WO2008138553A8 - System and method for analyte measurement using a nonlinear sample response - Google Patents

System and method for analyte measurement using a nonlinear sample response Download PDF

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Publication number
WO2008138553A8
WO2008138553A8 PCT/EP2008/003732 EP2008003732W WO2008138553A8 WO 2008138553 A8 WO2008138553 A8 WO 2008138553A8 EP 2008003732 W EP2008003732 W EP 2008003732W WO 2008138553 A8 WO2008138553 A8 WO 2008138553A8
Authority
WO
WIPO (PCT)
Prior art keywords
current response
component
methods
sample
linear component
Prior art date
Application number
PCT/EP2008/003732
Other languages
French (fr)
Other versions
WO2008138553A1 (en
Inventor
Harvey B. Buck
Original Assignee
Roche Diagnostics Gmbh
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, F. Hoffmann-La Roche Ag filed Critical Roche Diagnostics Gmbh
Priority to CN200880015027A priority Critical patent/CN101675338A/en
Priority to CA002686185A priority patent/CA2686185A1/en
Priority to JP2010506857A priority patent/JP2010526308A/en
Priority to EP08758428A priority patent/EP2147306A1/en
Publication of WO2008138553A1 publication Critical patent/WO2008138553A1/en
Publication of WO2008138553A8 publication Critical patent/WO2008138553A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/49—Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material

Abstract

The systems and methods of the present invention utilize a linear component of a non-linear, Faradaic current response generated by a biological fluid sample when an AC excitation potential sufficient to produce such a Faradaic current response is applied to the sample, in order to calculate the concentration of a medically significant component in the biological fluid sample. The current response is created by the excitation of electrochemical processes within the sample by the applied potential. Typically, the linear component of the current response to an applied AC potential contains phase angle and/or admittance information that may be correlated to the concentration of the medically significant component. Also typically, the fundamental linear component of the current response is utilized in the disclosed systems and methods. Harmonics of the fundamental linear component may also be used. Other methods and devices are disclosed.
PCT/EP2008/003732 2007-05-09 2008-05-09 System and method for analyte measurement using a nonlinear sample response WO2008138553A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN200880015027A CN101675338A (en) 2007-05-09 2008-05-09 System and method for analyte measurement using a nonlinear sample response
CA002686185A CA2686185A1 (en) 2007-05-09 2008-05-09 System and method for analyte measurement using a nonlinear sample response
JP2010506857A JP2010526308A (en) 2007-05-09 2008-05-09 System and method for analyte measurement using nonlinear sample response
EP08758428A EP2147306A1 (en) 2007-05-09 2008-05-09 System and method for analyte measurement using a nonlinear sample response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/746,465 2007-05-09
US11/746,465 US20070264721A1 (en) 2003-10-17 2007-05-09 System and method for analyte measurement using a nonlinear sample response

Publications (2)

Publication Number Publication Date
WO2008138553A1 WO2008138553A1 (en) 2008-11-20
WO2008138553A8 true WO2008138553A8 (en) 2010-06-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/003732 WO2008138553A1 (en) 2007-05-09 2008-05-09 System and method for analyte measurement using a nonlinear sample response

Country Status (7)

Country Link
US (1) US20070264721A1 (en)
EP (1) EP2147306A1 (en)
JP (1) JP2010526308A (en)
KR (1) KR20100005209A (en)
CN (1) CN101675338A (en)
CA (1) CA2686185A1 (en)
WO (1) WO2008138553A1 (en)

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Also Published As

Publication number Publication date
CA2686185A1 (en) 2008-11-20
EP2147306A1 (en) 2010-01-27
JP2010526308A (en) 2010-07-29
US20070264721A1 (en) 2007-11-15
WO2008138553A1 (en) 2008-11-20
KR20100005209A (en) 2010-01-14
CN101675338A (en) 2010-03-17

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