technologies, Inc. | Fluorescent dyes, energy transfer couples and methods |
GB0221391D0 (en) * | 2002-09-16 | 2002-10-23 | Secr Defence | Apparatus for directing particles in a fluid |
US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
US7108137B2 (en) | 2002-10-02 | 2006-09-19 | Wisconsin Alumni Research Foundation | Method and apparatus for separating particles by size |
GB0223562D0 (en) | 2002-10-10 | 2002-11-20 | Secr Defence | Apparatus for moving particles |
US7161665B2 (en) * | 2002-12-18 | 2007-01-09 | University Of Wyoming | High resolution imaging fountain flow cytometry |
US7047809B2 (en) * | 2003-01-21 | 2006-05-23 | Applied Sonics, Incorporated | Ultrasonic monitor of material composition and particle size |
CA2516481A1 (en) | 2003-02-18 | 2004-09-02 | Board Of Regents, The University Of Texas System | Dielectric particle focusing |
DE602004024874D1 (en) | 2003-03-28 | 2010-02-11 | Inguran Llc | EASTER-ASSORTED TIERSPERMIES |
US7008540B1 (en) * | 2003-04-07 | 2006-03-07 | The Ohio State University | Ultrasonically cleaned membrane filtration system |
US7362432B2 (en) | 2004-01-14 | 2008-04-22 | Luminex Corp. | Method and systems for dynamic range expansion |
KR101147147B1 (en) | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Modified polynucleotides for reducing off-target effects in rna interference |
US7477363B2 (en) | 2004-04-08 | 2009-01-13 | Nihon Kohden Corporation | Flow cytometer |
US7340957B2 (en) * | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
US20060034733A1 (en) | 2004-08-16 | 2006-02-16 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Separation of particles from a fluid by wave action |
WO2006034046A2 (en) | 2004-09-17 | 2006-03-30 | The Regents Of The University Of Michigan | Quantitative two-photon flow cytometry |
US7392908B2 (en) | 2005-01-12 | 2008-07-01 | Beckman Coulter, Inc. | Methods and apparatus for sorting particles hydraulically |
US7113266B1 (en) | 2005-03-30 | 2006-09-26 | Beckman Coulter, Inc. | Flow cytometer for differentiating small particles in suspension |
US7403125B2 (en) * | 2005-05-06 | 2008-07-22 | Accuri Cytometers, Inc. | Flow cytometry system with bubble detection |
JP4756948B2 (en) | 2005-08-08 | 2011-08-24 | ベイバイオサイエンス株式会社 | Flow cytometer and flow cytometry method |
US8173413B2 (en) * | 2005-08-11 | 2012-05-08 | University Of Washington | Separation and concentration of biological cells and biological particles using a one-dimensional channel |
US8264683B2 (en) | 2005-09-14 | 2012-09-11 | University Of Washington | Dynamic characterization of particles with flow cytometry |
US7804595B2 (en) * | 2005-09-14 | 2010-09-28 | University Of Washington | Using optical scattering to measure properties of ultrasound contrast agent shells |
US20070071683A1 (en) * | 2005-09-27 | 2007-03-29 | The Regents Of The University Of California | Ultrasonic concentration of carrier particles |
DE102005050167B4 (en) | 2005-10-19 | 2009-02-19 | Advalytix Ag | Concentration method, concentration apparatus and reaction method |
US7340951B2 (en) * | 2005-11-04 | 2008-03-11 | David S. Nyce | Distributed impedance sensor |
US7484414B2 (en) | 2005-11-30 | 2009-02-03 | Nanoalert Ltd. | Method and apparatus for determination of the concentration of particles in multi-component fluid systems |
AU2006335689A1 (en) | 2006-01-20 | 2007-07-26 | Agency For Science, Technology And Research | Biosensor |
WO2007128795A2 (en) * | 2006-05-05 | 2007-11-15 | Erysave Ab | Method for separation |
US7570676B2 (en) * | 2006-05-09 | 2009-08-04 | Spectralus Corporation | Compact efficient and robust ultraviolet solid-state laser sources based on nonlinear frequency conversion in periodically poled materials |
US8075786B2 (en) | 2006-09-05 | 2011-12-13 | The Board Of Regents Of The University Of Oklahoma | Acoustic/pressure wave-driven separation device |
US7835000B2 (en) * | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
ATE538377T1 (en) * | 2007-04-02 | 2012-01-15 | Acoustic Cytometry Systems Inc | METHOD FOR IMPROVED ANALYSIS OF CELLS AND PARTICLES FOCUSED IN AN ACOUSTIC FIELD |
US7837040B2 (en) * | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
US8083068B2 (en) | 2007-04-09 | 2011-12-27 | Los Alamos National Security, Llc | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
US8528406B2 (en) | 2007-10-24 | 2013-09-10 | Los Alamos National Security, LLP | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8263407B2 (en) | 2007-10-24 | 2012-09-11 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8266951B2 (en) * | 2007-12-19 | 2012-09-18 | Los Alamos National Security, Llc | Particle analysis in an acoustic cytometer |
US8714014B2 (en) * | 2008-01-16 | 2014-05-06 | Life Technologies Corporation | System and method for acoustic focusing hardware and implementations |
US7983189B2 (en) * | 2008-03-12 | 2011-07-19 | Embarq Holdings Company, Llc | System and method for tracking performance and service level agreement compliance for multipoint packet services |
US20100009333A1 (en) * | 2008-07-08 | 2010-01-14 | Beckman Coulter, Inc. | Methods for Acoustic Particle Focusing in Biological Sample Analyzers |
JP4679620B2 (en) * | 2008-09-25 | 2011-04-27 | 株式会社東芝 | Template inspection method and defect inspection apparatus |
AU2010326180B2 (en) | 2009-12-04 | 2015-06-18 | Life Technologies Corporation | Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry |
-
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9134271B2 (en) | 2007-04-02 | 2015-09-15 | Life Technologies Corporation | Particle quantifying systems and methods using acoustic radiation pressure |
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