WO2008154033A4 - Cardiac patterning for improving diastolic function - Google Patents
Cardiac patterning for improving diastolic function Download PDFInfo
- Publication number
- WO2008154033A4 WO2008154033A4 PCT/US2008/007351 US2008007351W WO2008154033A4 WO 2008154033 A4 WO2008154033 A4 WO 2008154033A4 US 2008007351 W US2008007351 W US 2008007351W WO 2008154033 A4 WO2008154033 A4 WO 2008154033A4
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- WO
- WIPO (PCT)
- Prior art keywords
- agent
- heart
- therapeutically effective
- injection
- elastic property
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2478—Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
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- A—HUMAN NECESSITIES
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
- A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
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- A—HUMAN NECESSITIES
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/2478—Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
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- A61B2017/00238—Type of minimally invasive operation
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- A—HUMAN NECESSITIES
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- A61F2/2478—Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
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Abstract
Cardiomyopathy may be treated by distributing a space-occupying diastole- assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space- modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
Claims
received by the International Bureau on 13 March 2009 (13.03.2009) introducing a biocompatible occluding agent into the segments ot tne cardiac venous system in a therapeutically effective amount to establish respective therapeutically beneficial structural members therein for thickening and strengthening the myocardium of the heart in accordance with the pattern, the structural members having an elastic property.
13. Use of a biocompatible space-occupying agent having an elastic property and comprising non-living material, in the manufacture of an agent for injection into a myocardial wall of a dilated chamber of a heart of a patient for improving diastolic function of the heart, the space-occupying agent being therapeutically effective, on injection in therapeutically effective amounts into a plurality of sites disposed in a therapeutically effective pattern within the myocardial wall of the dilated chamber, for thickening the myocardial wall and for expressing the elastic property by storing potential energy during systole and releasing the potential energy as kinetic energy during diastole.
14. Use of a biocompatible space-occupying agent having an elastic property and comprising non-living material, in the manufacture of an agent for injection into a myocardial wall of a ventricle of a heart of a patient for improving diastolic function of the heart, the space-occupying agent being therapeutically effective, on injection in therapeutically effective amounts into a plurality of sites disposed in a therapeutically effective pattern within and across a major portion of the myocardial wall of the ventricle, for thickening the myocardial wall and for expressing the elastic property by storing potential energy during systole and releasing the potential energy as kinetic energy during diastole.
15. Use of a biocompatible occluding agent having an elastic property and comprising non-living material, in the manufacture of an agent for injection into a cardiac venous system of a heart of a patient for improving diastolic function of the heart, the occluding agent being therapeutically effective, on injection in a therapeutically effective amount into a segment of the cardiac venous system, for forming a structural member to thicken and strengthen a myocardial wall of the heart and to express the elastic property by storing potential energy during systole and releasing the potential energy as kinetic energy during diastole.
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16. Use of a biocompatible occluding agent having an elastic property and comprising non-living material, in the manufacture of an agent for injection into a cardiac venous system of a heart of a patient for improving diastolic function of the heart, the occluding agent being therapeutically effective, on injection in therapeutically effective amounts into a plurality of segments of the cardiac venous system disposed in a therapeutically effective pattern across a major portion of a wall of a chamber of the heart, for forming a plurality of structural members to thicken and strengthen the chamber wall and to express the elastic property by storing potential energy during systole and releasing the potential energy as kinetic energy during diastole.
55
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93410907P | 2007-06-11 | 2007-06-11 | |
US93406907P | 2007-06-11 | 2007-06-11 | |
US93404207P | 2007-06-11 | 2007-06-11 | |
US93411107P | 2007-06-11 | 2007-06-11 | |
US60/934,111 | 2007-06-11 | ||
US60/934,109 | 2007-06-11 | ||
US60/934,042 | 2007-06-11 | ||
US60/934,069 | 2007-06-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008154033A2 WO2008154033A2 (en) | 2008-12-18 |
WO2008154033A3 WO2008154033A3 (en) | 2009-03-05 |
WO2008154033A4 true WO2008154033A4 (en) | 2009-04-30 |
Family
ID=40130418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/007351 WO2008154033A2 (en) | 2007-06-11 | 2008-06-11 | Cardiac patterning for improving diastolic function |
Country Status (2)
Country | Link |
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US (2) | US20090012413A1 (en) |
WO (1) | WO2008154033A2 (en) |
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-
2008
- 2008-06-11 WO PCT/US2008/007351 patent/WO2008154033A2/en active Application Filing
- 2008-06-11 US US12/157,711 patent/US20090012413A1/en not_active Abandoned
-
2013
- 2013-01-15 US US13/742,322 patent/US20130211182A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2008154033A2 (en) | 2008-12-18 |
WO2008154033A3 (en) | 2009-03-05 |
US20130211182A1 (en) | 2013-08-15 |
US20090012413A1 (en) | 2009-01-08 |
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